检索结果-南通市图书馆

细胞与分子免疫学杂志 1985年第4期 97-98页

作者： johnson.G.εLowery k.m.,刘琨 kallestab Laboratories Corporate Research Austin 7×78741 USA

阐明抗体特异性的分子基础仍然是免疫化学中的重要难题之一,抗体与氨基酸侧链接触

关键词：单克隆抗原决定簇抗体结合位点缓冲液茶硷抗体特异性 pH

对晚期慢性心力衰竭患者行心脏再同步化治疗致NYHA分级改善的临床预测因素和时机:多中心InSync随机临床评价(mIRACLE)和多中心InSyncICD随机临床评价(mIRACLE-ICD)试验的结果

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 13-13页

作者： Pires L.A. Abraham W.T. Young J.B. johnson k.m. 刘少伟 Heart Rhythm Center St.John Hospital and Medical Center22101 Moross RdDetroitMI 48236United StatesDr

Background: Based on current patient selection criteria, a significant proportion of recipients of cardiac resynchronization therapy(CRT) do not respond to treatment. The purpose of this analysis is to identify predictors and characterize the timing of response to CRT in patients with advanced heart failure. methods: Patients randomized to receive CRT in the mIRACLE and mIRACLE-ICD trials, designed to assess the benefit of CRT compared with standard medical therapy in patients with advanced heart failure, left ventricular ejection fractionmilliseconds, were included for this analysis. Patients with an improvement of ≥1 New York Heart Association(NYHA)class from baseline to the 6-month follow-up were considered responders and those who had no change or worse NYHA class or died were classified as nonresponders. Responders were subdivided into early(within 1-3 months) and late(6 months). Results: One hundred forty-three(64%) of 224 and 190(61%) of 313 patients in the mIRACLE and mIRACLEICD trials, respectively, responded to therapy, with 81(57%) of 143 and 100(53%) of 190 responding early. Several but differing factors predicted CRT response and timing in the two trials with a high sensitivity(89%-90%) but, owing to a low specificity(31%-49%), a modest predictive accuracy(66%-75%). Conclusions: Based on improvement of ≥1 NYHA class, less than two thirds of patients enrolled in the mIRACLE or mIRACLE-ICD trials responded to CRT, with just more than half responding within the first month. Several factors predicted CRT response and timing, but given their modest predictive accuracy, comparable for both studies, additional methods for selecting candidates most likely to benefit from CRT are needed.

关键词：心脏再同步化治疗慢性心力衰竭患者 NYHA分级晚期心力衰竭预测因素 InSync 随机分配 D试验

Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 8-11页

作者： Paul Raj k Irudayaraj V johnson m Patric Raja D Dartment of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)

Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(***)(L.) ***: morphological studies on epidermal glands were earned out by using light microscope and scanning electron *** prepare the extract,the shade-dried fronds of glandular morphotype were soaked in *** antibacterial studies paper disc method was followed by using various pathogenic ***:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern ***(L.) *** its inlraspecific variation in antibacterial *** presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this *** epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature *** of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in *** acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of *** phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in ***:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) *** several bioactive compounds and such rare moiphovariant should be conserved in *** next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands.

关键词： Epidermal glands Christella parasitica Bioactivity Phytochemical activity Anti-bacterial activity morphology Biochemistry Glandular morphotype Light microscope Shade-dried frond Bioactive compound morphovariant Preliminary phytochemical analysis Gland extract Flavonoid

Distilling physical origins of hardness in multi-principal element alloys directly from ensemble neural network.m.dels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational materials 2022年第1期8卷 1450-1460页

作者： D.Beniwal P.Singh S.Gupta m.J.kramer D.D.johnson P.k.Ray metallurgical&materials Engineering Indian Institute of Technology RoparRupnagar140001PunjabIndia Ames Laboratory US Department of EnergyAmesIA50011USA materials Science&Engineering Iowa State UniversityAmesIA50011USA

Despite a plethora of data being generated on the mechanical behavior of multi-principal element alloys,a systematic assessment remains inaccessible via Edisonian *** approach this challenge by considering the specific case of alloy hardness,and present a machine-learning framework that captures the essential physical features contributing to hardness and allows high-throughput exploration of multi-dimensional compositional *** model,tested on diverse datasets,was used to explore and successfully predict hardness in Al_(x)Ti_(y)(CrFeNi)_(1-x-y),Hf_(x)Co_(y)(CrFeNi)_(1-x-y)and Al_(x)(TiZrHf)_(1-x)systems supported by data from density-functional theory predicted phase stability and ordering *** experimental validation of hardness was done on *** selected systems pose diverse challenges due to the presence of ordering and clustering pairs,as well as vacancy-stabilized novel *** also present a detailed model analysis that integrates local partial-dependencies with a compositional-stimulus and model-response study to derive material-specific insights from the decision-making process.

