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Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography

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Neuroscience Bulletin 2014年第5期30卷 777-811页

作者： Peter Brust Jrg van den hoff Jrg Steinbach Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer ResearchPermoserstrasse 15Leipzig04318Germany

Positron emission tomography （PET） is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases. PET uses biomolecules as probes which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These probes are called radiotracers. Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min. The delivery of such radiotracers into the brain provides images of transport, metabolic, and neurotransmission processes on the molecular level. After a short introduction into the principles of PET, this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application. Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases, but also allow molecular neuroreceptor imaging studies in various small-animal models of disease, including genetically- engineered animals. Furthermore, they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets, to investigate pathophysiology, to discover potential drug candidates, and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo.

关键词： Alzheimer's disease autoradiography blood-brain barrier brain tumor cholinergic system kinetic modeling metabolism molecular imaging neurodegeneration positron emission tomography precursor psychiatric disorder radiotracer sigma receptor

Dpen,ng the Effector Protein Toolbox for Plant- Parasitic Cyst Nematode Interactions

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Molecular Plant 2016年第11期9卷 1451-1453页

作者： Sebastian Eves-van den Akker Paul R.J. Birch Division of Plant Sciences College of Life Sciences University of Dundee Dundee DD1 5EH UK The Department of Biological Chemistry John Innes Centre Norwich Research Park Norwich NR4 7UH UK

Some biotrophic plant pathogens have the remarkable ability to alter plant developmental morphology and subceliular archi- tecture. At least three examples of this ability arose indepen- dently within the phylum Nematoda. For one such example, the cyst nematodes, plant cell manipulation is rapid and pro- found; within days the cell cycle of a single cell in the vascular cylinder is arrested at G2, the vacuole reduces in size and frag- ments.

关键词： GIANT-CELLS

Symptomatic Val122del mutated hereditary transthyretin amyloidosis: Need for early diagnosis and prioritization for heart and liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 323-329页

作者： Adriano-Valerio Schettini Laura Llado JulieK Heimbach JoseGonzalez Costello Marie Tranäng Olivier van Caenegem Richard C Daly Peter van den Bergh Carlos Casasnovas Joan Fabregat john J Poterucha Maxime Foguenne Bo Göran Ericzon Jan Lerut Institute for Experimental and Clinical Research(IREC) Catholic University of Louvain(UCL)Avenue Hippocrate 55Brussels 1200Belgium Liver Transplant Unit Department of SurgeryHospital Universitari de BellvitgeCalle de la Feixa LlargaBarcelona 08907Spain Division of Transplantation Surgery William J.von Liebig Transplant CenterMayo Clinic2001st St SWRochesterMN 55905USA Advanced Heart Failure and Transplant Unit Cardiology DepartmentHospital Universitari de BellvitgeCalle de la Feixa LlargaBarcelona 08907Spain Familial Amyloidotic Polyneuropathy World Transplant Registry(FAPWTR) Division of Transplantation SurgeryKarolinska Universitetssjukhuset HuddingeF82Karolinska InstitutetStockholm 14186Sweden Cardiothoracic Intensive Care Unit Department of Cardiovascular DiseasesUniversity Hospitals Saint-Luc-UCLAvenue Hippocrate 10Brussels 1200Belgium Cardiovascular Surgery Department Mayo Clinic2001st St SWRochesterMN 55905USA Neuromuscular Reference Centre University Hospital Saint-Luc-UCLAvenue Hippocrate 10Brussels 1200Belgium Neuromuscular Unit Neurology DepartmentHospital Universitari de BellvitgeCalle de la Feixa LlargaBarcelona 08907Spain Division of Gastroenterology and Hepatology Mayo Clinic2001st St SWRochester MN 08907USA Division of Transplantation Surgery CLINTECKarolinska Universitetssjukhuset HuddingeF82Karolinska InstitutetStockholm 14186Sweden

