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Whole-eye transplantation: Current challenges and future perspectives

World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio Pier luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati leopoldo Spadea Glenda Caputo Pier Camillo Parodi Caterina Gagliano jonathan M Winograd Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible *** advancements,formidable challenges *** of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell *** the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory *** tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are imperative to navigate these ***,stem cell therapies,and precision immunomodulation represent promising avenues in this ***,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Immunological tolerance

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趣味无限化繁为简香港奕凨民宿

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室内设计与装修 2024年第1期 24-29页

作者： linehouse jonathan leijonhufvud(摄影) 联图linehouse

奕凨民宿的设计尝试突破传统酒店严肃正统的空间叙事,打造一家适合现代旅行者、迎合全球千禧一代和Z世代顾客群体的旅居品牌。考虑到可持续及经济适用性,空间设计以温暖、舒适、亲切的感觉为主,并强调设计的功能和质感。针对当下年轻人... 详细信息

奕凨民宿的设计尝试突破传统酒店严肃正统的空间叙事,打造一家适合现代旅行者、迎合全球千禧一代和Z世代顾客群体的旅居品牌。考虑到可持续及经济适用性,空间设计以温暖、舒适、亲切的感觉为主,并强调设计的功能和质感。针对当下年轻人追求精致极简的主张,利用本土语境打造充满活力的设计元素,赋予室内空间独具魅力的风格。

关键词：化繁为简顾客群体本土语境空间叙事旅行者空间设计室内空间设计元素

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美国免疫实施咨询委员会对询证推荐方法的采用和实施

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中国疫苗和免疫 2013年第4期19卷 365-368页

作者： jonathan l.Temte 段梦娟美国威斯康星大学医学与公共卫生学院 wi53715 中国疾病预防控制中心免疫规划中心

美国免疫实施咨询委员会（Advisory Committeeon Immunization Practices，ACIP）为疾病预防控制中心（Center for Disease Control and ***）的决策者，在疫苗的最优选择和其他疫苗可预防疾病在公众中的有效控制方面提供指导意见。

关键词：美国免疫实施咨询委员会询证

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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed Paige Deville Blake Platt Claudia leonardi lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt lance Stuke Patrick Greiffenstein jonathan Schoen Alan Marr Anil Paramesh Alison A Smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with Plly *** A total of 88 patients met inclusion criteria,69(78%)of whom received levothyroxine and steroids(ST/lT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,race,pertinent injury factors,age,or other hormone therapies used(P>0.05).In the ST/lT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONClUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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Optimizing ASReview Simulations:A generic Multiprocessing Solution for“light-data'and“Heavy-data'Users

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Data Intelligence 2024年第2期6卷 320-343页

作者： Sergei Romanov Abel Soares Siqueira jonathan de Bruin Jelle Teijema laura Hofstee Rens van de Schoot Applied Data Science Department of Information and Computing ScienceFaculty of ScienceUtrecht University Netherlands eScienceCenter AmsterdamNL Department of Research and Data Management Services Information Technology ServicesUtrecht UniversityUtrechtthe Netherlands Department of Methodology and Statistics Faculty of Social and Behavioral SciencesUtrecht University

Active learning can be used for optimizing and speeding up the screening phase of systematic *** simulation studies mimicking the screening process can be used to test the performance of different machine-learning models or to study the impact of different training *** paper presents an architecture design withamultiprocessing computational strategyforrunningmanysuch simulation studiesinparallel,using the ASReview Makita workflow generator and Kubernetes software for deployment with cloud *** provide a technical explanation of the proposed cloud architecture and its *** addition to that,we conducted 1140 simulations investigating the computational time using various numbers of CPUs and RAM *** analysis demonstrates the degree to which simulations can be accelerated with multiprocessing computing *** parallel computation strategy and the architecture design that was developed in the present paper can contribute to future research with more optimal simulation time and,at the same time,ensure the safe completion of the needed processes.

关键词： Active learning Systematic review Simulation study Multiprocessing Cloud architecture

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A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine life Science & Technology 2024年第1期6卷 168-181页

作者： Jiwen liu Da-Wei li Xinxin He Ronghua liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.lea-Smith jonathan D.Todd Xiaoshou liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

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2011年ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS颅外颈动脉和椎动脉疾病患者处理指南(续前) 美国心脏病学会基金会/美国心脏协会实践指南顾问委员会、美国卒中协会、美国神经科学护理协会、美国神经外科医师协会、美国放射学学会、美国神经放射学学会?

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国际脑血管病杂志 2013年第10期 721-758页

作者： Thomas G.Brott jonathan l.Halperin Suhny Abbara J.Michael Bacharach John D.Barr Ruth l.Bush Christopher U.Cates Mark A.Creager Susan B.Fowler Gary Friday Robert H.Rosenwasser Allen J.Taylor 曲东锋陈兴洲南京脑血管疾病分册杂志社

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证...

