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Kety创立了脑血流测定方法

中国卒中杂志 2019年第3期14卷 269-275页

作者：张和 Center for Neuroscience Research (NIh P01) Loma Linda University Neurosurgery Research Program Loma Linda University Basic Sciences Department Loma Linda University Physiology Program Loma Linda University Department of Anatomy and Pathology Loma Linda University Medical Center

Seymour Solomon Kety(1915-2000)是美国神经精神科学家,美国科学院院士(图1)。他对神经精神科学有两大贡献:一是创立了脑血流测量的方法,改变了神经科学的进程,也推动了卒中医学的发展,促生了脑灌注、脑循环、再灌注和侧支循环等新概念... 详细信息

Seymour Solomon Kety(1915-2000)是美国神经精神科学家,美国科学院院士(图1)。他对神经精神科学有两大贡献:一是创立了脑血流测量的方法,改变了神经科学的进程,也推动了卒中医学的发展,促生了脑灌注、脑循环、再灌注和侧支循环等新概念,帮助卒中诊断,指导卒中治疗。二是将基础科学应用于“精神疾病”的研究,改变了现代精神医学的发展方向,尤其是把遗传基因因素引入“精神分裂症”的病理生理研究。

关键词：脑血流铅中毒精神医学基因

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饮酒与卒中发生的乐与悲

中国卒中杂志 2020年第3期15卷 300-307页

作者：张和 Center for Neuroscience Research 11041 Campus Street Risley Hall Room 223 Loma Linda University

酒对健康是好是坏,是喜是悲的争论,大概从有了酒的那一天就开始了。中国人对酒的认识可谓高瞻远瞩又入木三分。明朝龚廷贤在《摄养诗》中写道:“惜气存精更养神,少思寡欲勿劳心。食惟半饱无兼味,酒止三分莫过频。每把戏言多取笑,常含乐... 详细信息

酒对健康是好是坏,是喜是悲的争论,大概从有了酒的那一天就开始了。中国人对酒的认识可谓高瞻远瞩又入木三分。明朝龚廷贤在《摄养诗》中写道:“惜气存精更养神,少思寡欲勿劳心。食惟半饱无兼味,酒止三分莫过频。每把戏言多取笑,常含乐意莫生嗔。炎凉变诈都休问,任我逍遥过百春。”

关键词：酒精脑出血缺血性卒中风险

卒中茶后——john hunter开创了动脉瘤结扎手术

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中国卒中杂志 2019年第2期14卷 156-163页

作者：张和 Center for Neuroscience Research (NIh P01) Loma Linda University Loma Linda University Full Professor in Physiology and Pharmacology Full Professor in NeurosurgeryDirector of Neurosurgery Research Program Basic Sciences Department Loma Linda University Loma Linda University the Department of Anatomy and Pathology Loma Linda University Medical Center

john hunter(1728-1793,图1)是十八世纪著名的苏格兰外科医师和解剖学家。john hunter对血管外科治疗动脉瘤的研究做出了三大贡献:一是研究了动脉瘤形成的病理,认为是血管壁病变导致动脉瘤;二是用动物实验证明了血管结扎后侧支循环形成... 详细信息

john hunter(1728-1793,图1)是十八世纪著名的苏格兰外科医师和解剖学家。john hunter对血管外科治疗动脉瘤的研究做出了三大贡献:一是研究了动脉瘤形成的病理,认为是血管壁病变导致动脉瘤;二是用动物实验证明了血管结扎后侧支循环形成,可能保持组织功能;三是创立了血管结扎手术治疗各种动脉瘤。他的动脉瘤理论为后来结扎颈动脉治疗颅内动脉瘤的手术打下了基础。从古希腊到十八世纪的英国,医学尚无麻醉和无菌操作的概念。

关键词：动脉瘤血管外科解剖手术

Cyclophilin A Signaling Induces Pericyte-associated Blood-Brain Barrier Disruption After Subarachnoid hemorrhage

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Cyclophilin A Signaling Induces Pericyte-associated Blood-Br...