Background: Hereditary transthyretin(ATTRv) amyloidosis is an autosomal dominant disease linked to transthyretin gene mutations which cause instability of the transthyretin tetramer. After dissociation and misfolding they reassemble as insoluble fibrils(i.e. amyloid). Apart from the common Val30 Met mutation there is a very heterogeneous group of non-Val30 Met mutations. In some cases, the clinical picture is dominated by a rapidly evolving restrictive and hypertrophic cardiomyopathy. Methods: A case series of four liver recipients with the highly clinically relevant, rare and particularly aggressive Val122 del mutation is presented. Medical and surgical therapeutic options, waiting list policy for ATTRv-amyloidosis, including the need for heart transplantation, and status of heart-liver transplantation are discussed. Results: Three patients needed a staged(1 patient) or simultaneous(2 patients) heart-liver transplant due to rapidly progressing cardiac failure and/or neurologic disability. Domino liver transplantation was impossible in two due to fibrotic hepatic transformation caused by cardiomyopathy. After a follow-up ranging from 3.5 to 9.5 years, cardiac(allograft) function was maintained in all patients, but neuropathy progressed in three patients, one of whom died after 80 months. Conclusions: This is the first report in(liver) transplant literature about the rare Val122 del ATTRv mutation. Due to its aggressiveness, symptomatic patients should be prioritized on the liver and, in cases with cardiomyopathy, heart waiting lists in order to avoid the irreversible neurological and cardiac damage that leads to a rapid lethal outcome.

关键词： Hereditary transthyretin amyloidosis Heart transplantation Liver transplantation Non-Val30Met mutation Val122del mutation Domino liver transplantation

The effect of particle size and amount of inoculum on fungal treatment of wheat straw and wood chips

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Journal of Animal Science and Biotechnology 2017年第1期8卷 217-225页

作者： Sandra J. A. van Kuijk Anton S. M. Sonnenberg Johan J. P. Baars Wouter H. Hendriks john W. Cone Animal Nutrition Group Wageningen University De Elst 1 6708WD Wageningen The Netherlands Plant Breeding Wageningen University Droevendaalsesteeg 1 6708PB Wageningen The Netherlands

Background： The aim of this study was to optimize the fungal treatment of lignocellulosic biomass by stimulating the colonization. Wheat straw and wood chips were treated with Ceriporiopsis subvermispora and Lentinula edodes with various amounts of colonized millet grains（0.5, 1.5 or 3.0 % per g of wet weight of substrate） added to the substrates. Also, wheat straw and wood chips were chopped to either 0.5 or 2 *** of the fungal treatment after 0, 2, 4, 6, or 8 wk of incubation was determined by changes in chemical composition, in vitro gas production（IVGP） as a measure for rumen degradability, and ergosterol content as a measure of fungal ***： Incomplete colonization was observed for C. subvermispora treated wheat straw and L. edodes treated wood chips. The different particle sizes and amounts of inoculum tested, had no significant effects on the chemical composition and the IVGP of C. subvermispora treated wood chips. Particle size did influence *** treatment of wheat straw. The L. edodes treatment of 2 cm wheat straw resulted in a more selective delignification and a higher IVGP than the smaller particles. Addition of 1.5 % or 3 % L. edodes inoculum to wheat straw resulted in more selective delignification and a higher IVGP than addition of 0.5 % ***： Particle size and amount of inoculum did not have an effect on C. subvermispora treatment of wood chips. At least 1.5 % L. edodes colonized millet grains should be added to 2 cm wheat straw to result in an increased IVGP and acid detergent lignin（ADL） degradation.

关键词： Amount of inoculum Fungal treatment In vitro rumen degradability Lignin degradation Lignocellulosic biomass Particle size

以热机械浆和旧报纸/旧杂志纸为原料的新闻纸厂活性污泥菌胶团的黏性膨胀

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中国造纸 2015年第4期 76-76页

作者： STEVEN NOTHROP DES RICHARDSON john van LEEUWEN MICHAEL MACHIN KOBUS THEUNISSEN TROY WATKINS BEN van den AKKER

在这项研究中,我们发现发生在一家新闻纸厂活性污泥废水处理厂的污泥膨胀是由菌胶团黏性膨胀(或水合膨胀)所导致的。在挪威诺斯克公司Albury工厂的活性污泥厂(ASP),菌胶团黏性膨胀表现为显微镜下的无定形团块,它在二次澄清过程中在曝气... 详细信息

