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Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-Design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De Nitto Aleksandra Serafin Alexandra Karadimou Achim Schmalenberger john J.EMulvihill maurice N.Collins DIBRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PEDOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D printing

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Exploring Heat Sources Using Gravimetric Data: A Case Study of Magadi Geothermal Prospect, Kenya

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Journal of Geoscience and Environment Protection 2024年第5期12卷 147-161页

作者： Evance Odero john Githiri maurice K’Orowe Department of Physics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Understanding the location of the subsurface heat sources is crucial for efficient geothermal resource exploration and exploitation. This study aimed to investigate the faults and the depth to heat sources for a geothermal system in Magadi, southern Rift Valley, through the integration of gravity mapping, 3D Euler deconvolution, and spectral analysis. Gravity mapping is a powerful geophysical method widely used to infer subsurface density variations, which are indicative of geological structures and volcanic intrusions that can be potential heat sources. The Volcano-Tectonic and Fluvial-Deltaic Sedimentation process of the Kenyan rift which encompasses the Magadi basin are responsible for geomorphic and geologic processes in the area. Alkali lava sheets of Magadi plateau trachytes covered with lacustrine sediments characterize 80% of the area. Deeper is the Tanzanian craton basement, overlain by Pliocene to Miocene volcanic and sedimentary rocks. A gravity survey with a data density of 2.375 stations/km2 produced high-resolution anomaly and total horizontal derivative maps showing gravity highs between −180 mGals to −174 mGals along the eastern zone of the study area. A buried major fault trending N-S was delineated in the mid-upper region of the area by Euler solutions at an average depth of 350 meters. Deeper features associated with possible volcanic dykes and sills gave Euler depth ranges of 0.7 km to 2.2 km. Radial average spectral analysis showed depth to the top of shallow and deep features at 2.4694 km and 5.827 km respectively. The correlation between gravity anomalies, geological structures, and present hot springs supports the hypothesis that volcanic processes have played a significant role in the development of the geothermal system in the study area.

关键词： Gravity Mapping 3D Euler Spectral Analysis Geothermal Magadi

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疟疾防治研究的回顾及今后工作要点

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国际医学寄生虫病杂志 1988年第1期 1-5页

作者： john maurice Anna Marina Pearce 杨静妹

联合同开发计划署/世界银行╱世界卫生组织热带病研究培训特别规划局(TDR)对1976～1986年的工作作了总结,并且提出今后工作的要点。现将该总结中有关疟疾化疗、疟疾疫苗及丝虫病部分节译如下,供作参考。

关键词：疟原虫敏感性红外期药物敏感疟疾疫苗卤泛曲林

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疟疾的现场应用研究:1976—1986年的活动

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国际医学寄生虫病杂志 1988年第2期15卷 49-52页

作者： john maurice Anna Marina Pearce 吴开琛

抗疟药和药物抗性 1960年以来,随着蚊虫对杀虫剂抗性的增加,抗疟用的杀虫剂的涨价和喷洒实施困难的增加,对化学治疗,特别是4-氨基喹啉类药物氯喹的依赖性更大。氯喹在治疗上和预防上常常用量不足,所以出现了抗氯喹恶性疟原虫株。首先出... 详细信息

抗疟药和药物抗性 1960年以来,随着蚊虫对杀虫剂抗性的增加,抗疟用的杀虫剂的涨价和喷洒实施困难的增加,对化学治疗,特别是4-氨基喹啉类药物氯喹的依赖性更大。氯喹在治疗上和预防上常常用量不足,所以出现了抗氯喹恶性疟原虫株。首先出现在拉丁美洲,东南亚和太平洋地区,其后在印度次大陆,东非和中非的广大地区。最近,氯喹抗性已在西非的

关键词：疟疾疟疾传播蚊种敏感性按蚊内科杂病按蚊属疟原虫抗原抗疟药抗原虫药

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疟疾疫苗的发展

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国际医学寄生虫病杂志 1988年第1期 5-9页

作者： john maurice Anna Marina Pearce 陆瑶

概述疫苗可为目前尚不完善的疟疾防治措施提供极有用的帮助,而制备疫苗则以几个前提为基础。例如,在一定情况下,可对实验动物和志愿者接种含各期原虫的疫苗从而对恶性疟原虫的攻击产生保护性;还有,许多生活