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PhB2/OPA1 pathway after subarachnoid hemorrhage in rats

中国生理学会基质生物学专业委员会第二次全国基质生物学学术会议

作者： Pengyu Pan hengli Zhao Xuan zhang Qiang Li Jie Qu Shilun Zuo Fan Yang john h.zhang haiyang he Xin Liu hua Feng 陈渝杰 Department of Neurosurgery Southwest HospitalThird Military Medical University Department of Pathophysiology and high Altitude Pathology College of High Altitude Military MedicineThird Military Medical University Neuroscience Research Center Loma Linda University Institute of Immunology Third Military Medical University 第三军医大学

Within vascular neural network,blood-brain barrier damage contributes to vasogenic brain edema,which is one of the most common pathophysiological changes after SAh and has become a focus of interest in the development of novel therapeutic strategies for SAh ***,the potential roles of pericytes in maintaining the integrity of the blood-brain barrier following SAh and the exact mechanisms of this process,which would be helpful for the development of therapeutic strategies,remain *** the present study,we sought to provide evidence on the potential role of pericytes in blood-brain barrier disruption and the possible involvement and mechanism of CypA signaling in both cultured primary pericytes and SAh *** hundred and ninety-four(394) adult male C57 B6 J mice weighing 22 to 30 g,30 CypA knockout(CypA-/-) mice,and 30 male neonatal C57 B6 J mice were used to investigate the time course of CypA expression in pericytes after SAh,the intrinsic function and mechanism of CypA in the pericytes,and whether the known receptor CD147 mediates the effects of *** data demonstrated that both intracellular CypA and CypA secretion increased after SAh and could activate its receptor CD147 and the downstream NF-κB inflammatory pathway to induce MMP-9 expression and proteolytic functions for the degradation of endothelium tight junction proteins and basal *** served as an autocrine or a paracrine ligand for its receptor,*** CypA could be endocytosed by pericytes,the specific endocytosis inhibitor chlorpromazine did not have an effect on MMP-9 activation following blood-brain barrier ***,the specific knockdown of CD 147 could reverse the harmful effects of CypA expression in the pericytes on the blood-brain barrier integrity after *** study demonstrated for the first time that CypA is elevated in the pericytes of the brain after SAh,and extraneous recombinant CypA damages the blood-brain barrier and diminishes the ne

关键词： Subarachnoid hemorrhage pericyte Cyclophilin A Blood-Brain Barrier endocytosis CD147

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Mitoquinone attenuates blood-brain barrier disruption throug...

Oh+hCl→Cl+h_(2)O反应中的反应物转动激发效应

第十四届中国医师协会神经外科医师年会

作者： Tongyu zhang Pei Wu Keren Zhou Lingyun Wu Zhiyi Xie Weilin Xu Xu Luo Peng Li Umut Ocak Pinar Eser Ocak Zachary D.Travis Jiping Tang huaizhang Shi john h.zhang Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Department of Physiology and Pharmacology Loma Linda University Department of Earth and Biological Sciences Loma Linda University

Background and Purpose— Mitochondrial dysfunction is involved in the mechanism of early brain injury（EBI） following subarachnoid hemorrhage（SAh）. Blood-brain barrier disruption is a devastating outcome in the early stage of SAh. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone（MitoQ） in blood-brain barrier disruption after SAh in rats. Methods— A total of 181 male Sprague–Dawley SAh rats with the endovascular perforation model were utilized. Intraperitoneal MitoQ was given 1 hour（h） post-SAh. Cerebroventricular ML385, an inhibitor of NF-E2-related factor 2（Nrf2） and Small interfering ribonucleic acid（siRNA） for Prohibitin 2（PhB2） were injected respectively 24 h and 48 h before SAh. Neurological function evaluation was performed before sacrifice. SAh grade was measured during the sacrifice of each animal. Brain water content was performed at 24 h. Coimmunoprecipitation was used to demonstrate the relationship of proteins Nrf2 and PhB2. Mitochondrial and cytoplasmic fractions were gathered using mitochondria isolation kits. Pathway related proteins were investigated with Western blot and immunofluorescence staining. Transmission electron microscopy was performed for mitochondrial morphology. Results— Expression of Nrf2 levels peaked at the 3 h time point following SAh and then decreased to normal levels at 24 h, while PhB2 and Optic Atrophy 1（OPA1） decreased at 24 h and 72 h after SAh compared with the Sham group. MitoQ treatment attenuated neurological deficits and brain edema, thereby resulting in a decreased expression of Albumin, while an increase of Nrf2, PhB2, OPA1 and Claudin-5 proteins compared with SAh+vehicle group. With co-immunoprecipitation, Nrf2 and PhB2 were further demonstrated to show their interaction. And MitoQ administration lead to more binding of the two proteins. ML385 abolished the effects of MitoQ on neurobehavior and protein levels post-SAh. Similarly, PhB2 siRNA reversed the neuroprotection of MitoQ

关键词： Mitoquinone NF-E2-related factor 2 Prohibitin 2 Optic Atrophy 1 Blood-brain barrier disruption Subarachnoid hemorrhage

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Chinese Journal of Chemical Physics 2024年第2期37卷 211-220,I0102页

