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Recent advances towards single biomolecule level understanding of protein adsorption phenomena unique to nanoscale polymer surfaces with chemical variations

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Nano Research 2020年第5期13卷 1295-1317页

作者： David H.Cho Tian Xie johnson Truong Andrew C.Stoner Jong-in Hahm Department of Chemistry Georgetown University37th&O Sts.NW.WashingtonDC 20057USA

Protein adsorption onto polymer surfaces is a very complex and ubiquitous phenomenon whose integrated process impacts essential applications in our daily lives such as food packaging materials,health devices,diagnostic tools,and medical ***,novel polymer materials with greater chemical intricacy and reduced dimensionality are used for various applications involving adsorbed proteins on their ***,the nature of protein-surface interactions to consider is becoming much more complicated than before.A large body of literature exists for protein ***,most of these investigations have focused on collectively measured,ensemble-averaged protein behaviors that occur on macroscale and chemically unvarying polymer surfaces instead of direct measurements at the single protein or sub-protein *** addition,interrogations of protein-polymer adsorption boundaries in these studies were typically carried out by indirect methods,whose insights may not be suitably applied for explaining individual protein adsorption processes occurring onto nanostructured,chemically varying polymer ***,an important gap in our knowledge still exists that needs to be systematically addressed via direct measurement means at the single protein and sub-protein *** efforts will require multifaceted experimental and theoretical approaches that can probe multilength scales of protein adsorption,while encompassing both single proteins and their collective ensemble behaviors at the length scale spanning from the nanoscopic all the way to the macroscopic *** this review,key research achievements in nanoscale protein adsorption to date will be ***,protein adsorption studies involving polymer surfaces with their defining feature dimensions and associated chemical partitions comparable to the size of individual proteins will be discussed in *** this regard,recent works bridging the crucial knowledge gap in protein adso

关键词： nanoscale protein adsorption nanoscale protein assembly protein self-assembly on polymer protein nanopatterning protein-nanosurface interaction

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Reduced protein diet with near ideal amino acid profile improves energy efficiency and mitigate heat production associated with lactation in sows

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Journal of Animal Science and Biotechnology 2020年第2期11卷 587-601页

作者： Sai Zhang Jay S.johnson Mu Qiao Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA USDA-ARS Livestock Behavior Research Unit West Lafayette 47907USA Institute of Animal Husbandry and Veterinary Hubei Academy of Agricultural SciencesWuhan 430064China

Background:The study objective was to test the hypothesis that 1)lowering dietary crude protein(CP)increases dietary energetic efficiency and reduces metabolic heat associated with lactation,and 2)excessive dietary leucine(Leu)supplementation in a low CP diet decreases dietary energetic efficiency and increases metabolic heat associated with ***:Fifty-four lactating multiparous Yorkshire sows were allotted to 1 of 3 isocaloric diets(10.80 MJ/kg net energy):1)control(CON;18.75%CP),2)reduced CP with a near ideal or optimal AA profile(OPT;13.75%CP)and 3)diet OPT with excessive Leu(OPTLEU;14.25%CP).Sow body weight and backfat were recorded on day 1 and 21 of lactation and piglets were weighed on day 1,4,8,14,18,and 21 of *** balance was measured on sows during early(day 4 to 8)and peak(day 14 to18)lactation,and milk was sampled on day 8 and ***:Over 21-day lactation,sows fed OPT lost body weight and body lipid(Pws fed OPT had higher milk energy output(Pwas lower(Pws,and did not differ between OPTLEU and OPT *** fed OPT had higher(Pwith lactation was lower(Pwer(P=0.082),respectively,in OPT and OPTLEU compared to CON ***:The OPT diet,in peak lactation,improved dietary energy utilization for lactation due to less urinary energy and metabolic heat loss,and triggered dietary energy deposition into milk at the expense of maternal lipid *** supplementation above requirement may reduce dietary energy utilization for lactation by decreasing the energy partitioning towards milk,partially explaining the effectiveness of OPT diet over CON diets.

