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Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

journal of Sport and Health Science 2021年第2期10卷 122-130页

作者： Eric R.Munoz jaclyn B.Caccese Brittany E.Wilson Kyle T.Shuler Fernando V.Santos Carolina T.Caban john j.jeka Dianne Langford Matthew B.Hudson Department of Kinesiology and Applied Physiology University of DelawareNewarkDE 19713USA School of Health and Rehabilitation Sciences The Ohio State University College of MedicineColumbusOH 43210USA Department of Neuroscience Lewis Katz School of MedicineTemple UniversityPhiladelphiaPA 19140USA

Background:Considering the potential cumulative effects of repetitive head impact(HI)exposure,we need sensitive biomarkers to track shortand long-term *** small extracellular vesicles(sEVs)(<200 nm)traffic biological molecules throughout the body and may have diagnostic value as biomarkers for *** purpose of this study was to identify the microRNA(miRNA)profile in circulating sEVs derived from human plasma following repetitive HI ***:Healthy adult(aged 18-35 years)soccer players were randomly assigned to one of 3 groups:the HI group performed 10 standing headers,the leg impact group performed 10 soccer ball trapping maneuvers over 10 min,and the control group did not participate in any soccer *** was collected before testing and 24 h afterward,and sEVs were isolated and characterized via nanoparticle tracking ***-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs,and candidate microRNAs were analyzed via quantitative polymerase chain *** silico target prediction was performed using TargetScan(Version 7.0;***)and miRWalk(http://***/)programs,and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney(HEK)293T/17 ***:Plasma sEV concentration and size were not affected across time and group following repetitive HI *** 24 h,the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p,miR-423-5p,and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p,miR-144-5p,miR-221-5p,and *** of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA *** our knowledge,miR-7844-5p is a previously unknown *** identified 8 miR-7844-5p mRNA targets:protein phosphatase 1 regulatory inhibitor subunit 1B(PPP1R1B),LIM and senescent cell antigen-like domains 1(LIMS1),au

关键词： Biomarker Concussion MicroRNA Repetitive head impact exposure Soccer heading

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry

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International journal of Ophthalmology(English edition) 2010年第2期3卷 104-111页

作者： john j Harding Nuffield Laboratory of Ophthalmology University of OxfordJohn Radcliffe HospitalHeadingtonOxfordUK

AIMTo attempt to identify the primary targets of carbamylation in bovine lenses incubated under physiological condition.

关键词： carbamylation cyanate cataract identification lens mass spectrometry post-translational modification ξ-crystallin

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Field observations of putative bone-based fluorescence in a gecko

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Current Zoology 2018年第3期64卷 319-320页

作者： john j, SLOGGETT Maastricht Science Programme Maastricht University P.O. Box 616 6200 MD Maastricht The Netherlands

A diversity of animals are biofluorescent, absorbing shortwavelength electromagnetic radiation, and re-emitting it at longer wavelengths, giving a distinctive pattern （Lagorio et al. 2015）. Among terrestrial organisms, biofluorescence has been commonly recorded in arthropods, but rarely from vertebrates （Lagorio et al. 2015）. It has long been known from parrots （Hausmann et al. 2003） and has recently been recorded from a frog （Taboada et al. 2017） and from chameleons （Chamaeleonidae： Protzel et al. 2018）.

关键词： biofluorescence bone Chondrodactylus bibronii Gekkonidae signaling Squarnata

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Apoptosis and DNA damage in human spermatozoa

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Asian journal of Andrology 2011年第1期13卷 36-42页

作者： R john Aitken Adam j Koppers ARC Centre of Excellence in Biotechnology and Development Priority Research Centre in Reproductive Science Discipline of Biological Sciences School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Department of Anatomy and Developmental Biology School of Biomedical Sciences Monash University Clayton VIC 3800 Australia

DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted preimplantation embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired spermiogenesis. We hypothesize that oxidative stress impedes spermiogenesis, resulting in the generation of spermatozoa with poorly remodelled chromatin. These defective cells have a tendency to default to an apeptotic pathway associated with motility loss, caspase activation, phosphatidylserine exteriorization and the activation of free radical generation by the mitochondria. The latter induces lipid peroxidation and oxidative DNA damage, which then leads to DNA fragmentation and cell death. The physical architecture of spermatozoa prevents any nucleases activated as a result of this apoptotic process from gaining access to the nuclear DNA and inducing its fragmentation. It is for this reason that a majority of the DNA damage encountered in human spermatozoa seems to be oxidative. Given the important role that oxidative stress seems to have in the etiology of DNA damage, there should be an important role for antioxidants in the treatment of this condition. If oxidative DNA damage in spermatozoa is providing a sensitive readout of systemic oxidative stress, the implications of these findings could stretch beyond our immediate goal of trying to minimize DNA damage in spermatozoa as a prelude to assisted conception therapy.

