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Genetic Analysis of Invertebrates From Great Salt Lake,Utah

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Acta Geologica Sinica(English Edition) 2014年第S1期88卷 65-65页

作者： jonathan clark Son NGUYEN Department of Zoology Weber State University

Great Salt Lake(GSL),in northern Utah,is one of the largest lakes in the United States,with a total surface area of 4400 square *** constitute the most conspicuous and abundant animals inhabiting the waters

关键词： DNA barcoding cytochrome c oxidase moleculaphylogeny

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太空超声波技术

航天员 2010年第2期 42-46页

作者： Scott A.Dulchavsky 焦立中 jonathan clark 郭亚光肖志军

超声技术一直是医疗界广泛运用的一项科技,它为人类在疾病的诊断防治等方面起到了很大作用。这不,它又走向了太空,并且经过在太空中的进一步研究和实践后又重回地面并且发扬光大。太空超声波技术能够让一个有点基础知识的普通人而非专... 详细信息

超声技术一直是医疗界广泛运用的一项科技,它为人类在疾病的诊断防治等方面起到了很大作用。这不,它又走向了太空,并且经过在太空中的进一步研究和实践后又重回地面并且发扬光大。太空超声波技术能够让一个有点基础知识的普通人而非专家在远程指导下就能合理应用,所以超声技术有可能出现在地球上任何一个地方,哪怕那里没有应用超声技术的专家。而且,太空超声技术还具备了很大的在未来拓展应用的潜力,相信它会在未来发挥出更重要的作用。

关键词：超声波技术太空超声技术合理应用诊断防治基础知识专家

扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究

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现代肿瘤医学 2015年第4期23卷 461-464页

作者：费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo jonathan clark Barbara Rose 昆明医科大学第三附属医院云南省肿瘤医院头颈外科悉尼大学皇家王子Alfred医院悉尼癌症中心头颈肿瘤研究所云南昆明650018 悉尼UNSW癌症研究中心综合癌症研究部悉尼大学感染性疾病与免疫学系悉尼大学医学院病理教研室悉尼利物浦医院解剖病理科

目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。

关键词：扁桃体癌鳞状细胞癌人乳头瘤病毒血管内皮生长因子表皮生长因子受体

Nutrition and metabolism in burn patients

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Burns & Trauma 2017年第2期5卷 95-106页

作者： Audra clark jonathan Imran Tarik Madni Steven E. Wolf University of Texas Southwestern Medical Center 5323 Harry Hines Blvd.Dallas TX 75390 USA

Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction,and susceptibility to infection. Adequate assessment and provision of nutritional needs is imperative to care for these patients. There is no consensus regarding the optimal timing, route, amount, and composition of nutritional support for burn patients, but most clinicians advocate for early enteral nutrition with highcarbohydrate *** support must be individualized, monitored, and adjusted throughout recovery. Further investigation is needed regarding optimal nutritional support and accurate nutritional endpoints and goals.

关键词： Burn Nutrition Metabolism Critical care

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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World Journal of Gastroenterology 2016年第11期22卷 3117-3126页

作者： jonathan Landy Emma Ronde Nick English Sue K clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi IBD Unit St Mark's Hospital Harrow London HA1 3UJ United Kingdom Antigen Presentation Research Group Department of Immunology Imperial College London HA1 3UJ United Kingdom Department of Biosurgery and Surgical Technology Imperial College London HA1 3UJ United Kingdom Department of Gastroenterology The Rayne Institute St Thomas' Hospital London HA1 3UJ United Kingdom

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

关键词： Claudin Tight junction Ulcerative colitis Pouchitis Crohn’ s disease

Relative Depth Effects on Corrugated Culvert Roughness

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Journal of Water Resource and Protection 2012年第10期4卷 838-841页

作者： jonathan Scott Toews Shawn Paul clark Civil Engineering University of Manitoba Winnipeg Canada

Fish passage is important to the overall health of an ecosystem. Therefore, it is important to be able to accurately predict flow conditions within a stream crossing for high and low flow periods. This paper evaluates the effect of relative water depth on the hydraulic roughness of culverts at low discharge. A 21 m long, 0.8 m diameter corrugated steel pipe with 0.068 × 0.013 m annular corrugations was used. For relative depths below 0.5, Manning’s n was found to increase with decreasing relative depth. An equation was developed to predict relative depths below 0.5 within a corrugated steel pipe based on the corrugation height, slope and culvert diameter. While Manning’s equation does perform reasonably well, the percent difference from the measured to predicted water levels warrants the use of an additional prediction method at low flows.

关键词： Culverts Fish Passage Low Flows Roughness Manning’s Equation

Ascorbic acid and low-volume polyethylene glycol for bowel preparation prior to colonoscopy:A meta-analysis

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World Journal of Meta-Analysis 2013年第1期1卷 10-15页

作者： jonathan D Godfrey Robert E clark Abhishek Choudhary Imran Ashraf Michelle L Matteson Srinivas R Puli Matthew L Bechtold Division of Gastroenterology University of Missouri Columbia MO 65212 United States OSF MG Gastroenterology University of Illinois Peoria IL 61604 United States

