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Next generation per-and poly-fluoroalkyl substances:Status and trends,aquatic toxicity,and risk assessment

Eco-Environment & Health 2022年第2期1卷 117-131页

作者： Hannah Mahoney Yuwei Xie Markus Brinkmann john p.giesy Toxicology Center University of SaskatchewanSaskatoonSaskatchewanS7N 5B3Canada School of Environment and Sustainability University of SaskatchewanSaskatoonSaskatchewanS7N 5C8Canada Global Institute for Water Security University of SaskatchewanSaskatoonSaskatchewanS7N 3H5Canada Centre for Hydrology University of SaskatchewanSaskatoonSaskatchewanS7N 1K2Canada Department of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSaskatchewanCanada Department of Integrative Biology and Center for Integrative Toxicology Michigan State UniversityEast LansingMIUSA Department of Environmental Science Baylor UniversityWacoTXUSA

Widespread application of poly-and per-fluoroalkyl substances(pFAS)has resulted in some substances being ubiquitous in environmental *** and their resistance to degradation have allowed them to accumulate in wildlife and humans with potential for toxic *** specific substances of concern have been phased-out or banned,other pFAS that are emerging as alternative substances are still produced and are being released into the *** review focuses on describing three emerging,replacement pFAS:perfluoroethylcyclohexane sulphonate(pFECHS),6:2 chlorinated polyfluoroalkyl ether sulfonate(6:2 Cl-pFAES),and hexafluoropropylene oxide dimer acid(HFpO-DA).By summarizing their physicochemical properties,environmental fate and transport,and toxic potencies in comparison to other pFAS compounds,this review offers insight into the viabilities of these chemicals as replacement *** the chemical scoring and ranking assessment model,the relative hazards,uncertainties,and data gaps for each chemical were quantified and related to perfluorooctane sulfonic acid(pFOS)and perfluorooctanoic acid(pFOA)based on their chemical and uncertainty *** substances were ranked pFOS>6:2 Cl-pFAES>pFOA>HFpO-DA>pFECHS according to their potential toxicity and pFECHS>HFpO-DA>6:2 Cl-pFAES>pFOS>pFOA according to their need for future *** future uses of pFAS remain uncertain in the face of governmental regulations and production bans,replacement pFAS will continue to emerge on the world market and in the environment,raising concerns about their general lack of information on mechanisms and toxic potencies.

关键词： pFAS Replacement pFAS Emerging contaminants Aquatic toxicity Chemical scoring

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Enlightenment from the COVID-19 pandemic:The Roles of Environmental Factors in Future public Health Emergency Response

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Engineering 2022年第1期8卷 108-115页

作者： Xiaolei Wang Fengchang Wu Xiaoli Zhao Xiao Zhang Junyu Wang Lin Niu Weigang Liang Kenneth Mei Yee Leung john p.giesy State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State Key Laboratory of Marine pollution&Department of Chemistry City University of Hong KongHong KongChina Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSK S7N 5E2Canada Department of Environmental Sciences Baylor UniversityWacoTX 76798USA

The coronavirus disease 2019(COVID-19)pandemic is challenging the current public health emergency response systems(pHERSs)of many *** environmental factors,such as those influencing the survival of viruses and their transmission between species including humans,play important roles in pHERSs,little attention has been given to these *** study describes and elucidates the roles of environmental factors in future *** improve countries’capability to respond to public health emergencies associated with viral infections such as the COVID-19 pandemic,a number of environmental factors should be considered before,during,and after the responses to such *** specifically,to prevent pandemic outbreaks,we should strengthen environmental and wildlife protection,conduct detailed viral surveillance in animals and hotspots,and improve early-warning *** the pandemic,we must study the impacts of environmental factors on viral behaviors,develop control measures to minimize secondary environmental risks,and conduct timely assessments of viral risks and secondary environmental effects with a view to reducing the impacts of the pandemic on human health and on *** the pandemic,we should further strengthen surveillance for viruses and the prevention of viral spread,maintain control measures for minimizing secondary environmental risks,develop our capability to scientifically predict pandemics and resurgences,and prepare for the next unexpected ***,we should restore the normal life and production of the public based on the“One Health”concept,that views global human and environmental health as inextricably *** recommendations are essential for improving nations’capability to respond to global public health emergencies.

