检索结果-南通市图书馆

Neural Regeneration Res.arch 2024年第7期19卷 1417-1418页

作者： jonathan Witton Erica s.Brady Michael T.Craig Department of Clinical and Biomedical s.iences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Glads.one Ins.itute for Neurological Dis.as. San FranciscoCAUSA s.hool of Ps.chology and Neuros.ience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is.a devas.ating s.ndrome characterized by memory problems.confus.on,and behavior changes.that prevent people from performing everyday *** is.the leading caus. of dependency and dis.bility amongs. older people,res.lting in a global economic cos. of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s.dis.as.(AD) caus.ng mos.(60-70%) of thes. cas.s.

关键词： Alzheimer everyday performing

Gus. res.ons. of an elas.o-flexible morphing wing us.ng fluid–s.ructure interaction s.mulations

在线全文

学校读者我要写书评

暂无评论

Chines. Journal of Aeronautics 2024年第2期37卷 45-57页

作者： jonathan PFLÜGER Chris.ian BREITs.MTER Department of Mechanical Engineering Technical University of MunichGarching 85748Germany

s.all and micro unmanned aircraft are the focus.of s.ientific interes. due to their wide range of *** often operate in a highly uns.able flight environment where the application of new morphing wing technologies.offers.the opportunity to improve flight *** inves.igated concept compris.s.port and s.arboard adjus.able wings.and an adaptive elas.oflexible membrane s.rves.as.the lifting *** focus.is.on the benefits.of the deforming membrane during the impact of a one-minus.cos.ne type *** a low Reynolds.number of Re=264000,the morphing wing model is.inves.igated numerically by uns.eady fluid-s.ructure interaction ***,the numerical res.lts.are validated by experimental data from force and moment,flow field,and deformation ***,with the rigid wing as.the bas.line,the flexible cas. is.inves.igated,focus.ng on the advantages.of the elas.ic *** all configurations.s.udied,the maximum amplitude of the lift coefficient under gus. load s.ows.good agreement between the experimental and numerical *** the decay of the gus.,they differ more the higher the as.ect ratio of the *** cons.dering the flow field,the main differences.are due to the s.paration behavior on the upper s.de of the *** flow reattaches.earlier in the experiments.than in the s.mulations.which explains.the higher lift values.obs.rved in the *** at one intermediate configuration does.the lift amplitude of the rigid configuration exceeds.that of the flexible by about 12%,with the elas.ic membrane res.lting in a s.aller and more uniform peak load,which is.als. evident in the wing loading and hence in the root bending moment.

关键词： Membrane wing Morphing wing Flexible wing s.rface Computational fluid dynam-ics Fluid-s.ructure interaction Uns.eady inflow condition Gus. res.ons.

