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Effect of cinnamaldehyde on Rhizopus stolonifer and on the conservation of sweet potato

Food Quality and Safety 2024年第1期8卷 212-225页

作者：陈晨薛智超 Penta Pristijono john B.Golding 陈刚李永新杨虎清 College of Food and Health Zhejiang A&F UniversityHangzhouChina Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine Zhejiang A&F UniversityHangzhouChina School of Environmental and Life Sciences University of NewcastleOurimbahNSWAustralia nSW Department of Primary Industries OurimbahNSWAustralia

Objectives:Rhizopus stolonifer,which causes soft rot of sweet potato,has resulted in substantial loss of economy *** and Methods:The antifungal effect and mechanism of cinnamaldehyde(CIn)against *** were explored by biochemical analysis and RnA-sequencing in this research,and the edible quality of CIn-treated sweet potato was ***:The results showed that CIn inhibited the growth of *** and reduced the incidence of soft rot in sweet potato at a minimum inhibitory concentration of 1000μL/*** damage of the cell walls of *** by CIn was associated with the upregulation of *** leakage and malondialdehyde content increased following CIn-treatment,which was correlated with increased reactive oxygen species levels and decreased catalase *** of ERG genes and oxidative stress-related genes following CIn treatment was associated with impaired cell membrane *** mitochondrial structure of *** was damaged by CIn treatment resulting in decreased respiration rates and ATP production,which was correlated with lower expression levels of IDH1,COX4,and ***:Our research suggests that the inhibition of CIn on *** was related to the disruption of its normal gene expression network,and CIn maintained the nutritional and edible quality of sweet *** study provides valuable insights into the antifungal mechanism of CIn on *** and the maintenance of root quality,which contributes to the effcient use of CIn for controlling soft rot in sweet potato.

关键词： Ipomoea batatas soft rot cinnamaldehyde antifungal mechanism transcriptome

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Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of Vehicles

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Engineering 2024年第2期33卷 178-189页

作者： Xiaoming Yuan Jiahui Chen ning Zhang Qiang(john)Ye Changle Li Chunsheng Zhu Xuemin Sherman Shen Qinhuangdao Branch Campus Northeastern UniversityQinhuangdao 066004China State Key Laboratory of Integrated Services networks&the Research Institute of Smart Transportation Xidian UniversityXi’an 710071China Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4Canada Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada SUSTech Institute of Future networks Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada

High-efficiency and low-cost knowledge sharing can improve the decision-making ability of autonomous vehicles by mining knowledge from the Internet of Vehicles(IoVs).However,it is challenging to ensure high efficiency of local data learning models while preventing privacy leakage in a high mobility *** order to protect data privacy and improve data learning efficiency in knowledge sharing,we propose an asynchronous federated broad learning(FBL)framework that integrates broad learning(BL)into federated learning(FL).In FBL,we design a broad fully connected model(BFCM)as a local model for training client *** enhance the wireless channel quality for knowledge sharing and reduce the communication and computation cost of participating clients,we construct a joint resource allocation and reconfigurable intelligent surface(RIS)configuration optimization framework for *** problem is decoupled into two convex *** to improve the resource scheduling efficiency in FBL,a double Davidon–Fletcher–Powell(DDFP)algorithm is presented to solve the time slot allocation and RIS configuration *** on the results of resource scheduling,we design a reward-allocation algorithm based on federated incentive learning(FIL)in FBL to compensate clients for their *** simulation results show that the proposed FBL framework achieves better performance than the comparison models in terms of efficiency,accuracy,and cost for knowledge sharing in the IoV.

关键词： Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces Resource allocation

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How Prime numbers Are Interconnected and Built with Two Equations: Addition and Subtraction Rules the Function (6µ)

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Advances in Pure Mathematics 2024年第4期14卷 228-241页

作者： john Richard Wisdom Centre of Pedagogical Innovation (Capsule) Sorbonne University Paris France

Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.

关键词： number Theory Prime number Groups Twin Primes Prime Structure and Sequence Prime Subtraction and Addition

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Wireless sequential dual light delivery for programmed PDT in vivo

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Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin Gan john S.Ho Juwita norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The n.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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当在小肠的囊内视镜检查法计算路易斯分数时，蓝模式不在白光上提供任何利益

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World Journal of Gastrointestinal Endoscopy 2012年第2期4卷 33-37页

作者： Anastasios Koulaouzidis Sarah Douglas john n plevris Endoscopy Unit Centre for Liver and Digestive Disorders The Royal Infi rmary of Edinburgh Edinburgh EH16 4SA Scotland United Kingdom Medical School The University of Edinburgh Edinburgh EH16 4SA Scotland United Kingdom

