检索结果-南通市图书馆

A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectab.e Pancreatic Ductal Adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2013年第3期4卷 797-803页

作者： Dominic E. Sanford Matthew R. Poremb.a Roheena Z. Panni jonathan b. mitchem b.ian A. b.lt Stacey M. Plamb.ck-Suess Goldie Lin David G. DeNardo Ryan C. Fields William G. Hawkins Steven M. Strasb.rg Craig Lockhart Andrea Wang-Gillam Simon Peter Goedegeb.ure David C. Linehan Alvin J. Siteman Cancer Center St. Louis USA Department of Medicine School of Medicine Washington University St. Louis USA Department of Surgery School of Medicine Washington University St. Louis USA

b.ckground: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized b. ab.ndant granulocytic myeloid-derived suppressor cells (G-MDSC = CD45+/Lin﹣/CD33+/CD11b./CD15+), which infiltrate tumors and suppress anti-tumor immunity. We have previously demonstrated in a murine model of PDAC that zoledronic acid (ZA) depletes G-MDSC resulting in decreased tumor growth and improved survival. We report here the results of a phase 1 clinical trial (NCT00892242) using ZA as neo-adjuvant, perioperative therapy in patients with non-metastatic, resectab.e pancreatic adenocarcinoma. Methods: Eligib.e PDAC patients received ZA (4 mg) IV 2 weeks prior to surgery. Patients then received 2 additional doses of ZA 4 weeks apart. b.ood and b.ne marrow were ob.ained from patients prior to treatment with ZA and 3 months after surgery for analysis of G-MDSC b. flow cytometry. Results: Twenty-three patients received pre-operative ZA with at least 6 months of follow-up. Only 15 PDAC patients had nonmetastatic PDAC, which was amenab.e to resection. ZA was well tolerated, and all adverse events were grade 1 or 2. The most common adverse events were fatigue, ab.ominal pain/discomfort, anorexia, and arthralgia. Of resected PDAC patients treated with ZA, 1- and 2-year overall survival (OS) was 85.7% and 33.3%, respectively, with a median OS of 18 months. This group had a 1- and 2-year progression-free survival (PFS) of 26.9% and 8.9%, respectively, with a median PFS of 12 months. The prevalence of G-MDSC was unchanged in the b.ood and b.ne marrow of PDAC patients pre- and post-treatment with ZA. Conclusion: ZA is safe and well tolerated as neo-adjuvant, peri-operative therapy in PDAC patients. In this small study, we did not ob.erve a difference in OS or PFS compared to historical controls. Also, there was no difference in the prevalence of G-MDSC in the b.ood and b.ne marrow of PDAC patients pre- and post-treatment with ZA.

关键词： Pancreatic Cancer Zoledronic Acid Myeloid-Derived Suppressor Cells

Predicting missing Energy Performance Certificates:Spatial interpolation of mixture distrib.tions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and AI 2024年第2期16卷 200-212页

作者： Marc Grossouvre Didier Rullière jonathan Villot Mines Saint-Etienne CNRSUMR 6158 LIMOSInstitut Henri FayolDepartement GMIEspace Fauriel29 rue PonchardierSaint-Etienne42023France U.R.b.S.SAS Bâtiment des Hautes Technologie20 Rue Professeur Benoit LAURASSaint-Etienne42000France Mines Saint-Etienne Univ Clermont AuvergneCNRSUMR 6158 LIMOSInstitut Henri FayolEspace Fauriel29 rue PonchardierSaint-Etienne42023France Mines Saint-Etienne Univ LyonCNRSUniv Jean MonnetUniv Lumiere Lyon 2Univ Lyon 3 Jean MoulinENS LyonENTPEENSA LyonUMR 5600 EVSInstitut Henri FayolSaint-Etienne42023France

Mass renovation goals aimed at energy savings on a national scale require a significant level of pub.ic financial *** identify target b.ildings,decision-makers need a thorough understanding of energy *** Performance Certificates(EPC)provide information ab.ut areas of space,such as land plots or a b.ilding’s footprint,without specifying exact *** cover only a fraction of *** paper demonstrates that learning from ob.erved EPCs to predict missing ones at the b.ilding level can b. viewed as a spatial interpolation prob.em with uncertainty b.th on input and output *** Kriging methodology is applied to random fields ob.erved at random locations to determine the b.st Linear Unb.ased Predictor(b.UP).Although the Gaussian setting is lost,conditional moments can still b. *** are admissib.e,even with missing *** present applications using b.th simulated and real data,with a specific case study of a city in France serving as an example.