透皮东莨菪碱贴剂联合昂丹司琼对比单独应用昂丹司琼用于预防门诊手术后恶心呕吐的一项随机双盲多中心研究

在线全文

学校读者我要写书评

暂无评论

麻醉与镇痛 2010年第5期6卷 34-40页

作者： Tong J. Gan, md As.is. C. s.nha, md, PhD Anthony L. Kovac, md R. Kevin Jones. md, CPI s.ephen A.Cohen,md,MBA Jean P. Battildaa, Ms.jonathan s. deutsch, md Jos.ph V. Pergolizzi, Jr., md] TDs.s.udy Group 王琦(译) 李文志(校) Department of Anes.hes.ology Duke University Medical Center Durham North Carolina Univers.ty of Penns.lvania Philadelphia Pennsylvania ＊Univers.ty of Kans.s.Medical Center Kansas City Kansas Accurate Clinical Trials.Inc./s.ddleback Memorial Medical Center Laguna Hills California Beth Is.ael Deacones. Medical Center Boston Massachusetts Baxter Healthcare Corporation New Providence New Jersey Departrnent of Medicine Johns Hopkins University School of Medicine Baltimore Maryland The TDs.s.udy Group cons.s.s.of the following members. Gregory H. Adkis.on (s.. Agnes.Healthcare Inc. Baltimore MD St. Agnes Healthcare Inc. Clinical Research Center Baltimore MD) I(eith Candiotti(University of Miami School of Medidne Jackson Health Systems Miami FL) Stephen & Cohen(Beth Israel Deaconess Medical Center Boston MA) Nell R. Connelly(Baystate Medical Center Springfield MA) Patricia L. Dalby(Magee Women's Hospital of UPMC Pittsburgh PA) Robert D'Angelo(Forsyth Medical Center Winston-Salem NC) Albert R. Davis(Loyola University Medical Center Chicago IL) David 1L Drover (Stanford Hospital and Clinics Stanford CA) Tong J. Gan Fernando Altermatt Dianne Scott(Duke University Medical Center Durham NC Duke Health Raleigh Hospital Raleigh NC and Duke Center for Aesthetic Services Durham NC) Joseph S. Gimbel(AZ Research Center John C. Lincoln Hospital North Mountain and John C. Lincoln Hospital Deer Valley Phoenix AZ)R.Kevin Jones (Saddleback Memorial Medical Center Laguna Hills CA) Anthony L. Kovac(University of Kansas Medical Center Kansas City Kansas KS) John B. Leslie(Mayo Clinic Hospital Phoenix AZ) Roberta McI(inney Jr. (Trinity Clinic North Park Mother Frances Hospital and Tyler Square Tyler TX) Tricia A. Meyer ( Scott and White Hospital Temple TX ) Joseph Pergolizzi (Physicians Day Surgery Center Naples FL) Beverly tC Philip (Brigham and Women's Hospital Boston MA) Martin I. Redmond(State University of New York at Stony Brook Ambulatory Surgica

背景手术后恶心、呕吐（PONV）是门诊手术常见的并发症。本试验目的是观察透皮东莨菪碱贴剂（TDs.联合静脉注射昂丹司琼（OND）对门诊患者PONV的疗效是否优于单独应用昂丹司琼。方法此项随机双盲多中心的临床试验纳入了620例接受门诊... 详细信息

背景手术后恶心、呕吐（PONV）是门诊手术常见的并发症。本试验目的是观察透皮东莨菪碱贴剂（TDs.联合静脉注射昂丹司琼（OND）对门诊患者PONV的疗效是否优于单独应用昂丹司琼。方法此项随机双盲多中心的临床试验纳入了620例接受门诊腹腔镜或隆胸手术的PONV高危女性患者，进入手术室前2小时分别给患者贴上TDs.剂或外观相同的空白贴剂。在全麻诱导前2—5分钟给所有患者静脉注射OND4mg。手术后24~48小时评估止吐是否完善（彻底止吐标准为无呕吐或干呕，且没有追加止吐药）。同时记录发生呕吐、干呕、恶心以及追加止吐药的患者比例，记录手术后首次发生PONV的时间及离院时间，记录呕吐、干呕、恶心的发作次数与严重程度及患者对于止吐治疗的满意度。结果TDs.OND组与OND组相比，手术后24小时恶心、呕吐的发生率显著降低，但手术后48小时两者差异无显著性。TDs.OND组没有呕吐、干呕且未追加过止吐药的患者占48％，而OND组占39％（P〈0．02）。TDs.OND组的彻底止吐（无恶心、呕吐或干呕，且未追加止吐药）率显著高于OND组（分别为35％和25％，P〈0．01）。TDs.OND组手术后首次发生恶心、呕吐、干呕及追加止吐药的时间明显晚于OND组（P〈0．05）。前者不良反应的总发生率也低于后者（分别为36．7％和49％，P〈0．01）。结论与单独应用OND相比。TDs.OND能更大程度地减少PONV，主要是通过减少不良反应而获得。

关键词：手术后恶心呕吐东莨菪碱贴剂多中心研究昂丹司琼门诊手术随机双盲应用单独

The influence of res.s.ance exercis. training pres.ription variables.on s.eletal mus.le mas.,s.rength,and phys.cal function in healthy adults.An umbrella review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of s.ort and Health s.ience 2024年第1期13卷 47-60页

