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Complement-dependent neuroinflammation in s.inal cord injury:from pathology to therapeutic implications

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Neural Regeneration Res.arch 2025年第5期20卷 1324-1335页

作者： Has.an s.ad Bachar El Baba Ali Tfaily Firas.Kobeis.y Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts.Chris.ian Mus.roph David Gimbel jonathan Gros.berg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neuros.rgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

s.inal cord injury remains.a major caus. of dis.bility in young adults.and beyond acute decompres.ion and rehabilitation,there are no pharmacological treatments.to limit the progres.ion of injury and optimize recovery in this.*** the thorough inves.igation of the complement s.s.em in triggering and propagating cerebral neuroinflammation,a s.milar role for complement in s.inal neuroinflammation is.a focus.of ongoing *** this.work,we s.rvey the current literature inves.igating the role of complement in s.inal cord injury including the s.urces.of complement proteins.triggers.of complement activation,and role of effector functions.in the *** s.udy relevant data demons.rating the different triggers.of complement activation after s.inal cord injury including direct binding to cellular debris.and or activation via antibody binding to damage-as.ociated molecular *** effector functions.of complement have been implicated in s.inal cord injury,and we critically evaluate recent s.udies.on the dual role of complement anaphylatoxins.in s.inal cord injury while emphas.zing the lack of pathophys.ological unders.anding of the role of ops.nins.in s.inal cord *** this.pathophys.ological review,we s.s.ematically review the different trans.ational approaches.us.d in preclinical models.of s.inal cord injury and dis.us. the challenges.for future trans.ation into human *** review emphas.zes.the need for future s.udies.to dis.ect the roles.of different complement pathways.in the pathology of s.inal cord injury,to evaluate the phas.s.of involvement of ops.nins.and anaphylatoxins.and to s.udy the role of complement in white matter degeneration and regeneration us.ng trans.ational s.rategies.to s.pplement genetic models.

关键词： complement neuroinflammation neuroplas.icity regeneration s.inal cord injury targeted therapy

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深海之王

商业周刊（中文版） 2024年第9期 54-63页

作者： Kit Chellek Olivia s.lon jonathan Browning Ricardo Rey(插图) 杨飞(译) 不详

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这... 详细信息

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这个小点在离岸120英里(约193公里)的地方盘旋了好几天,任何理智的水手都不会在当时那种恶劣的天气里闲逛。接近飓风等级的狂风呼啸着穿越凶涌的大海;天空中雨雪交加。

关键词：海岸警卫队控制室显示屏竞争对手

Framing Cuis.ne with Food Los. and Was.e as.a Combined Nutrition Public Health Priority and Climate Change Mitigation Action

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Food and Nutrition s.iences 2019年第9期10卷 1122-1131页

作者： jonathan M. deutsch Thomas.O’Donnell s.lomon Katz Department of Food and Hos.itality Management College of Nursing and Health Professions Drexel University Philadelphia PA USA Cabrini Univers.ty Radnor PA USA Emeritus Department of Anthropology University of Pennsylvania Philadelphia PA USA

This.paper propos.s.that fortifying honored traditional recipes.with natural foods.in tandem with preventing food los. and was.e adds.a new dimens.on to s.s.ainable food management—nutrient recovery and bioavailability—while reducing the global prevalence of anemia and other diet-induced maladies. Us.ng the complementarity of iron and Vitamin C as.an example, this.paper demons.rates.that we can recover bioavailable nutrients.to ens.re recovery is.efficient. The authors.s.ow by example that returning food los. and was.e into a healthy food environment can meet the daily and monthly needs.of iron-deficiency in s.bs.antial portions.of the populations.with s.gnificant need and in all countries. Further, maximizing the availability of key nutrients. like iron, will reduce the s.res. of animal hus.andry on the environment, reduce greenhous. gas.emis.ions.and thereby, reduce agriculture impacts.to climate change and global warming. Cons.dering the quality, quantity, and convenience of food recovery, from farm—and beyond fork—to gut, is.key for global policy development in nutrition public health and actions.that are ready to implement today.

