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Knowledge and attitudes towards the use of histological assessments in ulcerative colitis by gastroenterologists vs pathologists

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World Journal of Gastroenterology 2023年第2期29卷 378-389页

作者： Aviv Pudipeddi Caroline Fung Britt Christensen Robert v Bryant Kavitha Subramaniam john Chetwood Sudarshan Paramsothy Rupert W Leong Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139Australia Faculty of Medicine and Health Concord Clinical SchoolUniversity of SydneySydney 2138Australia Department of Anatomical Pathology Concord Repatriation General HospitalSydney 2139Australia Department of Gastroenterology Royal Melbourne HospitalMelbourne 3050Australia Department of Medicine University of MelbourneMelbourne 3052Australia Department of Gastroenterology and Hepatology The Queen Elizabeth HospitalAdelaide 5011Australia Gastroenterology and Hepatology Unit Canberra HospitalCanberra 2605Australia Australian National University Medical School Australian National UniversityCanberra 2601Australia Faculty of Medicine and Health Sciences Macquarie University HospitalSydney 2109Australia

BACKGROUND Histological remission is increasingly accepted as a treatment endpoint in the management of ulcerative colitis(UC).However,the knowledge of histology guidelines and the attitudes towards their use in clinical practice by gastroenterologists and pathologists is *** To evaluate the knowledge of histology guidelines and attitudes towards the use of histology in UC by gastroenterologists and *** A prospective,cross-sectional nationwide survey of gastroenterologists and pathologists who analyse UC specimens was *** survey consisted of 34 questions to assess gastroenterologists’and pathologists’knowledge(score out of 19)and attitudes towards histological assessment in *** questions were formulated using the European Crohn’s and Colitis position paper on histopathology and the British Society of Gastroenterology biopsy reporting *** included knowledge of histological assessment of disease activity and dysplasia,knowledge of histological scoring systems for ulcerative colitis,uptake of histology scoring systems in routine practice,attitudes towards the role of histological activity,and the use of histological activity in clinical *** Of 89 responders(77 gastroenterologists,12 pathologists),there was almost universal acceptance that histological assessment should form part of UC evaluation[95%gastroenterologists,92%pathologists].However,gastroenterologists reported that 92%of their pathologists do not use a histological scoring *** of a formal histological scoring system was preferred by 77%of gastroenterologists and 58%of *** groups lacked awareness of the Geboes Score,Nancy Index and Robarts Histopathological Index scoring systems with 91%,87%,and 92%of gastroenterologists respectively;and 83%,83%,and 92%pathologists respectively,being uncertain of scoring systems’remission *** knowledge score was not significantly different between gastroenterologist

关键词： Histology Scoring system Ulcerative colitis Survey

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A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

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分子细胞生物学报:英文版 2015年第6期7卷 517-528页

作者： Cristina Martin-Granados Alan R.Prescott Samantha Le Sommer Izabela P.Klaska Tian Yu Elizabeth Muckersie Claudiu v.Giuraniuc Louise Grant Mirela Delibegovic john v.Forrester Institute of Medical Sciences University of AberdeenCollege of Life Sciences and MedicineAberdeen AB252ZDUK Department of Pharmacology University of CambridgeCambridge CB21PDUK Division of Cell Biology and Immunology College of Life SciencesUniversity of DundeeDundee DD15EHUK Centre for Ophthalmology and visual Science The University of Western AustraliaPerthAustralia Centre for Experimental Immunology Lions Eye InstituteNedlandsWA 6009Australia

Dendritic cells(DC)are the major antigen-presenting cells bridging innate and adaptive immunity,a function they perform by converting quiescent DC to active,mature DC with the capacity to activate naı¨ve T *** do this by migrating from the tissues to the T cell area of the secondary lymphoid ***,wedemonstrate thatmyeloid cell-specific genetic deletion of PTP1B(LysM PTP1B)leads to defects in lipopolysaccharide-driven bone marrow-derivedDC(BMDC)activation associated with increased levels of phosphorylated *** showthatmyeloid cell-specific PTP1Bdeletion also causes decreased migratory capacity of epidermal DC,aswell as reduced CCR7 expression and chemotaxis to CCL19 by ***1B deficiency in BMDC also impairs their migration in ***,immature LysM PTP1B BMDC display fewer podosomes,increased levels of phosphorylated Src at tyrosine 527,and loss of Src localization to podosome *** co-culture with T cells,LysM PTP1B BMDC establish fewer and shorter contacts than control ***,LysMPTP1BBMDCfail to present antigen to T cells as efficiently as *** data provide first evidence for a key regulatory role for PTP1B in mediating a central DC function of initiating adaptive immune responses in response to innate immune cell activation.