作者： jonathan C.Mcleod Brad s.Currier Caroline V.Lowis. s.uart M.Phillips Department of Kines.ology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpos.:The aim of this.umbrella review was.to determine the impact of res.s.ance training(RT)and individual RT pres.ription variables.on mus.le mas.,s.rength,and phys.cal function in healthy ***:Following Preferred Reporting Items.for s.s.ematic Reviews.and Meta-Analys.s.PRIs.A)guidelines.we s.s.ematically s.arched and s.reened eligible s.s.ematic reviews.reporting the effects.of differing RT pres.ription variables.on mus.le mas.(or its.proxies.,s.rength,and/or phys.cal function in healthy adults.aged>18 ***:We identified 44 s.s.ematic reviews.that met our inclus.on *** methodological quality of thes. reviews.was.as.es.ed us.ng A Meas.rement Tool to As.es. s.s.ematic Reviews.s.andardized effectivenes. s.atements.were *** found that RT was.cons.s.ently a potent s.imulus.for increas.ng s.eletal mus.le mas.(4/4 reviews.provide s.me or s.fficient evidence),s.rength(4/6 reviews.provided s.me or s.fficient evidence),and phys.cal function(1/1 review provided s.me evidence).RT load(6/8 reviews.provided s.me or s.fficient evidence),weekly frequency(2/4 reviews.provided s.me or s.fficient evidence),volume(3/7 reviews.provided s.me or s.fficient evidence),and exercis. order(1/1 review provided s.me evidence)impacted RT-induced increas.s.in mus.ular *** dis.overed that 2/3 reviews.provided s.me or s.fficient evidence that RT volume and contraction velocity influenced s.eletal mus.le mas.,while 4/7 reviews.provided ins.fficient evidence in favor of RT load impacting s.eletal mus.le *** was.ins.fficient evidence to conclude that time of day,periodization,inter-s.t res.,s.t configuration,s.t end point,contraction velocity/time under tens.on,or exercis. order(only pertaining to hypertrophy)influenced s.eletal mus.le adaptations.A paucity of data limited ins.ghts.into the impact of RT pres.ription variables.on phys.cal ***:Overall,RT increas.d mus.le mas.,s.rength,and phys.cal function compared to no ***

关键词： Hypertrophy Res.s.ance training Res.s.ance training pres.ription variables s.rength Umbrella review

在线全文

学校读者我要写书评

暂无评论

Jumping droplets

Droplet 2024年第2期3卷 3-33页

作者： jonathan B.Boreyko Department of Mechanical Engineering Virginia TechBlacksburgVirginiaUSA

When microdroplets.with quas.-s.herical contact angles.coales.e together on a low-adhes.on s.bs.rate,the capillary-inertial expans.on of the liquid bridge induces.a dramatic out-of-plane jumping event due to s.mmetry *** the ons.t of merging,droplet jumping initiates.after a capillary-inertial time s.ale of tci∼1–100μs.with characteris.ic jumping s.eeds.of order vj∼0.1m/*** coales.enceinduced jumping-droplet effect is.mos. commonly obs.rved among a population of growing dew droplets.on a s.perhydrophobic condens.r,but can als. occur by colliding depos.ted droplets.together or during droplet s.iding on fog *** this.review,we cover the his.orical development of capillary-inertial jumping droplets.s.mmarize the decade-long effort to rationalize the ultra-low energy convers.on efficiency and critical droplet s.ze of the phenomenon,and then pres.nt 15 variations.on a theme of ***-inertial jumping droplets.are not only a vis.eral illus.ration of the s.rpris.ng power of s.rface tens.on at the micros.ale but they als. have the potential to enhance phas.-change heat trans.er,enable s.lfcleaning s.rfaces.combat fros. formation,harves. energy,and govern the rate of dis.as. s.read for wheat crops.

关键词： capillary illus.ration rational

NLRP3 inflammas.me plays.a vital role in the pathogenes.s.of age-related dis.as.s.in the eye and brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2024年第7期19卷 1425-1426页

作者： Jack jonathan Maran Odunayo Omolola Mugis.o Buchanan Ocular Therapeutics.Unit Department of OphthalmologyNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Key points.With aging,there is.increas.d nucleotide-binding oligomerization domain-(NOD-)like receptor(NLR) protein-3(NLRP3) activation in neural and ocular *** of the NLRP3 inflammas.me appears.to be a common denominator in the pathogenes.s.of age-related dis.as.s.of the eye and *** inhibition of the NLRP3 inflammas.me may be a potent therapy for preventing the development and progres.ion of age-related eye and brain dis.as.s.

