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Toward a self-driving ultrafast fiber laser

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Light(Science & Applications) 2020年第1期9卷 1757-1759页

作者： Fanchao meng john m.Dudley Universite Bourgogne Franche-Comte Institut FEMTO-ST UMR 6174BesançonFrance

Femtosecond pulses from an ultrafast mode-locked fiber laser can be optimized in real time by combining single-shot spectral measurements with a smart genetic algorithm to actively control and drive the intracavity dy... 详细信息

关键词： fiber laser Femto

Contemporary approaches to visual prostheses

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military medical Research 2019年第3期6卷 254-262页

作者： Rebecca m.mirochnik john S.Pezaris Department of Bioengineering Northeastern UniversityBostonMAUSA Department of Neurosurgery Massachusetts General HospitalBostonMAUSA.3Department of NeurosurgeryHarvard MedicalSchoolBostonMAUSA.

Visual prostheses serve to restore visual function following acquired blindness. Acquired blindness(as opposed to congenital blindness) has many causes, including diseases such as retinitis pigmentosa, glaucoma, and macular degeneration, or trauma such as caused by automobile accident or blast damage from explosions. many of the blindness-causing diseases target the retina or other ocular structure. Often, despite the loss of sensitivity to light, the remainder of the visual pathway is still functional, enabling electrical devices to deliver effective and meaningful visual information to the brain via arrays of electrodes. These arrays can be placed in any part of the early visual pathway, such as the retina, optic nerve, lateral geniculate nucleus, or visual cortex. A camera or other imaging source is used to drive electrical stimulation of remaining healthy cells or structures to create artificial vision and provide restoration of function. In this review, each approach to visual prostheses is described, including advantages and disadvantages as well as assessments of the current state of the art. most of the work to-date has been targeting stimulation of(a) the retina, with three devices approved for general use and two more in clinical testing;(b) the lateral geniculate nucleus, with efforts still in the pre-clinical stage;and(c) the cortex, with three devices in clinical testing and none currently approved for general use despite the longest history of investigation of the three major approaches. Each class of device has different medical indications, and different levels of invasiveness required for implantation. All contemporary devices deliver relatively poor vision. There has been remarkable progress since the first proof-ofconcept demonstration that used stimulation of the primary visual cortex, with the field exploring all viable options for restoration of function. much of the progress has been recent, driven by advances in microelectronics and biocompat

关键词： Visual prosthesis Blindness Artificial vision

TRS Scheduling for Improved QoS Performance in Cloud System

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Computers, materials & Continua 2023年第4期75卷 1547-1559页

作者： G.john Samuel Babu m.Baskar Department of Computer Science and Engineering School of ComputingCollege of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India Department of Computing Technologies School of ComputingCollege of Engineering andTechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Numerous methods are analysed in detail to improve task schedulingand data security performance in the cloud environment. The methodsinvolve scheduling according to the factors like makespan, waiting time,cost, deadline, and popularity. However, the methods are inappropriate forachieving higher scheduling performance. Regarding data security, existingmethods use various encryption schemes but introduce significant serviceinterruption. This article sketches a practical Real-time Application CentricTRS (Throughput-Resource utilization–Success) Scheduling with Data Security(RATRSDS) model by considering all these issues in task scheduling anddata security. The method identifies the required resource and their claim timeby receiving the service requests. Further, for the list of resources as services,the method computes throughput support (Thrs) according to the number ofstatements executed and the complete statements of the service. Similarly, themethod computes Resource utilization support (Ruts) according to the idletime on any duty cycle and total servicing time. Also, the method computesthe value of Success support (Sus) according to the number of completions forthe number of allocations. The method estimates the TRS score (ThroughputResource utilization Success) for different resources using all these supportmeasures. According to the value of the TRS score, the services are rankedand scheduled. On the other side, based on the requirement of service requests,the method computes Requirement Support (RS). The selection of service isperformed and allocated. Similarly, choosing the route according to the RouteSupport measure (RSm) enforced route security. Finally, data security hasgets implemented with a service-based encryption technique. The RATRSDSscheme has claimed higher performance in data security and scheduling.

关键词： Cloud task scheduling TRS quality of service RSm route security data security SDE RATRSDS

Nonuniform Dependence on the Initial Data for Solutions of Conservation Laws

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Communications on Applied mathematics and Computation 2024年第1期6卷 489-500页

作者： john m.Holmes Barbara Lee Keyfitz Department of mathematics The Ohio State UniversityColumbusOH43210USA

In this paper,we study systems of conservation laws in one space *** prove that for classical solutions in Sobolev spaces H^(s),with s>3/2,the data-to-solution map is not uniformly *** results apply to all nonlinear s... 详细信息

关键词： Conservation laws Data-to-solution map Nonuniform dependence

Structural and functional roles of ether lipids

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Protein & Cell 2018年第2期9卷 196-206页

作者： john m. Dean Irfan J. Lodhi Division of Endocrinology Metabolism and Lipid Research Department of Medicine Washington University School of Medicine Saint Louis MO 63110 USA

Ether lipids, such as plasmalogens, are peroxisome- derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seem- ingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential signifi- cance in human disorders, including neurological diseases, cancer, and metabolic disorders.