关键词： dendritic cell maturation podosomes T cell activation adaptive immune response protein tyrosine phosphatase 1B

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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

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Family Medicine and Community Health 2024年第S3期12卷 12-22页

作者： William B ventres Leslie A Stone Rupal Shah Tamala Carter Geoffrey M Gusoff Winston Liaw Bich-May Nguyen Joanna v Rachelson Mary Alice Scott Teresa L Schiff-Elfalan Seiji Yamada Robert C Like Kathleen Zoppi A Peter Catinella Richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn Center for Community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National Clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary Care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and Community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and Community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘Context—grounding family medicine in time,place and being’,‘Recentring community’,‘Community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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Submaximal oxygen uptake kinetics, functional mobility, and physical activity in older adults with heart failure and reduced ejection fraction

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Journal of Geriatric Cardiology 2016年第5期13卷 450-457页

作者： Scott L Hummel john Herald Craig Alpert Kimberlee A Gretebeck Wendy S Champoux Donald R Dengel Peter v vaitkevicius Neil B Alexander Department of lnternal Medicine University of Michigan Ann Arbor MI USA vA Ann Arbor Healthcare System Ann Arbor MI USA School of Nursing University of Wisconsin-Madison Madison WI USA William Beaumont School of Medicine Oakland University Royal Oak MI USA School of Kinesiology University of Minnesota Minneapolis MN USA Aspirus Health System Ontanagon ML USA

Background Submaximal oxygen uptake measures are more feasible and may better predict clinical cardiac outcomes than maximal tests in older adults with heart failure （HF）. We examined relationships between maximal oxygen uptake, submaximal oxygen kinetics, fianctional mobility, and physical activity in older adults with HF and reduced ejection fraction. Methods Older adults with HF and reduced ejection fraction （n = 25, age 75 ：i： 7 years） were compared to 25 healthy ageand gender-matched controls. Assessments included a maximal treadmill test for peak oxygen uptake （vO2p^ak）, oxygen uptake kinetics at onset of and on recovery from a submaximal treadmill test, functional mobility testing [Get Up and Go （GUG）, Comfortable Gait Speed （CGS）, Unipedal Stance （US）], and self-reported physical activity （PA）. Results Compared to controls, HF had worse performance on GUG, CGS, and US, greater delays in submaximal oxygen uptake kinetics, and lower PA. In controls, vO2peak was more strongly associated with functional mobility and PA than submaximal oxygen uptake kinetics. In HF patients, submaximal oxygen uptake kinetics were similarly associated with GUG and CGS as vO2peak, but weakly associated with PA. Conclusions Based on their mobility performance, older HF patients with reduced ejection fraction are at risk for adverse functional outcomes. In this population, submaximal oxygen uptake measures may be equivalent to vO2 peak in predicting functional mobility, and in addition to being more feasible, may provide better insight into how aerobic function relates to mobility in older adults with HF.

关键词： Aging Congestive heart failure Mobility Oxygen uptake The elderly

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Soil Detachment with Organic Mulching Using Rainfall Simulator in Comparison with a Short Duration Natural Rainfall for Effective Soil Conservation

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Journal of Environmental Protection 2020年第6期11卷 457-469页

作者： johnson Kayode Adewumi john Jiya Musa Olayemi johnson Adeosun Otuaro Ebierin Akpoebidimiyen Adebola Adekunle Babafemi Sunday Adewumi Department of Agricultural & Bioresources Engineering College of Engineering Federal University of Agriculture Abeokuta Nigeria Department of Agricultural & Bioresources Engineering School of Infrastructure Process Engineering and Technology Federal University of Technology Minna Nigeria Department of Civil Engineering Faculty of Engineering Maritime University Okerenkoko Nigeria Department of Civil Engineering College of Engineering Federal University of Agriculture Abeokuta Nigeria

