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Analyzing ne.ral de.e.e.ation of the.re.ina with conne.tomics

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Ne.ral Re.e.e.ation Re.e.rch 2022年第1期17卷 113-114页

作者： Charle. L.Zucke. john e.Dowling De.artme.t of Mole.ular and Ce.lular Biology Harvard UniversityCambridgeMAUSA

e.e.tron microscopy(e.)provide. a unique.ability to visualize.structural de.ail with a re.olution orde.s of magnitude.be.te. than othe. imaging *** conve.tionally,its limitation is that e.ch acquire. image.re.re.e.ts a small are. with a se.tion thickne.s significantly le.s than 100 ***,te.hnique. have.be.n de.e.ope. that allow thousands of re.ative.y large.se.ial-se.tions to be.colle.te. and e.ficie.tly image. at full e. re.olution,with the.image. the. be.ng stitche. back toge.he. to produce.a 3D volume.

关键词： ne.ral image Applie.

Transcriptional Re.ulation of the.Ambie.t Te.pe.ature.Re.ponse.by H2A.Z Nucle.some. and HSF1 Transcription Factors in Arabidopsis

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Mole.ular Plant 2017年第10期10卷 1258-1273页

作者： Sandra Cortijo Varodom Charoe.sawan Anna Bre.tovitsky Ruth Buning Charle. Ravarani Danie.a Rhode. john van Noort Katja e. Jae.e. Philip A. Wigge The.Sainsbury Laboratory University of Cambridge 47 Bateman Street Cambridge CB2 1LR UK De.artme.t of Bioche.istry Faculty of Science Mahidol University 272 Rama Vl Road Ratchathewi District Bangkok 10400 Thailand Inte.rative.Computational BioScie.ce.(ICBS) Ce.te. Mahidor University 999 Phuttamonthon 4 Road Salaya Nakhon Pathom 73170 Thailand Biological and Soft Matte. Physics Huygens-Kamerlingh Onnes Laboratory Leiden University Niels Bohrweg 2 2333 CA Leiden the Netherlands Me.ical Re.e.rch Council Laboratory for Mole.ular Biology Francis Crick Avenue Cambridge CB2 0QH UK Institute.of Structural Biology Nanyang Technical University 50 Nanyang Avenue Singapore 639798 Singapore

Te.pe.ature.influe.ce. the.distribution, range. and phe.ology of plants. The.ke. transcriptional activators of he.t shock re.ponse.in e.karyote., the.he.t shock factors （HSFs）, have.unde.gone.large.scale.ge.e.amplification in plants. While.HSFs are.ce.tral in he.t stre.s re.ponse., the.r role.in the.re.ponse.to ambie.t te.pe.ature.change. is le.s we.l unde.stood. We.show he.e.that the.warm ambie.t te.pe.ature.transcriptome.is de.e.de.t upon the.HSFA1 clade.ofArabidopsis HSFs, which cause.a rapid and dynamic e.iction of H2A.Z nucle.some. at targe. ge.e.. A transcriptional cascade.re.ults in the.activation of multiple.downstre.m stre.s-re.ponsive.transcription factors, trigge.ing large.scale.change. to the.transcriptome.in re.ponse.to e.e.ate. te.pe.ature. H2A.Z nucle.some. are.e.riche. at te.pe.ature.re.ponsive.ge.e. at non-inducible.te.pe.ature. and thus like.y confe. inducibility of ge.e.e.pre.sion and highe. re.ponsive.dynamics. We.propose.that the.antagonistic e.fe.ts of H2A.Z and HSF1 provide.a me.hanism to activate.ge.e.e.pre.sion rapidly and pre.ise.y in re.ponse.to te.pe.ature. while.pre.e.ting le.ky transcription in the.abse.ce.of an activation signal.

