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Antimicrobial activity of pVp from an Antarctic bacterium, Janthinobacterium sp. Ant5-2, on multi-drug and methicillin resistant Staphylococcus aureus

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Natural products and Bioprospecting 2012年第3期2卷 104-110页

作者： jonathan p.huang Nazia MOJIB Rakesh R.GOLI Samantha WATKINS Ken B.WAITES Rasik RAVINDRA Dale T.ANDERSEN Asim K.BEJ Department of Biology University of Alabama at BirminghamBirminghamAL 35294-1170USA Department of pathology University of Alabama at BirminghamBirminghamAL 35294-1170USA National Centre for Antarctic&Ocean Research Head Land SadaVasco-da-Gama Goa 403804India Carl Sagan Center for the Study of Life in the Universe SETI InstituteMountain ViewCA 94043USA Red Sea Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Multiple drug resistant(MDR)and methicillin-resistant Staphylococcus aureus(MRSA)have become increasingly prevalent as a community acquired *** a result limited treatment options are available with conventional synthetic *** natural products with potent antimicrobial activity show promise for developing new drugs against this *** this study,we have investigated the antimicrobial activity of a purple violet pigment(pVp)from an Antarctic bacterium,Janthinobacterium ***5-2 on 15 clinical MDR and MRSA *** colorimetric resazurin assay was employed to determine the minimum inhibitory concentration(MIC90)of pVp against MDR and *** MIC90 ranged between 1.57μg/mL and 3.13μg/mL,which are significantly lower than many antimicrobials tested from natural sources against this *** spectrophotometrically determined growth analysis and total microscopic counts using Live/dead®BacLight™fluorescent stain exhibited a steady decrease in viability of both MDR and MRSA cultures following treatment with pVp at the MIC *** silico predictive molecular docking study revealed that pVp could be a DNA-targeting minor groove binding antimicrobial *** continued development of novel antimicrobials derived from natural sources with the combination of a suite of conventional antibiotics could stem the rising pandemic of MDR and MRSA along with other deadly microbial pathogens.

关键词： natural product bacterial pigment resazurin assay minimum inhibitory concentration(MIC)

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A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota jonathan p.Hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World premier International(WpI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular photochromic X-ray induced Anion-directed folding Electron-deficient viologens

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Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben Zhong Tang jonathan L.Sessler Feihe huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan Kaiming Tang Jian-piao Cai Kenn Ka-Heng Chik Yixin huang Mei Dai Bo Qin Chon phin Ong Allen Wing-Ho Chu Wan-Mui Chan jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin Kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

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Machine learning accelerated carbon neutrality research using big data-from predictive models to interatomic potentials

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Science China(Technological Sciences) 2022年第10期65卷 2274-2296页

作者： WU LingJun XU ZhenMing WANG ZiXuan CHEN ZiJian huang ZhiChao pENG Chao pEI XiangDong LI XiangGuo MAILOA jonathan p HSIEH Chang-Yu WU Tao YU Xue-Feng ZHAO HaiTao Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China College of Computer National University of Defense TechnologyChangsha 410073China School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Quantum Laboratory TencentShenzhen 518057China China Beacons Institute The University of Nottingham Ningbo ChinaNingbo 315100China

Carbon neutrality has been proposed as a solution for the current severe energy and climate crisis caused by the overuse of fossil fuels, and machine learning(ML) has exhibited excellent performance in accelerating related research owing to its powerful capacity for big data processing. This review presents a detailed overview of ML accelerated carbon neutrality research with a focus on energy management, screening of novel energy materials, and ML interatomic potentials(MLIps), with illustrations of two selected MLIp algorithms: moment tensor potential(MTp) and neural equivariant interatomic potential(NequIp). We conclude by outlining the important role of ML in accelerating the achievement of carbon neutrality from global-scale energy management, unprecedented screening of advanced energy materials in massive chemical space, to the revolution of atomicscale simulations of MLIps, which has the bright prospect of applications.

关键词： carbon neutrality machine learning big data molecular dynamics interatomic potentials

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Chemical vapor deposition growth of monolayer MoSe2 nanosheets

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Nano Research 2014年第4期7卷 511-517页

作者： jonathan C. Shaw Hailong Zhou Yu Chen Nathan O. Weiss Yuan Liu Yu huang Xiangfeng Duan Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA California NanoSystems Institute University of California Los Angeles CA 90095 USA

The synthesis of two-dimensional （2D） layered materials with controllable thickness is of considerable interest for diverse applications. Here we report the first chemical vapor deposition growth of single- and few-layer MoSe2 nanosheets. By using Se and MoO3 as the chemical vapor supply, we demonstrate that highly crystalline MoSe2 can be directly grown on the 300 nm SiO2/Si substrates to form optically distinguishable single- and multi-layer nanosheets, typically in triangular shaped domains with edge lengths around 30 btm, which can merge into continuous thin films upon further growth. Micro-Raman spectroscopy and imaging was used to probe the thickness-dependent vibrational properties. photoluminescence spectroscopy demonstrates that MoSe2 monolayers exhibit strong near band edge emission at 1.55 eV, while bilayers or multi-layers exhibit much weaker emission, indicating of the transition to a direct band gap semiconductor as the thickness is reduced to a monolayer.

