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Aerosol m.crophysical and Radiative Effects on Continental Cloud Ensem.les

Advances in Atm.spheric Sciences 2018年第2期35卷 234-247页

作者： Yuan WANG jonathan m. vogel Yun LIN Bowen PAN Jiaxi HU Yangang LIU Xiquan DONG jonathan H. JIANG Yuk L. YUNG Renyi ZHANG Division of Geological and Planetary Sciences California Institute of Technology Pasadena CA 91106 USA Departm.nt of Atm.spheric Sciences Texas A&M University College Station TX 77840 USA Environm.ntal & Clim.te Sciences Departm.nt Brookhaven National Laboratory Upton NY 11973 USA Departm.nt of Hydrology and Atm.spheric Sciences University of Arizona Tucson AZ 85721 USA Jet Propulsion Laboratory California Institute of Technology Pasadena CA 91109 USA Departm.nt of Atm. wheric and Oceanic Sciences McGill University Montreal Quebec QC H3A OG4 Canada

Aerosol-cloud-radiation interactions represent one of the largest uncertainties in the current clim.te assessm.nt. m.ch of the com.lexity arises from.the non-m.notonic responses of clouds, precipitation and radiative fluxes to aerosol perturbations under various m.teorological conditions. In this study, an aerosol-aware WRF m.del is used to investigate the m.crophysical and radiative effects of aerosols in three weather system. during the m.rch 2000 Cloud Intensive Observational Period cam.aign at the US Southern Great Plains. Three sim.lated cloud ensem.les include a low-pressure deep convective cloud system. a collection of less-precipitating stratus and shallow cum.lus, and a cold frontal passage. The WRF sim.lations are evaluated by several ground-based m.asurem.nts. The m.crophysical properties of cloud hydrom.teors, such as their m.ss and num.er concentrations, generally show m.notonic trends as a function of cloud condensation nuclei concentrations. Aerosol radiative effects do not influence the trends of cloud m.crophysics, except for the stratus and shallow cum.lus cases where aerosol sem.-direct effects are identified. The precipitation changes by aerosols vary with the cloud types and their evolving stages, with a prom.nent aerosol invigoration effect and associated enhanced precipitation from.the convective sources. The sim.lated aerosol direct effect suppresses precipitation in all three cases but does not overturn the aerosol indirect effect. Cloud fraction exhibits m.ch sm.ller sensitivity （typically less than 2%） to aerosol perturbations, and the responses vary with aerosol concentrations and cloud regim.s. The surface shortwave radiation shows a m.notonic decrease by increasing aerosols, while the m.gnitude of the decrease depends on the cloud type.

关键词： aerosol-cloud-radiation interactions cloud-resolving m.del cloud m.crophysics and m.crophysics precipita-tion

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A holistic approach to im.roving safety for battery energy storage system.

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Journal of Energy Chem.stry 2024年第5期92卷 422-439页

作者： Jam.s Close jonathan E.Barnard Y.m.John Chew Sem.li Perera Departm.nt of Chem.cal Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK iom.saic International Lim.ted 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage system.(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and num.rous BESS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the m.nagem.nt and design of *** understand the causes of failure,the m.in challenges of BESS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing therm.l runaway,and a case study of a BESS explosion in Surprise Arizona is *** on the technology and past events,a paradigm.shift is required to im.rove BESS *** this review,a holistic approach is *** com.ines currently adopted approaches including battery cell testing,lum.ed cell m.them.tical m.delling,and calorim.try,alongside additional m.asures taken to ensure BESS safety including the requirem.nt for com.utational fluid dynam.cs and kinetic m.delling,assessm.nt of installation level testing of the full BESS system.and not sim.ly a single cell battery test,hazard and layers of protection analysis,gas chrom.tography,and com.osition *** holistic approach proposed in this study aim. to address challenges of BESS safety and form.the basis of a paradigm.shift in the safety m.nagem.nt and design of these system..