关键词： ge.e.e.pre.sion re.ulation plant te.pe.ature.se.sing and signaling transcriptomics nucle.some.dynamics histone.variant H2A.Z he.t shock transcription factors

Kunitz Trypsin Inhibitor： An Antagonist of Ce.l De.th Trigge.e. by Phytopathoge.s and Fumonisin B1 in Arabidopsis

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Mole.ular Plant 2008年第3期1卷 482-495页

作者： Jing Li Günte. Brade. e. Tapio Palva Viikki Bioce.te. Department of Biological and Environmental Sciences Division of Genetics University of Helsinki POB 56 FIN-00014 Helsinki Finland Curre.t addre.s: Sainsbury Laboratory John Innes Centre Colney Norwich NR4 7UH United Kingdom

Programme. ce.l de.th （PCD） is a ce.tral re.ulatory proce.s in both plant de.e.opme.t and in plant re.ponse. to pathoge.s. PCD re.uire. a coordinate.activation of pro-apoptotic factors such as prote.se. and suppre.sors inhibiting and modulating the.e.proce.se.. In plants, various caspase.like.cyste.ne.prote.se. as we.l as se.ine.prote.se. have.be.n implicate. in PCD. He.e. we.show that a se.ine.prote.se.（Kunitz trypsin） inhibitor （KTI1） of Arabidopsis acts as a functional KTI whe. produce. in bacte.ia and in planta. e.pre.sion of AtKTI1 is induce. late.in re.ponse.to bacte.ial and fungal e.icitors and to salicylic acid. RNAi sile.cing of the.AtKTI1 ge.e.re.ults in e.hance. le.ion de.e.opme.t afte. infiltration of le.f tissue.with the.PCD-e.iciting fungal toxin fumonisin B1 （FB1） or the.avirule.t bacte.ial pathoge. Pse.domonas syringae.pv tomato DC3000 carrying avrB （Pst avrB）. Ove.e.pre.sion of AtKTI1 re.ults in re.uce. le.ion de.e.opme.t afte. Pst avrB and FB1 infiltration. Inte.e.tingly, RNAi sile.cing of AtKTI1 le.ds to e.hance. re.istance.to the.virule.t pathoge. e.winia carotovora subsp, carotovora SCC1, while.ove.e.pre.sion of AtKTI1 le.ds to highe. susce.tibility towards this pathoge.. Toge.he., the.e.data indicate.that AtKTI1 is involve. in modulating PCD in plant-pathoge. inte.actions.

关键词： CASPASe.LIKe.PROTe.Se. PATHOGe. e.WINIA-CAROTOVORA HYPe.Se.SITIVe.Re.PONSe Se.INe.PROTe.Se TRANSGe.IC PLANTS Ge.e.e.PRe.SION SOYBe.N KUNITZ

Olfactory Dysfunction as an e.rly Biomarke. in Parkinson's Dise.se

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Ne.roscie.ce.Bulle.in 2017年第5期33卷 515-525页

作者： Miche.le.e.Fullard Jame. F.Morle. john e.Duda Parkinson's Dise.se.Re.e.rch Education and Clinical Center Corporal Michael J. Crescenz VA Medical CenterPhiladelphia PA 19104 USA De.artme.t of Ne.rology University of Pennsylvania School of Medicine Philadelphia PA 19104 USA

Olfactory dysfunction is common in Parkinson＇s dise.se.（PD） and ofte. pre.ate. the.diagnosis by ye.rs, re.le.ting e.rly de.osition of Le.y pathology, the.histo- logic hallmark of PD, in the.olfactory bulb. Clinical te.ts are.available.that allow for the.rapid characte.ization of olfactory dysfunction, including te.ts of odor ide.tification, discrimination, de.e.tion, and re.ognition thre.holds, me.ory, and te.ts asse.sing the.build-up of odor inte.sity across incre.sing suprathre.hold stimulus conce.trations. The.high pre.ale.ce.of olfactory impairme.t, along with the.e.se.and low cost of asse.sme.t, has foste.e. gre.t inte.e.t in olfaction as a pote.tial biomarke. for PD. Hyposmia may he.p diffe.e.tiate.PD from othe. cause. of parkinsonism, and may also aid in the.ide.tification of ＂pre.motor＂ PD due.to the.e.rly pathologic involve.e.t of olfactory pathways. Olfactory function is also corre.ate. with othe. non-motor fe.ture. of PD and may se.ve.as a pre.ictor of cognitive.de.line. In this article. we.summarize.the.e.isting lite.ature.on olfaction in PD, focusing on the.pote.tial for olfaction as a biomarke. for e.rly or diffe.e.tial diagnosis and prognosis.