关键词： public health emergency public health emergency response system Environmental factors prevention and control Viral infections

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Monthly variations of unregulated brominated disinfection by-products in chlorinated water are correlated with total bromine

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Eco-Environment & Health 2022年第3期1卷 147-155页

作者： Christena Watts Jianxian Sun paul D.Jones Hui peng john p.giesy Toxicology Centre University of SaskatchewanSaskatoonSK S7N 5B3Canada School of Environment and Sustainability University of SaskatchewanSaskatoonSK S7N 5C8Canada Department of Chemistry University of TorontoTorontoON M5S 3H6Canada Zoology Department Institute for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824USA State Key Laboratory of pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Department of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSK S7N 5B4Canada Department of Environmental Sciences Baylor UniversityWacoTX 76798-7266USA

Brominated disinfection by-products(Br-DBps)can form during the chlorination of drinking water in treatment plants(DWTp).Regulations exist for a small subset of Br-DBps;however,hundreds of unregulated Br-DBps have been detected,and limited information exists on their occurrence,concentrations,and seasonal ***,a data-independent precursor isolation and characteristic fragment(DIpIC-Frag)method were optimized to screen chlorinated waters for *** were 553 Br-DBps detected with m/z values ranging from 170.884 to 497.0278 and chromatographic retention times from 2.4 to 26.2 *** MS2 information,structures for 40 of the 54 most abundant Br-DBps were *** method was then applied to a year-long study in which raw,clear well,and finished water were analyzed *** 54 most abundant unregulated Br-DBps were subjected to trend ***-DBps with higher oxygen-to-carbon(O/C)and bromine-to-carbon(Br/C)ratios increased as water moved from the clear well to the finished stage,which indicated the dynamic formation of *** trends of unregulated Br-DBps were compared to raw water parameters,such as natural organic matter,temperature,and total bromine,but no correlations were *** was found that total concentrations of bromine(TBr)in finished water(0.04–0.12 mg/L)were consistently and significantly greater than in raw water(0.013–0.038 mg/L,pps atα?*** study provides the first evidence that monthly trends of unregulated Br-DBps can be associated with the concentration of TBr in treated waters.

关键词： Natural organic matter Bromine Chlorination Drinking water treatment High-resolution mass spectrometry

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Historical record of effects of human activities on absolute and relative concentrations of polycyclic aromatic hydrocarbons(pAHs) in Lake Chao,China

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Journal of Environmental Sciences 2016年第8期28卷 1-4页

作者： john p.giesy Zhi Tang Xiaoli Zhao Department of Veterinary Biomedical Sciences and Toxicology Centre University of Saskatchewan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences

polycyclic aromatic hydrocarbons（pAHs）are attracting concern because of their potential toxicity,posing serious threats to health of humans and ecosystems（Kim et al.,2013;Zhao et al.,2016）.Generally,similar to other contaminants＇behaviors（Wu et al.,2001;Zhang et al.,2007,2008;Lu et al.,2009）,pAHs result from natural organic matter and activities of humans,the latter＇s contribution usually outweighing the inputs from other sources（Fernández et al.,2000;Srogi,2007）.

关键词： polycyclic aromatic hydrocarbons Organic contaminants Aquatic environment Lake sediment pAHs

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perfluoroalkyl substances and organochlorine pesticides in sediments from Huaihe watershed in China

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Journal of Environmental Sciences 2014年第11期26卷 2198-2206页

作者： Jing Meng Tieyu Wang pei Wang john p.giesy Yonglong Lu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Veterinary Biomedical Sciences and Toxicology Centre University of Saskatchewan

Twelve perfluoroalkyl substances （pFASs） and nine organochlorine pesticides （OCps） were quantified in surface sediments from the Huaihe River, China, along which there are intensive industrial and agricultural activities. Concentrations of pFASs ranged from 0.06 to 0.46 ng/g dry weight （dw）, and concentrations of OCps ranged from 1.48 to 32.65 ng/g dw. Compared with other areas in China, concentrations of pFASs were lesser than the national mean value, while concentrations of OCps were moderate. Concentrations of perfluorooctanoic acid （pFOA） and perfluorooctane sulfonate （pFOS） ranged from n.d. （not detected） to 0.03 and n.d. to 0.10 ng/g dw, respectively. Among the three groups of OCps, mean concentrations of hexachlorocyclohexane and its isomers （HCHs）, dichlorodiphenyltrichloroethane and its metabolites （DDTs） and hexachlorobenzene （HCB） were 5.62 ± 4.35, 2.43 ± 3.12 and 1.55 ± 4.17 ng/g dw, respectively. Concentrations of HCHs and DDTs decreased from upstream to downstream along the mainstream of the Huaihe River. When compared to sediment quality guidelines （SQGs）, concentrations of HCHs, DDTs and HCB would pose adverse biological effects. In general, contamination by pFASs in the upstream of the Huaihe River was more severe than that in the downstream, which was mainly caused by interception from dams, locks and industrial emissions. And OCps from tributaries, especially the Yinghe River and Wohe River, were higher than those from Huaihe mainstream, and primarily came from historical inputs.

