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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong leo C.H.Tsang Sara Chaothai Tsz Chun Kwan john K.C.li Karl C.K.Chan leo l.H.luk Jenson C.H.Ho Wing Yan li Amos M.T.lee Jennifer H.Y.lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(Il-2)+CD4^(+),SNM-specific Il-2^(+)CD8^(+),S-specific Il-2^(+)CD8^(+),N-specific Il-2^(+)CD4^(+),N-specific Il-2^(+)CD8^(+)and M-specific Il-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific Il-2^(+)CD4^(+),interferon-γ+CD8^(+)and Il-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

分支河流体系河网形态演变规律——以格尔木河流扇为例

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地质论评 2024年第3期70卷 1047-1060页

作者：王浩楠张昌民孙家惠张祥辉徐清海刘洪平 Adrian john HARTlEY 长江大学地球科学学院中国武汉430100 阿伯丁大学地球科学学院英国阿伯丁AB243UE

为了探索分支河流体系河网分布规律,为创建储层建模训练图像提供知识库信息。利用Google Earth、Global Mapper、91卫图助手等现代地理信息软件,系统测量了现代格尔木河流扇表面河道分叉特征,应用Horton定律和分形方法建立了河流扇的河... 详细信息

为了探索分支河流体系河网分布规律,为创建储层建模训练图像提供知识库信息。利用Google Earth、Global Mapper、91卫图助手等现代地理信息软件,系统测量了现代格尔木河流扇表面河道分叉特征,应用Horton定律和分形方法建立了河流扇的河网形态模型。结果表明:①格尔木河流扇从顶点到入湖段共识别出26级河道,882个节点和2162个河道段,泉线上、下的河道表现出不同的河网形态;②泉线上部共发育64个节点,每级河道数目增长是上一级河道的R_(B)=1.8900倍,每级河道平均长度是下一级河道的R_(l)=1.0095倍,即河网形态特征参数R_(B)=1.8900和R_(l)=1.0095;泉线下部共发育818个节点,每级河道数目增长是上一级河道的R_(B)=1.0279倍,每级河道平均长度是下一级河道的R_(l)=0.9899倍,即河网形态特征参数是R_(B)=1.0279和R_(l)=0.9899;③河网形态特征参数受坡度影响变化较大,坡度较大则河网形态特征参数较大,坡度较小则河网形态特征参数较小。河网形态特征参数定量表征促进了分支河流体系沉积学发展,为开展陆相盆地储层建模和砂体预测提供了新的知识库信息.

关键词：分支河流体系河网形态河网模型 Horton定律格尔木河流扇

Typhoon disaster risk zoning for China’s coastal area

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Frontiers of Earth Science 2022年第2期16卷 291-303页

作者： Jing ZHU Yi lU Fumin REN john l McBRIDE longbin YE Xiamen Key laboratory of Straits Meteorology Xiamen Meteorological BureauXiamen 361012China Shanghai Typhoon Institute of China Meteorological Administration Shanghai 200030China State Key laboratory of severe weather Chinese Academy of Meteorological SciencesBeijing 10081China School of Earth Science (Honorary)University of MelbourneMelbourne 3010Australia Research and Development Division(Emeritus Scientist) Bureau of MeteorologyMelbourne 3010Australia

Previous studies on typhoon disaster risk zoning in China have focused on individual provinces or small-scale areas and lack county-level *** this study,typhoon disaster risk zoning is conducted for China’s coastal area,based on data at the county *** precipitation and wind data for China and typhoon disaster and social data at the county level for China’s coastal area from 2004 to 2013,first we analyze the characteristics of typhoon disasters in China’s coastal area and then develop an intensity index of factors causing typhoon disasters and a comprehensive social vulnerability ***,by combining the two indices,we obtain a comprehensive risk index for typhoon disasters and conduct risk *** results show that the maximum intensity areas are mainly the most coastal areas of both Zhejiang and Guangdong,and parts of Hainan Island,which is similar to the distribution of typhoon *** maximum values of vulnerability in the northwest of Guangxi,parts of Fujian coastal areas and parts of the Shandong *** comprehensive risk index generally decreases from coastal areas to inland *** high-risk areas are mainly distributed over Hainan Island,south-western Guangdong,most coastal Zhejiang,the coastal areas between Zhejiang and Fujian and parts of the Shandong Peninsula.