关键词： NLRP3 pathogenes.s inflam

Treatment of Helicobacter pylori with potas.ium competitive acid blockers.A s.s.ematic review and meta-analys.s

在线全文

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2024年第9期30卷 1213-1223页

作者： Jos.ph Edwin Kanu jonathan s.ldera Pos. Graduate Program at Acute Medicine and Gas.roenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects.over half the global population,caus.ng gas.rointes.inal dis.as.s.like dys.eps.a,gas.ritis.duodenitis.peptic ulcers.GMALT lymphoma,and gas.ric *** *** is.crucial for treating and preventing thes. *** conventional proton pump inhibitor(PPI)-bas.d triple therapy is.effective,there’s.growing interes. in longer acid s.ppres.ion *** competitive acid blocker(P-CAB)triple and dual therapy are new regimens.for *** *** us.d in As.an populations.vonoprazan(VPZ)has.been recently Food and Drug Adminis.ration-approved for *** *** To as.es. the efficacy of regimens.containing P-CABs.in eradicating *** *** This.s.udy,following PRIs.A 2020 guidelines.conducted a s.s.ematic review and meta-analys.s.by s.arching MEDLINE and s.opus.libraries.for randomized clinical trials.RCTs.or obs.rvational s.udies.with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potas.ium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"s.raprazan"OR"Tegoprazan")].s.udies.comparing the efficacy of P-CABs.bas.d treatment to clas.ical PPIs.in eradicating *** were *** criteria included cas. reports.cas. s.ries.unpublis.ed trials.or conference *** variables.encompas.ed age,diagnos.s.method,s.mple s.zes.s.udy duration,intervention and control,and *** eradication method were gathered by two independent ***-analys.s.was.performed in R s.ftware,and fores. plots.were *** A total of 256 references.were initially retrieved through the s.arch ***,fifteen s.udies.7 RCTs.7 retros.ective obs.rvational s.udies.and 1 comparative unique s.udy)were included,comparing P-CAB triple therapy to PPI triple *** intention-to-treat analys.s.involved 8049 patients.with 4471 in the P-CAB intervention g

关键词： Helicobacter pylori infection Potas.ium competitive acid blockers Proton pump inhibitors Vonoprazan Amoxicillin

A modular microfluidic platform to s.udy how fluid s.ear s.res. alters.es.rogen receptor phenotype in ER+breas. cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Micros.s.ems.& Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés.Ortega Ques.da jonathan Cuccia Rachael Coates.Blake Nas.ar Ethan Littlefield Elizabeth C.Martin Adam T.Melvin Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metas.atic breas. cancer leads.to poor prognos.s.and wors. outcomes.in patients.due to its.invas.ve behavior and poor res.ons. to *** is.s.ill unclear what biophys.cal and biochemical factors.drive this.more aggres.ive phenotype in metas.atic cancer;however recent s.udies.have s.gges.ed that expos.re to fluid s.ear s.res. in the vas.ulature could caus. *** this.s.udy a modular microfluidic platform capable of mimicking the magnitude of fluid s.ear s.res.(Fs.)found in human vas.ulature was.des.gned and *** device provides.a platform to evaluate the effects.of Fs. on MCF-7 cell line,an es.rogen receptor pos.tive(ER+)breas. cancer cell line,during circulation in the *** of the effects.of Fs. on MCF-7 cells.was.carried out utilizing two approaches.s.ngle cell analys.s.and bulk *** s.ngle cell analys.s.cells.were trapped in a microarray after exiting the s.rpentine channel and followed by immunos.aining on the device(on-chip).Bulk analys.s.was.performed after cells.were collected in a microtube at the outlet of the microfluidic s.rpentine channel for wes.ern blotting(off-chip).It was.found that cells.expos.d to an Fs. magnitude of 10 dyn/cm^(2) with a res.dence time of 60 s.enhanced expres.ion of the proliferation marker Ki67 in the MCF-7 cell line at a s.ngle cell *** unders.and pos.ible mechanis.s.for enhanced Ki67 expres.ion,on-chip and off-chip analys.s.were performed for pro-growth and s.rvival pathways.ERK,AKT,and JAK/*** demons.rated that after s.earing the cells.phos.horylation of p-AKT,p-mTOR,and p-s.AT3 were ***,there was.no change in p-ERK1/*** is.a mediator of ER rapid s.gnaling,analys.s.of phos.horylated ERαwas.carried out and no s.gnificant differences.between s.eared and non-s.eared populations.were *** together thes. res.lts.demons.rate that Fs. can increas. phos.horylation of proteins.as.ociated with a more aggres.ive phenotype in circulating cancer *** findin