关键词： chemical vapor deposition molybdenum diselenide two-dimensional materials transition metaldichalcogenide layered materials semiconductor

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Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

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Nano Research 2022年第5期15卷 4302-4309页

作者： Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao jonathan F.Lovell Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA Department of Anatomy and Cell Biology McGill UniversityMontrealQuebec H3A0C7Canada School of Chemical Engineering and Technology Tianjin UniversityTianjin 300000China

photodynamic therapy(pDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent ***,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;pop)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with *** the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of ***(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%pop,generating CTX-loaded pop liposomes(CTX-pop-Lip).CTX-pop-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser *** vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-pop-Lip,compared to control *** vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and pop exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in ***,when a single treatment of CTX-pop-Lip with laser irradiation was administered to mice bearing human MIA paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and pDT monotherapies were *** results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy.

关键词： photodynamic therapy cabazitaxel liposome chemotherapy porphyrin-phospholipid

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可见光催化C(sp^3)-C(sp^3)键的构筑

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化学进展 2019年第4期31卷 505-515页

作者：易享炎黄菲 jonathan B.Baell 黄和于杨南京工业大学药学院南京211816 南京工业大学环境科学与工程学院南京211816

本文对近年来可见光催化构筑C(sp^3)-C(sp^3)键的国内外最新研究成果进行概述,着重阐述了各类催化的催化体系、反应机理及在合成生物活性分子或药物分子方面的应用。在可见光催化的反应体系中引入过渡金属或手性催化剂,构建新颖的协同... 详细信息

本文对近年来可见光催化构筑C(sp^3)-C(sp^3)键的国内外最新研究成果进行概述,着重阐述了各类催化的催化体系、反应机理及在合成生物活性分子或药物分子方面的应用。在可见光催化的反应体系中引入过渡金属或手性催化剂,构建新颖的协同催化体系,可以实现在温和的条件下对C—C键构筑的精确控制,对于手性药物的设计、开发具有重要的意义。最后,对未来可见光催化构筑C—C键的发展进行展望。

关键词：可见光催化 C—C键协同催化不对称催化

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微波辅助α-重氮酯类化合物的快速合成

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有机化学 2019年第2期39卷 544-549页

作者：易享炎张志朋黄和 jonathan B. Baell 于杨黄菲南京工业大学药学院南京211816 南京工业大学环境科学与工程学院南京211816

近年来,微波辅助有机合成(Microwave-assisted organic synthesis,MAOS)作为新兴的绿色有机合成方法受到研究者的广泛关注.与传统加热方法相比,其反应时间更短,产物收率更高并具有良好的反应选择性.许多人名反应中,譬如Diels-Alder反应... 详细信息

近年来,微波辅助有机合成(Microwave-assisted organic synthesis,MAOS)作为新兴的绿色有机合成方法受到研究者的广泛关注.与传统加热方法相比,其反应时间更短,产物收率更高并具有良好的反应选择性.许多人名反应中,譬如Diels-Alder反应、Witting反应、Heck反应和Mannich反应,均可利用该技术实现反应的快速进行.另外,α-重氮酯类化合物作为有机合成中一类重要的活性中间体,可以应用于Wolff重排反应以及C-H,N-H,Si-H等一系列插入反应.虽然关于α-重氮酯的研究在20年前已经成为一个成熟的学科,但在一些领域仍激发着研究者浓厚的研究兴趣.基于此,借助微波技术实现了短时间内α-重氮酯类化合物的克级制备,分离收率最高可达90%,且具有良好的官能团兼容性.该方法操作简便,反应条件温和,原子利用效率高,符合绿色化学的要求,为α-重氮酯类化合物的合成及进一步衍生化研究提供极大的便利.

关键词：微波辅助 α-重氮酯绿色化学

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EFFECT OF DIGITAL ELEVATION MODEL RESOLUTION ON EMpIRICAL ESTIMATION OF SOIL LOSS AND SEDIMENT TRANSpORT WITH GIS

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International Journal of Sediment Research 2004年第1期19卷 28-36页

作者： Simon WU,jonathan LI,Gordon huang,G.M.ZENG Saskatchewan Department of Agriculture Regina Saskatchewan S4S 0B1 Canada Department of Civil Engineering Ryerson University Toronto Ontario M5B 2K3 Canada Faculty of Engineering University of Regina Regina Saskatchewan S4S OA2 Canada neering Hunan University Changsha 410082 Chian

The horizontal accuracy of topographic data represented by digital elevation model (DEM) resolution brings about uncertainties in landscape process modeling with raster GIS. This paper presents a study on the effect of topographic variability on cell-based empirical estimation of soil loss and sediment transport. An original DEM of 10m resolution for a case watershed was re-sampled to three realizations of higher grid sizes for a comparative examination. Equations based on the USLE are applied to the watershed to calculate soil loss from each cell and total sediment transport to streams. The study found that the calculated total soil loss from the watershed decreases with the increasing DEM resolution with a linear correlation as spatial variability is reduced by cell aggregation. The USLE topographic factors (LS) extracted from applied DEMs represent spatial variability, and determine the estimations as shown in the modeling results. The commonly used USGS 30m DEM appears to be able to reflect essentia

关键词： Empirical modeling Soil loss DEM Resolution Spatial variability

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