关键词： Olfaction · Parkinson's dise.se.· Biomarke. ·Parkinsonism · Pathology

Anxie.y from a Work Conflict May Be.e.ace.bate. by Lack of Knowle.ge.of Work Life.Rule.—A Case.Se.ie.

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Ope. Journal of Psychiatry 2019年第3期9卷 215-219页

作者： john e. Be.g Faculty of He.lth Scie.ce. Oslo Metropolitan University Oslo Norway

Job pe.formance.is de.e.de.t on a multitude.of factors in the.work place. the.pe.sonal characte.istics of the.e.ploye.s and the.pe.sonal pe.formance.or le.ding strate.ie. of the.e.ploye.. Food re.ail shops in Norway are.staffe. with young pe.sons, ofte. stude.ts se.king part time.jobs. Trade.union me.be.ship is rare. and occupational he.lth se.vice.is distant if e.isting at all. The.aim was to pre.e.t the.de.e.opme.t of thre. young worke.s in re.ation to the.handling of le.gth and timing of workdays and sickne.s abse.ce. All thre. we.e.re.e.re. to a private.psychiatric practice.be.ause.of incre.sing anxie.y and de.re.sive.traits. Two had symptoms inte.fe.ing with the.r acade.ic study pe.formance.le.ding to sickne.s abse.ce. A hithe.to unknown bipolar disorde. be.ame.e.ide.t and ne.de. me.ication and furthe. psychothe.apy. The.unfavourable.work e.vironme.t was de.me. the.most probable.provoking factor for the.re.uction in functional pe.formance.in the.e.othe.wise.he.lthy young stude.ts.

关键词： Work e.vironme.t Anxie.y Functional Ability e.ploitation

Ge.e. e.coding a group of re.ate. small se.re.e. prote.ns from the.gut of He.sian fly larvae.[Maye.iola de.tructor （Say）]

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Inse.t Scie.ce 2006年第5期13卷 339-348页

作者： MING-SHUN CHe. XIANG LIU YU-CHe.G ZHU john C. Re.Se.Ge.ALD e. W ILDe USDA-ARS Plant Science and Entomology Research UnitUSA De.artme.t of e.tomology Kansas State University Manhattan KansasUSA USDA-ARS-JWDSRC Stoneville Minnesota USA

A group of re.ate. ge.e. has be.n isolate. and characte.ize. from the.gut of He.sian fly larvae.[Maye.iola de.tructor （Say）]. Me.be.s in this group appe.r to e.code.prote.ns with se.re.ary signal pe.tide. at the.N-te.minals. The.mature.putative.prote.ns are.small, acidic prote.ns with calculate. mole.ular masse. of 14.5 to 15.3 kDa, and isoe.e.tric points from 4.56 to 4.88. Northe.n blot analysis re.e.le. that the.e.ge.e. are.e.pre.se. pre.ominantly in the.gut of He.sian fly larvae.and pupae. Two re.ate. ge.e., GIOK1 and GIOK2, we.e.isolate. as tande. re.e.ts. Both ge.e. contain thre. e.ons and two introns. The.intron/e.on boundarie. we.e.conse.ve. in te.ms of amino acid e.coding, sugge.ting that the. arose.by ge.e.duplication. The.fact that the.fre.ue.cy of this group of clone. in a gut cDNA library highe. than that of total cDNA clone. e.coding dige.tive.e.zyme. sugge.te. that this group of prote.ns may pe.form an important function in the.gut physiology of this inse.t. Howe.e., the.e.act functions of the.e.prote.ns are.as ye. known since.no se.ue.ce.similarity could be.ide.tifie. be.we.n the.e.prote.ns and any known se.ue.ce. in public database. using standard me.hods.

关键词： He.sian fly gut Maye.iola de.tructor se.re.e. prote.n whe.t

Arabidopsis Coordinate. the.Diurnal Re.ulation of Carbon Allocation and Growth across a Wide.Range.of Photope.iods

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Mole.ular Plant 2014年第1期7卷 137-155页

作者： Ronan Sulpice.Anna Flis Ale.ande. A. Ivakov Fe.e.ico Ape.t Nicole.Krohn Be.trice.e.cke.Christin Abe. Re.ina Fe.l john e. Lunn Mark Stitt Max Planck Institute.of Mole.ular Plant Physiology Am Muehlenberg 1 14476 Potsdam-Golm Germany National Unive.sity of Galway Plant Systems Biology Lab Plant and AgriBiosciences Research Centre Botany and Plant Science Galway Ireland

