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Small-scale self-driving cars:A systematic literature review

Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 271-292页

作者： Felipe Caleffi Lauren da silva Rodrigues joice da silva stamboroski Brenda Medeiros Pereira Autonomous Vehicles Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil Mobility and Logistics Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil

The autonomous vehicle(AV)technology has the potential to significantly improve safety and efficiency of the transportation and logistics ***-scale AV testing is limited by time,space,and cost,while simulation-based testing often lacks the necessary accuracy of AV and environmental *** recent years,several initiatives have emerged to test autonomous software and hardware on scaled *** systematic literature review provides an overview of the literature surrounding small-scale self-driving cars,summarizing the current autonomous platforms deployed and focusing on the software and hardware developments in this *** studies published in English-language journals or conference papers that present small-scale testing of self-driving cars were *** of Science,Scopus,Springer Link,Wiley,ACM Digital Library,and TRID databases were used for the literature *** systematic literature search found 38 eligible *** gaps in the reviewed papers were identified to provide guidance for future *** key takeaway emerging from this manuscript are:(i)there is a need to improve the models and neural network architectures used in autonomous driving systems,as most papers present only preliminary results;(ii)increasing datasets and sharing databases can help in developing more reliable control policies and reducing bias and variance in the training process;(iii)small-scaled vehicles to ensure safety is a major benefit,and incorporating data about unsafe driving behaviors and infrastructure problems can improve the accuracy of predictive models.

关键词： Self-driving car Autonomous vehicle Small-scale vehicle Systematic literature review

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Metamorphic disturbances of magnetite chemistry and the Sm-Nd isotopic system of reworked Archean iron formations from NE Brazil

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Geoscience Frontiers 2022年第5期13卷 227-241页

作者： joice Dias de Moraes Pedro Cordeiro Eduardo Abrahão Filho Juliana Rezende Oliveira Carlos Victor Rios da silva Filho Instituto de Geociências Universidade de Brasília(UnB)70910-900 BrasíliaDFBrazil Department of Mining Engineering Pontifical Catholic University of Chile7820436 SantiagoChile

Iron formations are valuable archives of sedimentary conditions and post-depositional ***,geochemical proxies commonly used to determine genetic characteristics can be variably modified during metamorphism and deformation,hampering their use as records of regional geological *** work focuses on strongly reworked magnetite-quartz-rich rocks from the São Josédo Campestre Massif,one of the oldest fragments of preserved crust in South *** genetic classification of these magnetite-quartz-rich rocks is not straightforward because primary assemblages and textures were variably modified by granulite facies metamorphism during a regional Paleoproterozoic migmatization *** address genetic ambiguities,we analyzed their magnetite and pyroxene chemistry,wholerock geochemistry,and Sm-Nd *** chemistry indicates that pyroxene-poor iron formations(Type B)are low in trace elements such as Ti,Al,V,and Mn,suggesting a chemical similarity to iron formations *** contrast,magnetites from pyroxene-enriched Type A iron formations are rich in trace elements and more akin to magnetite crystallized from higher temperature systems,such as skarn and ***^(147)Sm/^(144)Nd of these rocks show substantial variation even at the outcrop scale,indicating a locally-controlled,highly heterogeneous mixture of Archean,Paleoproterozoic,and Neoproterozoic ***,our geochemical tools point out to heterogenous signatures of these magnetitequartz rocks and proxies compatible with both low and high-temperature conditions and age of deposition spanning sources from the Archean to the *** interpret that the studied São Josédo Campestre magnetite-quartz rocks represent Archean iron formations with original magnetite chemistry and isotopic signatures variably modified by metamorphism and by at least one deformation-related hydrothermal *** results contrast with similar examples from China and Greenland where iron formation

关键词： Metamorphic disturbances of magnetite chemistry and the Sm-Nd isotopic system of reworked Archean iron formations from NE Brazil

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Downregulation of TNFR2 decreases survival gene expression,promotes apoptosis and affects the cell cycle of gastric cancer cells

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World Journal of Gastroenterology 2022年第24期28卷 2689-2704页

作者： Ana Flávia Teixeira Rossi Fernanda da silva Manoel-Caetano joice Matos Biselli Ágata silva Cabral Marilia de Freitas Calmon Saiki Marcelo Lima Ribeiro Ana Elizabete silva Department of Biological Sciences Sao Paulo State University(UNESP)São Josédo Rio Preto 15054-000São PauloBrazil Clinical Pharmacology and Gastroenterology Unit São Francisco University(USF)Bragança Paulista 12916-900São PauloBrazil

BACKGROUND Chronic inflammation due to Helicobacter pylori(***)infection promotes gastric *** necrosis factor-α(TNF-α),a key mediator of inflammation,induces cell survival or apoptosis by binding to two receptors(TNFR1 and TNFR2).TNFR1 can induce both survival and apoptosis,while TNFR2 results only in cell *** dysregulation of these processes may contribute to *** To evaluate the effects of TNFR1 and TNFR2 downregulation in AGS cells treated with *** extract on the TNF-α*** AGS cell lines containing TNFR1 and TNFR2 receptors downregulated by specific shRNAs and nonsilenced AGS cells were treated with *** extract for 6 ***,quantitative polymerase chain reaction with TaqMan®assays was used for the relative quantification of the mRNAs(TNFA,TNFR1,TNFR2,TRADD,TRAF2,CFLIP,NFKB1,NFKB2,CASP8,CASP3)and miRNAs(miR-19a,miR-34a,miR-103a,miR-130a,miR-181c)related to the TNF-αsignalling *** cytometry was employed for cell cycle analysis and apoptosis *** In nonsilenced AGS cells,*** extract treatment increased the expression of genes involved in cell survival and inhibited both apoptosis(NFKB1,NFKB2 and CFLIP)and the TNFR1 ***1 downregulation significantly decreased the expression of the TRADD and CFLIP genes,although no change was observed in the cellular process or miRNA *** contrast,TNFR2 downregulation decreased the expression of the TRADD and TRAF2 genes,which are both important downstream mediators of the TNFR1-mediated pathway,as well as that of the NFKB1 and CFLIP genes,while upregulating the expression of miR-19a and ***,a reduction in the number of cells in the G0/G1 phase and an increase in the number of cells in the S phase were observed,as well as the promotion of early *** Our findings mainly highlight the important role of TNFR2 in the TNF-αpathway in gastric cancer,indicating that silencing it can reduce the