关键词： Amino acid Energy balance Heat production Lactating sows Leucine Reduced protein diet

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Map Difference Indication Using CNN Based Deep Learning Algorithm

Map Difference Indication Using CNN Based Deep Learning Algo...

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作者： JERKER johnson KALAMA 浙江工商大学

学位级别：硕士

在遥感领域,当前存在多种图像变化检测模型,但由于其准确性、性能和延迟,这些方法在变化检测方面各有优劣势,往往存在效率不高问题。这类方法的时间复杂度高,预测的准确性仍有提升空间。为了提供不同日期的地图变化检测解决方案,我们提... 详细信息

在遥感领域,当前存在多种图像变化检测模型,但由于其准确性、性能和延迟,这些方法在变化检测方面各有优劣势,往往存在效率不高问题。这类方法的时间复杂度高,预测的准确性仍有提升空间。为了提供不同日期的地图变化检测解决方案,我们提出了一种基于LSTM与CNN结合的新型混合CNN模型。该模型将图像作为输入并转换为灰度以提取特征,根据像素值创建矩阵。此外,所提出的框架使用基于图像像素的欧几里得距离来提供地图中的图像变化检测,所提出的模型使用公开可用的数据集进行训练,特别是我们使用了1994年和2014年的阿根廷历史地图以及其他公共地图,以便评估我们的模型。我们所提出的模型基于有效的地图变化检测框架,可以用于识别在两个不同时间查看时在同一区域的地图上发生变化的地点。为了证明所提出的框架的合理性,我们通过模拟进行了比较分析,并证明所提出的框架在变化检测准确性和整体性能方面优于参考的基准模型。

关键词：地图变化分类变化检测卷积神经网络全卷积神经网络空洞卷

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Modern drug discovery for inflammatory bowel disease: The role of computational methods

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world Journal of Gastroenterology 2023年第2期29卷 310-331页

作者： Titilayo Omolara johnson Augustina Oduje Akinsanmi Stephen Adakole Ejembi Olugbenga Eyitayo Adeyemi Jane-Rose Oche Grace Inioluwa johnson Abayomi Emmanuel Adegboyega Department of Biochemistry University of JosJos 930222PlateauNigeria Faculty of Clinical Sciences College of Health SciencesUniversity of JosJos 930222PlateauNigeria

Inflammatory bowel diseases(IBDs)comprising ulcerative colitis,Crohn’s disease and microscopic colitis are characterized by chronic inflammation of the gastrointestinal *** has spread around the world and is becoming more prevalent at an alarming rate in developing countries whose societies have become more *** therapy,intestinal microecology,apheresis therapy,exosome therapy and small molecules are emerging therapeutic options for ***,it is thought that low-molecular-mass substances with good oral bio-availability and the ability to permeate the cell membrane to regulate the action of elements of the inflammatory signaling pathway are effective therapeutic options for the treatment of *** small molecule inhibitors are being developed as a promising alternative for IBD *** use of highly efficient and time-saving techniques,such as computational methods,is still a viable option for the development of these small molecule *** computeraided(in silico)discovery approach is one drug development technique that has mostly proven *** approaches when combined with traditional drug development methodology dramatically boost the likelihood of drug discovery in a sustainable and cost-effective *** review focuses on the modern drug discovery approaches for the design of novel IBD drugs with an emphasis on the role of computational *** computational approaches to IBD genomic studies,target identification,and virtual screening for the discovery of new drugs and in the repurposing of existing drugs are discussed.

关键词： Inflammatory bowel disease Computer-aided drug design Janus Kinase Molecular docking Genome-wide association study Molecular dynamics simulation

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Biochar compost blends facilitate switchgrass growth in mine soils by reducing Cd and Zn bioavailability

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Biochar 2019年第1期1卷 97-114页

作者： Jeffrey M.Novak James A.Ippolito Donald w.watts Gilbert C.Sigua Thomas F.Ducey Mark G.johnson Coastal Plains Soil Water and Plant Research CenterUnited States Department of AgricultureAgricultural Research ServiceFlorenceSC 29501USA Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCO 80523USA National Health and Environmental Effects Research Laboratory United States Environmental Protection AgencyCorvallisOR 97331USA