关键词： fluid breas. es.rogen

Formadinium Cation Doping s.abilized Ultra-deep-blue Lead Halide Perovs.ite Nanocrys.al Light-emitting Diodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Res.arch in Chines. Univers.ties 2024年第3期40卷 556-560页

作者： Pui Kei KO jonathan E.HALPERT Department of Chemis.ry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-bas.d perovs.ite is.a s.rious.problem hindering the development of its.dis.lay *** this.s.udy,we have s.cces.fully addres.ed this.is.ue by reporting formadinium(FA)doped mixed-halide perovs.ite nanocrys.als.NCs.with ultra-deep-blue emis.ion of 450 nm,narrow bandwidth of 16 nm,and a high photolumines.ence quantum yield(PLQY)of 66%.The perovs.ite nanocrys.al light-emitting diodes.NC-LEDs.us.ng this.nanocrys.al as.an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pris.ine and s.able electrolumines.ence(EL)s.ectra at 450 nm under a 4.9–8.0 V *** findings.demons.rate the potential of our approach in developing s.able and efficient deep blue perovs.ite NC-LEDs.

关键词： Halide perovs.ite Light-emitting diode Deep-blue

On the calibration of a s.ear s.res. criterion for rock joints.to repres.nt the full s.res.-s.rain profile

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics.and Geotechnical Engineering 2024年第2期16卷 379-392页

作者： Akram Deiminiat jonathan D.Aubertin Yannic Ethier Department of Cons.ruction Engineering École de Technologie Supérieure(ÉTS)MontréalCanada

Conventional numerical s.lutions.developed to des.ribe the geomechanical behavior of rock interfaces.s.bjected to differential load emphas.ze peak and res.dual s.ear *** detailed analys.s.of preand pos.-peak s.ear s.res.-dis.lacement behavior is.central to various.time-dependent and dynamic rock mechanic problems.s.ch as.rockburs.s.and s.ructural ins.abilities.in highly s.res.ed *** complete s.res.-dis.lacement s.rface(Cs.s.model was.developed to des.ribe analytically the pre-and pos.-peak behavior of rock interfaces.under differential *** formulations.of the Cs.s.model required extens.ve curve-fitting iterations.which limited its.practical applicability and trans.arent integration into engineering *** pres.nt work propos.s.modifications.to the Cs.s.model aimed at developing a comprehens.ve and modern calibration protocol to des.ribe the complete s.ear s.res.dis.lacement behavior of rock interfaces.under differential *** propos.d update to the Cs.s.model incorporates.the concept of mobilized s.ear s.rength to enhance the pos.-peak ***’s.concepts.of joint roughnes. coefficient(JRC)and joint compres.ive s.rength(JCs.are incorporated to facilitate empirical es.imations.for peak s.ear s.res. and normal clos.re ***/uniaxial compres.ion tes. and direct s.ear tes. res.lts.are us.d to validate the updated model and exemplify the propos.d calibration *** res.lts.illus.rate that the revis.d model s.cces.fully predicts.the pos.-peak and complete axial s.res.es.rain and s.ear s.res.edis.lacement curves.for rock joints.

关键词： Full s.ear profile Pos.-peak s.ear behavior Rock joint Joint roughnes. coefficient(JRC) Axial s.res.-s.rain curve