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Ecofriendly E-Nose Based in PLA and Only 0.3 wt%of CNTs

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Journal of Renewable materials 2019年第4期7卷 355-363页

作者： Laura Ribba jonathan Cimadoro Silvia Goyanes Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de FísicaLaboratorio de Polímeros y Materiales Compuestos(LP&MC)Instituto de Física de Buenos Aires(IFIBA-CONICET)Ciudad Universitaria(1428)Ciudad Autónoma de Buenos AiresArgentina

In this work,conductive polymer nanocomposites were developed based on a biodegradable and biobased polymer(poly(lactic acid)),with the incorporation of only 0.3 wt%of carbon nanotubes(CNTs)to be used as volatile solvent *** correct dispersion of the nanofiller was achieved thanks to a CNT non-covalent modification with an azo-dye(disperse orange 3)which allowed to reach the percolation for electric conduction in values as low as 0.3 wt%.The chemo-resistive properties of the developed sensors were investigated by exposure to organic vapors(ethanol,tetrahydrofuran and toluene)and water vapor,showing good *** addition,considering the manipulation to which the sensor will be exposed,wear resistance was characterized,finding that the incorporation of CNTs produced an increase in more than a 50%.

关键词： Poly(lactic acid) carbon nanotubes sensor CPC organic solvent vapor DO3

LHCb gets closer to discovering the second doubly charmed baryon

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Science China(Physics,mechanics & Astronomy) 2020年第2期63卷 25-26页

作者： marek Karliner jonathan L.Rosner School of Physics and Astronomy Tel Aviv UniversityTel Aviv 69978Israel Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637USA

Recently the LHCb Collaboration [1] published the results of a search for the doubly charmed baryon ■. No significant signal is seen in the mass range from 3.4 to3.8 Ge V. To put this result in context, the ■baryon was seen by LHCb in decay modes ΛcK-π^+π^+[2](2017) and ■^+cπ^+[3](2018). The weighted average of the ■^++cc mass is 3621.24±0.65 (stat.)±0.31 (syst.) meV [3].

关键词： doubly closer LHCb

Flu DRiPs in mHC Class Ⅰ Immunosurveillance

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Virologica Sinica 2019年第2期34卷 162-167页

作者： Jiajie Wei jonathan W.Yewdell Cellular Biology Section Laboratory of Viral DiseasesNational Institute of Allergy and Infectious DiseasesNational Institutes of Health

Since the publication of the DRiP(defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8^+T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.

关键词： Influenza A virus(IAV) mHC-restricted cytotoxicity Immune responses mHC class Ⅰ DRiP

Nearly invariant subspaces for shift semigroups

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Science China mathematics 2022年第9期65卷 1895-1908页

作者： Yuxia Liang jonathan R.Partington School of mathematical Sciences Tianjin Normal UniversityTianjin 300387China School of mathematics University of LeedsLeeds LS 29JTUK

Let{T(t)}_(t≥0) be a C_(0)-semigroupon an infinite-dimensional separable Hilbert space;a suitable definition of near{T(t)^(*)}_(t≥0) invariance of a subspace is presented in this paper.A series of prototypical examples for minimal nearly{S(t)^(*)}_(t≥0) invariant subspaces for the shift semigroup{S(t)}_(t≥0) on L^(2)(0,∞)are demonstrated,which have close links with near T_(θ)^(*)invariance on Hardy spaces of the unit disk for an inner functionθ.Especially,the corresponding subspaces on Hardy spaces of the right half-plane and the unit disk are related to model *** work further includes a discussion on the structure of the closure of certain subspaces related to model spaces in Hardy spaces.

关键词： nearly invariant subspace C_(0)-semigroup shift semigroup model space

NLRP3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain

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Neural Regeneration Research 2024年第7期19卷 1425-1426页

作者： Jack jonathan maran Odunayo Omolola mugisho Buchanan Ocular Therapeutics Unit Department of OphthalmologyNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Key points:With aging,there is increased nucleotide-binding oligomerization domain-(NOD-)like receptor(NLR) protein-3(NLRP3) activation in neural and ocular *** of the NLRP3 inflammasome appears to be a common denominator in the pathogenesis of age-related diseases of the eye and *** inhibition of the NLRP3 inflammasome may be a potent therapy for preventing the development and progression of age-related eye and brain diseases.

关键词： NLRP3 pathogenesis inflam

An unusual presentation of primary sclerosing cholangitis

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World Journal of Gastroenterology 2008年第43期14卷 6748-6749页

作者： Franklin Whitney Goldwire William E Norris jonathan m Koff Zachary D Goodman milton T Smith Internal medicine Walter Reed Army medical Center Washington DC 20307United States Gastroenterology Walter Reed Army medical Center Washington DC 20307United States Armed Forces Institute of Pathology Washington DC 20307United States

This case report describes the unusual presentation of a patient who had findings which were initially suggestive of a type Ⅳ choledochal cyst. Her liver biopsy demonstrated biliary cirrhosis. She was treated with endoscopic retrograde cholangiopancreatography and biliary stent exchanges over one year. Her cholangiogram one year later demonstrated resolution of the biliary cystic dilation which led to her initial diagnosis, with beading and stricturing of the hepatic ducts consistent with primary sclerosing cholangitis. Liver-associated enzymes and physical findings also improved. A liver biopsy one year later demonstrated a marked improvement in hepatic fibrosis with no evidence of cirrhosis.