The impact of raindrop on sandy soil was studied using rainfall simulator and natural rainfall to determine average soil detached. Erosion by rainfall is one of the major hazards threatening the productivity of farmlands. This study determined the rate of soil detachment in comparison between natural rainfall and simulated rainfall for effective soil conservation measure. The height of the simulator was varied considering the diameter of the nozzles which were considered during the design stage of the rain simulator. Two plots of dimensions 2 m × 2 m each were cleared with one considered for bare and treated soils for both the natural rainfall and simulated rainfall. Splash cups were installed on each of the plots at half depth of the cup after the clearing of the area at 0.4 m × 0.4 m apart. Two sets of rain gauge were placed at the experimental site to note the volume of natural rainfall on the farm. The average soil detached was analysed using statistical analysis where t-test was also carried out to know the difference in mean. There was a significant difference in the degree of soil detachment between bare and treated soil under natural rainfall experiment;t(18) = 8.917, p η2) = 0.8154) reveals that the nature of soil accounted for 81.5% variance in the average detachment rate. For simulated experiments with a mean value of 7.3360 have higher tendency of detachment than treated soil with a mean value of 4.2240. Size of effect (Eta-square (η2) = 0.630) reveals that the soil types accounted for 63% variance in the average detachment. It was concluded that 40.33% soil was found to be conserved using the cow dungs mixe

关键词： Bare Rainfall Simulator Soil Treated

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A Biomimetic Approach to Robot Locomotion in Unstructured and Slippery Environments

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Journal of Bionic Engineering 2005年第1期2卷 1-14页

作者： Giovanni La Spina Thomas Hesselberg john Williams Julian F v vincent Scuola Superiore Sant'Anna Centre for Biomimetic and Natural TechnologiesCentre for Biomimetic and Natural TechnologiesCentre for Biomimetic and Natural Technologies Polo Sant'Anna ValderaCRIM LabViale Rinaldo Piaggio3456025-Pontedera (Pisa)ItalyDepartment of Mechanical Engineering University of BathBathBA2 7AYUKDepartment of Mechanical Engineering University of BathBathBA2 7AYUKDepartment of Mechanical Engineering University of BathBathBA2 7AYUK

While much attention has been given to bio-robotics in recent years, not much of this has been given to the challenging subject of locomotion in slippery conditions. This study begins to rectify this by proposing a biomimetic approach to generating the friction required to give sufficient propulsive force on a slippery substrate. We took inspiration from a successful biological solution-that of applying hair-like structures to the propulsive appendages, similar to the setae found in nereid polychaetes living in muddy habitats. We began by examining the morphology and the mean locomotion parameters of one of the most common nereids.. Nereis diversicolor. Following this study, we designed and fabricated a robotic system with appendages imitating the biological shape found in the worm. A flexible control system was developed to allow most of the locomotion parameters observed in the real worm to be applied to the robot. Experiments on three different natural substrates ranging from fine sand to gravel showed that, whereas a plate attached to the appendage generated most thrust on a small particle substrate, a bundle of artificial setae attached to the appendage generated most thrust on a large particle substrate. On all types of substrate tested, an appendage without any attachment did significantly worse than one with. This suggests that hair-like structures can be advantageous.

关键词： bio-robotics biomimetics polychaeta thrust generation friction

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The petrogenesis of modern and ophiolitic lavas reconsidered:Ti-v and Nb-Th

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Geoscience Frontiers 2022年第2期13卷 90-109页

作者： john W.Shervais Department of Geosciences Utah State UniversityLoganUT 84322-4500United States

