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Ophthalmic manifestations of Cryptococcus gattii species complex:a case series and review of the literature

International Journal of Ophthalmology(English edition) 2022年第1期15卷 119-127页

作者： Grace A.McCabe Jack w.McHugh Todd Goodwin Douglas F.johnson Anthony Fok Thomas G.Campbell Department of Ophthalmology the Royal Melbourne HospitalMelbourneVictoria 3050Australia Department of Internal Medicine Mayo ClinicRochesterMinnesota 55902USA James Cook University TownsvilleQueensland 4811Australia NQ Eye Foundation TownsvilleQueensland 4811Australia Department of Infectious Disease the Royal Melbourne HospitalMelbourneVictoria 3050Australia Department of Neurology the Royal Melbourne HospitalMelbourneVictoria 3050Australia Centre for Eye Research Australia East MelbourneVictoria 3002Australia Ophthalmology Department of Surgerythe University of MelbourneMelbourneVictoria 3010Australia

AIM:To report 4 cases of Cryptococcus gattii(***)species complex infection with diverse ophthalmic manifestations,and to review the literature to examine pathobiology of disease,classical ophthalmic presentations and outcomes,and treatment modalities for this emerging ***:Cases of *** meningoencephalitis with ophthalmic manifestations were identified via chart review at two institutions in Australia and one institution in the mid-west region of the United States and are reported as a case ***,a MEDLINE literature review was conducted to identify all reported cases of *** with ophthalmic manifestations from *** were reviewed and tabulated,together with our series of patients,in this ***:Four cases of *** with ophthalmic manifestations are presented;three from Australia and one from the USA.A literature review identified a total of 331 cases of *** with visual *** majority of cases occurred in immunocompetent *** vision and diplopia were the most common presenting symptoms,with papilloedema the most common sign,reported in 10%-50%of *** loss was reported in 10%-53%of cases,as compared to rates of visual loss of 1%-9%in *** *** intracranial pressure,cerebrospinal fluid(CSF)fungal burden,and abnormal neurological exam at presentation correlated with poor visual *** mainstays of treatment are anti-fungal agents and aggressive management of intracranial hypertension with serial lumbar *** diversion procedures should be considered for refractory *** and mannitol are associated with high complication rates,and adjuvant corticosteroids have demonstrated higher mortality rates;these treatments should be ***:Permanent visual loss represents a devastating yet potentially preventable sequelae of *** *** hypertension needs to be recognised early and aggressively ***

关键词： Cryptococcus Cryptococcus gattii cryptococcosis ophthalmic manifestation

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Atomic Crosschain Transactions for Ethereum Private Sidechains

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Blockchain(Research and Applications) 2022年第1期3卷 23-39页

作者： Peter Robinson Raghavendra Ramesh Sandra johnson ConsenSys Software R&D Brisbane4520Australia School of Information Technology and Electrical Engineering The University of QueenslandQueensland 4072Australia ARC Centre of Excellence for Mathematical and Statistical Frontiers(ACEMS) Queensland University of TechnologyQueensland 4001Australia

The Atomic Crosschain Transaction for Ethereum Private Sidechains protocol allows composable programming across permissioned Ethereum *** allows for inter-contract and inter-blockchain function calls that are both synchronous and atomic:if one part fails,the whole call tree of function calls is *** protocol is not based on existing techniques such as Hash Time Locked Contracts,relay chains,block header transfer,or trusted *** uses(a)threshold signatures to prove values across blockchains,(b)coordination contracts to manage the state of crosschain transactions,and(c)a function call tree commitment scheme to allow users to commit to a call tree and then later check that the correct function calls have been *** paper analyses the processing overhead of using this technique compared to using multiple standard non-atomic single blockchain *** additional processing is analysed for four scenarios involving multiple blockchains:a Trade–Finance system,the Hotel–Train problem,a Supply Chain with Provenance,and an *** protocol is shown to have both safety and liveness properties.