在这项研究中,我们发现发生在一家新闻纸厂活性污泥废水处理厂的污泥膨胀是由菌胶团黏性膨胀(或水合膨胀)所导致的。在挪威诺斯克公司Albury工厂的活性污泥厂(ASP),菌胶团黏性膨胀表现为显微镜下的无定形团块,它在二次澄清过程中在曝气池的废水表面形成硬壳,同时在曝气池生成大量泡沫。使用亚甲蓝染色法确认了能引起发泡的多糖/胞外聚合物类物质(EPS)产生,另外(污泥)絮状物比较分散并且呈淡蓝色。这一条件导致大量的白色泡沫,对活性污泥的沉降性能和脱水性能产生了不利影响。菌胶团黏性膨胀可以通过以下方面进行控制:减少营养物/微生物(F/M)的比例;维持宏观养分(正磷酸盐和氨;磷和氮)的残余浓度;通过在好氧选择器后添加厌氧选择器和/或在好氧选择器前减少缺氧程度来控制微生物增长率等。在活性污泥厂,当进入选择器1的化学耗氧度的F/M比例为20∶1时,菌胶团膨胀非常严重。通过使用缺氧选择器2并在两个曝气池中保持适当的铵和正磷酸盐的浓度来控制菌胶团的生长速率成功地控制EPS的产生。在此情况下,使用亚甲蓝染色法观测到的絮状物呈现紧实特性(深蓝色和低多糖)。消泡剂的用量也减少了90%。

关键词：菌胶团黏性膨胀增长速度缺氧选择器生物可利用的营养物质胞外聚合物

脂肪来源的干细胞单培养或与人脐带血静脉内皮细胞共培养:体外和大鼠颅骨缺损的体内成骨研究

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脂肪来源的干细胞单培养或与人脐带血静脉内皮细胞共培养:体外和...

The Land- Potential Knowledge System (LandPKS): mobile apps and collaboration for optimizing climate change investments

中华口腔医学会口腔修复学专业委员会第十次全国口腔修复学术大会

作者：马金玲 SanneK Both 纪伟阳芳 Henk-Jan Prins Marco N Helder 潘巨利陈溯崔福斋 john A Jansen Jeroen JJP van den Beucken Radboud University Nijmegen Medical Center 首都医科大学附属北京口腔医院武汉大学口腔医学院 Academic Centre for dentistry Amsterdam University of Amsterdam VU University Amsterdam VU University Medical Center/ACTA VU University Medical Center 清华大学材料科学与工程系

目的:口腔种植是当今修复牙缺失的热门方法,然而,口腔种植中经常存在骨量不足的问题。组织工程技术是当今的热门话题,本研究的目的是比较脂肪来源的干细胞(AT-MSCs)单培养或其与人脐带血静脉内皮细胞(HUVECs)共培养的体外和体内成骨能... 详细信息

目的:口腔种植是当今修复牙缺失的热门方法,然而,口腔种植中经常存在骨量不足的问题。组织工程技术是当今的热门话题,本研究的目的是比较脂肪来源的干细胞(AT-MSCs)单培养或其与人脐带血静脉内皮细胞(HUVECs)共培养的体外和体内成骨能力研究。方法:首先,通过把AT-MSCs和HUVECs以不同的比例(100:0:100)接种在细胞培养板上来确定成骨方向分化共培养的最佳细胞比例。之后,AT-MSCs单培养或AT-MSCs/HUVECs(50:50)共培养组被接种于多孔钛纤维网状支架上(Ti)进行体外和体内成骨能力研究。体外,碱性磷酸酶活性和钙含量被用来评估细胞的成骨分化潜能。体内,上述支架材料被移植于大鼠双侧颅骨缺损(5mm直径)中,8周后组织学和定量组织学评估骨形成情况。结果:50:50是共培养的最佳比例,因为此种比例可以用最少的AT-MSCs获得与其他共培养组相似的钙含量。其次,体外研究表明AT-MSCs单培养组的成骨能力优于ATMSCs/HUVECs共培养组。最后,在大鼠颅骨缺损模型中,AT-MSCs的成骨能力优于AT-MSCs/HUVECs。结论:在体外和体内研究中都发现,AT-MSCs的成骨能力优于AT-MSCs/HUVECs。本研究结果为未来口腔种植骨缺损修复的骨组织工程研究方向提供了参考。

关键词：骨再生脂肪干细胞共培养大鼠颅骨缺损

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Ecosystem Health and Sustainability 2016年第3期2卷 31-38页