关键词： pFASs OCps Sediment Risk assessment Huaihe River

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Determination of water environment standards based on water quality criteria in China:Limitations and feasibilities

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Journal of Environmental Sciences 2017年第7期29卷 127-136页

作者： Tieyu Wang Yunqiao Zhou Cencen Bi Yonglong Lu Guizhen He john p.giesy State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Toxicology Centre and Department of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSaskatchewanCanada

There is a need to formulate water environment standards（WESs） from the current water quality criteria（WQC） in *** this end,we briefly summarize typical mechanisms applied in several countries with longer histories of developing WESs,and three limitations to formulating WESs in China were *** analyzing the feasibility factors including economic development,scientific support capability and environmental policies,we realized that China is still not ready for a complete change from its current nation-wide unified WES system to a local-standard-based ***,we proposed a framework for transformation from WQC to WESs in *** framework consists of three parts,including responsibilities,processes and *** responsibilities include research authorization,development of guidelines,and collection of information,at both national and local levels;the processes include four steps and an impact factor system to establish water quality standards;and the policies include seven specific proposals.

关键词： Water quality Environmental criteria Standards Regulations

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Three decades of changes in water environment of a large freshwater Lake and its relationship with socio-economic indicators

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Journal of Environmental Sciences 2019年第3期31卷 156-166页

作者： Cuicui Li Weiying Feng Fanhao Song Zhongqi He Fengchang Wu Yuanrong Zhu john p.giesy Yingchen Bai Guangzhou Institute of Geochemistry Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences USDA-ARS Southern Regional Research Center Department of Biomedical Veterinary Sciences and Toxicology Centre University of Saskatchewan

Tai Lake(Ch: Taihu) has attracted international attention forcyanobacteria ***, the drivers of cultural eutrophication, especially long-term socio-economic indicators have been little researched. The results of research demonstrate how socioeconomic development affected quality of water and how it has been improved by anthropogenic activities. This study described variability in indicators of water quality in Tai Lakeand investigated thedrivers. Significant relationships existed between concentrations of annual mean total nitrogen(TN), total phosphorous(Tp), chemical oxygen demand(COD) and biological oxygen demand(BOD), and population, per capital gross domestic production(GDp) and sewage discharge(p p, COD and BOD. Before 2000, the main contributors to increases in concentrations of TN were human population, GDp and volumes of domestic sewage discharges. After 2000, discharges of industrial sewage become the primary contributor. After 1998, the regressions of annual mean TN, Tp and COD on per capital GDp, population and domestic sewage discharge were reversed compared to the former period. Since 1999, an apparent inverted U-shaped relationship between environmental pollution and economic development has developed, which indicated that actions taken by governments have markedly improved quality of water in Tai Lake. The statistical relationship between BOD and per capital GDp didn't conform to the Kuznet curve. The Ushaped Kuznet curve may offer hope for the future that with significant environmental investments a high GDp can be reached and maintained without degradation of the environment, especially through appropriate management of industrial sewage discharge.

关键词： Eutrophic lake Water environment indicators population GDp Sewage discharge Asia

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Fluorescence regional integration and differential fluorescence spectroscopy for analysis of structural characteristics and proton binding properties of fulvic acid sub-fractions

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Journal of Environmental Sciences 2018年第12期30卷 116-125页

作者： Fanhao Song Fengchang Wu Weiying Feng Zhi Tang john p.giesy Fei Guo Di Shi Xiaofei Liu Ning Qin Baoshan Xing Yingchen Bai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Science Department of Biomedical and Veterinary Biosciences and Toxicology Centre University of Saskatchewan College of Resources Environment and Tourism Capital Normal University Stockbridge School of Agriculture University of Massachusetts