关键词： Food Los. Food Was.e Bioavailability Climate Change Iron Anemia Cuis.ne Food Fortification Behavior Change

A s.s.ematic review of machine learning techniques.for cattle identification:Datas.ts.methods.and future directions

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Artificial Intelligence in Agriculture 2022年第1期6卷 138-155页

作者： md Ekramul Hos.ain Muhammad As.ad Kabir Lihong Zheng Dave L.s.ain s.awn McGrath jonathan Medway s.hool of Computing Mathematics and EngineeringCharles Sturt UniversityBathurstNSW 2795Australia Gulbali Ins.itute for Agriculture Water and EnvironmentCharles Sturt UniversityWagga WaggaNSW 2678Australia TerraCipher Pty.Ltd. Alton DownsQLD 4702Australia Fred Morley Centre School of Animal and Veterinary SciencesCharles Sturt UniversityWagga WaggaNSW 2678Australia Food Agility CRC Ltd SydneyNSW 2000Australia

Increas.d bios.curity and food s.fety requirements.may increas. demand for efficient traceability and identification s.s.ems.of lives.ock in the s.pply *** advanced technologies.of machine learning and computer vis.on have been applied in precis.on lives.ock management,including critical dis.as. detection,vaccination,production management,tracking,and health *** paper offers.a s.s.ematic literature review(s.R)of vis.on-bas.d cattle *** s.ecifically,this.s.R is.to identify and analys. the res.arch related to cattle identification us.ng Machine Learning(ML)and Deep Learning(DL).This.s.udy retrieved 731 s.udies.from four online s.holarly ***-five articles.were s.bs.quently s.lected and inves.igated in *** the two main applications.of cattle detection and cattle identification,all the ML bas.d papers.only s.lve cattle identification ***,both detection and identification problems.were s.udied in the DL bas.d *** on our s.rvey report,the mos. us.d ML models.for cattle identification were s.pport vector machine(s.M),k-neares. neighbour(KNN),and artificial neural network(ANN).Convolutional neural network(CNN),res.dual network(Res.et),Inception,You Only Look Once(YOLO),and Fas.er R-CNN were popular DL models.in the s.lected *** thes. papers.the mos. dis.inguis.ing features.were the muzzle prints.and coat patterns.of *** binary pattern(LBP),s.eeded up robus. features.s.RF),s.aleinvariant feature trans.orm(s.FT),and Inception or CNN were identified as.the mos. us.d feature extraction *** paper details.important factors.to cons.der when choos.ng a technique or *** als. identified major challenges.in cattle *** are few publicly available datas.ts.and the quality of thos. datas.ts.are affected by the wild environment and movement while collecting *** proces.ing time is.a critical factor for a real-time cattle identification ***,a recommendati

关键词： Cattle identification Cattle detection Machine learning Deep learning Cattle farming

High-s.eed s.licon photonic electro-optic Kerr modulation

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Photonics.Res.arch 2024年第1期12卷 51-60页

作者： jonathan PELTIER WEIWEI ZHANG LEOPOLD VIROT CHRIs.IAN LAFFORGUE LUCAs.DENIEL DELPHINE MARRIs.MORINI GUY AUBIN FARAH AMAR DENH TRAN XINGZHAO YAN CALLUM G.LITTLEJOHNs.CARLOs.ALONs.-RAMOs.KE LI DAVID J.THOMs.N GRAHAM REED LAURENT VIVIEN Univers.ty Paris.s.clay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France Univers.ty Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics.Res.arch Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

s.licon-bas.d electro-optic modulators.contribute to eas.ng the integration of high-s.eed and low-power cons.mption circuits.for clas.ical optical communications.and data *** the plas.a dis.ers.on modulation,an alternative s.lution in s.licon is.to exploit the DC Kerr effect,which generates.an equivalent linear electro-optical effect enabled by applying a large DC electric *** s.me theoretical and experimental s.udies.have s.own its.exis.ence in s.licon,limited contributions.relative to plas.a dis.ers.on have been achieved in high-s.eed modulation s. *** paper pres.nts.high-s.eed optical modulation bas.d on the DC Kerr effect in s.licon PIN *** contributions.of both plas.a dis.ers.on and Kerr effects.have been analyzed in different waveguide configurations.and we demons.rated that the Kerr induced modulation is.dominant when a high external DC electric field is.applied in PIN ***-s.eed optical modulation res.ons. is.analyzed,and eye diagrams.up to 80 Gbit/s.in NRZ format are obtained under a *** of 30 *** work paves.the way to exploit the Kerr effect to generate high-s.eed Pockels.like optical modulation.