关键词： Crosschain Blockchain Transaction Atomic Ethereum

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Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

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Journal of Animal Science and Biotechnology 2018年第2期9卷 306-318页

作者： Yasser Y.Lenis Gregory A.johnson Xiaoqiu wang wendy w.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao wu Thomas R.Hansen Fuller w.Bazer Department of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Center for Animal Biotechnology and Genomics Texas A&M UniversityCollege StationTX 77843USA Centauro Research Group School of Veterinary MedicineFaculty of Agrarian ScienceUniversidad de AntioquiaCalle 70 No52-21 MedellínColombia Faculty of Agricultural Sciences Calle 222 No.55-37UDCABogotaColombia Present address:National Institute of Environmental Health Sciences Research Triangle ParkNC 27709USA Animal Reproduction and Biotechnology Laboratory Department of Biomedical SciencesCollege of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsCO 80523USA

Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGMAT).Methods: Morpholino antisense oligonucleotides(MAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine ***: The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(MAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, MAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than MAO control conceptuses, while MAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with MAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and ***: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of int

关键词： Agmatine Arginine Interferon tau Polyamines Trophectoderm cells

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Lakoff和johnson的体验哲学

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当代语言学 2002年第2期4卷 144-151页

作者： Lakoff johnson 王寅苏州大学外国语学院江苏苏州215006

1.引言Lakoff和johnson合作出版了(1980)之后,于1999年又出版了另一本著作:(Philosophy in theFlesh--The Embodied Mind and Its Challenge to western Thought,以下简称).书中提出了一个全新的哲学理论:体验哲学,论述了体验哲学的三项基本原则:'心智的体验性'、'认知的无意识性'和'思维的隐喻性'(the embodied mind, the cognitive un-consciousness, the metaphorical thought),并认为认知语言学是以体验哲学为其哲学基础的1.

关键词：体验哲学隐喻心智著作身体 99年挑战西方思想出版

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Greenhouse gases fluxes and soil thermal properties in a pasture in central Missouri

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Journal of Environmental Sciences 2010年第7期22卷 1029-1039页

作者： Nsalambi Vakanda Nkongolo Shane johnson Kent Schmidt Frieda Eivazi Department of Agriculture and Environmental Sciences College of Agriculture and Natural Science Lincoln University Harvard Forest Faculty of Arts and Sciences Harvard University

Fluctuations of greenhouse gases emissions and soil properties occur at short spatial and temporal scales, however, results are often reported for larger scales studies. we monitored CO2, CH4, and N2O fluxes and soil temperature （T）, thermal conductivity （K）, resistivity （R） and thermal diffusivity （D） from 2004 to 2006 in a pasture. Soil air samples for determination of CO2, CH4 and N2O concentrations were collected from static and vented chambers and analyzed within two hours of collection with a gas chromatograph. T, K, R and D were measured in-situ using a KD2 probe. Soil samples were also taken for measurements of soil chemical and physical properties. The pasture acted as a sink in 2004, a source in 2005 and again a sink of CH4 in 2006. CO2 and CH4 were highest, but N2O as well as T, K and D were lowest in 2004. Only K was correlated with C02 in 2004 while T correlated with both N2O （r = 0.76, p = 0.0001） and CO2 （r = 0.88, p = 0.0001） in 2005. In 2006, all gases fluxes were significantly correlated with T, K and R when the data for the entire year were considered. However, an in-depth examination of the data revealed the existence of month-to-month shifts, lack of correlation and differing spatial structures. These results stress the need for further studies on the relationship between soil properties and gases fluxes. K and R offer a promise as potential controlling factors for greenhouse gases fluxes in this pasture.

关键词： greenhouse gases soil thermal properties fluxes

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Accelerated carbonation and leaching behavior of the slag from iron and steel making industry

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Journal of University of Science and Technology Beijing 2007年第4期14卷 297-301页

作者： Quanyuan Chen johnson Lingyun Zhu Menghong Yuan Hills School of Environmental Science and Engineering Donghua University Shanghai 200051 China School of Science University of Greenwich Chatham Maritime Kent ME4 4TB UK School of Information Science and Technology Donghua University Shanghai 200051 China