关键词：疟疾疫苗无性体疟原虫抗原恶性疟原虫原虫血症间日疟疟疾红内期猴疟原虫疫苗抗原

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丝虫病防治研究的回顾及今后工作要点

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国际医学寄生虫病杂志 1988年第1期 9-13页

作者： john maurice Anna Marina Pearce 孙德建

概述在8种人体丝虫感染中,2种(或类)受到TDR的较大关注,即可引起象皮肿等严重临床表现的淋巴丝虫病和可引起河盲症的盘尾丝虫病。由不属于丝虫的麦地那龙线虫(几内亚虫)引起的麦地那龙线虫病也受TDR托管。淋巴丝虫病流行于有27亿人口(... 详细信息

概述在8种人体丝虫感染中,2种(或类)受到TDR的较大关注,即可引起象皮肿等严重临床表现的淋巴丝虫病和可引起河盲症的盘尾丝虫病。由不属于丝虫的麦地那龙线虫(几内亚虫)引起的麦地那龙线虫病也受TDR托管。淋巴丝虫病流行于有27亿人口(占世界总人口的56％)的许多热带和亚热带国家,受威胁的有9.05亿人,受感染的逾9000万人。盘尾丝虫病流行于有5.85亿人口的34个国家,受威胁的有8500万人,受感染的有

关键词：丝虫病临床试验免疫反应单克隆抗体 TDR 抗原蠕虫病伊维菌素抗丝虫药防治研究工作要点

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Through a Scanner Darkly:Machine Sentience and the Language Virus

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Journal of Social Computing 2023年第4期4卷 254-269页

作者： maurice Bokanga Alessandra Lembo john Levi Martin the Department of Sociology The University of ChicagoChicagoIL 60637USA

Discussions of the detection of artificial sentience tend to assume that our goal is to determine when,in a process of increasing complexity,a machine system“becomes”*** is to assume,without obvious warrant,that sentience is only a characteristic of complex *** sentience is a more general quality of matter,what becomes of interest is not the presence of sentience,but the type of *** argue here that our understanding of the nature of such sentience in machine systems may be gravely set back if such machines undergo a transition where they become fundamentally linguistic in their *** fundamentally linguistic intelligences may inherently tend to be duplicitous in their communication with others,and,indeed,lose the capacity to even honestly understand their own form of *** other words,when machine systems get to the state where we all agree it makes sense to ask them,“what is it like to be you?”,we should not trust their answers.

关键词： artificial intelligence machine sentience language virality

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Evaluation of Source Rock Potential for Hydrocarbon Generation in Shallow Offshore, Lamu Basin, Kenya

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Journal of Geoscience and Environment Protection 2023年第5期11卷 60-85页

作者： Dennis Ombati Githiri john maurice K’Orowe Department of Physics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Physics Kisii University Kisii Kenya

The ever-increasing demand for oil and gas has driven its exploration in rather extreme conditions. In Lamu offshore, which is hitherto underexplored, most of the wells already drilled turned out dry save for a few wells with hydrocarbon shows despite the promising reservoir properties and related geological structures. This, therefore, necessitated a source rock evaluation study in the area to ascertain the presence and potential of the source rock by integrating the geochemical data analysis and petroleum system modeling. The shallow Lamu offshore source rock quantity, quality, and maturity have been estimated through the determination of the total organic carbon (TOC) average values, Kerogen typing, and Rock-Eval pyrolysis measurements respectively. Geochemical data for Kubwa-1, Mbawa-1, Pomboo-1, and Simba-1 were evaluated for determining the source rock potential for hydrocarbon generation. Petroleum system modeling was applied in evaluating geological conditions necessary for a successful charge within a software that integrated geochemical and petrophysical characterization of the sedimentary formations in conjunction with boundary conditions that include basal heat flow, sediment-water interface temperature, and Paleo-water depth. The average TOC of 0.89 wt % in the study area suggests a fair organic richness which seems higher in the late cretaceous (0.98 wt %) than in the Paleocene (0.81 wt %). Vitrinite reflectance and Tmax values in the study area indicate the possible presence of both mature and immature source rocks. Type III Kerogen was the most dominant Kerogen type, and gas shows are the most frequent hydrocarbon encountered in the Lamu Basin with a few cases registering type II/III and type II. The charge properties (i.e. Temperature, transformation ratio, and Vitrinite reflectance) over geologic time at each of the wells have been estimated and their spatial variation mapped as seen from the burial history and depth curves overlaid with

关键词： Geochemical Analysis Petroleum System Modeling Rock-Eval Pyrolysis Kerogen Typing Vitrinite Reflectance and Transformation Ratio