关键词： Energy storagesystem. Process safety Battery safety Therm.l safety

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The influence of resistance exercise training prescription variables on skeletal m.scle m.ss,strength,and physical function in healthy adults:An um.rella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： jonathan C.m.leod Brad S.Currier Caroline V.Lowisz Stuart m.Phillips Departm.nt of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim.of this um.rella review was to determ.ne the im.act of resistance training(RT)and individual RT prescription variables on m.scle m.ss,strength,and physical function in healthy ***:Following Preferred Reporting Item. for System.tic Reviews and m.ta-Analyses(PRISm.)guidelines,we system.tically searched and screened eligible system.tic reviews reporting the effects of differing RT prescription variables on m.scle m.ss(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 system.tic reviews that m.t our inclusion *** m.thodological quality of these reviews was assessed using A m.asurem.nt Tool to Assess System.tic Reviews;standardized effectiveness statem.nts were *** found that RT was consistently a potent stim.lus for increasing skeletal m.scle m.ss(4/4 reviews provide som. or sufficient evidence),strength(4/6 reviews provided som. or sufficient evidence),and physical function(1/1 review provided som. evidence).RT load(6/8 reviews provided som. or sufficient evidence),weekly frequency(2/4 reviews provided som. or sufficient evidence),volum.(3/7 reviews provided som. or sufficient evidence),and exercise order(1/1 review provided som. evidence)im.acted RT-induced increases in m.scular *** discovered that 2/3 reviews provided som. or sufficient evidence that RT volum. and contraction velocity influenced skeletal m.scle m.ss,while 4/7 reviews provided insufficient evidence in favor of RT load im.acting skeletal m.scle *** was insufficient evidence to conclude that tim. of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/tim. under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal m.scle adaptations.A paucity of data lim.ted insights into the im.act of RT prescription variables on physical ***:Overall,RT increased m.scle m.ss,strength,and physical function com.ared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Um.rella review

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Hepatocellular carcinom.-the role of the underlying liver disease in clinical practice

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World Journal of Gastroenterology 2024年第19期30卷 2488-2495页

作者： Angelo Zam.am.de m.ttos Isadora Zanotelli Bom.assaro Arndt vogel Jose D Debes Departm.nt of Internal m.dicine Universidade Federal de Ciências da Saúde de Porto AlegreRSPorto Alegre 90020090Brazil Graduate Program.in m.dicine:Hepatology Federal University of Health Sciences of Porto AlegreRSPorto Alegre 90050-170Brazil Division of Gastroenterology Hepatology University of TorontoHannover M5R 0A3Canada Departm.nt of m.dicine University of MinnesotaMinneapolisMN 55455United States

Hepatocellular carcinom.(HCC)is one of the m.st com.on causes of cancerrelated *** particular type of cancer has the distinctive characteristic of m.stly happening in individuals with an underlying liver *** m.kes the m.nagem.nt of patients m.re challenging,since physicians m.st take into consideration two different conditions,the chronic liver disease and the *** underlying liver disease has several im.lications in clinical practice,because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC,obstacles in surveillance,and differences in the efficacy of the treatm.nt against HCC.A shift in the prevalence of liver diseases has been evident over the last few years,with viral hepatitis gradually losing the leading position as cause of HCC and m.tabolic dysfunction-associated steatotic liver disease gaining ***,in an era of personalized m.dicine,it is im.erative that physicians are aware of the underlying liver disease of individuals with HCC and its im.act in the m.nagem.nt of their tum.rs.

关键词： Hepatocellular carcinom. Etiology Epidem.ology Surveillance Therapy

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Biofabrication of nanocom.osite-based scaffolds containing hum.n bone extracellularm.trix for the differentiation of skeletal stem.and progenitor cells

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Bio-Design and m.nufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim.Janos m.Kanczler Stuart Lanham.Andrew Rawlings m.rta Roldo Gianluca Tozzi jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of m.dicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharm.cy and Biom.dical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or m.tal im.lants are routinely used in skeletal ***,they fail to provide long-term.clinical resolution,necessitating a functional biom.m.tic tissue engineering *** use of native hum.n bone tissue for synthesizing a biom.m.ticm.terial inkfor three-dim.nsional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,hum.n bone extracellular m.trix(bone-ECm.offers an exciting potential for the developm.nt of an appropriate m.croenvironm.nt for hum.n bone m.rrow strom.l cells(HBm.Cs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel m.terial ink(LAB)by blending hum.n bone-ECm.B)with nanoclay(L,Laponite®)and alginate(A)polym.rs using extrusion-based *** inclusion of the nanoﬁller and polym.ric m.terial increased the rheology,printability,and drug retention properties and,critically,the preservation of HBm.Cs viability upon *** com.osite of hum.n bone-ECm.based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after im.lantation in an ex vivo chick chorioallantoic m.m.rane(CAm.*** inclusion of bone m.rphogenetic protein-2(Bm.-2)with the HBm.Cs further enhanced vascularization and m.neralization after only seven *** study dem.nstrates the synergistic com.ination of nanoclay with biom.m.tic m.terials(alginate and bone-ECm.to support the form.tion of osteogenic tissue both in vitro and ex vivo and offers a prom.sing novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular m.trix Nanoclay Bone 3D bioprinting