作者： Jeffrey E.Herrick Adam Beh Edmundo Barrios Ioana Bouvier Marina Coetzee David dent Emile Elias Tomislav Hengl Jason W.Karl Hanspeter Liniger john Matuszak Jason CNeff Lilian Wangui Ndungu Michael Obersteiner Keith D.Shepherd Kevin C.Urama Rik van den Bosch Nicholas P.Webb U.S.Department of Agriculture-Agricultural Research Service New Mexico State UniversityJornada Experimental Range MSC 3JERBox 30003Las CrucesNew Mexico 88003-8003 USA World Agroforestry Centre United Nations AvenueGigiriP.O.Box 30677Nairobi00100Kenya U.S.Agency for International Development 3014th StreetSW SA-44(Rm 848)WashingtonD.C.20024 USA Namibia University of Science and Technology 13 Storch StreetPrivate Bag 13388WindhoekNamibia Merchants of Light Ltd Forncett EndNorfolkEngland ISRIC-World Soil information Droevendaalsesteeg 36708PB WageningenThe Netherlands Center for the development and Environment University of BernHallerstrasse 103012BernSwitzerland U.S.Department of State/OES 2201 C St.NWWashingtonD.C.20520USA Environmental Studies Program University of Colorado at BoulderCampus Box 397BoulderColorado 80309 USA RCMRD SERVIR-Eastern&Southern AfricaP.O.Box 63200618 RuarakaNairobiKenya International Institute for Applied Systems Analysis Schlossplatz 1 A-2361LaxenburgAustria African Development Bank Avenue Jean-Paul II01 BP 1387Abidjan 01Côte d’Ivoire

Massive investments in climate change mitigation and adaptation are projected during coming *** of these investments will seek to modify how land is *** return on both types of investments can be increased through an understanding of land potential:the potential of the land to support primary production and ecosystem services,and its resilience.A Land-Potential Knowledge System(LandPKS)is being developed and implemented to provide individual users with point-based estimates of land potential based on the integration of simple,geo-tagged user inputs with cloud-based information and *** system will rely on mobile phones for knowledge and information exchange,and use cloud computing to integrate,interpret,and access relevant knowledge and information,including local knowledge about land with similar *** system will initially provide management options based on long-term land potential,which depends on climate,to-pography,and relatively static soil properties,such as soil texture,depth,and *** mod-ules will provide more specific management information based on the status of relatively dynamic soil properties such as organic matter and nutrient content,and of *** paper includes a discus-sion of how this system can be used to help distinguish between meteorological and edaphic drought.

关键词： agriculture analytics crowdsourcing expert systems extension knowledge management land evaluation land-use planning mobile apps sustainability sustainable land management

抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)

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环境与职业医学 2014年第2期31卷 151-157页

作者： Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer john R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel van den Eede Edward Topp 王晓宇张伊人操仪 U.S.Environmental Protection Agency Office of Research and Development Unilever-Safety and Environmental Assurance Centre Department of Biological and Environmental Sciences Gothenburg University Veterinary Medicines Directorate Department of Plant and Environmental Sciences University of Copenhagen The Canberra Hospital and Canberra Clinical School Australian National University ECT Oekotoxikologie GmbH Fl?rsheim/Main Public Health Agency of Canada European Centre for Environment and Human Health Exeter University Medical School Knowledge Spa Royal Cornwall Hospital Federal Office of Consumer Protection and Food Safety Department 3: Veterinary Drugs Environment Canada Saskatoon Institute for Biomedicine The Sahlgrenska Academy University of Gothenburg Department of Population Medicine University of Guelph Environment Health and Safety GlaxoSmithKline Umweltbundesamt Federal Environment Agency MB Consult Limited Southampton University of Bradford Brixham Environmental Laboratory Pfizer Animal Health VMRD Agriculture and Agri-Food Canada London Ontario Canada

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性... 详细信息

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生"热点区域"的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的"热点区域"中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。

关键词：抗生素耐药性健康风险评估环境评估人类健康基因转移剂量反应决策分析方法耐药性细菌

在FDG PET/CT中,孤立性肺结节的SUV量化的恢复效应和移动模糊的联合校正

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国际医学放射学杂志 2010年第5期 504-504页

作者： I.Apostolova R.Wiemker T.Paulus S.Kabus T.Dreilich J.van den hoff 肖立志 Department of Nuclear Medicine University Medicine Charité BerlinCampus Charité Mitte

关键词：孤立性肺结节脱氧葡萄糖标准摄取值恢复校正移动校正