关键词： apoptosis DNA damage oxidative stress spermatozoa

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Particulate matter and metals partitioning in highway rainfall-runoff

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Frontiers of Environmental Science & Engineering 2010年第1期4卷 35-46页

作者： Gaoxiang YING john j.SANSALONE Environmental Engineering Sciences University of Florida108 Black HallGainesvilleFL 32611USA

This study investigated the particulate matter(PM)and metals in highway dry deposition and rainfallrunoff as a function of hydrologic transport and settling on an event *** were differentiated as mass-limited(ML)and flow-limited(FL).Results indicate that unique and separate suspended sediment concentration(SSC)relationships with turbidity occurred for ML and FL *** minutes of quiescent settling produced a single SSC-turbidity relationship for all *** events transport higher proportions of settleable and sediment PM while FL events transported relatively higher suspended *** batch clarification with one hour of settling,ML events had generally higher treatment efficiencies compared to FL events for the same settling *** dry deposition PM was hetero-disperse and coarse(d50 m=304µm).Results indicate that the acidic rainfall is not a significant contributor to metals in runoff but is capable of leaching metals from dry deposition PM into *** in retained runoff resulted in a particulate-bound predominance for most metals except Ca and *** the finer fraction of dry deposition PM(75µm).

关键词： stormwater particulate matter(PM) turbidity suspended sediment concentration(SSC) unit operations metals dry deposition acid rain

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Importance of Quaternary research to society

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Episodes 2008年第2期31卷 203-206页

作者： john j. Clague Cenlre for Natural Hazard Research Simon Fraser University Burnaby BC Canada V5A 1S6

The Quaternary Period, although only an instant in the 4.5 billion year expanse of geologic time, is disproportionately important because it is the interval during which humans evolved and because it includes the present. Events of the Quaternary are preserved in sediments, ice sheets, and landforms with a greater degree of completeness and temporal resolution than those of any earlier period of comparable length. Studies of these historical and environmental archives continue to provide the essential context that allows scientists to evaluate what is happening with Earth＇s climate today and to clarify our vulnerability to hazardous natural processes, for example earthquakes, tsunami, volcanic eruptions, floods, and landslides.

关键词：地质学科学研究第四纪地质年代

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Did natural fission of^(235)U in the earth lead to formation of the supercontinent Columbia?

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Geoscience Frontiers 2012年第4期3卷 369-374页

作者： john j.W.Rogers Department of Geological Sciences University of North Carolina at Chapel HillChapel HillNC 27599-3315USA

Steady decline in the percentage of 235U in terrestrial uranium made natural fission impos- sible after about 1.8 Ga. Fission before 1.8 Ga disturbed the lead isotope system at various places world- wide, such as Oklo, Gabon, and may have caused the first lead isotope paradox. Fission in areas of high uranium concentration may also have generated enough heat to localize sparse Archean and Paleoproter- ozoic UHT belts. The oldest widespread orogenic systems formed at approximately 2.0-1.8 Ga after fission stopped contributing to the earth＇s heat flow. These early orogenic systems partly created the supercontinent Columbia.

关键词： Natural fission Archean Paleoproterozoic Columbia supercontinent Tectonics

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Hyponatremia in cirrhosis:Pathophysiology and management

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World journal of Gastroenterology 2015年第11期21卷 3197-3205页

作者： Savio john Paul j Thuluvath Division of Gastroenterology Department of MedicineSUNY Upstate Medical University University of Maryland School of Medicine and Mercy Medical Center

Hyponatremia is frequently seen in patients with ascites secondary to advanced cirrhosis and portal *** development of ascites in patients with cirrhosis is *** hypertension and the associated systemic vasodilation lead to activation of the sodium-retaining neurohumoral mechanisms which include the renin-angiotensin-aldosterone system,sympathetic nervous system and antidiuretic hormone(ADH).The net effect is the avid retention of sodium and water to compensate for the low effective circulatory volume resulting in the development of *** not apparent in the early stages of cirrhosis,the progression of cirrhosis and ascites leads to impairment of the kidneys to eliminate solutefree *** leads to additional compensatory mechanisms including non-osmotic secretion of ADH,also known as arginine vasopressin,further worsening excess water retention and thereby *** is associated with increased morbidity and mortality in patients with cirrhosis,and is an important prognostic marker both before and after liver *** management of hyponatremia in this setting is a challenge as conventional therapy for hyponatremia including fluid restriction and loop diuretics are frequently *** this review,we discuss the pathophysiology and various treatment modalities,including selective vasopressin receptor antagonists,for the management of hyponatremia in patients with cirrhosis.

关键词： Hyponatremia in cirrhosis Dilutional hypo-natremia

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A statistical study of the interdependence of solar wind parameters

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Chinese journal of Astronomy and Astrophysics 2009年第4期9卷 485-493页

作者： Shollykutty john P. j. Kurian Department of Physics St Joseph’s CollegeAlappuzha.Kerala-688012 India Physics Research Centre St.Berchmans’ CollegeChanganacherry Kerala-686101 India

Correlation analysis of solar wind parameters, namely solar wind velocity, proton density, proton temperature and mean interplanetary magnetic field （IMF） from the ACE spacecraft data near Earth, was done. To our best knowledge, this study is a novel one since we consider here only the parameters inside the solar wind, including the mean IMF and, hence, the solar wind is a self consistent system. We have proposed a Multiple Linear Regression （MLR） model for the prediction of the response variable （solar wind velocity） using the parameters proton density, proton temperature and mean IMF measured as daily averages. About 60% of the observed value can be predicted using this model. It is shown that, in general, the correlation between solar wind parameters is significant. A deviation from the prediction at the solar maximum is interpreted. These results are verified by a graphical method.

关键词： solar wind-statistical model-correlation-solar wind parameters

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