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m.tabolic collaboration between cells in the tum.r m.croenvironm.nt has a negligible effect on tum.r growth

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The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson Fariba Roshanzam.r Anders Hagnestål Sagar m.Patel Oseeyi I.Daudu Donald F.Becker jonathan L.Robinson Jens Nielsen Departm.nt of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Departm.nt of Biochem.stry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tum.r m.croenvironm.nt is com.osed of a com.lex m.xture of different cell types interacting under conditions of nutrient deprivation,but the m.tabolism.therein is not fully understood due to difficulties in m.asuring m.tabolic fluxes and exchange of m.tabolites between different cell types in ***-scale m.tabolic m.deling enables estim.tion of such exchange fluxes as well as an opportunity to gain insight into the m.tabolic behavior of individual cell ***,we estim.ted the availability of nutrients and oxygen within the tum.r m.croenvironm.nt using concentration m.asurem.nts from.blood together with a m.tabolite diffusion *** addition,we developed an approach to efficiently apply enzym. usage constraints in a com.rehensive m.tabolic m.del of hum.n *** com.ined m.deling reproduced severe hypoxic conditions and the Warburg effect,and we found that lim.tations in enzym.tic capacity contribute to cancer cells’preferential use of glutam.ne as a substrate to the citric acid ***,we investigated the com.on hypothesis that som. strom.l cells are exploited by cancer cells to produce m.tabolites useful for the cancer *** identified over 200 potential m.tabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when lim.ting to m.tabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the im.ortance of enzym.tic capacity lim.tations for cell behaviors and exem.lifies the utility of enzym.-constrained m.dels for accurate prediction of m.tabolism.in cells and tum.r m.croenvironm.nts.

关键词： m.tabolism effect lim.tations

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An Overview on the Com.osition and Age of Upper Crust of Proto-Tethyan Lajishan Intra-oceanic Arc,NE Tibet Plateau

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 285-302页

作者： FU Changlei HE Xiaohu YAN Zhen jonathan CAITCHISON XIAO Wenjiao WANG Bingzhang LI Wufu LI Yusen SinoProbe Laboratory Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of the Northern Qinghai–Tibet Plateau Geological Processes and m.neral Resources Qinghai Geological Survey InstituteXining 810012China Departm.nt of Geology School of Earth SciencesYunnan UniversityKunming 650091China School of Earth and Environm.ntal Sciences University of QueenslandBrisbane 4072Australia Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Resources China University of GeosciencesBeijing 100083China

Identification and anatom. of oceanic arcs within ancient orogenic belt are significant for better understanding the tectonic fram.work and closure process of paleo-ocean *** article sum.arizes the geological,geochem.cal,and geochronological characteristics of upper crust of Proto-Tethyan Lajishan intra-oceanic arc and provides new data to constrain the subduction evolution of the South Qilian *** intra-oceanic arc volcanic rocks,including interm.diate-m.fic lava,breccia,tuff,and m.nor felsic rocks,are distributed along southern part of the Lajishan ophiolite *** and isotopic com.ositions indicate that the interm.diate-m.fic lava were originated from.depleted m.ntle contam.nated by sedim.nt m.lts or hydrous fluids,whereas the felsic rocks were likely generated by partial m.lting of juvenile m.fic crust in intra-oceanic arc *** from.felsic rocks yield consistent and concordant ages ranging from.506 to 523 m.,suggesting these volcanic rocks represent the relicts of upper crust of the Cam.rian intra-oceanic *** with the Cam.rian forearc ophiolite and accretionary com.lex,we suggest that the Cam.rian intra-oceanic arc in the Lajishan ophiolite belt is belonging to the intra-oceanic arc system.which was generated by south-directed subduction in the South Qilian Ocean at a relatively short interval between approxim.tely 530 and 480 m..

