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The heterogeneity of store-operated calcium entry in melanoma

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Science China(Life Sciences) 2016年第8期59卷 764-769页

作者： Robert Hooper m.Raza Zaidi jonathan Soboloff Fels Institute for Cancer Research and molecular Biology Lewis Katz School of Medicine at Temple University Department of medical Genetics & molecular Biochemistry Lewis Katz School of Medicine at Temple University

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIm and Orai mediate store-operated calcium entry(SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIm and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIm, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

关键词： melanoma STIm1 Orail metastasis

Current taxane formulations and emerging cabazitaxel delivery systems

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Nano Research 2018年第10期11卷 5193-5218页

作者： Boyang Sun Robert m. Straubinger jonathan F. Lovell Department of Biomedical Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Chemical and Biological Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Pharmaceutical Sciences University at Buffalo State University of New York Buffalo NY 14214 USA

Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes （i.e. paclitaxel and docetaxel） have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

关键词： cabazitaxel Jevtana taxanes drug delivery systems nanocarriers

Sequential fusion estimation for multisensor systems with non-Gaussian noises

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Science China(Information Sciences) 2020年第12期63卷 153-165页

作者： Liping YAN Chenying DI Q.m.jonathan WU Yuanqing XIA Key Laboratory of Intelligent Control and Decision of Complex Systems School of AutomationBeijing Institute of Technology Department of Electrical and Computer Engineering University of Windsor

The sequential fusion estimation for multisensor systems disturbed by non-Gaussian but heavytailed noises is studied in this paper. Based on multivariate t-distribution and the approximate t-filter,the sequential fusion algorithm is presented. The performance of the proposed algorithm is analyzed and compared with the t-filter-based centralized batch fusion and the Gaussian Kalman filter-based optimal centralized fusion. Theoretical analysis and exhaustive experimental analysis show that the proposed algorithm is effective. As the generalization of the classical Gaussian Kalman filter-based optimal sequential fusion algorithm, the presented algorithm is shown to be superior to the Gaussian Kalman filter-based optimal centralized batch fusion and the optimal sequential fusion in estimation of dynamic systems with non-Gaussian noises.

关键词： state estimation sequential fusion non-Gaussian disturbance heavy-tailed noise multivariate $t$-distribution

A Fractal Dimension Based Framework for Night Vision Fusion

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 220-227页

作者： Gaurav Bhatnagar Q.m.jonathan Wu IEEE the Department of mathematics Indian Institute of Technology Jodhpur the Department of Electrical and Computer Engineering University of Windsor

In this paper, a novel fusion framework is proposed for night-vision applications such as pedestrian recognition,vehicle navigation and surveillance. The underlying concept is to combine low-light visible and infrared imagery into a single output to enhance visual perception. The proposed framework is computationally simple since it is only realized in the spatial domain. The core idea is to obtain an initial fused image by averaging all the source images. The initial fused image is then enhanced by selecting the most salient features guided from the root mean square error(RmSE) and fractal dimension of the visual and infrared images to obtain the final fused *** experiments on different scene imaginary demonstrate that it is consistently superior to the conventional image fusion methods in terms of visual and quantitative evaluations.

关键词： Fractal dimension image fusion navigation and surveillance night vision

Targeting the body to protect the brain:inducing neuroprotection with remotely-applied near infrared light

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Neural Regeneration Research 2015年第3期10卷 349-351页

作者： Daniel m.Johnstone John mitrofanis jonathan Stone Bosch Institute University of Sydney Discipline of Physiology University of Sydney Discipline of Anatomy & Histology University of Sydney

The incidence of intractable age-related neurodegenerative conditions such as Alzheimer＇s and Parkinson＇s diseases and age-related macular degeneration is projected to increase substantially over the coming decades with the ageing of the global population. While the burden of disease associ- ated with other chronic conditions has decreased in recent times due to improved diagnosis and treatment, current therapies for neurodegenerative diseases still fall short in that they are only effective in treating signs and symptoms - they do little to slow or prevent disease progress. Thus, there is an urgent need for treatments that address disease progression.

关键词： body mPTP Targeting the body to protect the brain mSCs

The consequences of genomic architecture on ecological speciation in postglacial fishes

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Current Zoology 2013年第1期59卷 53-71页

作者： Sean m. ROGERS jonathan A. mEE Ella BOWLES Department of Biological Sciences University of Calgary 2500 University Drive NW Calgary Alberta T2N 1N4 Canada

The quest for the origin of species has entered the genomics era. Despite decades of evidence confirming the role of the environment in ecological speciation, an understanding of the genomics of ecological speciation is still in its infancy. In this review, we explore the role of genomic architecture in ecological speciation in postglacial fishes. Growing evidence for the num- ber, location, effect size, and interactions among the genes underlying population persistence, adaptive trait divergence, and re- productive isolation in these fishes reinforces the importance of considering genomic architecture in studies of ecological speci- ation. Additionally, these populations likely adapt to new freshwater environments by selection on standing genetic variation, as de novo mutations are unlikely under such recent divergence times. We hypothesize that modular genomic architectures in post- glacial fish taxa may be associated with the probability of population persistence. Empirical studies have confirmed the genic na- ture of ecological speciation, implicating surprisingly extensive linkage disequilibrium across the genome. An understanding of these genomic mosaics and how they contribute to reproductive barriers remains unclear, but migration rates and the strength of selection at these loci is predicted to influence the likelihood of population divergence. Altogether, understanding the role of ge- nomic architecture is an important component of speciation research and postglacial fishes continue to provide excellent organ- isms to test these questions, both from the perspective of variation in architectures among taxa, and with respect to the distinct environments they have colonized. However, more empirical tests of ecological speciation predictions are needed [Current Zoo- logy 59 （1）： 53-71, 2013].

