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Improved QoS-Secure Routing in mANET Using Real-Time Regional mE Feature Approximation

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Computer Systems Science & Engineering 2023年第9期46卷 3653-3666页

作者： Y.m.mahaboob john G.Ravi mahendra College of Engineering SalemTamilnaduIndia Sona College of Technology SalemTamilnaduIndia

mobile Ad-hoc Network(mANET)routing problems are thoroughly studied several approaches are identified in support of *** the Quality of Service(QoS)performance of mANET is achieving higher *** reduce this drawback,this paper proposes a new secure routing algorithm based on real-time partial mE(mobility,energy)*** routing method RRmE(Real-time Regional mobility Energy)divides the whole network into several parts,and each node’s various characteristics like mobility and energy are randomly selected neighbors *** is done in the path discovery phase,estimated to identify and remove malicious *** addition,Trusted Forwarding Factor(TFF)calculates the various nodes based on historical records and other characteristics of multiple ***,the calculated QoS Support Factor(QoSSF)calculating by the Data Forwarding Support(DFS),Throughput Support(TS),and Lifetime maximization Support(LmS)to any given *** route was found to implement the path of maximizing mANET QoS based on QoSSF *** the proposed technique produces the QoS based on real-time regional mE feature *** proposed simulation implementation is done by the Network Simulator version 2(NS2)tool to produce better performance than other *** achieved a throughput performance had 98.5%and a routing performance had 98.2%.

关键词： mobile ad-hoc network(mANET) routing problem regional approximation secure routing QoS support factor trusted forwarding factor data forwarding support(DFS) mobility energy

Hepatic metastatic disease in pediatric and adolescent solid tumors

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World Journal of Hepatology 2015年第14期7卷 1807-1817页

作者： Israel Fernandez-Pineda john A Sandoval Andrew m Davidoff Department of Surgery St. Jude Children’s Research Hospital

The management of hepatic metastatic disease from solid tumors in adults has been extensively described and resection of metastatic liver lesions from colorectal adenocarcinoma, renal adenocarcinoma, breast cancer, testicular cancer, and neuroendocrine tumors(NET) havedemonstrated therapeutic benefits in select patients. However, there are few reports in the literature on the management of hepatic metastatic disease in the pediatric and adolescent populations and the effectiveness of hepatic metastasectomy. This may be due to the much lower incidence of pediatric malignancies and the higher chemosensitivity of childhood tumors which make hepatic metastasectomy less likely to be required. We review liver involvement with metastatic disease from the main pediatric solid tumors, including neuroblastoma and Wilms tumor focusing on the management and treatment options. We also review other solid malignant tumors which may have liver metastases including germ cell tumors, gastrointestinal stromal tumors, osteosarcoma, desmoplastic small round cell tumors and NET. However, these histological subtypes are so rare in the pediatric and adolescent populations that the exact incidence and best management of hepatic metastatic disease are unknown and can only be extrapolated from adult series.

关键词： Hepatic metastatic disease Pediatric andadolescent solid tumors Neuroblastoma Wilms tumor

Newly Discovered Scheelite in Quartz Vein-type Gold Deposits, Xiaoqinling Gold District, and its Geological Significance

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Acta Geologica Sinica(English Edition) 2020年第4期94卷 1305-1307页

作者： CHANG ming LIU Jiajun CARRANZA Emmanuel john m YIN Chao ZHAI Degao WU Tong State Key Laboratory of Geological Processes and mineral Resources China University of GeosciencesBeijing 100083China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Geological Sciences School of AgriculturalEarth and Environmental SciencesUniversity of KwaZulu-NatalDurban 4000Republic of South Africa

Objective The Xiaoqinling district is the second largest goldbearing province in China after the Jiaodong region located in the eastern North China Craton. At present, seven large, 20 medium-sized and 28 small gold deposits have been discovered, and more than 1200 gold-bearing quartz veins have been identified within the metamorphic rocks of the Taihua Group. The total gold reserves are over 800 tons.

