检索结果-南通市图书馆

Synthesis of liSm_(0.01)Mn_(1.99)O_4 by molten salt technique

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2010年第2期28卷 255-259页

作者： M Helan l john Berchmans Department of Chemistry Jamal Mohamed College (Autonomous) Electropyrometallurgy Division Central Electrochemical Research Institute

Samarium substituted lithium manganese oxide powders were successfully prepared by molten-salt synthesis(MSS) using eutectic mixture of liCl,SmCl3.6H2O and MnO2 salt at 700 °*** synthesis was carried out in open *** crystalline powders were characterized for their phase identification using X-ray diffraction(XRD) *** physico-chemical properties of the samarium substituted lithium manganese oxide powders were investigated by thermal analysis(TGA/DTA),FT-IR spectroscopy,EDAX,electron par...

关键词： liSm0.01Mn1.99O4 molten salt synthesis cathode materials rare earth ion

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen lin Wen-Feng Fang Jui-Ning Yeh john Y Chiang Hsin-Ju Chiang Pei-lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including l2 cells treated with lipopolysaccharide(lPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-l2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Plevels of inflammation[interleukin(Il)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TlR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(lPS)-treated l2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pls were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pl oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

Configuration-Sensitive Molecular Sensing on Doped Graphene Sheets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2010年第7期3卷 472-480页

作者： john Russell Petr Král Department of Chemistry University of Illinois at ChicagoChicagoIL 60607USA

We show by molecular dynamics simulations that configuration-sensitive molecular spectroscopy can be realized on optimally doped graphene sheets vibrated by an oscillatory electric *** selectivity of the spectroscopy is achieved by maximizing Coulombic binding between the detected molecule and a specific nest,formed for this molecule on the graphene sheet by substituting selected carbon atoms with boron and nitrogen *** can detect binding of different isomers to the nest from the frequency shifts of selected vibrational modes of the combined *** an illustrative example,we simulate detection of hexanitrostilbene enantiomers in chiral nests formed on graphene.

关键词： Molecular sensing enantiomer graphene functionalization molecular dynamics

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng john V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

Integration of the Coupled Orbit-Attitude Dynamics Using Modified Chebyshev-Picard Iteration Methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2016年第2期111卷 129-146页

作者： Xiaoli Bai john l.Junkins Rutgers The State University of New JerseyPiscatawayNJU.S.A Texas A&M College StationTXU.S.A

This paper presents Modified Chebyshev-Picard Iteration(MCPI)methods for long-term integration of the coupled orbit and attitude *** most orbit predictions for operational satellites have assumed that the attitude dynamics is decoupled from the orbit dynamics,the fully coupled dynamics is required for the solutions of uncontrolled space debris and space objects with high area-to-mass ratio,for which cross sectional area is constantly changing leading to significant change on the solar radiation pressure and atmospheric *** is a set of methods for solution of initial value problems and boundary value *** methods refine an orthogonal function approximation of long-time-interval segments of state trajectories iteratively by fusing Chebyshev polynomials with the classical Picard iteration and have been applied to multiple challenging aerospace *** the studies on integrating a torque-free rigid body rotation and a long-term integration of the coupled orbit-attitude dynamics through the effect of solar radiation pressure,MCPI methods are shown to achieve several times speedup over the Runge-Kutta 7(8)methods with several orders of magnitudes of better *** methods are further optimized by integrating the decoupled dynamics at the beginning of the iteration and coupling the full dynamics when the attitude solutions and orbit solutions are converging during the *** approach of decoupling and then coupling during iterations provides a unique and promising perspective on the way to warm start the solution process for the longterm integration of the coupled orbit-attitude ***,an attractive feature of MCPI in maintaining the unity constraint for the integration of quaternions within machine accuracy is illustrated to be very appealing.

关键词： Orbit propagation orbit-attitude dynamics Modified Chebyshev-Picard Iteration(MCPI)Methods

ANAlYSIS OF COMPOSITE lAMINATE BEAMS USING COUPlING CROSS-SECTION FINITE ElEMENT METHOD

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2006年第12期27卷 1709-1718页

作者：姜文光 john l.Henshall School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004Hebei ProvinceP. R. China Department of Aerospace Engineering University of BristolBS8 1TRUK Department of Mechanical Engineering and Manufacturing Engineering Nottingham Trent UniversityNottinghamNG1 4BUUK

Beams and plates manufactured from laminates of composite materials have distinct advantages in a significant number of applications. However, the anisotropy arising from these materials adds a significant degree of complexity, and thus time, to the stress and deformation analyses of such components, even using numerical approaches such as finite elements. The analysis of composite laminate beams subjected to uniform extension, bending, and/or twisting loads was performed by a novel implementation of the usual finite element method. Due to the symmetric features of the deformations, only a thin slice of the beam to be analysed needs to be modelled. Conventional threedimensional solid finite elements were used for the structural discretization. The accurate deformation relationships were formulated and implemented through the coupling of nodal translational degrees of freedom in the numerical analysis. A sample solution for a rectangular composite laminate beam is presented to show the validity and accuracy of the proposed method.

关键词： composite material beam coupling equation finite element method extension bending torsion

Effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Erica Gobbi Pedro l.Valenzuela Simon J.Bennett Pierluigi Aschieri Manuel Martin-loeches Antonio Paoli Oscar Martinez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Department of Biomolecular Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of Systems Biology University of AlcaláMadrid 28805Spain Research Institute for Sport and Exercise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behavioural Sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical Sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,*** included academic performance(average grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;plance(d=0.24;p=0.015).There was a trend towards significant benefits for flexibility(d=0.24;p=0.056).No significant benefits were observed for other variables,including psychosocial difficulties,emotional symptoms,hyperactivity/inattention,peer problems,or prosocial behaviour(all p>0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

Effect of l-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan ling Na Wang john Shi Wei-Chun Pan Qi-Zhen Du Jun-Feng Yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored l-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57Bl/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting l-theanine and geniposide’s potential as a novel depression therapy.

关键词：

Recent trends in the surgical management of inflammatory bowel disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第3期14卷 408-412页

作者： Robert E Roses john l Rombeau University of Pennsylvania School of Medicine Philadelphia Pennsylvania Temple University School of Medicine Philadelphia Pennsylvania United States

Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have occurred in surgery. Advances in CD include an emphasis upon conservatism as exemplified by more limited resections, strictureplasties, and laparoscopic resections. The use of probiotics in selected patients has improved the outcome in patients with pouchitis following restorative proctocolectomy for UC. It is anticipated that ongoing discoveries in the molecular basis of IBD will in turn identify those patients who will best respond to surgery.

关键词： Crohn's disease Ulcerative colitis Ileal pouchanal anastomosis laparoscopic colectomy