Biochars have the potential to reclaim mine-impacted soils;however,their variable physico-chemical properties incite specu-lation about their successful remediation *** investigation examined the capability of biochars produced from three different feedstocks along with a compost blend to improve switchgrass growth conditions in a mine-impacted soil by examining influences on soil pH,grass metal contents,and soil-extractable metal ***(Cd)-and zinc(Zn)-contaminated mine soil was collected from a site near webb City,Missouri,USA-a location within the Tri-State Min-ing *** a full factorial design,soil was treated with a 0%,2.5%,and 5%(w/w)compost mixture(wood chips+beef cattle manure),and 0%,2.5%and 5%of each biochar pyrolyzed from beef cattle manure,poultry litter,and lodgepole pine ***(Panicum virgatum,‘Cave-In-Rock’variety)was grown in a greenhouse for 50 days and the mass of shoots(above-ground biomass)and roots was assessed,while soil pH,deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations were *** litter biochar and compost had the greatest ability to raise soil pH(from 4.40 to 6.61),beef cattle manure biochar and compost moderately raised pH(from 4.4 to 5.92),and lodgepole pine biochar and compost weakly raised pH(from 4.40 to 5.05).Soils treated with beef cattle manure biochar,poultry litter biochar signifi-cantly reduced deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations,while lodgepole pine biochar-treated soils showed mixed *** shoot and root masses were greatest in soil treated with compost in combination with either beef cattle manure biochar or poultry litter *** treated with 5%beef cattle manure biochar+5%compost had greater reductions in total Cd and Zn concentrations measured in switchgrass shoots and roots compared to the other two *** three biochars and compost mixtures applied to heavy metal,mine-im

关键词： Biochar Heavy metals Metal sorption Tri-State Mine soil Remediation Switchgrass

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3D Nanoporous Graphene Based Single-Atom Electrocatalysts for Energy Conversion and Storage

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Accounts of Materials Research 2022年第10期3卷 1011-1021页

作者： Isaac johnson Jiuhui Han Mingwei Chen Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMaryland 21218United States wPI Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversitySendai 980-8578Japan

CONSPECTUS:This Account will provide an overview and analysis on recent research of 3D nanoporous graphene based single-atom electrocatalysts for energy conversion and storage *** order to meet the increasing energy demands and assist in the transition from a global economy that relies heavily on fossil fuels to one that utilizes more renewable energy sources,there is urgent need to develop highperforming electrocatalysts toward renewable energy related *** catalysts are expected to have low overpotentials,high reaction selectivity,long cycling stability,and,importantly,lower materials costs to address the challenges of traditional nanoparticulate noble metal catalysts.

关键词： utilize selectivity stability

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Electrical geophysical evaluation of susceptibility to flooding in University of Nigeria, Nsukka main campus and its environs, Southeastern Nigeria

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Journal of Groundwater Science and Engineering 2023年第4期11卷 422-434页

作者： Daniel Nnaemeka Obiora johnson Cletus Ibuot Department of Physics and Astronomy University of NigeriaNsukkaEnugu State

Flooding occurs when rainfall exceeds the absorption capacity of soil and causes significant environmental *** this study,electrical resistivity techniques were employed to assess the flood susceptibility of the study area by examining variations in electrical *** to flooding,Vertical Electrical Sounding(VES)and Electrical Resistivity Tomography(ERT)profiles were conducted to determine the variations in resistivity within subsurface lithologies exposed to the injected *** injected current penetrated the subsurface units characterised by resistivity ranging from 190.5Ω·m to 6,775.7Ω·m,42.3Ω·m to 7,297.4Ω·m,and 320.2Ω·m to 24,433.3Ω·m in the first,second and third layers,*** layers were identified as lateritic topsoil,medium-coarse brownish grained sand,and coarse pebbly blackish sand,*** calculated reflection coefficients between layers 1,2,and 3 reveal alternation in layers with values ranging from−0.04 to 0.66 and 0.36 to 0.95 for and,*** transverse resistivity,longitudinal resistivity and anisotropy ranged from 243.59Ω·m to 24,115.42Ω·m,199.61Ω·m to 14,950.76Ω·m,and 1.02 to *** derived from the ERT profiles reveal variations in resistivity,pinpointing areas of low resistivity which correspond to waterlogged and impermeable *** result of this study underscores the importance of integrated resistivity techniques in the study of floods,as it provides valuable insights into flood behaviour,and subsurface dynamics.