关键词： Biliary cysts Cholangiogram Endoscopic retrograde cholangiopancreatography Liver fibrosis Primary sclerosing cholangitis

Transitions of care across hospital settings in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2019年第17期25卷 2122-2132页

作者： Leigh R Warren jonathan m Clarke Sonal Arora mauricio Barahona Naila Arebi Ara Darzi Patient Safety Translational Research Centre Imperial College London Department of Surgery and Cancer Imperial College London Centre for Health Policy Imperial College London Centre for Mathematics of Precision HealthcareImperial College London Department of Biostatistics Harvard University Department of mathematics Imperial College London Department of Gastroenterology St.Marks Academic Institute

BACKGROUND Inflammatory bowel disease(IBD) is a chronic, inflammatory disorder characterised by both intestinal and extra-intestinal pathology. Patients may receive both emergency and elective care from several providers, often in different hospital settings. Poorly managed transitions of care between providers can lead to inefficiencies in care and patient safety issues. To ensure that the sharing of patient information between providers is appropriate, timely, accurate and secure, effective data-sharing infrastructure needs to be developed. To optimise inter-hospital data-sharing for IBD patients, we need to better understand patterns of hospital encounters in this *** To determine the type and location of hospital services accessed by IBD patients in *** was a retrospective observational study using Hospital Episode Statistics, a large administrative patient data set from the National Health Service in *** patients with a diagnosis of IBD following admission to hospital were followed over a 2-year period to determine the proportion of care accessed at the same hospital providing their outpatient IBD care, defined as their ‘home provider'. Secondary outcome measures included the geographic distribution of patient-sharing, regional and age-related differences in accessing services, and type and frequency of outpatient ***95055 patients accessed hospital services on 1760156 occasions over a 2-year follow-up period. The proportion of these encounters with their identified IBD‘home provider' was 73.3%, 87.8% and 83.1% for accident and emergency,inpatient and outpatient encounters respectively. Patients living in metropolitan centres and younger patients were less likely to attend their ‘home provider' for hospital services. The most commonly attended specialty services were gastroenterology, general surgery and *** Transitions of care between secondary care settings are common for patients with IBD. E

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Transitions of care Continuity of care Fragmentation multi-morbidity

Reduced chemistries with the Quantemol database (QDB)

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Plasma Science and Technology 2019年第6期21卷 38-51页

作者： Adetokunbo AYILARAN martin HANICINEC Sebastian mOHR jonathan TENNYSON Quantemol Ltd 320 City Rd London EC1V 2NZ United Kingdom Department of Physics and Astronomy University College London London WC1E 6BT United Kingdom

Typical feed gas mixtures used in technological and other plasmas may give rise to reaction networks involving several hundred *** chemistries are often too large to be used in full reactor simulations and it is therefore desirable to construct reduced chemistry networks which mimic as closely as possible the behavior of the full chemistry but employ far fewer individual reactions and *** chemistries are available from the Quantemol database (QDB) and two approaches to constructing reduced chemistry from these chemistries based on (a) physical intuition and (b) sensitivity analysis of dominant reaction pathways,are *** doing this it is necessary to consider different pressure and power *** chemistry sets are presented for CF4/O2/N2/H2,for which 396 reactions and 52 species are reduced to 71 reactions and 26 species,and for pure O2,for which 45 reactions and 10 species are reduced to 34 reactions.

关键词： plasma chemistries quantemol database chemical reactions chemistry reduction stoichiometry

Alcohol-induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment

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Animal models and Experimental medicine 2020年第2期3卷 200-207页

作者： Esha m.Kapania Taylor JReif Aaron Tsumura jonathan m。Eby John J.Callaci Internal medicine-Pediatric Resident Rush University Medical CenterChicagoILUSA Limb Lengthening and Complex Reconstruction Fellowship Hospital for Special SurgeryNew YorkNYUSA Department of Orthopaedic Surgery and Rehabilitation Loyola University Medical CenterMaywoodILUSA Alcohol Research Program(ARP) Loyola University Chicago Stritch School of MedicineMaywoodILUSA

Nearly half of orthopaedic trauma patients are intoxicated at the time of injury, and excess alcohol consumption increases the risk for fracture nonunion. Previous studies show alcohol disrupts fracture associated Wnt signaling required for normal bone fracture repair. Intermittent parathyroid hormone(PTH) promotes bone growth through canonical Wnt signaling, however, no studies have investigated the effect of PTH on alcohol-inhibited bone fracture repair. male C57 BL/6 mice received two-3 day alcohol binges separated by 4 days before receiving a mid-shaft tibia fracture. Postoperatively, mice received PTH daily until euthanasia. Wnt/β-catenin signaling was analyzed at 9 days post-fracture. As previously observed, acute alcohol exposure resulted in a >2-fold decrease in total and the active form of β-catenin and a 2-fold increase in inactive β-catenin within the fracture callus. Intermittent PTH abrogated the effect of alcohol on β-catenin within the fracture callus. Upstream of β-catenin, alcohol-treated animals had a 2-fold decrease in total LRP6, the Wnt co-receptor, which was restored with PTH treatment. Alcohol nor PTH had any significant effect on GSK-3β. These data show that intermittent PTH following a tibia fracture restores normal expression of Wnt signaling proteins within the fracture callus of alcohol-treated mice.

关键词： ethanol fracture callus parathyroid hormone Wnt signaling pathway