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Performance of three rapid diagnostic tests for the detection of Cryptosporidium *** Giardia duodenalis in children with severe acute malnutrition and diarrhoea

引用

Infectious Diseases of Poverty 2019年第6期8卷 76-83页

作者： Joseph Bitilinyu-Bangoh Wieger Voskuijl johnstone thitiri Sandra Meriting Nienke Verhaar Laura Mwalekwa Daisy B.de Jong Merlin van Loenen Petra F.Mens James A.Berkley Robert H.J.Bandsma Henk D.F.H.Schallig Academ ic Medical Centre Department of Medical MicrobiologyParasitology UnitAmsterdam University Medical CentresMeibergdreef 91105AZAmsterdamThe Netherlands Queen Elizabeth Central Hospital BlantyreMalawi College of Medicine Department of Paediatrics and Child HealthUniversity of MalawiBlantyreMalawi Global Child Health Group Emma Children's HospitalAmsterdam University Medical CentresAmsterdamThe Netherlands The Childhood Acute Illness and Nutrition Network(CHAIN) NairobiKenya KEMRIA/Vellcome Trust Research Programme KilifiKenya Translational Medicine Program Hospital for Sick ChildrenTorontoCanada

Background:There is significant need for accurate diagnostic tools for Cryptosporidium *** Qiordia duodenalis infections in resource limited countries where diarrhoeal disease caused by these parasites is often *** present study assessed the diagnostic performance of three commercially available rapid diagnostic tests(RDTs)based on faecal-antigen detection for Cryptosporidium ***/or *** infections in stool samples of children admitted with severe acute malnutrition(SAM)and *** established multiplex PCR was used as reference ***:Stool samples from children with SAM and diarrhoea enrolled in a randomized controlled trial(registered at ***/ct2/show/NCT02246296)in Malawi(n=175)and Kenya(n=120)between December 2014 and December 2015 were analysed by a multiplex PCR for the presence of Cryptosporidium sppv *** or Entomoebo histolytica parasite ***-positive samples were species typed using restriction fragment length polymorphism analysis.A sub-sample of the stool specimens(n=236)was used for testing with three different *** accuracy of the tests under evaluation was assessed using the results of PCR as reference standard using MedCalc *** Chi-square test and Fisher's exact test were used to determine(significant)difference between the number of cryptosporidiosis or giardiasis cases found by PCR in Malawi and *** overall diagnostic accuracy of each RDT was calculated by plotting a receiver operating characteristic(ROC)curve for each test and to determine the area under the curve(AUC)using SPSS8 ***:Prevalence of Cryptosporidium *** PCR was 20.0 and 21.7%in Malawi and Kenya respectively,mostly *** prevalence was 23.4 and 5.8%in Malawi and Kenya respectively.E histolytica was not detected by *** testing followed the same pattern of *** sensitivities ranged for cryptosporidiosis from 42.9 to 76.9%and for ***

关键词： Diagnosis Cryptosporidium Giordio Rapid diagnostic test Severe acute malnutrition

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