关键词： alloys alloy element

Fix and replace:An emerging paradigm for treating acetabular fractures in older patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2017年第3期8卷 218-220页

作者： Elizabeth k Tissingh Abigail johnson Joseph m Queally Andrew D Carrothers Cambridge University Hospitals NHS Foundation Trust Addenbrooke’s and Rosie Hospitals

Acetabular fractures in older patients are challenging to *** "fix and replace" construct may present a new paradigm for the management of these *** present the current challenge of acetabular fractures in older *** present this in the context of the current *** invited editorial presents early results from our centre and the ongoing challenges are discussed.

关键词： Acetabular fracture Total hip arthroplasty Trauma

Observations of defect propagation in [100]-oriented opal-type photonic crystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2008年第4期17卷 1298-1304页

作者：金崇君 Richard m.De La Rue Nigel P.johnson Department of Electronics & Electrical Engineering University of Glasgow School of Physics and Engineering Laboratory of Optoelectronic Materials and TechnologiesSun Yat-Sen University

Charged colloidal suspensions have been used as experimental models for the study of crystal nucleation. Here we propose that the technique of template-assisted colloidal self-assembly can be used to visualize the effects of defect propagation in atomic crystal films produced using epitaxial growth. Templates with periodic line defects were used to grow [100]-oriented three-dimensional photonic crystals by means of the template-assisted colloidal self-assembly method, aided by capillary and gravitational forces. The defect propagation in the [100]-oriented photonic crystal was observed using scanning electron microscopy, both at the surface of the crystal and on cleaved facets. This method is useful in the understanding of defect propagation in the growth of colloidal films on templates - and the same approach may also prove useful for the understanding of atomic crystal growth on substrates with defects. Additionally, the deliberate incorporation of line defects may prove valuable as a way of introducing waveguide channels into three-dimensional photonic crystals.

关键词： photonic crystal colloidal crystal self-assembly

Effect of Laser Injection Seeder on Rotationally Resolved Spectra of Benzonitrile

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2010年第8期27卷 77-79页

作者：徐海峰 johnson Philip m. SEARS Trevor J. Institute of Atomic and molecular Physics 3ilin University~ Changchun 130012 Chemistry Department Stony Brook University Stony Brook NY 11974 USA Department of Chemistry Brookhaven National Laboratory Upton NY 11973 USA

High resolution lasers are necessary to derive the most information from molecular spectra. However, their use uncovers some photophysical processes that compromise the ability to resolve rotational structure. We study the influence of laser optical mode structure on the high resolution spectra of the S1 states of benzonitrile in a supersonic molecular beam using an Ar^＋ pumped cw ring dye laser which is amplified by a pulsed Nd： YA G laser. The latter could be operated either in one optical mode by injecting （seeding） its oscillator with a single mode diode laser, or with many optical modes by not using the seeder. Rotationally resolved lines are obtained when the oscillator of the YAG laser are operated in one single optical mode, but only a continuum is seen when the YAG laser has multiple modes. It is argued that the ac Stark effect is the most probable reason for broadening and blurring the rotational lines.

关键词： OPTICAL detectors INJECTION lasers NITRILES mOLECULAR spectra mOLECULAR beams ND-YAG lasers STARk effect

Antibacterial activity of leaves and inter-nodal callus extracts of mentha arvensis L

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical medicine 2011年第3期4卷 196-200页

作者： johnson m Wesely EG kavitha mS Uma V Department of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)Palayamkottai-627 002Tamil NaduIndia Department of Botany Arignar Anna Government Arts CollegeNamakkalTamil NaduIndia Centre for Biotechnology Muthayammal College of Arts and ScienceNamakkal Dist.Rasipuram-637 408Tamil NaduIndia Department of Botany V.H.N.S.N.CollegeVirudhunagar-626 001Tamil NaduIndia

