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Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic ***

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j.urnal of Animal Science and Biotechnology 2017年第1期8卷 143-153页

作者： j.e Cheol Kim Bruce P. Mullan john L. Black Robert j. E. Hewitt Robert j. van Barneveld john R. Pluske School of Veterinary and Life Sciences Murdoch University Murdoch WA 6150 Australia Department of Agriculture and Food Pork Innovation South Perth WA 6151 Australia john L Black Consulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia Barneveld Nutrition Pry Ltd Loganholme QLD 4129 Australia

Background： This experiment was conducted to test the hypothesis that vitamin E（Vit E） and acetylsalicylic acid（ASA）, a cyclooxygenase-2（COX-2） inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2（PGE_2） and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. ***： The experiment was conducted in a research facility with 192 individually-housed male weaner pigs（Landrace × Large White） weighing 6.6 ± 0.04 kg（mean ± SEM）. The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation（50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate）.Results： Acetylsalicylic acid supplementation improved average daily gain（P 〈 0.05） and tended to improve feed：gain ratio（P 〈 0.10） during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved（P 〈 0.001） amino acid utilization efficiency（as assessed by plasma urea level） and tended to decrease（P 〈 0.10） PGE2 production in the liver without affecting smal intestinal histology and tight j.nction protein mR NA expression in the j.j.nal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration（P 〈 0.001） and plasma haptoglobin content（P 〈 0.001） after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned ***： Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli.

关键词： Acetylsalicylic acid E.coli infection PGE_2 Vitamin E Weaner pigs

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Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.S.Viana A.j.S.Fernandes A.j.Fielding R.A.Videira M.C.Oliveira CQ-VR and Chemistry Department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （<15 nm）.In parallel,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NMR XPS Hydrophilic carbon Paramagnetic

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Inferior outcomes of liver transplantation for hepatocellular carcinoma during early-COVID-19 pandemic in the United States

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World j.urnal of Hepatology 2023年第4期15卷 554-563页

作者： Inkyu S Lee Kenj. Okumura Ryosuke Misawa Hiroshi Sogawa Gregory veillette Devon john Thomas Diflo Seigo Nishida Abhay Dhand Department of Surgery Westchester Medical CenterValhallaNY 10595United States Department of Medicine Westchester Medical CenterValhallaNY 10595United States

BACKGROUND Early in the coronavirus disease 2019(COVID-19)pandemic,there was a significant impact on routine medical care in the United States,including in fields of transplantation and *** To analyze the impact and outcomes of early COVID-19 pandemic on liver transplantation(LT)for hepatocellular carcinoma(HCC)in the United *** WHO declared COVID-19 as a pandemic on March 11,*** retrospectively analyzed data from the United Network for Organ Sharing(UNOS)database regarding adult LT with confirmed HCC on explant in 2019 and *** defined pre-COVID period from March 11 to September 11,2019,and early-COVID period as from March 11 to September 11,*** Overall,23.5%fewer LT for HCC were performed during the COVID period(518 vs 675,Pj.ly *** LT recipients for HCC,concurrent diagnosis of non-alcoholic steatohepatitis significantly increased(23 vs 16%)and alcoholic liver disease(ALD)significantly decreased(18 vs 22%)during the COVID *** age,gender,BMI,and MELD score were statistically similar between two groups,while waiting list time decreased during the COVID period(279 days vs 300 days,P=0.041).Among pathological characteristics of HCC,vascular invasion was more prominent during COVID period(P<0.01),while other features were the *** the donor age and other characteristics remained same,the distance between donor and recipient hospitals was significantly increased(P<0.01)and donor risk index was significantly higher(1.68 vs 1.59,P<0.01)during COVID *** outcomes,90-day overall and graft survival were the same,but 180-day overall and graft were significantly inferior during COVID period(94.7 vs 97.0%,P=0.048).On multivariable Coxhazard regression analysis,COVID period emerged as a significant risk factor of post-transplant mortality(Hazard ratio 1.85;95%CI:1.28-2.68,P=0.001).CONCLUSION Durin

关键词： Liver transplantation Hepatocellular carcinoma COVID-19 Mortality Graft failure United Network for Organ Sharing database

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识别液态和固态水的四波段水指数及其在咸海流域的应用

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中国科学：地球科学 2024年第3期54卷 788-807页

作者：岳兵陈曦李赛博杜正平 john WILSON 杨筠慧焦毅蒙黄双燕周成虎中国科学院新疆生态与地理研究所乌鲁木齐830011 中国科学院大学资源与环境学院北京100049 中国科学院地理科学与资源研究所北京100101 Spatial Sciences Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km... 详细信息