Ground granulated blast furnace slag （GGBFS） and steelmaking slag have been used as a raw material for cement production or as an aggregate to make concrete, which contribute aluminum, calcium, iron, and silicon oxides. The suitability of the slag for a particular application depends on its reactivity, cost, availability, and its influence on the properties of the resulting concrete. For the interest of durability studying of concrete in the presence of slag, the accelerated carbonation products and leaching behavior of the slag and Portland cement （PC） were studied. The experimental results confirmed that the slag was more resistant to carbonation compared to PC. The carbonation degree of GGBFS reduced by 17.74%; and the carbonation degrees of steelmaking slags reduced by 9.51%- 11.94%. Carbonation neutralized the alkaline nature of the hydrated pastes and gave rise to the redox potential of the leachate slightly （30-77 mV）. The carbonation also increased the release of most of the elements presented, except for calcium, to the aqueous environment. It is concluded that blend cements （PC plus slag） have economical advantages and better durability compared to PC,

关键词： carbonation slag cement leachate durability

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On the Forcing of the Radial-vertical Circulation within Cyclones-Part 1: Concepts and Equations

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Advances in Atmospheric Sciences 1998年第3期15卷 64-85页

作者： D.R.johnson Space Science and Engineering Center University of Wisconsin-Madison 53706 Madison WI USA

お? Following the theoretical result of Eliassen, the Sawyer-Eliassen equation for frontal circulations and the equation for forcing the meridional circulation within a circumpolar vortex are extended in isentropic coordinates to describe the forcing of the azimuthally averaged mass-weighted radial-vertical circulation within translating extratropical and tropical cyclones. Several physical processes which are not evident in studies employing isobaric coordinates are isolated in this isentropic study. These processes include the effects of pressure torque, inertial torque and storm translation that are associated with the asymmetric structure in isentropic coordinates. This isentropic study also includes the effects of eddy angular momentum transport, diabatic heating and frictional torque that are common in both isentropic and isobaric studies. All of the processes are modulated by static, inertial and baroclinic stabilities.  Consistent with the theoretical result of Eliassen, the numerical solution from this isentropic study shows that the roles of torque, diabatic heating and hydrodynamic stability in forcing the radial-vertical circulation within stable vortices are that 1) positive (negative) torque which results in the counterclockwise (clockwise) rotation of vortices also forces the outflow (inflow) branch of the radial-vertical circulation, 2) diabatic heating (cooling) forces the ascent (descent) branch of the radial-vertical circulation and 3) for given forcing, the weaker hydrodynamic stability results in a stronger radial-vertical circulation. It is the net inflow or convergence (net outflow or divergence), vertical motions and the associated redistribution of properties that favor the evolution of vortices with colorful weather events.  Numerical solutions of this isentropic study are given in companion articles. The relatively important contribution of various physical processes to the forcing of the azimuthally-averaged mass-weighted radial-

关键词： The forcing of the radial-vertical circulation Quasi-Lagrangian diagnostics of cyclones,Balanced equation

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Effectiveness of a fixed-depth sensor deployed from a buoy to estimate water-column cyanobacterial biomass depends on wind speed

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Journal of Environmental Sciences 2020年第7期32卷 23-29页

作者： Justin D.Chaffin Douglas D.Kane Alex johnson F.T Stone Laboratory and Ohio Sea Grant the Ohio State UniversityOH 43456USA Division of Natural Science Applied Scienceand MathematicsDefiance CollegeDefiance OHF.T Stone LaboratoryThe Ohio State University and Ohio Sea GrantOH 43456USA

water quality sondes have the advantage of containing multiple sensors,extended deployment times,high temporal resolution,and telecommunication with stakeholder accessible data ***,sondes that are part of buoy deployments often suffer from typically being fixed at one *** water treatment plants are interested in water quality at a depth of the water intake and other stakeholders(*** and swimmers)are interested in the surface,we examined whether a fixed depth of approximately 1 m could cause over-or under-estimation of cyanobacterial *** sampled the vertical distribution of cyanobacteria adjacent to a water quality sonde buoy in the western basin of Lake Erie during the summers of 2015–2017.A comparison of buoy cyanobacteria RFU(Relative Fluorescence Unit)at 1 m to cyanobacteria chlorophyll a(chla)measured throughout the water column showed occurrences when the buoy both under and overestimated the cyanobacteria chl a at specific *** differences between buoy measurements and at-depth grab samples occurred during low wind speeds(w winds allowed cyanobacteria to accumulate at the surface above the buoy’s *** wind speeds(>4.5 m/sec)resulted in better agreement between the buoy and at-depth *** wind speeds 12 hr before sample collection decreased the difference between the buoy and at-depth samples for high wind speeds but not low *** suggest that sondes should be placed at a depth of interest for the appropriate stakeholder group or deploy sondes with the ability to sample at various depths.