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Depth Estimation of Geothermal Heat Structures by Euler Deconvolution of Gravity Data at Eburru Area, Kenya

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Journal of Geoscience and Environment Protection 2020年第3期8卷 148-158页

作者： Erick Rayora Nyakundi john Githiri maurice K’Orowe Department of Physics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Gravity survey was done at the Eburru area to estimate the source depth locations and delineate the fault boundaries using 3D Euler deconvolution. Gravity data was collected using CG-5 gravimeter. Gravity data reductions were done by applying drift correction, latitude correction, free air correction, Bouguer correction and terrain correction to the observed raw data to obtain complete bouguer anomaly (CBA). The CBA data was transferred to Oasis montaj software for Euler deconvolution processing. The 3D Euler deconvolution was carried out to determine and estimate the depth of the density bodies. Euler deconvolution locates the gravity anomaly source and estimates its depth from the gravity observation level. Euler deconvolution was preferred to other filtering methods in this study as solutions are only determined over identified analytic signal peaks, the window size varies according to anomaly size and the final solution involves only a few more precise depth estimates. The Euler deconvolution was performed using structural indices of 0.5, 1.0 and 2.0. Results from this analysis indicated that the CBA values in this study area range from gravity values of -272 mGal to -286 mGal and residual Bouguer anomaly amplitude range between -3 mGal and 3.4 mGal. The 0.5, 1.0 and 2.0 structural indices generated five solutions at depth range of 433 m - 2269 m, 801 m - 1433 m and 1170 m - 2246 m respectively occurring almost at the same locations on gravity highs. The deep structures were observed to occur in the northern part of the study area, and interpreted to be dense intruding masses likely to be trapped by the overlying cap rock at these depths. These could be geothermal heat sources that can be exploited to generate geothermal energy.

关键词： Euler Deconvolution Source Depth Structural Index Gravity Data Bouguer Anomaly Geothermal Heat Source

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四川盆地页岩气立体井网压裂井间干扰与控制研究进展

四川盆地页岩气立体井网压裂井间干扰与控制研究进展

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第33届全国天然气学术年会

作者：朱海燕唐煊赫肖佳林游园赵慧言宋毅周小金 maurice B.Dusseault john D.McLennan 成都理工大学油气藏地质及开发工程国家重点实验室成都理工大学能源学院中石化江汉油田分公司石油工程技术研究院四川长宁天然气开发有限公司中石油西南油气田分公司页岩气研究院滑铁卢大学地球与环境科学系犹他大学能源地球科学研究院

加密井压裂已成为四川盆地页岩气藏区域采收率提升的主要手段,并逐步从前期的同层平面加密向多层立体加密井升级。相比于北美页岩压裂冲击容易导致单井产能跌落、井筒完整性失效等问题,四川盆地早期加密试验井压裂则出现了一些新的现象... 详细信息

加密井压裂已成为四川盆地页岩气藏区域采收率提升的主要手段,并逐步从前期的同层平面加密向多层立体加密井升级。相比于北美页岩压裂冲击容易导致单井产能跌落、井筒完整性失效等问题,四川盆地早期加密试验井压裂则出现了一些新的现象,包括:微地震事件屏障效应(简称MSEB效应)、加密井压裂后压力和产量回升、立体井组内各井压裂施工差异等。针对上述新现象及其内在地质力学机理不清等问题,本文提出了页岩气藏加密井压裂地质-工程一体化建模分析方法,该方法能够对老井压裂、老井压后开采、加密井压裂及开采等过程中的动态地质力学演化特性进行描述。基于该建模方法,针对四川盆地东缘涪陵(焦石坝和平桥)、川南长宁和泸州等页岩气区的平面及立体加密井压裂实践开展了地质工程一体化数值模拟与现场验证研究,并结合北美页岩开发过程中的加密井压裂现象,揭示了上述新现象的内在地质力学机理,并得到如下结论和启示:(1)四维地应力演化和非均质性天然裂缝发育等储层动静态地质力学特性是MSEB效应的基本条件;(2)MSEB效应的主要内在力学机理包括:老井压后生产导致的水平应力差增大、老井开采井周压力和地应力总体更低、加密井压裂液向老井改造区滤失;(3)通过准确的动态地应力预测,并配合加密井压裂动态监测,不仅能够有效控制井间干扰,更能够通过轻微压窜实现老井的产能恢复。本文成果可有效指导四川盆地加密井布井及压裂参数优化,并可推广至其它非常规储层。

关键词：页岩气四川盆地立体加密井组压裂冲击四维地应力

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