AIM: To check the usefulness of blue mode (BM) review in lewis score (LS) calculation, by comparing it with respective LS results obtained by white light (WL) small-bowel capsule endoscopy (SBCE) review and mucosal inflammation as reflected by faecal calprotectin (FC) levels, considered as ’gold standard’ for this study. METHODS: Computational analysis of our SBCE database to identify patients who underwent SBCE with PillCam? and had FC measured within a 30-day period from their test. Only patients with prior colonoscopy were included, to exclude any colon pathology-associated FC rise. Each small bowel tertile was reviewed (viewing speed 8 fps) with WL and BM, in a back-to-back mode, by a single experienced reviewer. LS were calculated after each WL and BM reviews. Pearson rank correlation (rho, r) statistic was ***: Twenty-seven (n = 27, 20F/7M) patients were included. Thirteen (n = 13) had SBCE with PillCam?SB1, and the remainder (n = 14) with PillCam? SB2. The median level of FC in this cohort was 125 μg/g. LS (calculated in WL SBCE review) correlation with FC levels was r = 0.490 (P = 0.01), while for BM review and LS correlation with FC was r = 0.472 (P = 0.013).

关键词： Capsule endoscopy Lewis score PillCam Blue mode Rapid

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The Quantum Microverse: A Prime number Framework for Understanding the Universe

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American Journal of Computational Mathematics 2024年第2期14卷 264-274页

作者： john R. Crary Independent Researcher Lake Zurich IL USA

This study aims to demonstrate a proof of concept for a novel theory of the universe based on the Fine Structure Constant (α), derived from n-dimensional prime number property sets, specifically α = 137 and α = 139. The FSC Model introduces a new perspective on the fundamental nature of our universe, showing that α = 137.036 can be calculated from these prime property sets. The Fine Structure Constant, a cornerstone in Quantum Electrodynamics (QED) and Quantum Chromodynamics (QCD), implies an underlying structure. This study identifies this mathematical framework and demonstrates how the FSC model theory aligns with our current understanding of physics and cosmology. The results unveil a hierarchy of α values for twin prime pairs U{3/2} through U{199/197}. These values, represented by their fraction parts α♊ (e.g., 0.036), define the relative electromagnetic forces driving quantum energy systems. The lower twin prime pairs, such as U{3/2}, exhibit higher EM forces that decrease as the twin pairs increase, turning dark when they drop below the α♊ for light. The results provide classical definitions for Baryonic Matter/Energy, Dark Matter, Dark Energy, and Antimatter but mostly illustrate how the combined α♊ values for three adjacent twin primes, U{7/5/3/2} mirrors the strong nuclear force of gluons holding quarks together.

关键词： Fine Structure Constant Fractional Coupling Constants Matter/Antimatter Dark Matter/Energy Quantum Gravity Prime numbers Set Theory

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Molar ratio induced crystal transformation from coordination complex to coordination polymers

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Chinese Chemical Letters 2024年第4期35卷 539-543页

作者： Peng Meng Qian-Cheng Luo Aidan Brock Xiaodong Wang Mahboobeh Shahbazi Aaron Micallef john McMurtrie Dongchen Qi Yan-Zhen Zheng Jingsan Xu School of Chemistry and Physics&Centre for Materials Science Queensland University of TechnologyBrisbaneQLD 4000Australia Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054China Central Analytical Research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQLD 4000Australia

Coordination complex of a copper cyanurate(Cu(Ⅱ)-CA) was transformed into coordination polymers upon the stimulus of extra Cu(Ⅱ) through “directed Ostwald ripening”. By increasing the molar ratio of Cu(Ⅱ) to CA, we obtained two coordination polymers with selective coordination sites: Cu(Ⅱ)-κ n(HCA)κ nCu(Ⅱ) and Cu(Ⅱ)-κ n(HCA)κ O-Cu(Ⅱ), which display disparate magnetic interactions.

关键词： Molar ratio dependent crystal transformation Copper cyanurate Ostwald ripening Molecular magnetism One-dimensional chain

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从H1n1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用

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Engineering 2024年第1期32卷 41-56页

作者： Ram Prasad Aganja Amal Senevirathne Chandran Sivasankar john Hwa Lee Department of Veterinary Public Health College of Veterinary MedicineJeonbuk National UniversityIksan 54596Republic of Korea Department of Preventive Medicine College of Veterinary MedicineChungnam National UniversityDaejeon 34134Republic of Korea