关键词： Anisotropy Vertical electrical sounding Electrical resistivity tomography Geoelectric layer Permeability

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Applied multivariate statistical analysis, 5th Edition 5th ed.

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2002年

作者： Richard Arnold johnson Dean w. wichern

来源：畅想之星图书光盘版（南... 评论

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科威特石油大火烟云物理及化学特性的机载观测

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气象科技 1992年第4期20卷 67-72页

作者： D.w.johnson 章育仲英国气象局

1991年3月底在距科威特燃烧油井约120km的烟云最密集区所进行的机载测量表明:典型的粒子质量浓度为500-1000μgm^(-3),SO_2的体积混合比为500-1000p.p.b.v.,氮的氧化物的体积混合比为30-60p.p.b.v..在距科威特1000km处烟云中的臭氧含量... 详细信息

1991年3月底在距科威特燃烧油井约120km的烟云最密集区所进行的机载测量表明:典型的粒子质量浓度为500-1000μgm^(-3),SO_2的体积混合比为500-1000p.p.b.v.,氮的氧化物的体积混合比为30-60p.p.b.v..在距科威特1000km处烟云中的臭氧含量超过背景水准约50p.p.b.v..由硫通量估计的石油燃烧率为每天3.9±1.6百万桶.只在5000m以下的高度观测到大量烟尘,由烟尘造成的太阳辐射衰减的测量值与新近评估中的假定值相似.

关键词：石油火灾烟云物理性能化学性能

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Degree of compaction and compression strength of Nigerian Alfisol under tilled condition and different machinery traffic passes

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International Journal of Agricultural and Biological Engineering 2012年第2期5卷 34-41页

作者： Fasinmirin johnson Toyin Adesigbin Adedayo Joseph Department of Agricultural Engineering Federal University of TechnologyAkureNigeria

Information on the effect of soil compaction on soil mechanical properties such as degree of compaction,compression and shear strength of tropical soils of Nigeria under different machinery traffic passes is very *** experiment was conducted in a tilled and compacted sandy clay loam(Alfisol)in Akure,Nigeria,under different machinery traffic passes to determine compaction effects on bulk density,compression strength,degree of compaction and the shear strength of *** plots,A,B,C and D of area 20 m×50 m each were used for the field *** plot A was tilled with a tractor-mounted disc plough,and the remaining three plots:B,C and D were subjected to 5,10 and 15 to and fro passes,respectively,using heavy duty Mercy Fergusson tractor model 4355(3.82 Mg).The treatments were replicated three times in a randomized complete block *** plots progressively increased the bulk density from 1.63 g/cm^(3) to 1.90 g/cm^(3),but the highest bulk density was observed in plots under 15 traffic passes with the value of(1.90±0.23)g/*** percentage of soil compaction varies from 90.5%to 97%at the 0-10 cm soil *** compression strength of soil increased from 31.00 kPa to 42.05 kPa and from 29.68 to 65.44 kPa at the 0-10 cm and 10-20 cm soil layers,respectively,which resulted in the increased shear strength from 15.79 kPa to 21.03 kPa and 14.8 kPa to 32.72 kPa at the 0-10 cm and 10-20 cm in plots under 5 and 15 traffic passes,*** A(tilled soil)had the lowest bulk density,degree of compaction and compression strength with values(1.51±0.19)g/cm^(3),88.2%,and(12.15±0.37)kPa,respectively,and consequently the lowest shear strength of(6.02±1.23)kPa,which enhanced air movement and microbial activities in the *** under 15 traffic passes,especially at the 10-20 cm soil layer,may result in poor root penetration when cropped but can be very reliable and consistent when used for structural purposes.

关键词： soil compaction tillage degree of compaction compression strength shear strength farm machine traffic passes bulk density

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