关键词： ether lipids plasmalogen phospholipid peroxisomes cancer metabolic disorders

Identification of isopeptidase activity in the midgut of insects： Purification, properties and nutritional ecology of a Hofmannophila pseudospretella （Lepidoptera： Oecophoridae） larval enzyme

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Insect Science 2010年第4期17卷 325-334页

作者： Robert m. Simpson john T. Christeller Plant and Food Research Institute Tennant Drive Palmerston North 4474 Private Bag 11 030 New Zealand

A γ-glutamyl transpeptidase （isopeptidase） has been purified 580-fold to homogeneity from the midgut of keratinophagous larvae of Hofmannophila pseudospretella. The enzyme is a single polypeptide of molecular mass 80 kDa. The enzyme was identified by its hydrolytic activity against the synthetic substrate, γ-glutamyl-AmC, its molecular mass and inhibition profile compared to other γ-glutamyl transpeptidases. The enzyme is low or absent from most other insect digestive systems apart from other keratinophagous lepidopteran larvae and predatory carabids. While isopepfide bonds are present in high levels of the proteins in the diet of keratinophages, their presence in the diet of predatory beetles has not been established.

关键词： γ-glutamyl transpeptidase Hofmannophila pseudospretella isopeptidase,keratinophagous nutritional ecology

Immunological roulette: Luck or something more? Considering the connections between host and environment in TB

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Cellular & molecular Immunology 2018年第3期15卷 226-232页

作者： john E Pearl mrinal Das Andrea m Cooper Department of Infection Immunity and Inflammation Leicester Tuberculosis Research Group(LTBRG)University of LeicesterUniversity RoadLeicesterLE17RHUK

Accurate prediction of which patient will progress from a sub-clinical mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research *** the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad ***,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated *** infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental *** disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is *** apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological *** discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and *** suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota.

关键词： gut-liver-lung axis microbiome tuberculosis

Some insights into how barnacles survive as sessile organisms

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Integrative Zoology 2009年第4期4卷 395-401页

作者： john S.BUCKERIDGE Jessica m.REEVES Earth and Oceanic Systems Research Group RMIT UniversityMelbourneAustralia

During routine chemical analyses of the stalked ibliform barnacle Chaetolepas calcitergum Buckeridge&Newman 2006,peaks of more than 7%(by dry mass)of bromine were *** bromine ions occur in seawater(up to 66 ppm),this level of accumulation,in the soft tissue of the barnacle,is *** concentration of bromine compounds occurs in a number of invertebrates,such as algae and sponges,but this is the first record of elevated bromine in goose *** high accumulation of bromine compound(s)is most likely a defense *** present paper includes a review of the mechanisms deployed by barnacles to repel predators.

关键词： bromine Chaetolepas calcitergum Cirripedia defense mechanisms Ibliformes.

The Relationship between the Wintertime Blocking over Greenland and the Sea Ice Distribution over North Atlantic

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Advances in Atmospheric Sciences 1993年第4期10卷 453-464页

作者： john m.W allace Department of Atmospheric Sciences University of Washington Seattle WA 98195

The sea-ice concentration in the Northern Hemisphere, 500 hPa height, sea-level pressure and 1000-500 hPa thickness of monthly mean data are examined for the period 1953-1989, with emphasis on the winter *** between large-scale patterns of atmospheric variability and sea-ice variability are investigated, making use of the correlation method. The analysis is conducted for the Atlantic sectors. In agreement with earlier studies based upon monthly mean data on sea-ice concentration, the strongest sea-ice pattern is composed of a dipole with opposing centers of action in the Davis Straits / Labrador Sea region and the Greenland and Barents Seas. Its temporal variability is strongly coupled to the atmospheric North Atlantic Oscillation (NAO). The relationship between the two patterns is strongest with the atmosphere leading the ocean. The polarity of the NAO is associated with Greenland blocking episodes, during which the influence of the atmosphere is strong enough to temporarily halt the climatological mean advance of the ice edge in some regions and substantially accelerate it in *** relationships between the fields are indicative of local forcing of sea-ice in most regions, with wind stress and thermodynamic fluxes at the air-sea interface both contributing.

关键词： Sea-ice index Sea-ice distribution North Atlantic Oscillation Greenland Blocking Auto-correlation Correlation method