Objective:To determine the anti-bacterial efficacy of chloroform,ethanol,ethyl acetate and water extracts of inter-nodal and leaves derived calli extracts from mentha arvensis(***) against Salmonella typhi(***),Streptococcus pyogenes(***),Proteus vulgaris(P. vulgaris) and Bacillus subtilis(***).methods:The inter-nodal and leaves segments of *** were cut into 0.5-0.7 cm in length and cultured on murashige and Skoog solid medium supplemented with 3%sucrose,gelled with 0.7%agar and different concentration of 2,4-Dichlorophenoxyacetie acid(2,4-D) either alone or in *** preliminary phytochemical screening was performed by Brindha et al *** efficacy was performed by disc diffusion method and incubated for 24 h at 37℃.Results:maximum percentage of callus formation(inter-nodal segments 84.3±0.78;leaves segments 93.8±1.27) was obtained on murashige and Skoog’s basal medium supplemented with 3%sucrose and 1.5 mg/L of 2,*** ethanol extracts of leaves derived calli showed the maximum bio-efficacy than other *** leaves and stem derived calli extracts on Proteus *** that the plants can be used in the treatment of urinary tract infection associated with Proteus *** the bacterial efficacy studies,it is confirmed that the in vitro raised calli tissue was more effective compared to in vivo ***:The bio-efficacy study confirmed that the calli mediated tissues showed the maximum zone of *** present study paved a protocol to establish high potential cell lines by in vitro culture.

关键词： In vitro Callus Bacterial efficacy mentha

Preliminary phytochemical and antimicrobial studies on a spike-moss Selaginella inaequalifolia(hook.& grev.) Spring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical medicine 2010年第12期3卷 957-960页

作者： Varaprasadham Irudayaraj Janaky m marimuthu johnson Nallayan Selvan Department of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)Palayamkottai - 627 002Tamil NaduIndia Centre for Biotechnology Muthayammal College of Arts & ScienceRasipuram - 637 408Tamil NaduIndia

Objective:To screen the anti-cancer spike-mosses for the presence of various bioactivities and to identify the important bioactive chemicals present in Selaginella inaequalifolia(S. inaequalifolia)(Hook.& Grev.) ***:Preliminary phytochemical screening was done by following the method of Brindha et *** study was carried out by disc diffusion ***:Results of preliminary phytochemical screening on five different extracts(petroleum ether,benzene,chloroform,ethanol and distilled water) of the spike-moss *** show the presence steroids,triterpenes,phenolic group,tannin,sugars and ***,amino acids,anthraquinone and reducing sugar did not show any positive *** the five different extracts,ethanol and chloroform extracts show the presence of maximum number(4 each) of *** results on antimicrobial studies show that all the three microbes[Staphylococcus aureus(***),Escherichia coli(***) and Candida albicans (***)]tested are resistant to the ethanol extract and susceptible to petroleum ether *** petroleum ether extract shows maximum inhibition with 45 mm of inhibition zone in *** inhibition zone in *** and *** are 26 mm and 22 mm respectively. Conclusions:The present study shows *** having potent antibacterial and anticandidal activities.

关键词： Spike moss Selaginella inaequalifolia Phytochemical screening Antimicrobial activity

Testing the potential mechanisms for the maintenance of a genetic color polymorphism in bluefin killifish populations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2018年第6期64卷 733-743页

作者： Ashley m.johnson Chia-Hao CHANG Rebecca C.FULLER Department of Animal Biology School of Integrative BiologyUniversity of Illinois at Urbana-ChampaignChampaignIL 61820USA

The maintenance of genetic variation in the face of natural selection is a long-standing question in evolutionary *** the bluefin killifish Lucania goodei,male coloration is *** can produce either red or yellow coloration in their anal fins,and both color morphs are present in all *** 2 morphs are heritable and how they are maintained in nature is ***, we tested 2 mechanisms for the maintenance of the red/yellow color *** frequency-dependent mating success predicts that rare males have a mating advantage over common males. Spatial variation in fitness predicts that different color morphs have an advantage in different microhabitat *** a breeding experiment,we tested these hypotheses by creating populations with different ratios of red to yellow males (5 red:1 yellow;1 red:5 yellow)and determining male mating success on shallow and deep spawning *** found no evidence of negative frequency-dependent mating *** morphs tended to have higher mating success, and this was particularly so on shallow spawning ***,on deep substrates,red males enjoyed higher mating success than yellow males,particularly so when red males were rare. However,yellow males did not have an advantage at either depth nor when *** suggest that preference for red males is expressed in deeper water,possibly due to alterations in the lighting ***,male pigment levels were correlated with one another and predicted male mating ***,pigmentation plays an important role in male mating success.

关键词： carotenoid color polymorphism environmental heterogeneity melanin negative frequency dependence pterin