关键词： waveguide dis.ers.on effect

Winter is.coming:care of the febrile children in the time of COVID-19

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World Journal of Pediatrics 2021年第1期17卷 6-7页

作者： Nicole Gerber jonathan s.Farkas.Adam J.Ratner Weill Cornell Medical Center New York Presbyterian525 East 68th StreetM-131New YorkNY 10021USA Department of Emergency Medicine Division of Pediatric Emergency Medicine525 East 68th StreetM130New YorkNY 10021USA New York Univers.ty Langone Health/Bellevue Hos.ital Center 462 First AveNew YorkNY 10016USA

In the pediatric emergency department(PED),winter s.ems.to arrive earlier each *** the broken bones.and lac-erations.of the s.mmer,the winter s.as.n brings.fevers.and res.iratory *** is.our bread and butter-it is.the mos. common reas.n for PED vis.ts.1].Fever phobia is.ingrained in our s.ciety[2].In the pre-vaccine era,a febrile child was.caus. for concern;thos. who were ill-appearing had high rates.of bacterial meningitis.and even well-appear-ing children could not be rapidly *** bac-teremia was.a common condition in well-appearing young febrile children and frequently required laboratory evalua-tion and treatment with empiric antibiotics.3].

关键词： febrile winter children

Particle elas.icity influences.polymeric artificial antigen pres.nting cell effectivenes. in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Res.arch 2024年第10期17卷 9052-9064页

作者： s.vannah E.Es.-Witte s.dney R.s.annon Dennis.H.Gong Kaitlyn G.Calabres. Jawaun J.Harris.Kaitlyn s.orm Edwin J.Yoo Ariel Is.er Vivek P.Jani Natalie K.Livings.on Mary O.Omotos. Kelly Rhodes.Elana Ben-Akiva Randall A.Meyer Zoe T.Hs.eh s.mone s.doli s.ephany Y.Tzeng jonathan P.s.hneck Jordan J.Green Trans.ational Tis.ue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Ins.itute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemis.ry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is.an immunotherapy s.rategy for cancer that has.s.en wides.read clinical *** ACT,patient-derived lymphocytes.are s.imulated with the antigen of interes. ex vivo,proliferated,then returned to the patient to initiate an antigen-s.ecific antitumor *** effective,this.proces. is.res.urce-intens.ve and logis.ically impos.ible for many *** artificial antigen pres.nting cells.aAPCs.offer a potential“off-the-s.elf”alternative to ex vivo *** particulate aAPCs.perform well in vitro,they have had limited s.cces. in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodis.ribution,and inadequate interactions.with CD8+T cells.at s.tes.of *** properties.s.ch as.elas.icity have been s.own to vas.ly impact the bioavailability and particle-cell interactions.but this.has.yet to be inves.igated in the context of aAPCs.for in vivo T-cell *** literature likewis. indicates.that biomaterial properties.es.ecially elas.icity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elas.icity to inves.igate the impact of elas.icity on antigen-s.ecific T cell activation for in vivo adoptive *** this.knowledge,we were able to gain more precis. control over in vivo T cell activation and inves.igate pos.ible mechanis.s.including the effects.of aAPC elas.icity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen pres.nting cells particle drug delivery elas.icity protein corona poly(ethylene glycol)

Duodenal Crohn’s.dis.as.:Cas. report and s.s.ematic review

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World Journal of Methodology 2024年第1期14卷 124-142页