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km^(2)到2百万km^(2)不等.因此,我们首先界定咸海流域、锡尔河和阿姆河流域以及它们的上、中、下游的边界,然后提出可识别液态水和固态水的四波段指数(ILSW),以解决传统水指数的误别偏差问题.ILSW基于绿色、红色、近红外和热红外波段反射值,是归一化差异水指数(NDWI)和地表温度(LST)的合成.验证结果显示,ILSW水指数在咸海流域的准确性远远超过其他指数.研究结果表明,南咸海的水域面积平均每年缩小963km^(2),而北咸海几乎没有变化;由于气候变暖,咸海流域上游常年冰雪面积有大幅度退缩趋势,阿姆河上游和锡尔河上游常年冰雪的退缩速率分别为年均6233和384km^(2)/a.气候变化和人类活动引起了严重的水亏问题.自20世纪90年代以来,水亏呈增长趋势,平均每年增长3.778亿m^(3).2011~2020年期间,整个咸海流域平均总水亏量为76.967亿m^(3),而锡尔河流域上游(咸海流域的一个组成部分)水盈余量为25.461亿m^(3).研究结果对制定咸海流域可持续发展战略具有重要意义.

关键词：咸海流域锡尔河流域阿姆河流域水指数水面积覆盖水亏缺气候变化

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Continued development of azithromycin as a neuroprotective therapeutic for the treatment of spinal cord inj.ry and other neurological conditions

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Neural Regeneration Research 2021年第3期16卷 508-509页

作者： Timothy j.Kopper john C.Gensel Spinal Cord and Brain Inj.ry Research Center Department of PhysiologyUniversity of KentuckyLexingtonKYUSA

Spinal cord inj.ry(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain *** these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after SCI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary inj.ry pathways.

关键词： protective inj.ry therapeutic

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Neurochemistry as a bridge between morphology and behavior： Perspectives on aggression in insects

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Current Zoology 2014年第6期60卷 778-790页

作者： Andrew N. BUBAK j.ime L. GRACE Michael j. WATT Kenneth j. RENNER john G. SWALLOW Neuroscience Program University of Colorado-Denver Anschutz Medical Campus Aurora CO 80045 USA Department of Integrative Biology University of Colorado-Denver Denver CO 80217-3364 USA Center for Brain and Behavior Research Basic Biomedical Sciences University of South Dakota Vermillion SD 57069 USA Department of Biology University of South Dakota Vermillion SD 57069 USA

Aggression is a common behavioral trait shared in many animals, including both vertebrates and invertebrates. However, the type and intensity of agonistic encounters and displays can vary widely both across and within species, resulting in complicated or subj.ctive interpretations that create difficulties in developing theoretical models that can be widely applied. The need to easily and obj.ctively identify quantifiable behaviors and their associated morphologies becomes especially important when attempting to decipher the neurological mechanisms underlying this complex behavior. Monoamines, neuropeptides, and pheromones have been implicated as important neuromodulators for agonistic displays in both invertebrates and vertebrates. Ad- ditionally, recent breakthroughs in insect research have revealed exciting proximate mechanisms important in aggression that may be broadly relevant, due to the relatively high conservation of these neurochemical systems across animal taxa. In this review, we present the latest research demonstrating the importance of monoamines, neuropeptides, and pheromones as neuromodulators for aggression across a variety of insect species. Additionally, we describe the stalk-eyed fly as a model system for studying aggres- sion, which integrates physiological, morphological, and neurochemical approaches in exploring detailed mechanisms responsible for this common yet complex behavior. We conclude with our perspective on the most promising lines of future research aimed at understanding the proximate and ultimate mechanisms underlying aggressive behaviors .

关键词： Monoamines Aggression Insects Evolutionary physiology Sexual Selection

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Cellular modelling using P systems and process algebra

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Progress in Natural Science:Materials International 2007年第4期17卷 375-383页

作者： Francisco j. Romero-Campero Marian Gheorghe Gabriel Ciobanu john M. Auld Mario j. Pérez-j.ménez Research Group on Natural Computing Department of Computer Science and Artificial IntelligenceUniversity of SevilleAvda.Reina Mercedes41012 SevillaSpain Department of Computer Science The University of Sheffield Regent CourtPortobello StreetSheffield S1 4DPUK Romanian Academy Institute of Computer ScienceBlvd. Carol I nr. 11700505IasiRomania

In this paper various molecular chemical interactions are modelled under different computational paradigms. P systems andπ-calculus are used to describe intra-cellular reactions like protein-protein interactions and ... 详细信息

关键词： cellular modelling P systems process algebra.

