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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery

Bioactive Materials 2023年第2期20卷 137-163页

作者： Mahsa Janmohammadi Zahra Nazemi Amin Orash Mahmoud Salehi Amir Seyfoori johnson v.john Mohammad Sadegh Nourbakhsh Mohsen Akbari Faculty of New Sciences and Technologies Semnan UniversitySemnanP.O.Box:19111-35131Iran Laboratory for Innovations in Micro Engineering(LiME) Department of Mechanical EngineeringUniversity of Victori1Victori1BCV8P 5C2Canada Terasaki Institute for Biomedical Innovations Los AngelesCA90050USA Biotechnology Center Silesian University of TechnologyAkademicka 2A44-100GliwicePoland Faculty of Materials and Metallurgical Engineering Semnan UniversitySemnanP.O.Box:19111-35131Iran

Natural bone constitutes a complex and organized structure of organic and inorganic components with limited ability to regenerate and restore injured tissues,especially in large bone *** improve the reconstruction of the damaged bones,tissue engineering has been introduced as a promising alternative approach to the conventional therapeutic methods including surgical interventions using allograft and autograft *** composite scaffolds consisting of multifunctional biomaterials in combination with the cells and bioactive therapeutic agents have great promise for bone repair and *** and its derivatives are renewable and biodegradable natural polymers that have shown promising potential in bone tissue engineering ***-based scaffolds possess numerous advantages attributed to their excellent properties of non-toxicity,biocompatibility,biodegradability,availability through renewable resources,and the low cost of preparation and ***,cellulose and its derivatives have been extensively used for delivering growth factors and antibiotics directly to the site of the impaired bone tissue to promote tissue *** review focuses on the various classifications of cellulose-based composite scaffolds utilized in localized bone drug delivery systems and bone regeneration,including cellulose-organic composites,cellulose-inorganic composites,cellulose-organic/inorganic *** will also highlight the physicochemical,mechanical,and biological properties of the different cellulose-based scaffolds for bone tissue engineering applications.

关键词： Cellulose Cellulose derivatives Bone tissue engineering Drug delivery system

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Recent advances in biopolymer-based hemostatic materials

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Regenerative Biomaterials 2022年第1期9卷 1080-1105页

作者： Marvin Mecwan Jinghang Li Natashya Falcone Menekse Ermis Emily Torres Ramon Morales Alireza Hassani Reihaneh Haghniaz Kalpana Mandal Saurabh Sharma Surjendu Maity Fatemeh Zehtabi Behnam Zamanian Rondinelli Herculano Mohsen Akbari johnson v.john Ali Khademhosseini Terasaki Institute for Biomedical Innovation Los AngelesCA 90064USA Department of Molecular and Cell Biology University of CaliforniaBerkeleyCA 94720USA Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Bioengineering&Biomaterials Group School of Pharmaceutical SciencesSao Paulo State University(UNESP)AraraquaraSP 14800-903Brazil Department of Mechanical Engineering University of VictoriaVictoriaBC V8P 5C2Canada Biotechnology Center Silesian University of TechnologyGliwice 44-100Poland

Hemorrhage is the leading cause of trauma-related deaths,in hospital and prehospital *** is a complex mechanism that involves a cascade of clotting factors and proteins that result in the formation of a strong *** certain surgical and emergency situations,hemostatic agents are needed to achieve faster blood coagulation to prevent the patient from experiencing a severe hemorrhagic ***,it is critical to consider appropriate materials and designs for hemostatic *** materials have been fabricated as hemostatic agents,including synthetic and naturally derived *** to synthetic polymers,natural polymers or biopolymers,which include polysaccharides and polypeptides,have greater biocompatibility,biodegradability and ***,in this review,we focus on biopolymer-based hemostatic agents of different forms,such as powder,particles,sponges and ***,we discuss biopolymer-based hemostatic materials currently in clinical trials and offer insight into next-generation hemostats for clinical translation.