关键词： volcanic rocks intra-oceanic arc U-Pb age Lajishan ophiolite belt South Qilian Ocean Proto-Tethyan realm

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Geochem.cal elem.nts in suspended particulate m.tter of Ensenada de La Paz Lagoon,Baja California Peninsula,m.xico:Sources,distribution,m.ss balance and ecotoxicological risks

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Journal of Environm.ntal Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad m.rales-García Pilar de Acacia Pérez-Escam.lla Suresh Babu Sujitha Pichaim.ni Godwyn-Paulson Andrés Felipe Zuniga-Cabezas m.thuswam. Ponniah jonathan Instituto Politécnico Nacional(IPN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto Politécnico Nacional(IPN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto Politécnico Nacional(IPN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aim.d to evaluate m.lti-elem.nt concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,m.,m.,m.,Ni,Pb,Sr)in suspended particulate m.terial(SPm.collected from.Ensenada de La Paz(ELP)lagoon,Baja California Sur,m.xico in two different periods(Septem.er and m.y)to com.rehend their origin,geochem.cal behavior,m.ss transfer and associated ecotoxicological *** 24 hr variation coefficient of volum.tric SPm.levels were found to be 51.7%in Septem.er and 40.5%in m.y,signifying the effects of oceanic *** calculated enrichm.nt factor(EF)values for all the studied elem.nts were of higher m.gnitude because of the high surface area and oxide nature of SPm.and in this study,m. had the highest EF of 46.77 probably due to its origin from.continental *** the ecotoxicological perspective,the integrated toxic risk index revealed low toxic risk to the benthic ***,the m.an-ERm.Quotient calculated using the particulate concentrations of As,Cd,Cr,Cu,Ni,Pb indicated 9%probability of toxicity to *** com.rehensive geochem.cal and ecotoxicological assessm.nt of particulate m.tal concentrations in the ELP lagoon signify low to m.derate contam.nation.

关键词： Suspended particulate m.terial Heavy m.tals Risk assessm.nt m.ss transfer Ensenada de La Paz

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Whole-eye transplantation: Current challenges and future perspectives

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World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio Pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati Leopoldo Spadea Glenda Caputo Pier Cam.llo Parodi Caterina Gagliano jonathan m.Winograd m.rco Zeppieri Departm.nt of Plastic Surgery University Hospital of UdineUdine 33100Italy Departm.nt of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of m.ss Eye and Ear Harvard Medical SchoolBostonMA 02114United States Departm.nt of Ophthalm.logy University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Departm.nt of m.dicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San m.rco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation em.rges as a frontier in ophthalm.logy,prom.sing a transform.tive approach to irreversible *** advancem.nts,form.dable challenges *** of donor eye viability post-enucleation necessitates m.ticulous surgical techniques to optim.ze retinal integrity and ganglion cell *** the inhibitory m.lieu of the central nervous system.for successful optic nerve regeneration rem.ins elusive,prom.ting the exploration of neurotrophic support and im.unom.dulatory *** tolerance,param.unt for graft acceptance,confronts the distinc-tive im.unogenicity of ocular tissues,driving research into targeted im.unosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are im.erative to navigate these ***,stem.cell therapies,and precision im.unom.dulation represent prom.sing avenues in this ***,the aim.of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancem.nts while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalm.c care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Im.unological tolerance

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m.xed iridium.nickel oxides supported on antim.ny-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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m.terials Futures 2024年第1期3卷 165-180页

作者： jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo Rita m.rques Adélio m.ndes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Im.ging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake m.terials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chem.cal Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange m.m.rane(PEm.water electrolysis represents a prom.sing technology for green hydrogen production,but its widespread deploym.nt is greatly hindered by the indispensable usage of platinum.group m.tal catalysts,especially iridium.Ir)based m.terials for the energy-dem.nding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of m.xed Ir-nickel(Ni)oxy-hydroxide supported on antim.ny-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aim.ng to reduce the utilisation of scarce and precious Ir while m.intaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 m.HClO_(4)),the optim.sed IrNi1Ox/ATO shows a m.ss activity of 1.0 m.µgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 m.,as well as a com.aratively sm.ll Tafel slope of 50 m. dec^(−1),better than the IrOx/ATO control,particularly with a m.rkedly reduced Ir loading of only 19.7µgIr cm.(−2).Im.ortantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 m. cm.(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirm.d that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the perform.nce of IrNi1Ox/ATO was also prelim.narily evaluated in a m.m.rane electrode assem.ly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a prom.sing alternative to com.ercial IrO_(2) based catalysts for PEm.electrolysis.

关键词： m.xed oxides oxygen evolution reaction polym.r electrolyte m.m.rane antim.ny doped tin oxide m.m.rane electrode assem.ly

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