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证据）或经导管血管造影显示同侧颈内动脉内径减少>50%[20,70,83,359]（B级证据）且预期围手术期卒中或死亡发生率低于6%,应行CEA。2对于血管内介入治疗风险中等或较低的有症状患者,当无创性成像显示同侧颈内动脉内径

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全球机器视觉市场发展及其在物流领域的应用前景分析

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物流技术与应用 2024年第6期29卷 84-88页

作者： jonathan Sparkes Samantha Mou Interact Analysis

近期,Interact Analysis基于全球机器视觉市场进行调研,发布《机器视觉》研究报告。在本文中,Interact Analysis的两位分析师对该报告进行了重点梳理,全面解读机器视觉技术的市场规模、增长情况及推动其未来发展的驱动因素,并详细分析... 详细信息

近期,Interact Analysis基于全球机器视觉市场进行调研,发布《机器视觉》研究报告。在本文中,Interact Analysis的两位分析师对该报告进行了重点梳理,全面解读机器视觉技术的市场规模、增长情况及推动其未来发展的驱动因素,并详细分析了机器视觉技术在物流领域的主要应用、需求变化与发展前景。

关键词：物流领域机器视觉分析师全面解读驱动因素应用前景分析变化与发展全球

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Hydrogeological and Physico-Chemical Study of the Groundwater of Mitendi South-East in the Commune of Mont-Ngafula around the Kimwenza Quarry (Province of Kinshasa, DR Congo)

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Journal of Geoscience and Environment Protection 2024年第4期12卷 96-114页

作者： jonathan Mayi Nkolomonyi Ivon Ndala Tshiwisa Hervé Khonde Mbumba Samuel Ingila Asanga Clement N’zau Umba-Di-Mbudi Geo-Hydro-Energy-Research Group Geosciences Department Faculty of Sciences and Technologies University of Kinshasa Kinshasa Democratic Republic of Congo Geosciences Department Faculty of Sciences and Technologies University of Kinshasa Kinshasa Democratic Republic of Congo Polytechnic Faculty President Joseph Kasa-Vubu University Boma Democratic Republic of Congo

The exploitation of groundwater by drilling in the Mitendi South-East district constitutes a solution to the water shortage in this peripheral part of the Mont-Ngafula township in Kinshasa, the capital of the DR Congo. Individuals exploit groundwater in boreholes to serve the population without taking into account certain necessary aspects such as the origin of the groundwater table and the quality which constitute the major problems of this work such as: What is the quantity of water from the recharge of our aquifer? What is the state of the Mitendi South-East aquifer water in relation to some physico-chemical parameters? The cardinal objective of this work is to provide chemical data and trace elements in each analyzed borehole and determine the type of recharge of the underground aquifer. The specific objectives are as follows: analyze the potability of groundwater on a physico-chemical level and their chemical facies, take the geographical coordinates of water samples from the aquifer in each targeted borehole in order to develop the sampling map of the area under study;also check each parameter analyzed in relation to WHO standards. We carried out a general investigation of the study area by carrying out observations, sampling and in-situ measurements of each borehole, as well as the good conservation of the samples taken in a cooler. The various measurements that we took in-situ: pH, electrical conductivity, turbidity, salinity, temperature, and TDS were carried out by using a multi-parameter probe in the laboratory of appropriate methods such as titled-sorting, spectrophotometry, atomic absorption spectrometry, ArcGise and Excel software. With regard to the results from laboratory analysis (physical and chemical analysis), the parameters showed that the standards recommended by the WHO were not respected. We affirm that the water consumed in the Mitendi South-East district in Mont-Ngafula town ship is not drinkable. Since, it can cause several water-borne dis

关键词： Groundwater Aquifer Physicochemical Parameters Mitendi Kimwenza Quarry

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巴菲特提醒投资者勿忘芒格的至诚忠告

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商业周刊（中文版） 2024年第3期 22-24页

作者： jonathan levin 逸思(译) 不详

在追忆已故合作伙伴芒格的一段话中,有着“奥马哈先知”之称的巴菲特总结了在变化的市场中的一则重要教训——时代变化,沃伦·巴菲特的理念从来都不是一成不变的教条。去年11月,这位“奥马哈先知”在他的伟大合伙人查理·芒格去世后的... 详细信息

在追忆已故合作伙伴芒格的一段话中,有着“奥马哈先知”之称的巴菲特总结了在变化的市场中的一则重要教训——时代变化,沃伦·巴菲特的理念从来都不是一成不变的教条。去年11月,这位“奥马哈先知”在他的伟大合伙人查理·芒格去世后的第一封致股东信中提醒投资者,顺势而为是多么重要:1965年,查理及时向我建议称:“沃伦,别再想着买进一只像伯克希尔这样的公司股票了。不过,既然你已经掌控了伯克希尔,那就在其中加人以公道价格购买的优秀企业,放弃以优惠价格购买好企业的想法。换句话说,要放弃从你的崇拜对象本·格雷厄姆(Ben Graham)那里学到的一切。”这招很管用,但只能小规模实施。我做了很多退让,随后遵从了他的指示。

关键词：优惠价格巴菲特格雷厄姆伯克希尔奥马哈顺势而为查理合作伙伴

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