关键词： Adaptation Ecological speciation Genomic architecture modularity Postglacial fishes QTL

Partial Shape matching Without Point-Wise Correspondence

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Numerical mathematics(Theory,methods and Applications) 2013年第1期6卷 223-244页

作者： jonathan Pokrass Alexander m.Bronstein michael m.Bronstein School of Electrical Engineering Tel Aviv UniversityIsrael Institute of Computational Science Faculty of InformaticsUniversitàdella Svizzera Italiana(USI)LuganoSwitzerland

Partial similarity of shapes is a challenging problem arising in many important applications in computer vision,shape analysis,and graphics,*** one has to deal with partial information and acquisition *** problem is especially hard when the underlying shapes are non-rigid and are given up to a *** matching is usually approached by computing local descriptors on a pair of shapes and then establishing a point-wise non-bijective correspondence between the two,taking into account possibly different *** this paper,we introduce an alternative correspondence-less approach to matching fragments to an entire shape undergoing a non-rigid *** use region-wise local descriptors and optimize over the integration domains on which the integral descriptors of the two parts *** problem is regularized using the mumford-Shah *** show an efficient discretization based on the Ambrosio-Tortorelli approximation generalized to triangular point clouds and meshes,and present experiments demonstrating the success of the proposed method.

关键词： Deformable shapes partial matching partial correspondence partial similarity diffusion geometry Laplace-Beltrami operator shape descriptors heat kernel signature mumford-Shah regularization

Convergence Detection in Direct Simulation monte Carlo Calculations for Steady State Flows

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Communications in Computational Physics 2011年第9期10卷 807-822页

作者： jonathan m.Burt Iain D.Boyd U.S.Air Force Research Laboratory Wright-Patterson Air Force BaseOH 45433USA Department of Aerospace Engineering University of Michigan1320 Beal AvenueAnn ArborMI 48109USA

A new criterion is presented to detect global convergence to steady state,and to identify local transient characteristics,during rarefied gas flow simulations performed using the direct simulation monte Carlo(DSmC)*** deterministic computational fluid dynamics(CFD)schemes,DSmC is generally subject to large statistical scatter in instantaneous flow property evaluations,which prevents the use of residual tracking procedures as are often employed in CFD ***,reliable prediction of the time to reach steady state is necessary for initialization of DSmC sampling *** currently used in DSmC to identify steady state convergence are usually insensitive to weak transient behavior in small regions of relatively low density or recirculating *** proposed convergence criterion is developed with the goal of properly identifying such weak transient behavior,while adding negligible computational expense and allowing simple implementation in any existing DSmC *** of the proposed technique over existing convergence detection methods are demonstrated for representative nozzle/plume expansion flow,hypersonic blunt body flow and driven cavity flow problems.

关键词： monte Carlo methods particle methods direct simulation monte Carlo

Cardiorespiratory fitness and cancer in women:A prospective pilot study

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Journal of Sport and Health Science 2019年第5期8卷 457-462页

作者： Baruch Vainshelboim Ricardo m.Lima jonathan myers master of Cancer Care Program School of Health SciencesSaint Francis UniversityLorettoPA 15940USA Cardiology Division Veterans Affairs Palo Alto Health Care System/Stanford UniversityPalo AltoCA 94304USA Faculty of Physical Education University of BrasiliaBrasilia 70910-900Brazil

Purpose:To assess the association between cardiorespiratory fitness(CRF)and the incidence and mortality from cancer in women,and to evaluate the potential public health implications for cancer ***:maximal exercise testing was performed in a pilot cohort of 184 women(59.3 ± 15.2 years)who were followed for 12.0 ± 6.9 *** hazard models adjusted for established cancer risk factors and accounting for competing events were analyzed for all-type cancer incidence and mortality from ***-attributable risks and exposure impact number were determined for low CRF(metabolic equivalents(mETs))as a risk ***:During the follow-up,11.4% of the participants were diagnosed with cancer and 3.2% died from *** was inversely and independently associated with cancer *** every 1-metabolic equivalent increase in CRF,there was a 20% decrease in the risk of cancer incidence(hazard ratio(HR)= 0.80,95% confidence interval(CI):0.69-0.92;p=0.001)and a 26% reduction in risk of cancer mortality(HR = 0.74,95%CI:0.61-0.90;p=0.002).The population-attributable risks of low CRF were 11.6% and 14% for incidence and mortality of cancer,respectively,and the respective exposure impact numbers were 8 and ***:Greater CRF was independently associated with a lower risk of incidence and mortality from cancer in *** for low CRF as a cancer risk factor and referring unfit individuals to a supervised exercise program could be a public health strategy for cancer prevention in middle-age women.

关键词： Exercise capacity Exercise testing Fitness Public health