Tectonic discrimination diagrams are a key tool for understanding ancient volcanic rock *** this contribution we compile over 15,000 whole rock compositions to re-evaluate the Ti-v discrimination diagram and compare it to another commonly used tool,the Nb/Yb-Th/Yb *** have reformulated the Ti-v diagram into a log-log plot to distinguish samples more clearly at lower *** compilation shows that MORB are dominated by Ti/v=20-43,whereas juvenile arc tholeiites and boninites are characterized by Ti/vverlap at the boundary(Ti/v=20-22).Plume-related volcanic rocks(ocean island basalts,oceanic plateaux,and continental flood basalts)generally have Ti/v>43,although there may be significant overlap with MORB-like ratios for ridgecentered OIB and for some oceanic *** 56%of alkaline OIB have Ti/v>***-arc basins are dominantly *** models show that MORB and juvenile arc volcanics most likely formed under different fO;conditions,but are permissive of similar fO_(2)if the arc rocks form by much higher melt *** Nb/Yb ***/Yb plot clearly distinguishes most oceanic basalts(MORB,plateaux,OIB)from subduction-related volcanic rocks(boninite,juvenile arc tholeiite,calc-alkaline)and from flood *** propose here a new two-proxy diagram of Ti/v ***/Nb,which incorporates the advantages of both.

关键词： Ophiolite Discrimination diagrams Trace element geochemistry vanadium

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Therapeutic molecules for multiple human diseases identified from pigeon pea(Cajanus cajan ***.)through GC–MS and molecular docking

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Food Science and Human Wellness 2017年第4期6卷 202-216页

作者： Deepu Mathew Lidiya john P. Manila T.M. Divyasree P. Sandhya Rajan v.T.K. Finishing School in Biotechnology Centre for Plant Biotechnology and Molecular BiologyKerala Agricultural UniversityThrissurKerala 680656India

Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis,breast cancer,type II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified phyto-compound ligands with candidate disease *** the 242 ligands,three dimensional structures of 47 compounds had to be drawn using ChemSketch and the remaining structures were retrieved from PubChem and docked with the active sites of candidate *** molecules identified through docking were further subjected to ADMET analysis and promising drug candidates were identified for each *** paper presents a precise account of the chemoprofile of pigeon pea leaves,stems and seeds,interaction of these molecules with target proteins and suggests 26 highly potential molecules which are drug candidates for multiple human *** pea seeds are especially proven as invaluable source for therapeutic molecules.

关键词： Breast cancer Drug discovery Herbal medicine In silico Malaria Measles Phyto-compounds Rheumatoid arthritis Sickle cell disease Type II diabetes

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Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study

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World Journal of Gastroenterology 2007年第10期13卷 1585-1594页

作者： Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T johnston Harry Comber Jim Mc Guigan john v Reynolds Liam J Murray Centre for Clinical and Population Sciences Queen's UniversityBelfastNorthern Ireland Royal Group of Hospitals BelfastNorthern Ireland National Cancer Registry CorkIreland St.James's Hospital DublinIreland

AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal ***:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 *** participants underwent a structured interview with information obtained about potential lifestyle and environmental risk ***:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's *** but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

关键词： Barrett's oesophagus Oesophagealadenocarcinoma Smoking Gastro-oesophageal reflux Body mass index Diet Case-control

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Anterior glenohumeral instability:Current review with technical pearls and pitfalls of arthroscopic soft-tissue stabilization

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World Journal of Orthopedics 2021年第1期12卷 1-13页

作者： john M Apostolakos Joshua Wright-Chisem Lawrence v Gulotta Samuel A Taylor Joshua S Dines Department of Sports Medicine and Shoulder Surgery Hospital for Special SurgeryNew YorkNY 10021United States

The glenohumeral joint(GHJ)allows for a wide range of motion,but is also particularly vulnerable to episodes of *** GHJ instability is especially frequent among young,athletic populations during contact sporting *** first time dislocators can be managed non-operatively with a period of immobilization and rehabilitation,however certain patient populations are at higher risk for recurrent instability and may require surgical intervention for adequate *** of the optimal treatment strategy should be made on a case-by-case basis while weighing both patient specific factors and injury patterns(i.e.,bone loss).The purpose of this review is to describe the relevant anatomical stabilizers of the GHJ,risk factors for recurrent instability including bony lesions,indications for arthroscopic vs open surgical management,clinical history and physical examination techniques,imaging modalities,and pearls/pitfalls of arthroscopic soft-tissue stabilization for anterior glenohumeral instability.

关键词： Arthroscopic Soft-tissue Anterior instability Glenohumeral Functional anatomy Recurrent instability

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