Structural characteristics and proton binding properties of sub-fractions（FA3–FA13） of fulvic acid（FA）, eluted stepwise by pyrophosphate buffer were examined by use of fluorescence titration combined with fluorescence regional integration（FRI） and differential fluorescence spectroscopy（DFS）. Humic-like（H-L） and fulvic-like（F-L） materials, which accounted for more than 80% of fluorescence response, were dominant in five sub-fractions of FA. Based on FRI analysis, except the response of F-L materials in FA9 and FA13, maximum changes in percent fluorescence response were less than 10% as pH was increased from 2.5 to *** of carboxylic and phenolic groups were compared for fluorescence peaks of FA sub-fractions based on pH-dependent fluorescence derived from DFS. Static quenching was the dominant mechanism for binding of protons by FA sub-fractions. Dissociation constants（p Ka） were calculated by use of results of DFS and the modified Stern-Volmer relationship. The p Kaof H-L, F-L, tryptophan-like and tyrosine-like materials of FA subfractions exhibited ranges of 3.17–4.06, 3.12–3.97, 4.14–4.45 and 4.25–4.76, respectively, for acidic pHs. At basic pHs, values of p Ka for corresponding materials were in ranges of 9.71–10.24, 9.62–10.99, 9.67–10.31 and 9.33–10.28, respectively. At acidic pH, protein-like（p-L）materials had greater affinities for protons than did either H-L or F-L materials. The dicarboxylic and phenolic groups were likely predominant sites of protonation for both H-L and F-L materials at both acidic and basic pHs. Amino acid groups were significant factors during proton binding to protein-like materials of FA sub-fractions at basic pH.

关键词： Fluorescence titration protonation Modified Stern-Volmer equation Dissociation constant Binding

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Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain

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Environmental Science and Ecotechnology 2022年第4期12卷 26-36页

作者： Zhenfei Yan Chenglian Feng Xiaowei Jin Fangkun Wang Cong Liu Na Li Yu Qiao Yingchen Bai Fengchang Wu john p.giesy State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China College of Environment Hohai UniversityNanjing210098China China National Environmental Monitoring Centre Beijing100012China Department of preventive Veterinary Medicine College of Veterinary MedicineShandong Agricultural UniversityTaian271018China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Department of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSKCanada Toxicology Centre University of SaskatchewanSaskatoonSKCanada Department of Environmental Sciences Baylor UniversityWacoTXUSA

Organophosphate esters(OpEs)are widespread in various environmental media,and can disrupt thyroid endocrine signaling *** by which OpEs disrupt thyroid hormone(TH)signal transduction are not fully ***,we present in vivo-in vitro-in silico evidence establishing OpEs as environmental THs competitively entering the brain to inhibit growth of zebrafish via multiple signaling *** can bind to transthyretin(TTR)and thyroxine-binding globulin,thereby affecting the transport of TH in the blood,and to the brain by TTR through the blood-brain *** GH3 cells were exposed to OpEs,cell proliferation was significantly inhibited given that OpEs are competitive inhibitors of *** diphenyl phosphate was shown to be an effective antagonist of *** exposure to OpEs significantly inhibited the growth of zebrafish by interfering with thyroperoxidase and thyroglobulin to inhibit TH *** on comparisons of modulations of gene expression with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,signaling pathways related to thyroid endocrine functions,such as receptor-ligand binding and regulation of hormone levels,were identified as being affected by exposure to *** were also associated with the biosynthesis and metabolism of lipids,and neuroactive ligand-receptor *** findings provide a comprehensive understanding of the mechanisms by which OpEs disrupt thyroid pathways in zebrafish.

关键词： Organophosphate ester Molecular docking simulation Competitive inhibition assay Thyroid endocrine function Transcriptome sequencing

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MEASUREMENT OF ESTROGENIC ACTIVITY IN RIVER SEDIMENTS USING AN ER-MEDIATED RECEpTOR CELL BIOASSAY

MEASUREMENT OF ESTROGENIC ACTIVITY IN RIVER SEDIMENTS USING ...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： Maoyong SONG Xuefei LV Guibin JIANG paul K.S.LAM john p.giesy State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences Research Centre for Coastal pollution and Conservation Department of Biology and ChemistryCity University of Hong Kong Department of Zoology National Food Safety and Toxicology CenterInstitute of Environmental ToxicologyMichigan State University

Some chemicals released to the environment are able to mimic the behavior of natural estrogens and are suspected to be responsible for the increasing of disrupting effects on normal physiological function of the endoc...

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