关键词： typhoon disaster risk zoning comprehensive social vulnerability index China’s coastal area

Systemic Il-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel-Moreno Anthony M.Franchini john R.Owen john C.Martinez john l.Daiss Karen l.de Mesy Bentley Stephen l.Kates Edward M.Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of Allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathology and laboratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum Il-27 levels(20-fold higher,Plthy ***,Il-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(Ple of *** test this hypothesis,we evaluated *** osteomyelitis in WT and Il-27Rα^(−/−)mice with and without exogenous Il27 induction by intramuscular injection of rAAV-Il-27p28 or rAAV-GFP,*** found that Il-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteoblasts but not by ***,exogenous Il-27p28(~2 ng·ml^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local Il-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in Il-27Rα^(−/−)mice compared with WT mice,suggesting that Il-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that Il-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of Il-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic Il-27 in osteomyelitis.

关键词： abscess protective immunity

Missed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecystectomy

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Surgical Science 2024年第7期15卷 451-464页

作者： Dylan S. Goto larissa Fujii-lau linda l. Wong Department of Surgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecystectomy has been recommended for patients with acute cholecystitis and gallstone pancreatitis. However, patients with pancreaticobiliary malignancy may present acutely with similar symptoms. We hypothesize that the diagnoses of these malignancies may potentially be delayed as an unintended consequence of expedited cholecystectomies. This study reviews a cohort of patients who underwent pancreaticoduodenectomy (PD) to identify those who underwent a separate cholecystectomy before their PD. Methods: We retrospectively reviewed 162 PDs performed between 2012 and 2022. Data collected included: demographics, disease etiology and the presence of cholelithiasis. We identified patients who had a previous cholecystectomy and the time elapsed before PD as well as procedures done during the interval. We reported detailed case summaries on those patients who had a cholecystectomy within 1 year of PD. Results: In the entire cohort, mean age was 65 years, 54% were males, and 83% had a malignant reason for PD. Thirty-one patients had cholelithiasis with 23 (14%) patients having had previous cholecystectomy. Six patients had cholecystectomy within 1 year of PD. They had the following malignancies: ampullary—3, pancreas—1, cholangiocarcinoma—1 and neuroendocrine—1. Four of these patients had expedited cholecystectomy on their index hospital admission and were later found to have a periampullary malignancy with further work up. Conclusions: Pancreaticobiliary malignancies can be difficult to diagnose, and surgeons should not overlook these potential diagnoses when considering expedited cholecystectomy. Future studies in large cohorts are needed to identify high risk candidates who should undergo more detailed testing to exclude malignancy before proceeding with cholecystectomy.

关键词： Cholecystectomy Periampullary Malignancy Pancreas Malignancy Pancreaticoduodenectomy

Rapid accessibility evaluation for ballistic lunar capture via manifolds: A Gaussian process regression application

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Astrodynamics 2022年第4期6卷 375-397页

作者： Sandeep K.Singh john l.Junkins Manoranjan Majji Ehsan Taheri Department of Aerospace Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Aerospace Engineering Auburn UniversityAuburnAL 36849USA

In this study,a supervised machine learning approach called Gaussian process regression(GPR)was applied to approximate optimal bi-impulse rendezvous maneuvers in the cis-lunar *** demonstrate the use of the GPR approximation of the optimal bi-impulse transfer to patch points associated with various invariant manifolds in the cis-lunar *** proposed method advances preliminary mission design operations by avoiding the computational costs associated with repeated solutions of the optimal bi-impulsive lambert transfer because the learned map is computationally *** approach promises to be useful for aiding in preliminary mission *** use of invariant manifolds as part of the transfer trajectory design offers unique features for reducing propellant consumption while facilitating the solution of trajectory optimization *** ballistic capture coasts are also very attractive for mission guidance,navigation,and control robustness.A multi-input single-output GPR model is presented to represent the fuel costs(in terms of theΔV magnitude)associated with the class of orbital transfers of interest *** developed model is also proven to provide efficient *** multi-resolution use of local GPRs over smaller sub-domains and their use for constructing a global GPR model are also *** of the unique features of GPRs is that they provide an estimate of the quality of approximations in the form of covariance,which is proven to provide statistical consistency with the optimal trajectories generated through the approximation *** numerical results demonstrate our basis for optimism for the utility of the proposed method.