关键词： Gastric cancer Helicobacter pylori Tumour necrosis factor-αsignalling pathway TNFR1 TNFR2 miRNAs

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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse Holanda joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio silva dos Santos Thais Benincá Patrícia da silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Euborellia annulipes Mortality and Predation on Diatraea saccharalis Eggs after Application of Chemical and Biological Insecticides

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Agricultural Sciences 2023年第1期14卷 11-22页

作者： Rodrigo Marin Arroyo joice Mendonça De Souza Gilmar da silva Nunes dagmara Gomes Ramalho Sergio Antonio De Bortoli UNESP S&#227 o Paulo State University Jaboticabal SP Brazil Manserv Porto Nacional Tocantins Brazil

Chemical and biological insecticides have been frequently used in sugarcane fields to control insects-pests, including the sugarcane borer, Diatraea saccharalis. Among the products used, those based on chlorantraniliprole and Metarhizium anisopliae entomopathogenic fungus, stand out. Euborellia annulipes is an insect of the order Dermaptera considered a potential predator of sugarcane borer eggs. This study aimed to evaluate the direct and indirect effects of the bioinsecticide based on M. anisopliae (Metarril®) and the chemical insecticide chlorantraniliprole (Altacor®) on the mortality of E. annulipes nymphs and adults, the predation and feeding preference of earwigs in eggs treated with the formulated products. Predator mortality was evaluated for seven days after treatment, while the effect on predation was analyzed by preference tests with and without choice, using prey eggs. The products tested were selective to the predator, causing ≤ 2% mortality and not affecting predation. The application of M. anisopliae on sugarcane borer eggs favored the food preference of fourth-instar nymphs, males, and females of the predator. Our results show that Metarril® and Altacor® can be used to control D. saccharalis when associated with the predator E. annulipes.

关键词： Sugarcane Borer Biological Control Food Preference Earwigs

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Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis

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World Journal of Gastroenterology 2018年第47期24卷 5351-5365页

作者： Marcela Alcantara Proenca joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis david J Hughes Ana Elizabete silva Department of Biology UNESPUniv. Estadual PaulistaCampus of Sao Jose do Rio PretoSao Jose do Rio PretoSao Paulo 15054-000Brazil Department of Surgery and Orthopedics Faculty of MedicineUNESPUniv. Estadual PaulistaCampus of BotucatuBotucatuSao Paulo 18618-687Brazil Endoscopy Center of Rio Preto Sao Jose do Rio PretoSao Paulo 15015-700Brazil Molecular Oncology Research Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Life and Health Sciences Research Institute University of MinhoCampus GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Campus GualtarBraga 4710-057Portugal Cancer Biology and Therapeutics Group UCD Conway InstituteUniversity College DublinDublin D04 V1W8Ireland

AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction *** Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high *** Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4.

关键词： Colorectal cancer Colorectal adenoma Fusobacterium nucleatum Inflammation Cytokines MicroRNAs

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β-Globin Gene Cluster Haplotypes and Clinical Severity in Sickle Cell Anemia Patients in Southern Brazil

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Open Journal of Blood Diseases 2014年第2期4卷 16-23页

作者： Maria ALda silva Joao RFriedrisch Christina MBittar Meide Urnau joice Merzoni Vanessa SValim Bruna Amorin Annelise Pezzi Jose Artur BChies Lucia Mda Rocha Silla Laboratory of Hematopoietic Cell Culture and Molecular Analysis Center for Experimental ResearchPorto AlegreBrazil Hematology and Bone Marrow Transplantation of Hospital de Clinicas de Porto Alegre Porto AlegreBrazil Post-Graduation in Medicine:Medical Sciences Federal University of Rio Grande do SulPorto AlegreBrazil Laboratory of Immunogenetics Department of GeneticsUFRGSPorto AlegreBrazil

Hematopoietic stem cell transplantation(HSCT)has emerged as a curative strategy for sickle cell anemia(SCA);it is necessary to find markers of SCA clinical severity to spare those SCA patients whose clinical course is mild from the morbidity and mortality associated with HSCT. Haplotypes have been correlated with the severity of clinical manifestations in SCA patients, and fetal hemoglobin(HbF)and socioeconomic status(SeS)have also been described as negative factors. We studied these factors and their impact on clinical manifestations in a population of Southern Brazilian patients attending the Center for Sickle Cell Anemia at Hospital de Clínicas de Porto Alegre/RS, Brazil. Clinical severity was defined as two or more veno-occlusive episodes per year. The βS haplotypes were determined by PCR in 75 SCA patients. Among the 150 βS chromosomes analyzed, 99(66%)were identified as Bantu(Ban), 41(27%)asBenin(Ben), and 10(7%)as other haplotypes. Most patients in our sample(62.7%)belonged to lower SeS groups, precluding meaningful statistical analysis of SeS impact on clinical severity. There was no correlation between haplotypes or HbF level and SCA clinical severity. Gene polymorphisms and environmental issues have to be taken into consideration.

关键词： Sickle Cell Anemia β-Globin Fetal Hemoglobin and Clinical Severity

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