作者：徐昕陈俊刘舒张东辉中国科学院大连化学物理研究所分子反应动力学国家重点实验室大连116023 中国科学院大学北京100049 中国科学院福建物质结构研究所结构化学国家重点实验室福州350002

本文在最近构建的F12a势能面上,对Oh+hCl→Cl+h_(2)O的一系列反应物转动激发态进行了势能平均的五维含时波包计算,得到了初始态选择的反应几率和速率常数。研究发现,除了很低碰撞能量,单独激发反应物hCl到j_(1)=2或者Oh到j_(2)=1得到了... 详细信息

本文在最近构建的F12a势能面上,对Oh+hCl→Cl+h_(2)O的一系列反应物转动激发态进行了势能平均的五维含时波包计算,得到了初始态选择的反应几率和速率常数。研究发现,除了很低碰撞能量,单独激发反应物hCl到j_(1)=2或者Oh到j_(2)=1得到了总反应几率的最大值.在低能区域,随着Oh转动激发的增加,反应几率的共振增强迅速减小,导致250K以下的速率常数迅速下降hCl和Oh同时转动激发的速率常数不是单独激发结果的简单叠加。最后,通过对(5,5)态以下初始转动态的速率常数进行玻尔兹曼平均,得到了反应的热速率常数,与实验结果基本吻合。

关键词：反应物转动激发含时波包反应几率 Feshbach共振速率常数

Stable hydrogen isoscape in precipitation generated using data fusion for East China

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Science China Earth Sciences 2024年第9期67卷 2972-2988页

作者： Jiacheng ChEN Jie ChEN Xunchang john zhang Peiyi PENG State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China hubei Key Laboratory of Water System Science for Sponge City Construction Wuhan UniversityWuhan 430072China USDA-ARS Oklahoma and Central Plains Agricultural Research Center El Reno OK 73036USA Southwest Research Institute for hydraulic and Water Transport Engineering Chongqing Jiaotong UniversityChongqing 400016China

The stable hydrogen isotope in precipitation is an effective environmental tracer for climatic and hydrologic ***,accurate and high-precision precipitation hydrogen isoscapes are currently unavailable in *** this study,a data fusion method based on Convolutional Neural Networks(CNN)is used to fuse the hydrogen isotopic composition(δ^(2)h_(p))of observations and isotope-equipped general circulation model(iGCM)simulations.A precipitation hydrogen isoscape with a temporal resolution of monthly and a spatial resolution of 50-60 km is established for East China for the 1969-2017 *** to building the isoscape,the performance of three data fusion methods(DFMs)and two bias correction methods(BCMs)is *** results indicate that the CNN fusion method performs the best with a correlation coefficient larger than 0.90 and root mean square error smaller than 10.5‰ when using observation as a *** fusion methods based on back propagation and long short-term memory neural network perform similarly,while slightly outperforming the bias correction ***,the CNN method is used to generate the hydrogen isoscape,and the temporal and spatial distribution characteristics of the hydrogen isotope in precipitation are analyzed based on this *** generated isoscape shows similar spatial and temporal distribution characteristics to *** general,the distribution pattern of δ^(2)h_(p) is consistent with the temperature effect in northern China,and consistent with the precipitation amount effect in southern *** trend of the δ^(2)h_(p) time series is consistent with that of observed precipitation and ***,the generated isoscape effectively reproduces the observations,and has the characteristics of time continuity and relative spatial regularity,which can provide valuable data support for tracking atmospheric and hydrological processes.

关键词： Precipitation Precipitation isotope General circulation model Data fusion Dataset

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Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li Danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni h.Yucel Sonya A.MacParland haibo zhang john W.Semple john Freedman Qizhen Shi heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. however, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

The inauguration of the English issue of the Chinese Neurosurgical Journal

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Chinese Neurosurgical Journal 2015年第1期1卷 -页

作者： Sheng Chen Brandon J.Dixon john h.zhang Department of Neurosurgery Second Affiliated Hospital Zhejiang UniversitySchool of Medicine Hangzhou China Department of Physiology Loma Linda University School of Medicine Loma Linda CA USA Department of Physiology Loma Linda University School of Medicine Loma Linda CA USADepartment of Anesthesiology Neurosurgery and Physiology Loma Linda University School of Medicine Loma Linda CA USA

Editorial Almost a hundred years has passed since neurosurgery became an official surgical specialty of *** from the field of general surgery, the founders of modern neurosurgery were able to progress the field despite having rudimentary methods of anesthesia, electrocautery, understanding of post-operative hematomas, and ways to monitor intracranial pressure.

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