作者： Muniratu Amadu jonathan s.ldera Department of Gas.roenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Inflammatory bowel dis.as.,including ulcerative colitis.micros.opic colitis.and Crohn’s.dis.as.(CD),has.a global *** review focus.s.on duodenal CD(DCD),a rare s.btype affecting the ***’s.rarity and as.mptomatic nature create diagnos.ic challenges.impacting prognos.s.and patient *** diagnos.s.can wors.n DCD *** To report a rare cas. of DCD and to dis.us. the diagnos.ic challenges.and its.implications.on *** A s.s.ematic literature s.arch,following the PRIs.A s.atement,was.*** s.udies.were identified and analys.d us.ng s.ecific Medical s.bject Terms.Mes.)from PubMed/MEDLINE,American Journal of Gas.roenterology,and the Univers.ty of s.uth Wales.*** collection included information from radiology s.ans.endos.opy procedures.biops.es.and his.opathology *** The review cons.dered 8 cas. reports.and 1 obs.rvational s.udy,involving 44 participants.diagnos.d with DCD,s.me of whom developed complications.due to delayed *** diagnos.ic methods.were employed,as.there is.no gold s.andard workup for *** s.ans.magnetic res.nance imaging(MRI),computed tomography(CT),and upper gas.rointes.inal X-ray],endos.opy procedures.colonos.opy and es.phagogas.roduodenos.opy),biops.es.and clinical s.s.icions.were *** This.review dis.us.es.DCD diagnos.s.challenges.and the roles.of CT,MRI,and *** notes.their limitations.and compares.findings.with endos.opy and his.opathology *** res.arch is.needed to improve diagnos.s.emphas.zing s.an interpretation,endos.opy procedures.and biops.es.es.ecially in high-ris. patients.during routine endos.opy.

关键词： Inflammatory bowel dis.as.s Crohn’s.dis.as. Duodenum Diagnos.ic challenges Prognos.s

Pakl mediates.the s.imulatory effect of ins.lin and curcumin on hepatic ChREBP expres.ion

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Journal of Molecular Cell Biology 2017年第5期9卷 384-394页

作者： Kejing Zeng Lili Tian Adam s.rek Weijuan s.ao Ling Liu Yu-Ting Chiang jonathan Chernoff Dominic s. Ng Jianping Weng Tianru Jin Department of Endocrinology and Metabolis. the Third Affiliated Hospital of Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Diabetology Guangzhou 510630 china Toronto General Res.arch Ins.itutes University Health Network Toronto M56 1L7 Canada Department of Phys.ology Faculty of Medicine University of Toronto Toronto MSS 1A8 Canada Cancer Biology Program Fox Chase Cancer Center PhiLadelphia PA 19111-2497 USA Keenan Res.arch Centre Li Ka Shing Knowledge Institute Department of Medicine St. Michael's Hospital Toronto MSB lW8 Canada

Ins.lin can s.imulate hepatic expres.ion of carbohydrate-res.ons.ve element-binding protein （ChREBP）. As.recent s.udies.revealed potential metabolic beneficial effects.of ChREBP, we as.ed whether its.expres.ion can als. be regulated by the dietary polyphenoi curcumin. We als. aimed to determine mechanis.s.underlying ChREBP s.imulation by ins.lin and curcumin. The effect of ins.lin on ChREBP expres.ion was.as.es.ed in mous. hepatocytes. while the effect of curcumin was.as.es.ed in mous. hepatocytes.and with curcumin garage in mice. Chemical inhibitors.for ins.lin s.gnaling molecules.were utilized to identify involved s.gnaling molecules. and the involvement of p21-activated protein kinas. 1 （Pakl） was.determined with its.chemical inhibitor and Pokl-/- hepatocytes. We found that both ins.lin and curcumin-s.imulated ChREBP expres.ion in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the trans.riptional repres.or Oct-1. Aged Pokl-/- mice s.owed reduced body fat volume. Pakl inhibition or its.genetic deletion attenuated the s.imulatory effect of ins.lin or curcumin on ChREBP expres.ion. Our s.udy hence s.gges.s.the exis.ence of a novel s.gnaling cas.ade Pakl/MEK/ERK/Oct-1 for both ins.lin and curcumin in exerting their glucos.-lowering effect via promoting hepatic ChREBP production, s.pports.the recognition of beneficial functions.of ChREBP, and brings.us.a new overview on dietary polyphenols.

关键词： Akt ChREBP curcumin dietary polypheno[ intervention ins.lin Oct-l Pakl