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Mitochondrial membrane protein Bcl-xl, a regulator of adult neuronal growth and synaptic plasticity: multiple functions beyond apoptosis

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Neural Regeneration Research 2014年第19期9卷 1706-1707页

作者： Han-A Park Elizabeth A.jonas Department of Internal Medicine Section of EndocrinologyYale University

The B-cell lymphoma 2 （Bcl2） family of proteins participates in cell death or survival through a mitochondrial pathway. The pro-apoptotic members of the Bcl2 family such as Bim, Bid, Bax and Bak trigger cell death by contributing to the enhancement of mitochondrial outer membrane permeabil- ity to pro-apoptotic factors such as cytochrome c, with the subsequent activation of caspases. The anti-apoptotic mem- bers, such as B-cell lymphoma-extra large （Bd-xl）, block the pro-apoptotic Bcl2 members and prevent cell death. Bcl-xl is abundantly expressed during development and in mature neurons, suggesting that it plays a role in protection from death from untoward events occurring in adult life such as ischemia, inflammation or trauma. When these neurotoxic in- sults occur, Bcl-xl translocates to mitochondria and prevents activation and homo-oligomerization of pro-apoptotic family members such Bax and Bak. Numerous studies have shown pro-survival roles for Bcl-xl in adult neurons using various models; nevertheless, the role of Bcl-xl outside of the field of neuronal death, i.e., in adult neuronal growth, excitability or synaptic plasticity, has not been studied in depth.

关键词： Mitochondrial membrane protein Bcl-xl a regulator of adult neuronal growth and synaptic plasticity RNAi Bax

Correction:The interplay between dendritic cells and CD8 T lymphocytes is a crucial component of SARS-CoV-2 immunity

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Cellular & Molecular Immunology 2022年第12期19卷 1441-1441页

作者： jonas Buttenschon Jochen Mattner Mikrobiologisches Institut - Klinische Mikrobiologie Immunologie und Hygiene Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg Erlangen Germany Medical Immunology Campus Erlangen FAU Erlangen-Nürnberg Erlangen Germany

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-020-00624-1,published online 08 January 2021 The licence information was missing from this article and should *** original article has been correc... 详细信息

关键词： immunity lymphocytes Immunology

Ambulatory blood-pressure monitoring, antihypertensive therapy and the risk of fall injuries in elderly hypertensive patients

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Journal of Geriatric Cardiology 2018年第4期15卷 284-289页

作者： Michael jonas Rasisa Kazarski Gil Chemin Department of Cardiology Kaplan Medical Center Hebrew University School of Medicine Rehovot Israel Department of Nephrology and Hypertension Kaplan Medical Center Hebrew University School of Medicine Rehovot Israel

BackgroundFall 损害是普通的在之中老。这研究的目的是调查是否血压模式由 24-h 测量了监视的回廊血压( ABPM )，或跟随 24-h ABPM 的 antihypertensive 治疗的增强，可以在高血压的老 *** 与秋天损害被联系回顾的研究，是的基于社区... 详细信息

BackgroundFall 损害是普通的在之中老。这研究的目的是调查是否血压模式由 24-h 测量了监视的回廊血压( ABPM )，或跟随 24-h ABPM 的 antihypertensive 治疗的增强，可以在高血压的老 *** 与秋天损害被联系回顾的研究，是的基于社区的老病人(年龄 70 年)指了 24-h ABPM 在一个年 post-ABPM 以内为秋天损害被评估。我们比较了临床的特征， 24-h ABPM 模式和高血压的治疗追随者 24-h ABPM 的增强，在有或没有秋天 *** 的病人之间 1032 个高血压的老病人被评估。(5.3%) 55 在跟随 ABPM 的一年有一个秋天损害事件。有秋天损害的病人显著地更老，并且与以前的下降的更高的率。更低的 24-h 心脏舒张的血压(到 2014 年 12 月的 67.3 2011 年 1 月) ， 1164 个病人作为有尖锐大动脉的解剖被识别。corr？？

关键词：高血压损害秋天治疗风险心脏压力脉搏

Recent results of laparoscopic surgery in inflammatory bowel disease

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World Journal of Gastroenterology 2011年第9期17卷 1116-1125页

作者： Hermann Kessler jonas Mudter Werner Hohenberger Department of Surgery University of Erlangen Department of Internal Medicine 1 GastroenterologyUniversity of Erlangen

Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional *** alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed *** current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is *** limited to the terminal ileum has become a common indication for laparoscopic surgical *** severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative *** comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic *** complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low *** UC, restorative proctocolectomy is the standard procedure in elective *** demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various *** increased body mass index and acute inflammation of the bowel may be relative *** and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic *** studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under *** considerations are playing an important role for the co

关键词：肠道疾病手术方法腹腔镜炎症溃疡性结肠炎手术治疗标准程序技术因素

litter removal impacts on soil biodiversity and eucalypt plantation development in the seasonal tropics

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Journal of Forestry Research 2023年第3期34卷 735-748页

作者： jonas Inkotte Barbara Bomfim Sarah Camelo da Silva Marco Bruno Xavier Valadão Márcio Gonçalves da Rosa Roberta Batista Viana Alcides Gatto Reginaldo SPereira Department of Forestry Engineering University of BrasiliaBrasíliaDistrito FederalBrazil Climate and Ecosystem Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA SESI/SENAI Social Service Industry Santa Catarina StateChapecóBrazil

The little layer of tree plantations provides primary nutrients for uptake,buff ers changes in soil moisture,and provides habitat and substrate to soil epigeic ***,this layer in eucalypt plantations is often removed to reduce fuel load during the fi re season in the Brazilian savanna(Cerrado).Therefore,it is necessary to quantify the eff ects of changes in litter dynamics on the function of these plantations,on key nutrient cycling processes and on epigeic fauna diversity and *** two adjacent stands(one juvenile and one mature),the consequences of two years of litter removal were quantifi ed as monthly litterfall,leaf and fi ne wood litter decomposition,epigeic fauna abundance and diversity,soil biogeochemical variables,and tree diameter and basal area *** litterfall rates in juvenile and mature stands did not change with litter removal over the study *** litterfall ranged from 4.1 to 4.9 Mg ha^(−1)a^(−1)in litter removal plots and from 3.9 to 4.8 Mg ha^(−1)a^(−1)in control *** wood litter decomposition was slower in litter removal plots compared to controls,while leaf decomposition rates were similar in *** years of litter removal in the juvenile stand did not aff ect topsoil biogeochemical parameters but decreased available phosphorus at 20–40 cm depth relative to *** the mature stand,total cation exchange capacity(0–20 cm)was higher in controls(6.4 cmol c dm^(−3))relative to litter removal plots(6.3 cmol c dm^(−3)),while soil moisture(0–40 cm depth)was lower in litter removal(25.45 m 3 m^(−3))compared to control plots(26 m^(3)m^(−3))in the dry season.A non-metric multidimensional scaling ordination revealed an increased homogeneity in epigeic fauna where litter was ***,decomposition,diameter increment,four soil physical parameters and fourteen chemical parameters at 0–20 and 20–40 cm depth explained the diff erences in soil epigeic fauna composition between litter removal and control p

关键词： Cerrado Nutrient cycling Soil ecology Soil epigeic fauna Plantation management

Seminal HPV detection:a pilot study comparing the preservation effectiveness and cost between a methanol-based solution and cryopreservation with liquid nitrogen

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Asian Journal of Andrology 2022年第5期24卷 560-561页

作者： Jynfiaf Francis Cecilia Kärrberg jonas Hermansson Magnus lindh Sofia Ganidou Ann Thurin-Kjellberg Kersti lundin Randa Akouri Panagiotis Tsiartas Department of Reproductive Medicine Sahlgrenska University HospitalGothenburg 41345Sweden Department of Obstetrics and Gynecology Institute of Clinical SciencesSahlgrenska AcademyGothenburg UniversityGothenburg 40530Sweden Department of Research and Development Angered HospitalAngered 42465Sweden Department of Clinical Microbiology Sahlgrenska University HospitalGothenburg 41346Sweden Department of OncologyPathology Karolinska InstituteStockholm 17177Sweden

Dear Editor,Human papillomavirus(HPV)is the most common sexually transmitted virus worldwide,and high-risk HPV infection is the most important risk factor for cervical cancer.1 However,few conclusive data are available on the prevalence of the male HPV infection and its health *** has been found that the prevalence of seminal HPV infection is higher in men with unexplained infertility,ranging between 10%and 35%compared with the general population(range:2%to 11%).2–4 In three recent systematic reviews,it was seen that HPV sperm infection may be associated with impaired sperm function that could lead to male infertility.2,4,5 HPV sperm infection with high-risk HPV among infertile men was shown to be associated with lower progressive sperm motility and higher DNA fragmentation index.6 Moreover,a high rate of pregnancy loss has been found among couples with HPV sperm infection after in vitro fertilization(IVF).7 In the majority of the studies performed to assess seminal HPV infection.