AIM: To evaluate the benefits of low-volume polyethylene glycol(PEG) with ascorbic acid compared to fulldose PEG for colonoscopy preparation. METHODS: MEDLINE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, CINAHL, Pub Med, and recent abstracts from major conferences were searched(January 2012). Only randomized-controlled trials on adult subjects comparing lowvolume PEG(2 L) with ascorbic acid vs full-dose PEG(3 or 4 L) were included. Meta-analysis for the efficacy of low-volume PEG with ascorbic acid and full-dose PEG were analyzed by calculating pooled estimates of number of satisfactory bowel preparations as well as adverse patient events(abdominal pain, nausea, vomiting). Separate analyses were performed for each main outcome by using OR with fixed and random effects models. Heterogeneity was assessed by calculating the I2 measure of inconsistency. Rev Man 5.1 was utilized for statistical ***: The initial search identified 242 articles and trials. Nine studies(n = 2911) met the inclusion criteria and were analyzed for this meta-analysis with mean age range from 53.0 to 59.6 years. All studies were randomized controlled trials on adult patients comparing large-volume PEG solutions(3 or 4 L) with low-volume PEG solutions and ascorbic acid. No statistically significant difference was noted between lowvolume PEG with ascorbic acid and full-dose PEG for number of satisfactory bowel preparations(OR 1.07, 95%CI: 0.86-1.33, P = 0.56). No statistically significant difference was noted between low-volume PEG with ascorbic acid and full-dose PEG for abdominal pain(OR 1.09, 95%CI: 0.81-1.48, P = 0.56), nausea(OR 0.70, 95%CI: 0.49-1.00, P = 0.05), or vomiting(OR 0.99, 95%CI: 0.78-1.26, P = 0.95). No publication bias was ***: Low-volume PEG with the addition of ascorbic acid demonstrates no statistically significant difference to full-dose PEG for satisfactory bowel preparation and side-effects.

关键词： Polyethylene glycol Ascorbic acid Colonoscopy Meta-analysis Bowel preparation

From Swift to Mr. Ed： Comedic Representations of the Noble Horse in High and Low Culture

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Journal of Literature and Art Studies 2012年第1期2卷 233-241页

作者： John Esperian Christian clark College of Southern Nevada Las Vegas USA

Few would deny the nobility of an animal which has played a significant role, historically, in the lives of humankind： the fabled unicorn, the Trojan Horse, and Pegasus, together with the Houyhnhnms of jonathan Swift are testaments to the nobility of horses. In a modern context, Seabiscuit, Black Beauty, Silver, steed of the iconic Lone Ranger, and Tir na nog, from Irish folk tale history, have maintained the tradition of nobility. High comedic elements such as TV＇s Mr. Ed, Aspercel, from The Horse in the Gray Flannel Suit （1968）, Ollie, of Laurel and Hardy fame, reincarnated as a horse, and Tir na nog, hiding in an elevator to avoid being apprehended by the law, help to complete the comedic portrait of equine nobility

关键词： jonathan Swift Gulliver Mr. Ed Aspercel Seabiscuit Laurel and Hardy satire surrealism

Microalgae Cultivation Using Offshore Membrane Enclosures for Growing Algae (OMEGA)

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Journal of Sustainable Bioenergy Systems 2013年第1期3卷 18-32页

作者： Patrick Wiley Linden Harris Sigrid Reinsch Sasha Tozzi Tsegereda Embaye Kit clark Brandi McKuin Zbigniew Kolber Russel Adams Hiromi Kagawa Tra-My Justine Richardson John Malinowski Colin Beal Matthew A. Claxton Emil Geiger Jon Rask J. Elliot Campbell jonathan D. Trent Advanced Organic Methods Penryn USA Department of Chemistry University of California Santa Cruz USA Department of Mechanical Engineering University of Nevada Reno USA Department of Ocean Sciences University of California Santa Cruz USA Dynamac Corporation NASA Ames Research Center Moffett Field USA NASA Ames Research Center Moffett Field USA School of Engineering University of California Merced USA SETI Institute Mountain View USA Universities Space Research Association Columbia USA

OMEGA is a system for cultivating microalgae using wastewater contained in floating photobioreactors (PBRs) deployed in marine environments and thereby eliminating competition with agriculture for water, fertilizer, and land. The offshore placement in protected bays near coastal cities co-locates OMEGA with wastewater outfalls and sources of CO2-rich flue gas on shore. To evaluate the feasibility of OMEGA, microalgae were grown on secondary-treated wastewater supplemented with simulated flue gas (8.5% CO2 V/V) in a 110-liter prototype system tested using a seawater tank. The flow-through system consisted of tubular PBRs made of transparent linear low-density polyethylene, a gas exchange and harvesting column (GEHC), two pumps, and an instrumentation and control (I&C) system. The PBRs contained regularly spaced swirl vanes to create helical flow and mixing for the circulating culture. About 5% of the culture volume was continuously diverted through the GEHC to manage dissolved oxygen concentrations, provide supplemental CO2, harvest microalgae from a settling chamber, and add fresh wastewater to replenish nutrients. The I&C system controlled CO2 injection and recorded dissolved oxygen levels, totalized CO2 flow, temperature, circulation rates, photosynthetic active radiation (PAR), and the photosynthetic efficiency as determined by fast repetition rate fluorometry. In two experimental trials, totaling 23 days in April and May 2012, microalgae productivity averaged 14.1 ± 1.3 grams of dry biomass per square meter of PBR surface area per day (n = 16), supplemental CO2 was converted to biomass with >50% efficiency, and >90% of the ammonia-nitrogen was recovered from secondary effluent. If OMEGA can be optimized for energy efficiency and scaled up economically, it has the potential to contribute significantly to biofuels production and wastewater treatment.

关键词： Biofuels Wastewater Treatment Microalgae Photobioreactor CO2 Mass Transfer Fast Repetition Rate Fluorometry Instrumentation and Control