关键词： hemostasis coagulation polysaccharides polypeptides biomaterials

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy johnson v.john Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Antifragility Analysis and Measurement Framework for Systems of Systems

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International Journal of Disaster Risk Science 2013年第4期4卷 159-168页

作者： john johnson Adrian v.Gheorghe Engineering Management and Systems Engineering Department Old Dominion University Norfolk VA 23529 USA

The twenty-first century is defined by the social and technical hazards we face.A hazardous situation is a condition,or event,that threatens the well-being of people,organizations,societies,environments,and *** most extreme of the hazards are considered X-Events and are an exogenous source of extreme stress to a system.X-Events can also be the unintended outputs of a system with both positive(serendipitous) and negative(catastrophic) *** can vary in their ability to withstand these stress *** ability exists on a continuum of fragility that ranges from fragile(degrading with stress),to robust(unchanged by stress),to antifragile(improving with stress).The state of the art does not include a method for analyzing or measuring *** that “what we measure we will improve,” the absence of a measurement approach limits the effectiveness of governance in making our systems less fragile and more robust if not *** authors present an antifragile system simulation model,and propose a framework for analyzing and measuring antifragility based on system of systems *** framework reduces a multidimensional concept of fragility into a two-dimensional continuous interval scale.

关键词： extreme unchanged consequences

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Floating production storage and offloading systems＇ cost and motion performance： A systems thinking application

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Frontiers of Engineering Management 2018年第3期5卷 357-368页

作者： Rini NISHANTH Andrew WHYTE v.john KURIAN Civil & Environmental Engineering University Tech. PETRONASBandar Seri Iskandar Malaysia Civil Engineering Curtin University Perth Australia

Floating production storage and offloading （FPSO） units increasingly represent a practical and economic means for deep-water oil extraction and production. Systems thinking gives a unique opporamity to seek a balance between FPSO technical performance（s）, with whole-cost; stakeholder decision-making is charged to align different fit-for-use design specification options＇ that address technical-motion（s）, with respective life-cycle cost analyses （LCCA）. Soft system methodology allows situation based analyses over set periods-of-time by diagnosing the problem-at-hand; namely, assessing the antecedents of life-cycle cost relative to FPSO sub- component design alternatives. Alternative mooring- component comparisons for either new-build hulls or refurbished hulls represent an initial necessary considera- tion to facilitate extraction, production and storage of deep- water oil reserves. Coupled dynamic analysis has been performed to generate FPSO motion in six degrees of freedom using SESAM DeepC, while life-cycle cost analysis （LCAA） studies give net-present-value comparsons reflective of market conditions. A parametric study has been conducted by varying wave heights from 4 - 8 m to understand FPSO motion behavior in the presence of wind and current, as well as comparing the motions of turreted versus spread mooring design alternatives. LCCA data has been generated to compare the cost of such different mooring options/hull conditions over 10 and 25- year periods. Systems thinking has been used to explain the interaction of problem variables; resultantly this paper is able to identify explicit factors affecting the choice of FPSO configurations in terms of motion and whole-cost, toward assisting significantly with the front-end engineering design （FEED） phase of fit-for-purpose configured FPSOs, in waters off Malaysia and Australia.

关键词： FPSO LCCA spread/turret-mooring DeepC cost motion soft-systems

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Condition Assessment Techniques for Aged Fixed-Type Offshore Platforms Considering Decommissioning:a Historical Review

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Journal of Marine Science and Application 2020年第4期19卷 584-614页

作者： Mohamed Mubarak Abdul Wahab v.john Kurian Mohd Shahir Liew Do Kyun Kim Department of Civil and Environmental Engineering Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia Administration Department Providence College of EngineeringChengannur 689122India Group of Marine Offshore and Subsea Technology School of EngineeringNewcastle UniversityNewcastle upon Tyne NE17RUUK Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea

In this study,the technical papers on structural condition assessment of aged fixed-type offshore platforms reported over the past few decades are *** ancillary related works are also *** numbers of researches are available in the area of requalification for life extension of offshore jacket *** of these studies involve reassessment of existing platforms by means of conducting pushover analysis,a static nonlinear collapse analysis method to evaluate the structure nonlinear behaviour and capacity beyond the elastic *** here,the failure mechanism and inherent reserve strength/capacity of the overall truss structure are *** method of doing reassessment is described clearly in the industry-adopted codes and standards such the API,ISO,PTS and NORSOK *** may help understand the structural behaviour of aged fixed offshore jacket structures for maintenance or decommissioning.

关键词： Strength of offshore platforms Reliability Jacket platform Fixed structure,oil and gas Fixed-type offshore platform Offshore structures

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Evolutionary diversity as a catalyst for biological discovery

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Integrative Zoology 2018年第6期13卷 616-633页

作者： Zachary v.johnson Larry J.YOUNG School of Biological Sciences Georgia Institute of TechnologyAtlantaGeorgiaUSA Center for Translational Social Neuroscience Silvio O.Conte Center for Oxytocin and Social CognitionDepartment of Psychiatry and Behavioral SciencesYerkes National Primate Research CenterEmory UniversityAtlantaGeorgiaUSA

The tremendous diversity of animal behaviors has inspired generations of scientists from an array of biological *** complement investigations of ecological and evolutionary factors contributing to behavioral evolution,modern sequencing,gene editing,computational and neuroscience tools now provide a means to discover the proximate mechanisms upon which natural selection acts to generate behavioral *** behaviors are motivated behaviors that can differ tremendously between closely related species,suggesting phylogenetic plasticity in their underlying biological *** addition,convergent evolution has repeatedly given rise to similar forms of social behavior and mating systems in distantly related *** behavioral divergence and convergence provides an entry point for understanding the neurogenetic mechanisms contributing to behavioral *** argue that the greatest strides in discovering mechanisms contributing to social behavioral diversity will be achieved through integration of interdisciplinary comparative approaches with modern tools in diverse species *** review recent advances and future potential for discovering mechanisms underlying social behavioral variation;highlighting patterns of social behavioral evolution,oxytocin and vasopressin neuropeptide systems,genetic/transcriptional“toolkits,”modern experimental tools,and alternative species systems,with particular emphasis on Microtine rodents and Lake Malawi cichlid fishes.

关键词： cichlids oxytocin and vasopressin social behavior toolkits voles

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Differential responses to feeding by the tomato/potato psyllid between two tomato cultivars and their implications in establishment of injury levels and potential of damaged plant recovery

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Insect Science 2006年第3期13卷 195-204页

作者： DEGUANG LIU LINDSEY johnson john T. TRUMBLE Department of Entomology Unversity of California Riverside CA USA

An invasive new biotype of the tomato/potato psyllid （Bactericera [Paratrioza] cockerelli [Sulc.]）（Homoptera： Psyllidae） recently has caused losses exceeding 50% on fresh market tomatoes in western North America. Despite these extensive losses, little is known regarding the threshold levels at which populations must be suppressed in order to prevent economic losses. A series of experiments were therefore designed using combinations of two common tomato cultivars （QualiT 21 and Yellow Pear）, five pest-densities （0, 20, 30, 40 and 50 nymphs/plant）, and three feeding-duration （5 days, 10 days, and lifetime） treatments to test the relative importance of pest density, feeding period, and cumulative psyllid-days to establish economic threshold levels for psyllids. The cultivars differed considerably in their response to the toxin injected by the psyllid nymphs. ‘Yellow Pear＇ plants could recover from feeding by up to 40 nymphs for as long as 10 d, whereas ‘QualiT 21＇ plants were irreparably damaged by densities of 20 nymphs feeding for only 5 days. On ‘Yellow Pear＇, all plant measurements such as the number of yellow leaves and plant height were significantly better correlated with cumulative psyUid-days than with either pest density or feeding duration. On ‘QualiT 21 ＇, all plant measurements other than the number of yellow leaflets and leaves were significantly better correlated with pest density than with feeding duration or cumulative psyUid-days, and pest density was a better predictor of psyUid damage. Potential reasons for the variable responses between cultivars and the implications for psyllid sampling and integrated pest management are discussed.