关键词： impaired methanol HPV

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老年心脏病学杂志:英文版 2023年第8期20卷 555-566页

作者： Alexander Schmitt Kathrin Weidner jonas Rusnak Marinela Ruka Sascha Egner-Walter Kambis Mashayekhi Péter Tajti Mohamed Ayoub Ibrahim Akin Michael Behnes Tobias Schupp Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre Mannh-eimMedical Faculty MannheimHeidelberg UniversityMannheimGermany European Center for AngioScience(ECAS) German Center for Cardiovascular Research(DZHK)partner site Heidelberg/MannheimMannheimGermany Depar-tment of Internal Medicine and Cardiology Mediclin Heart Centre LahrLahrGermany Gottsegen György National Ca-rdiovascular Center BudapestHungary Division of Cardiology and Angiology Heart Center University of Bochum-Bad OeynhausenBad OeynhausenGermany

BACKGROUND As a result of improved and novel treatment strategies,the spectrum of patients with cardiovascular disease is consistently ***,those patients are typically older and characterized by increased burden with *** data on the prognostic impact of age in cardiogenic shock(CS)is ***,this study investigates the prognostic impact of age in patients with *** From 2019 to 2021,consecutive patients with CS of any cause were *** prognostic value of age(i.e.,60-80 years and>80 years)was investigated for 30-day all-cause ***’s correlations,Kaplan-Meier analyses,as well as multivariable Cox proportional regression analyses were performed for *** risk assessment was performed based on the presence or absence of CS related to acute myocardial infarction(AMI).RESUlTS 223 CS patients were included with a median age of 77 years(interquartile range:69-82 years).No significant difference in 30-day all-cause mortality was observed for both age-groups(54.6%vs.63.4%,log-rank P=0.169;HR=1.273,95%CI:0.886-1.831,P=0.192).In contrast,when analyzing subgroups stratified by CS-etiology,AMI-related CS patients of the group>80 years showed an increased risk of 30-day all-cause mortality(78.1%vs.60.0%,log-rank P=0.032;HR=1.635,95%CI:1.000-2.673,P=0.050),which was still evident after multivariable adjustment(HR=2.072,95%CI:1.174-3.656,P=0.012).CONClUSIONS Age was not associated with 30-day all-cause mortality in patients with CS of mixed ***,increasing age was shown to be a significant predictor of increased mortality-risk in the subgroup of patients presenting with AMI-CS.

关键词： patients etiology mortality

Colorectal cancer in patients with inflammatory bowel disease:Can we predict risk?

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World Journal of Gastroenterology 2012年第31期18卷 4091-4094页

作者： Vibeke Andersen jonas Halfvarson Ulla Vogel Medical Department Sygehus Sφnderjylland AabenraaDK-6200 AabenraaDenmark Institute of Regional Health Services Research University of Southern DenmarkDK-5000 OdenseDenmark Department of Internal Medicine rebro University Hospitalrebro Universityrebro 70185Sweden National Research Centre for the Working Environment DK-2100 CopenhagenDenmark

The inflammatory bowel diseases(IBD),Crohn's disease(CD) and ulcerative colitis(UC),may be complicated by colorectal cancer(CRC).In a recent populationbased cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of *** overall risk of CRC among patients with UC and CD was comparable with that of the general ***,patients diagnosed with UC during childhood or as adolescents,patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased *** this commentary,we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD *** advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated *** ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic *** challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD *** achieved knowledge may also be relevant for other inflammation-associated cancers.

关键词：风险预测肠道疾病预测模型大肠癌患者鸡传染性法氏囊病溃疡性结肠炎临床实践

Ophthalmology： potential future developments in China and worldwide

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Chinese Medical Journal 2014年第8期127卷 1401-1404页

作者： Jost B. jonas Songhomitra Panda-jonas Wang Yaxing Wei Wenbin Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Science Key laboratory Beijing 100730 China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg Germany

With a volume of about 6 ml and weight of approximately 6 g, the eye makes out only 1/10 000part of the body. Despite this minuscule proportion of the eye on the whole body, quality of life is profoundly influenced by the quality of vision. It shows the high importance of ophthalmology in the field of public health in general and in clinical medicine in particular.

关键词： ophthalmology " cataract " glaucoma " cornea " macular degeneration " retinal vein occlusion " optic nerve " retina