关键词： Quartz sized quartz

Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice:effects of 4-aminopyridine

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Neural Regeneration Research 2023年第2期18卷 439-444页

作者： Jung Il Lee m A Hassan Talukder Zara Karuman Anagha A.Gurjar Prem Kumar Govindappa Jagadeeshaprasad m.Guddadarangaiah Kristen m.manto Grant D.Wandling john P.Hegarty David L.Waning john C.Elfar Department of Orthopaedics and Rehabilitation Center for Orthopaedic Research and Translational ScienceThe Pennsylvania State University College of MedicineHersheyPAUSA Department of Orthopaedic Surgery Korea University Guro HospitalSeoulSouth Korea Department of Cellular and molecular Physiology The Pennsylvania State University College of MedicineHersheyPAUSA

We recently demonstrated a repurposing beneficial effect of 4-aminopyridine(4-AP),a potassium channel blocker,on functional recove ry and muscle atrophy after sciatic nerve crush injury in ***,this effect of 4-AP is unknown in nerve transection,gap,and grafting *** evaluate and compare the functional recovery,nerve morphology,and muscle atrophy,we used a novel stepwise nerve transection with gluing(STG),as well as 7-mm irreparable nerve gap(G-7/0)and 7-mm isografting in 5-mm gap(G-5/7)models in the absence and presence of 4-AP *** surgery,sciatic functional index was determined wee kly to evaluate the direct in vivo global motor functional *** 12 weeks,nerves were processed for whole-mount immunofluorescence imaging,and tibialis anterior muscles were harvested for wet weight and quantitative histomorphological analyses for muscle fiber crosssectional area and minimal Feret's *** post-injury sciatic functional index values in STG and G-5/7 models were significantly greater than those in the G-7/0 model.4-AP did not affect the sciatic functional index recovery in any *** to STG,nerve imaging revealed more misdirected axons and distorted nerve architecture with *** muscle weight,cross-sectional area,and minimal Feret's diameter were significantly smaller in G-7/0 model compared with STG and G-5/7,4-AP treatment significantly increased right TA muscle mass,cross-sectional area,and minimal Feret's diameter in G-7/0 *** findings demonstrate that functional recovery and muscle atrophy after peripheral nerve injury are directly related to the intervening nerve gap,and 4-AP exerts diffe rential effects on functional recove ry and muscle atrophy.

关键词： 4-aminopyridine functional recovery muscle atrophy nerve gap nerve grafting nerve imaging nerve transection

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

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Liver Research 2020年第2期4卷 47-63页

作者： john Y.L.Chiang Jessica m.Ferrell Department of Integrative medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Cholesterol 7 alpha-hydroxylase(CYP7A1,EC1.14)is the first and rate-limiting enzyme in the classic bile acid synthesis *** progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying molecular mechanisms of bile acid feedback regulation of CYP7A1 and bile acid synthesis in the last three *** of bile acid-activated receptors and their roles in the regulation of lipid,glucose and energy metabolism have been translated to the development of bile acid-based drug therapies for the treatment of liver-related metabolic diseases such as alcoholic and non-alcoholic fatty liver diseases,liver cirrhosis,diabetes,obesity and hepatocellular *** review will provide an update on the advances in our understanding of the molecular biology and mechanistic insights of the regulation of CYP7A1 in bile acid synthesis in the last 40 years.

关键词： Cholesterol 7 alpha-hydroxylase(CYP7A1) Bile acid metabolism Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Bile acid receptors Liver metabolism

Predicting glass structure by physics-informed machine learning

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npj Computational materials 2022年第1期8卷 1839-1847页

作者： mikkel L.Bødker mathieu Bauchy Tao Du john C.mauro morten m.Smedskjaer Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark Physics of AmoRphous and Inorganic Solids Laboratory(PARISlab) Department of Civil and Environmental EngineeringUniversity of CaliforniaLos AngelesCA90095USA Department of materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA

machine learning(mL)is emerging as a powerful tool to predict the properties of materials,including *** mL models with knowledge of how glass composition affects short-range atomic structure has the potential to enhance the ability of composition-property models to extrapolate accurately outside of their training ***,we introduce an approach wherein statistical mechanics informs a mL model that can predict the non-linear composition-structure relations in oxide *** combined model offers an improved prediction compared to models relying solely on statistical physics or machine learning ***,we show that the combined model accurately both interpolates and extrapolates the structure of Na_(2)O–SiO_(2)***,the model is able to extrapolate predictions outside its training set,which is evidenced by the fact that it is able to predict the structure of a glass series that was kept fully hidden from the model during its training.