关键词： Buoyancy Harmful algal bloom Lake Erie Microcystis water quality

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FTY720,a sphingosine analog,altered placentome histoarchitecture in ewes

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Journal of Animal Science and Biotechnology 2020年第2期11卷 380-392页

作者： Kathrin A.Dunlap Bryan G.white David w.Erikson M.Carey Satterfield Christiane Pfarrer Guoyao wu Fuller w.Bazer Robert C.Burghardt Kayla J.Bayless Greg A.johnson Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Okanagan College Salmon Arm Campus Salmon ArmBritish ColumbiaCanada Endocrine Technologies Core Oregon National Primate Research CenterOregon Health&Science UniversityBeavertonORUSA Department of Anatomy University of Veterinary Medicine HannoverBischofsholer Damm 1530173 HannoverGermany Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Department of Molecular and Cellular Medicine Texas A&M Health Science CenterCollege StationTX 77843USA

Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic ***,as well as the sphingosine phosphorylating enzyme sphingosine kinase 1,are expressed in the placentomes of sheep and the decidua of rodents;however,a function for this signaling pathway during pregnancy has not been *** objective of this study was to investigate whether sphingosine-1-phosphate promoted angiogenesis within the placentomes of pregnant *** were given daily jugular injections of FTY720(2-amino-2[2-(−4-octylphenyl)ethyl]propate-1,3-diol hydrochloride),an S1P ***:FTY720 infusion from days 30 to 60 of pregnancy did not alter maternal organ weights nor total number or mass of placentomes,but did alter placentome *** of caruncular crypts and cotyledonary villi was decreased,as was the relative area of cotyledonary tissue within ***,the percentage of area occupied by cotyledonary villi per unit of placentome was increased,while the thickness of the caruncular capsule was decreased in ewes treated with ***,FTY720 infusion decreased the number and density of blood vessels within caruncular tissue near the placentome capsule where the crypts emerge from the ***,FTY720 infusion decreased asparagine and glutamine in amniotic fluid and methionine in allantoic fluid,and decreased the crown rump length of day 60 ***:while members of the sphingosine-1-phosphate signaling pathway have been characterized within the uteri and placentae of sheep and mice,the present study uses FTY720 to address the influence of S1P signaling on placental *** present evidence that modulation of the S1P signaling pathway results in the alteration of caruncular vasculature,placentome architecture,abundance of amino acids in allantoic and amniotic fluids,and fetal growth during pregnancy in *** marked morphological changes in placentome histoarchitec

关键词： Placentome Pregnancy Sheep Sphingosine1 phosphate(S1P)

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Analysis of Social Media Impact on Stock Price Movements Using Machine Learning Anomaly Detection

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Intelligent Automation & Soft Computing 2023年第6期36卷 3405-3423页

作者： Richard Cruz johnson Kinyua Charles Mutigwe College of Information Sciences and Technology Pennsylvania State UniversityState CollegePA16801USA western New England University College of Business1215 Wilbraham RdSpringfieldMA01119USA

The massive increase in the volume of data generated by individuals on social media microblog platforms such as Twitter and Reddit every day offers researchers unique opportunities to analyze financial markets from new *** meme stock mania of 2021 brought together stock traders and investors that were also active on social *** mania was in good part driven by retail investors’discussions on investment strategies that occurred on social media plat-forms such as Reddit during the COVID-19 *** stock trades by these retail investors were then executed using services like *** this paper,machine learning models are used to try and predict the stock price movements of two meme stocks:GameStop($GME)and AMC Entertainment($AMC).Two sentiment metrics of the daily social media discussions about these stocks on Red-dit are generated and used together with 85 other fundamental and technical indi-cators as the feature set for the machine learning *** is demonstrated that through the use of a carefully chosen mix of a meme stock’s fundamental indica-tors,technical indicators,and social media sentiment scores,it is possible to pre-dict the stocks’next-day closing ***,using an anomaly detection model,and the daily Reddit discussions about a meme stock,it was possible to identify potential market manipulators.

关键词： Machine learning deep learning anomaly detection Reddit r/walstreetbets meme stocks

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