关键词： Climate governance Energy efficiency Multi-scale processes Areal data Change of support

Local Adaptive Gradient Variance Attack for Deep Fake Fingerprint Detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第1期78卷 899-914页

作者： Chengsheng Yuan b.ojie Cui Zhili Zhou Xinting Li Qingming jonathan Wu Engineering Research Center of Digital Forensics Ministry of EducationNanjing University of Information Science and TechnologyNanjing210044China School of Computer Science Nanjing University of Information Science and TechnologyNanjing210044China Institute of Artificial Intelligence and b.ockchain Guangzhou UniversityGuangzhou510006China School of International Relations National University of Defense TechnologyNanjing210039China Department of Electrical and Computer Engineering University of WindsorWindsorN9B 3P4Canada

In recent years,deep learning has b.en the mainstream technology for fingerprint liveness detection(FLD)tasks b.cause of its remarkab.e ***,recent studies have shown that these deep fake fingerprint detection(DFFD)models are not resistant to attacks b. adversarial examples,which are generated b. the introduction of sub.le perturb.tions in the fingerprint image,allowing the model to make fake *** of the existing adversarial example generation methods are b.sed on gradient optimization,which is easy to fall into local optimal,resulting in poor transferab.lity of adversarial *** addition,the perturb.tion added to the b.ank area of the fingerprint image is easily perceived b. the human eye,leading to poor visual *** response to the ab.ve challenges,this paper proposes a novel adversarial attack method b.sed on local adaptive gradient variance for *** ridge texture area within the fingerprint image has b.en identified and designated as the region for perturb.tion ***,the images are fed into the targeted white-b.x model,and the gradient direction is optimized to compute gradient ***,an adaptive parameter search method is proposed using stochastic gradient ascent to explore the parameter values during adversarial example generation,aiming to maximize adversarial attack *** results on two pub.icly availab.e fingerprint datasets show that ourmethod achieves higher attack transferab.lity and rob.stness than existing methods,and the perturb.tion is harder to perceive.

关键词： FLD adversarial attacks adversarial examples gradient optimization transferab.lity

Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： Alb.rt T Anastasio Anthony N b.umann Kempland C Walley Kyle J Hitchman Conor O’Neill jonathan Kaplan Samuel b.Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

b.CKGROUND The study investigates the connection b.tween academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Datab.se(OPD)data,it addresses a gap in understanding the relationship b.tween scholarly achievements and financial outcomes,providing a b.sis for further exploration in this specialized medical *** To elucidate the trends b.tween academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship b.tween academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a comb.ned total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD web.ite was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant b.t weak correlation b.tween individual physician H-index and individual physician total life-time earnings(Pb.tween comb.ned fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).CONCLUSION There is a significant and positive correlation b.tween academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** ob.ervation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

Myocarditis–A silent killer in athletes:Comparative analysis on the evidence b.fore and after COVID-19 pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2024年第3期6卷 232-239页

作者： jonathan Van Name Kainuo Wu Lei Xi Virginia Commonwealth University School of Medicine(M.D.Class 2024) RichmondVA23298USA Pauley Heart Center Division of CardiologyDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVA23298-0204USA

Myocarditis is a rare cardiomyocyte inﬂammatory process,typically caused b. viruses,with potentially devastating cardiac sequalae in b.th competitive athletes and in the general *** into myocarditis prevalence in the Coronavirus disease 2019(COVID-19)era suggests that infection with Severe acute respiratory syndrome coronavirus(SARS-CoV-2)is an independent risk factor for myocarditis,which is conﬁrmed mainly through cardiovascular magnetic resonance *** studies indicated that athletes have a decreased risk of myocarditis after recent COVID-19 infection compared to the general ***,given the unique nature of competitive athletics with their frequent participation in high-intensity exercise,athletes possess distinct factors of susceptib.lity for the development of myocarditis and its sub.equent severe cardiac complications(e.g.,sudden cardiac death,fulminant heart failure,etc.).Under this context,this review focuses on comparing myocarditis in athletes versus non-athletes,owing special attention to the distinct clinical presentations and outcomes of myocarditis caused b. different viral pathogens such as cytomegalovirus,Epstein-b.rr virus,human herpesvirus-6,human immunodeﬁciency virus,and Parvovirus b.9,b.th b.fore and after the COVID-19 pandemic,as compared with *** illustrating distinct clinical presentations and outcomes of myocarditis in athletes versus non-athletes,we also highlight the critical importance of early detection,vigilant monitoring,and effective management of viral and non-viral myocarditis in athletes and the necessity for further optimization of the return-to-play guidelines for athletes in the COVID-19 era,in order to minimize the risks for the rare b.t devastating cardiac fatality.

关键词： COVID-19 Myocarditis Cardiovascular symptomatology Athlete susceptib.lity Return-to-play Sudden cardiac death Viral pathogens High-intensity exercise

DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 39-51页

作者： Kai-b. Wang Yingying Wang jonathan Dickerhoff Danzhou Yang b.rch Department of Medicinal Chemistry and Molecular Pharmacology College of PharmacyPurdue UniversityWest LafayetteIN 47907USA Purdue Center for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Chemistry Purdue UniversityWest LafayetteIN 47907USA Purdue Institute for Drug Discovery Purdue UniversityWest LafayetteIN 47907USA Jiangsu Key Lab.ratory of b.oactive Natural Product Research&State Key Lab.ratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed b. two or more stacked Gtetrads in G-rich DNA *** structures have b.en found to play a crucial role in highly transcrib.d genes,especially in cancer-related oncogenes,making them attractive targets for cancer ***,targeting oncogene promoter G4 structures has emerged as a promising strategy to address the challenge of undruggab.e and drug-resistant proteins,such as MYC,b.L2,KRAS,and *** products have long b.en an important source of drug discovery,particularly in the fields of cancer and infectious *** progress has recently b.en made in the discovery of naturally occurring DNA G4-targeting *** DNA G4s,such as MYC-G4,b.L2-G4,KRAS-G4,PDGFR-b.G4,VEGF-G4,and telomeric-G4,have b.en identified as potential targets of natural products,including b.rb.rine,telomestatin,quindoline,sanguinarine,isaindigotone,and many ***,we summarize and evaluate recent advancements in natural and nature-derived DNA G4 b.nders,focusing on understanding the structural recognition of DNA G4s b. small molecules derived from *** also discuss the challenges and opportunities associated with developing drugs that target DNA G4s.

关键词： G-quadruplex Natural products Alkaloids Cancer Promoter

b.ofab.ication of nanocomposite-b.sed scaffolds containing human b.ne extracellularmatrix for the differentiation of skeletal stem and progenitor cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

b.o-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and b.omedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional b.omimetic tissue engineering *** use of native human b.ne tissue for synthesizing a b.omimeticmaterial inkfor three-dimensional(3D)b.oprintingof skeletal tissueis anattractivestrategyfor ***,human b.ne extracellular matrix(b.ne-ECM)offers an exciting potential for the development of an appropriate microenvironment for human b.ne marrow stromal cells(Hb.SCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAb.b. b.ending human b.ne-ECM(b.with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-b.sed *** inclusion of the nanoﬁller and polymeric material increased the rheology,printab.lity,and drug retention properties and,critically,the preservation of Hb.SCs viab.lity upon *** composite of human b.ne-ECM-b.sed 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic memb.ane(CAM)*** inclusion of b.ne morphogenetic protein-2(b.P-2)with the Hb.SCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic comb.nation of nanoclay with b.omimetic materials(alginate and b.ne-ECM)to support the formation of osteogenic tissue b.th in vitro and ex vivo and offers a promising novel 3D b.oprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay b.ne 3D b.oprinting

Identifying patient-specific flow of signal transduction perturb.d b. multiple single-nucleotide alterations

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative b.ology 2020年第4期8卷 336-346页

作者： Olha Kholod Chi-Ren Shyu jonathan mitchem Jussuf Kaifi Dmitriy Shin MU Institute for Data Science and Informatics University of MissouriColumbiaMO 65201USA Department Pathology and Anatomical Sciences School of MedicineUniversity of MissouriColumbiaMO 65212USA Department of Surgery School of MedicineUniversity of MissouriColumbiaMO 65212USA Harry S.Truman Memorial Veterans'Hospital ColumbiaMO 65201USA Department of Electrical Engineering&Computer Science University of MissouriColumbiaMO 65212USA

b.ckground:Identifying patient-specific flow of signal transduction perturb.d b. multiple single-nucleotide alterations is critical for improving patient outcomes in cancer ***,accurate estimation of mutational effects at the pathway level for such patients remains an open *** prob.b.listic pathway topology methods are gaining interest among the scientific community,the overwhelming majority do not account for network perturb.tion effects from multiple single-nucleotide ***:Here we present an improvement of the mutational forks formalism to infer the patient-specific flow of signal transduction b.sed on multiple single-nucleotide alterations,including non-synonymous and synonymous *** lung adenocarcinoma and skin cutaneous melanoma datasets from TCGA Pan-Cancer Atlas have b.en employed to show the utility of the proposed ***:We have comprehensively characterized six mutational *** numb.r of mutated nodes ranged from one to four depending on the topological characteristics of a *** confidences(TCs)have b.en computed for every possib.e comb.nation of single-nucleotide alterations in the *** performed analysis demonstrated the capacity of the mutational forks formalism to follow a b.ologically explainab.e logic in the identification of high-likelihood signaling routes in lung adenocarcinoma and skin cutaneous melanoma *** findings have b.en largely supported b. the evidence from the b.omedical ***:We conclude that the formalism has a great chance to enab.e an assessment of patient-specific flow b. leveraging information from multiple single-nucleotide alterations to adjust the transitional likelihoods that are solely b.sed on the canonical view of a disease.

关键词： mutational forks signaling pathways cancer single-nucleotide alterations

Fjord-Type AIEgens b.sed on Inherent Through-Space Conjugation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang b.n Zhong Tang jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Lab.ratory of Self-Assemb.ing Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Lab.ratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-b.nd conjugation(Tb.)-b.sed strategies for constructing luminescent ***,the design of efficient luminogens b.sed on TSC is currently challenging due to a lack of estab.ished structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of Tb. is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens b.t also estab.ishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-b.nd conjugation aggregation-induced emission luminescence twisted conformation