关键词： IPM psyllid yellows tomato cultivar toxic saliva

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Future of non-invasive graft evaluation:A systematic review of proteomics in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 135-149页

作者： Eleni Avramidou Konstantina Psatha Kallisti St john Georgios Tsoulfas Michalis Aivaliotis Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece Laboratory of Medical Biology-Genetics School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Functional Proteomics and Systems Biology(FunPATh) Center for Interdisciplinary Research and Innovation(CIRI-AUTH)Thessaloniki GR-57001Greece Laboratory of Biological Chemistry School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered *** biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies(serum,urine)represent a promising innovation in the monitoring of kidney transplant *** To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft *** A systematic review was conducted in accordance with PRISMA guidelines,based on research results from the PubMed and Scopus *** primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related *** criteria included protein biomarkers and urine and blood samples,while exclusion criteria were language other than English and the use of low resolution and sensitivity *** selected research articles,were categorized based on the biological sample,condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and *** and network analysis of the selected proteins was *** In 17 included studies,58 proteins were studied,with the cytokine CXCL10 being the most *** pathways related to immune response and fibrosis have shown to be *** of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were ***,all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods,as far as renal graft assessment is *** Our review suggests that protein biomarkers,evaluated in specific biological fluids,can make a significant contribution to the timely,valid and non-invasive assessment of kidney graft.

关键词： Proteomics Kidney transplantation Graft evaluation Non-invasive diagnosis Kidney graft function

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Antibacterial activity of leaves and inter-nodal callus extracts of Mentha arvensis L

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 196-200页

作者： johnson M Wesely EG Kavitha MS Uma v Department of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)Palayamkottai-627 002Tamil NaduIndia Department of Botany Arignar Anna Government Arts CollegeNamakkalTamil NaduIndia Centre for Biotechnology Muthayammal College of Arts and ScienceNamakkal Dist.Rasipuram-637 408Tamil NaduIndia Department of Botany V.H.N.S.N.CollegeVirudhunagar-626 001Tamil NaduIndia

Objective:To determine the anti-bacterial efficacy of chloroform,ethanol,ethyl acetate and water extracts of inter-nodal and leaves derived calli extracts from Mentha arvensis(***) against Salmonella typhi(***),Streptococcus pyogenes(***),Proteus vulgaris(P. vulgaris) and Bacillus subtilis(***).Methods:The inter-nodal and leaves segments of *** were cut into 0.5-0.7 cm in length and cultured on Murashige and Skoog solid medium supplemented with 3%sucrose,gelled with 0.7%agar and different concentration of 2,4-Dichlorophenoxyacetie acid(2,4-D) either alone or in *** preliminary phytochemical screening was performed by Brindha et al *** efficacy was performed by disc diffusion method and incubated for 24 h at 37℃.Results:Maximum percentage of callus formation(inter-nodal segments 84.3±0.78;leaves segments 93.8±1.27) was obtained on Murashige and Skoog’s basal medium supplemented with 3%sucrose and 1.5 mg/L of 2,*** ethanol extracts of leaves derived calli showed the maximum bio-efficacy than other *** leaves and stem derived calli extracts on Proteus *** that the plants can be used in the treatment of urinary tract infection associated with Proteus *** the bacterial efficacy studies,it is confirmed that the in vitro raised calli tissue was more effective compared to in vivo ***:The bio-efficacy study confirmed that the calli mediated tissues showed the maximum zone of *** present study paved a protocol to establish high potential cell lines by in vitro culture.

关键词： In vitro Callus Bacterial efficacy Mentha

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