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza *** this study,a strategy called computationally optimized broadly reactive antigen(COBRA)was used to generate a consensus sequence of the hemagglutinin globular head portion(HA1)of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed *** carrying different HA1regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RnA-dependent RnApolymerase(RdRp)-based eukaryotic expression system,*** protein expression was confirmed by Western blot and immunofluorescence *** immunized with the designed constructs produced a humoral response,with a significant increase in immunoglobulin G(IgG)levels,and a cell-mediated immune response,including a 1.5-fold increase in CD4^(+) and CD8^(+)T ***,constructs #1 and #5 increased the production of interferon-γ(IFn-γ)producing CD4^(+)and CD8^(+)T cells,skewing the response toward the T helper type 1 cell(Th1)***,interleukin-4(IL-4)-producing T cells were upregulated *** efficacy was demonstrated,with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer>40 against the selected viral *** designed constructs conferred a broadly protective immune response,resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34,A/Brisbane/59/2007,A/California/07/2009,KBPV VR-92,and nCCP 43021 *** discovery revolutionizes influenza vaccine design and delivery;Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation *** approach can effectively combat seasonal H1n1 influenza strains and potential pandemic outbreaks.

关键词： COBRA Influenza A Salmonella Vaccine Broad spectral protection

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Adjuvant Rectal Diclofenac for Post Operative Analgesia after Caesarean Section—A Randomized Controlled Study

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 591-609页

作者： Eziaha Eric S. Ede Ayodele A. Olaleye john C. Irechukwu Uchenna nelson nwaedu Borniface n. Ejikeme Vincent Chidiebere Ali Bartholomew I. Olinya Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria

BACKGROUnD: Pain management following caesarean section still remains a challenge in our environment. Most potent analgesics are either not readily available or expensive. Diclofenac suppository is an nSAID that can be used for postoperative analgesia. It is available and affordable. OBJECTIVE: To compare the efficacy and safety of combined rectal diclofenac and intramuscular pentazocine with intramuscular pentazocine alone for post operative pain control following lower segment caesarean section. METHODOLOGY: A total of 120 women who met the selection criteria scheduled for caesarean section under spinal anaesthesia with bupivacaine were randomized into two equal groups to receive either 75 mg diclofenac suppository 12 hourly for 24 hours or one anusol suppository (the placebo) 12 hourly for 24 hours. Both groups received pentazocine as primary analgesia. RESULT: The primary outcome measure is the proportion of patients with severe pain at 24 hours using the visual analogue rating scale. Secondary outcome measures are the time from surgery to ambulation, Passage of flatus, maternal satisfaction and presence of complications. Statistical analysis was done using spss version 22 and graph pad statistical package. Student T-test was used for continuous variables whereas chi square was used for categorical variables P COnCLUSIOn: Adjuvant rectal diclofenac is superior to pentazocine alone in the management of pain after caesarean section. Less number of patients had moderate to severe pain at 24 hours post operation. Maternal satisfaction in relation to pain management is better with diclofenac suppository. The levels of complications were comparable in both groups.

关键词： Pain Caesarean Section Diclofenac Placebo Suppository

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Exploring Heat Sources Using Gravimetric Data: A Case Study of Magadi Geothermal Prospect, Kenya

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Journal of Geoscience and Environment Protection 2024年第5期12卷 147-161页

作者： Evance Odero john Githiri Maurice K’Orowe Department of Physics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Understanding the location of the subsurface heat sources is crucial for efficient geothermal resource exploration and exploitation. This study aimed to investigate the faults and the depth to heat sources for a geothermal system in Magadi, southern Rift Valley, through the integration of gravity mapping, 3D Euler deconvolution, and spectral analysis. Gravity mapping is a powerful geophysical method widely used to infer subsurface density variations, which are indicative of geological structures and volcanic intrusions that can be potential heat sources. The Volcano-Tectonic and Fluvial-Deltaic Sedimentation process of the Kenyan rift which encompasses the Magadi basin are responsible for geomorphic and geologic processes in the area. Alkali lava sheets of Magadi plateau trachytes covered with lacustrine sediments characterize 80% of the area. Deeper is the Tanzanian craton basement, overlain by Pliocene to Miocene volcanic and sedimentary rocks. A gravity survey with a data density of 2.375 stations/km2 produced high-resolution anomaly and total horizontal derivative maps showing gravity highs between −180 mGals to −174 mGals along the eastern zone of the study area. A buried major fault trending n-S was delineated in the mid-upper region of the area by Euler solutions at an average depth of 350 meters. Deeper features associated with possible volcanic dykes and sills gave Euler depth ranges of 0.7 km to 2.2 km. Radial average spectral analysis showed depth to the top of shallow and deep features at 2.4694 km and 5.827 km respectively. The correlation between gravity anomalies, geological structures, and present hot springs supports the hypothesis that volcanic processes have played a significant role in the development of the geothermal system in the study area.

关键词： Gravity Mapping 3D Euler Spectral Analysis Geothermal Magadi

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