关键词： glasses structure glass

GANscan:continuous scanning microscopy using deep learning deblurring

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Light(Science & Applications) 2022年第10期11卷 2378-2387页

作者： michael john Fanous Gabriel Popescu Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA

most whole slide imaging(WSI)systems today rely on the"stop-and-stare"approach,where,at each field of view,the scanning stage is brought to a complete stop before the camera snaps a *** procedure ensures that each image is free of motion blur,which comes at the expense of long acquisition *** order to speed up the acquisition process,especially for large scanning areas,such as pathology slides,we developed an acquisition method in which the data is acquired continuously while the stage is moving at high *** generative adversarial networks(GANs),we demonstrate this ultra-fast imaging approach,referred to as GANscan,which restores sharp images from motion blurred *** allows us to complete image acquisitions at 30x the throughput of stop-and-stare *** method is implemented on a Zeiss Axio Observer Z1 microscope,requires no specialized hardware,and accomplishes successful reconstructions at stage speeds of up to 5000 μm/*** validate the proposed method by imaging H&E stained tissue *** method not only retrieves crisp images from fast,continuous scans,but also adjusts for defocusing that occurs during scanning within+/-5 μ*** a consumer GPU,the inference runs atms/image.

关键词： hardware continuous image

Tyrosine metabolic enzymes from insects and mammals：A comparative perspective

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Insect Science 2014年第1期21卷 13-19页

作者： Christopher john Vavricka Qian Han Prajwalini mehere Haizhen Ding Bruce m. Christensen and Jianyong Li Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences BeUing China Department of Biochemistry Virginia Polytechnic and State University Blacksburg VA 24061 USA Department of Tuberculosis The Foundation for Medical Research Mumbai India and Department of Pathobiology University of Wisconsin-Madison Madison Wl 53706 USA

Differences in the metabolism of tyrosine between insects and mammals present an interesting example of molecular evolution. Both insects and mammals possess finetuned systems of enzymes to meet their specific demands for tyrosine metabolites; however, more homologous enzymes involved in tyrosine metabolism have emerged in many insect species. Without knowledge of modem genomics, one might suppose that mammals, which are generally more complex than insects and require tyrosine as a precur sor for important catecholamine neurotransmitters and for melanin, should possess more enzymes to control tyrosine metabolism. Therefore, the question of why insects actually possess more tyrosine metabolic enzymes is quite interesting. It has long been known that insects rely heavily on tyrosine metabolism for cuticle hardening and for innate immune responses, and these evolutionary constraints are likely the key answers to this question. In terms of melanogenesis, mammals also possess a high level of regulation; yet mam malian systems possess more mechanisms for detoxification whereas insects accelerate pathways like melanogenesis and therefore must bear increased oxidative pressure. Our research group has had the opportunity to characterize the structure and function of many key proteins involved in tyrosine metabolism from both insects and mammals. In this mini review we will give a brief overview of our research on tyrosine metabolic enzymes in the scope of an evolutionary perspective of mammals in comparison to insects.

关键词： arylalkylamine N-acetyltransferase (aaNAT) Enzymology L-DOPAdecarboxylase (DDC) melanogenesis tyrosine metabolism

A History of Fischer-Tropsch Wax Upgrading at BP-from Catalyst Screening Studies to Full Scale Demonstration in Alaska

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Journal of Natural Gas Chemistry 2006年第1期15卷 1-10页

作者： john P. Collins Joep J. H. m. Font Freide Barry Nay BP Exploration America Inc. BP Exploration Operating Company

Conversion of Fischer-Tropsch wax into high quality synthetic crude or finished transportation fuels such as premium diesel has been studied over the past 15 years within BP. Catalyst screening and selection was carried out in dedicated micro-reactors and pilot plants, whose designs are critical to the performance selection. Variation in catalyst composition and defining the gas to oil feed ratios with the operating temperature are a few of the parameters studied. Product selection and maximizing diesel yield combined with stability （catalyst life） were the ultimate drivers. The selected catalyst was then tested under commercial conditions in a dedicated 300 barrel per day demonstration plant. The products were also tested in engines to assess their combustion characteristics.

关键词： Fischer-Tropsch wax upgrading hydrocracking synthetic crude diesel naphtha engine emission