关键词： Gaussian process regression supervised learning invariant manifolds ballistic transfers Bayesian inference

Growth, Development and Yield of Kenaf as Affected by Planting Dates and N Fertilization

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Open Journal of Applied Sciences 2024年第3期14卷 707-720页

作者： Julius Yirzagla Peter Quandahor Iddrisu Yahaya Olivia Aguriboba Akanbelum listowell Aditwin Akologo john Bokaligidi lambon Abdul-Wahab M. Imoro Kwadwo Gyasi Santo CSIR-SARI Nyankpala Ghana St Vincent College of Education Yendi Ghana Gbewaah College of Education Pusiga-Bawku Ghana CSIR-Head Office Accra Ghana C.K. Tedam University of Technology and Applied Sciences Navrongo Ghana University of Energy and Natural Resources Sunyani Ghana

Kenaf (Hibiscus cannabinus l) consists of various beneficial components like stalks, seeds, leaves, fibers, oils, proteins, allelopathic chemicals, and fiber strands, among other things. Despite the numerous uses of the crop, there is little or no information on optimum agronomic practices such as planting date and N fertilization of the crop in the Upper East Region (UER) of Ghana where the crop is widely cultivated by smallholder farmers. Field experiments were therefore carried out in 2020 and repeated during the 2021 cropping season in the study area. The objective of the study was to determine appropriate planting date and N fertilization for increased kenaf productivity. In each year, the treatments consisted of 3 × 5 factorial combinations of three planting dates (1st July, 7th July and 14th July) and five levels of N (0, 20, 40, 60 and 80 kg/ha) replicated three times. The design of the experiment was a split-plot with the N fertilizer as the main plot and the planting date assigned to sub plot. The results showed that, planting kenaf in early (1st) July or N fertilization at the rate of 60 kg/ha increased plant density, stem height, stem diameter, dry bast and core yields in both cropping seasons.

关键词： Growth Fibres Bast Yield Core Yield

Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance

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World Journal of Gastroenterology 2022年第32期28卷 4516-4526页

作者： Dariush Shahsavari Praneeth Kudaravalli john Erikson l Yap Kenneth J Vega Division of Gastroenterology and Hepatology Augusta University-Medical College of GeorgiaAugustaGA 30912United States

Barrett’s esophagus(BE)is a condition that results from replacement of the damaged normal squamous esophageal mucosa to intestinal columnar mucosa and is the most significant predisposing factor for development of esophageal *** guidelines recommend endoscopic evaluation for screening and surveillance based on various risk factors which has limitations such as invasiveness,availability of a trained specialist,patient logistics and ***-nasal endoscopy is a less invasive modality but still has similar limitations such as limited availability of trained specialist and ***-endoscopic modalities,in comparison,require minimal intervention,can be done in an office visit and has the potential to be a more ideal choice for mass public screening and surveillance,particularly in patents at low risk for *** include newer generations of esophageal capsule endoscopy which provides direct visualization of BE,and tethered capsule endomicroscopy which can obtain high-resolution images of the *** cell collection devices coupled with biomarkers have been used for BE ***,in combination with TFF3,as well as EsophaCap and EsoCheck have shown promising results in various studies when used with various *** modalities including circulatory microRNAs and volatile organic compounds that have demonstrated favorable *** of these cell collection methods for BE surveillance is a potential area of future research.

关键词： Barrett’s esophagus Screening Surveillance Non-endoscopic Cytosponge Esophacap Esocheck

高、低核酸含量原核生物应对资源可利用性降低和原生动物选择性摄食的适应性策略

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中国科学：地球科学 2024年第6期54卷 1901-1913页

作者：胡晨余柳倩陈晓炜刘纪化张瑶 john BATT 肖喜林石蔷张锐骆庭伟焦念志徐大鹏厦门大学环境与生态学院厦门361102 近海海洋环境科学国家重点实验室厦门大学海洋与地球学院福建省海洋碳汇重点实验室厦门361102 Joint lab for Ocean Research and Education(lORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China 香港科技大学(广州)地球与海洋大气科学学域广州510000 山东大学海洋研究院青岛266237 Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada 深圳大学高等研究院深圳518060 厦门大学碳中和创新研究中心厦门361102

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(lNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体... 详细信息

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(lNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体系中进行了73天的培养实验,深入研究HNA和lNA亚群对资源可利用性降低和原生动物选择性摄食随时间变化的动态响应.研究结果显示,当培养环境资源充足时, HNA亚群的代谢活性高于lNA亚群,但随着资源日益稀缺, HNA亚群代谢下降速度比lNA亚群快,从而使lNA亚群对原核生物活性的贡献稳步增加.与此同时,随着培养体系资源可利用性逐步降低,原生动物的摄食偏好从HNA亚群转向lNA亚群,使得lNA亚群对培养体系的碳流贡献增加.这些结果突显了lNA亚群在资源有限环境中的韧性,阐明了原生动物选择性摄食在资源条件变化时平衡不同亚群中的关键作用,并展示了在不同环境背景下原生动物和原核生物之间复杂的相互适应性.

关键词：微生物环大体积培养实验原核生物自上而下和自下而上调控作用碳流