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A Characteristic Non-Reflecting Boundary Treatment in Lattice Boltzmann Method

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Chinese Physics Letters 2008年第6期25卷 1964-1967页

作者： KIM Dehee KIM Hyung Min j.ON Myung S VINAY Ⅲ Stephen j. BUCHANAN john Department of Chemical Engineering Carnegie Mellon University 5000 Forbes Ave Pittsburgh PA 15213 USA Division of Mechanical System Design Engineering Kyonggi University Suwon Kyonggi-do Korea Bechtel Bettis Inc West Mifflin PA 15122 USA

In lattice Boltzmann methods, disturbances develop at the initial stages of the simulation, the decay characteristics depend mainly on boundary treatment methods; open boundary conditions such as equilibrium and bounce-back schemes potentially generate uncontrollable disturbances. Excessive disturbances originate from non-physical reflecting waves at boundaries. Characteristic boundary conditions utilizing the signs of waves at boundaries which suppress these reflecting waves, as well as their implementation in the lattice Boltzmann method, are introduced herein. The performance of our novel boundary treatment method to effectively suppress excessive disturbances is verified by three different numerical experiments.

关键词： HYPERBOLIC SYSTEMS EQUATION FLOWS

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An improved culturing method for opiine fruit fly parasitoids and its application to parasitoid monitoring in the field

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Insect Science 2018年第1期25卷 99-108页

作者： Ayad Masry Michael j. Furlong Anthony R. Clarke john Paul Cunningham School of Earth Environmental and Biological Sciences School Queensland University of Technology (QUT) Brisbane Queensland Australia School of Biological Sciences the University of Queensland St Lucia Queensland Australia plant Biosecurity Cooperative Research Centre Bruce ACT Australia Department of Economic Development Jobs Transport and Resources AgriBio Centre La Trobe University Bundoora Victoria Australia

Good culturing methods play an important role in the study of insect behavior and its application to pest management. Here, we describe and validate a new method for rearing the parasitoid wasp, Diachasmirnorpha kraussii, which attacks some of the world＇s worst fruit fly pests and is an internationally used biological control agent. Our method differs from standard culturing approaches by presenting adult wasps with host- infested artificial media within a ＂culturing bag,＂ which mimics a natural （fruit） oviposition substrate. In laboratory trials using wild collected D. kraussii, the culturing bag method was compared to the use of host-infested nectarines, and a commonly used laboratory method of presenting host-infested artificial media within Petri dishes. The culturing bag method proved to be a significant improvement on both methods, combining the advantages of high host survival in artificial media with parasitism levels that were the equivalent to those recorded using host-infested fruits. In our field study, culturing bags infested with the Queensland fruit fly, Bactrocera tryoni, and hung in a mixed peach and nectarine orchard proved to be effective ＂artificial fruits＂ attracting wild D. kraussii for oviposition. Significantly more adult wasps were reared from the culturing bags compared to field collected fruits. This was shown to be due to higher fruit fly larval density in the bags, as similar percentage parasitism rates were found between the culturing bags and ripe fruits. We discuss how this cheap, time-efficient method could be applied to collecting and monitoring wild D. kraussii populations in orchards, and assist in maintaining genetic variability in parasitoid laboratory cultures.

关键词： Bactrocera biological control fruit fly mass rearing natural enemies Tephritidae wasp

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On localization with robust power control for safety critical wireless sensor networks

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控制理论与应用（英文版） 2011年第1期9卷 83-92页

作者： Michael j. WALSH Anthony FEE john BARTON Brendan O'FLYNN Martin j. HAYES Cian O'MATHUNA Clarity Center for Web Technologies Microsystems Centre-Tyndall National Institute Lee MaltingsUniversity College CorkCorkIreland Wireless Access Research Center University of LimerickLimerickIreland

A hybrid methodology is proposed for use in low power, safety critical wireless sensor network applications, where quality-of-service orientated transceiver output power control is required to operate in parallel with radio frequency-based localization. The practical implementation is framed in an experimental procedure designed to track a moving agent in a realistic indoor environment. An adaptive time synchronized approach is employed to ensure the positioning technique can operate effectively in the presence of dataloss and where the transmitter output power of the mobile agent is varying due to power control. A deterministic multilateration-based positioning approach is adopted and accuracy is improved by filtering signal strength measurements overtime to account for multipath fading. The location estimate is arrived at by employing least-squares estimation. Power control is implemented at two separate levels in the network topology. First, power control is applied to the uplink between the tracking reference nodes and the centralized access point. A number of algorithms are implemented highlighting the advantage associated with using additional feedback bandwidth, where available, and also the need for effective time delay compensation. The second layer of power control is implemented on the uplink between the mobile agent and the access point and here quantifiable improvements in quality of service and energy efficiency are observed. The hybrid paradigm is extensively tested experimentally on a fully compliant 802.15.4 testbed, where mobility is considered in the problem formulation using a team of fully autonomous robots.

关键词： Wireless sensor network Power control Localization

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