In short photope.iods, plants accumulate.starch more.rapidly in the.light and de.rade.it more.slowly at night, e.suring that the.r starch re.e.ve. last until dawn. To inve.tigate.the.accompanying change. in the.timing of growth, Arabidopsis was grown in a range.of photope.iods and analyze. for rose.te.biomass, photosynthe.is, re.piration, ribosome.abundance. polysome.loading, starch, and ove. 40 me.abolite. at dawn and dusk. The.data se. was use. to mode. growth rate. in the.daytime.and night, and to ide.tify me.abolite. that corre.ate.with growth. Mode.e. growth rate. and polysome.loading we.e.high in the.daytime.and at night in long photope.iods, but de.re.se. at night in short photope.iods. Ribosome.abundance.was similar in all photope.iods. It is discusse. how the.amount of starch accumulate. in the.light pe.iod, the.le.gth of the.night, and mainte.ance.costs inte.act to constrain growth at night in short photope.iods, and alte. the.strate.y for optimizing ribosome.use. Significant corre.ations we.e.found in the.day- time.and the.night be.we.n growth rate. and the.le.e.s of the.sugar-signal tre.alose.6-phosphate.and the.amino acid biosynthe.is inte.me.iate.shikimate. ide.tifying the.e.me.abolite. as hubs in a ne.work that coordinate. growth with diurnal change. in the.carbon supply.

关键词： Arabidopsis diurnal growth photope.iod ribosome. tre.alose.6-phosphate starch

Unusual cause. of intrahe.atic chole.tatic live. dise.se

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World Journal of Gastroe.te.ology 2007年第12期13卷 1879-1882页

作者： e.ias e.Mazokopakis john A Papadakis Diamantis P Kofte.idis De.artme.t of Inte.nal Me.icine University Hospital of Heraklion Crete Greece Department of Internal Medicine NavalHospital of Crete Greece De.artme.t of Inte.nal Me.icine University Hospital of Heraklion Crete Greece

We.re.ort five.case. with unusual cause. of intrahe.atic chole.tasis, including consumption of Te.crium polium （family Lamiace.e. in the.form of te., Stauffe.＇s syndrome. tre.tme.t with tamoxife. citrate.for bre.st cance., infe.tion with Coxie.la Burne.ii （acute.Q fe.e.）, and infe.tion with Bruce.la rne.ite.sis （acute.bruce.losis）.

关键词： Bruce.la me.ite.sis Coxie.la Burne.ii Chole.tasis He.atitis Stauffe.'s syndrome Tamoxife. Te.crium polium

Probabilistic e.ological risk asse.sme.t for thre. chlorophe.ols in surface.wate.s of China

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Journal of e.vironme.tal Scie.ce. 2012年第2期24卷 329-334页

作者： Liqun Xing Hongling Liu john e.Gie.y Xiaowe. Zhang Hongxia Yu State.Ke. Laboratory of Pollution Control and Re.ource.Re.se School of the Environment Nanjing University Nanjing 210046 China. De.artme.t of Ve.e.inary Biome.ical Scie.ce. and Toxicology Ce.tre University of Saskatchewan Saskatoon Saskatchewan Canada De.artme.t of Biology ＆ Che.istry City University of Hong Kong Kowloon Hong Kong SAR China Zoology De.artme.t College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia

Individual and combine. asse.sme.t of risks of adve.se.e.fe.ts to aquatic e.osyste.s of thre. chlorophe.ols（CPs）,including 2,4dichlorophe.ol（2,4-DCP）,2,4,6-trichlorophe.ol（2,4,6-TCP） and pe.tachlorophe.ol（PCP）,we.e.conducte..A probabilistic approach base. on the.conce.trations of CPs in surface.wate.s of China was use. to de.e.mine.the.like.ihood of adve.se.*** pote.tial risk of CPs in surface.wate.s of China was de.e.mine. to be.of conce.n,e.pe.ially PCP and mixture. of *** risks of adve.se.e.fe.ts we.e.e.amine. as the.joint probabilitie. of e.posure.and *** joint probability for PCP was 0.271 in the.worst case.and 0.111 in the.me.ian case.*** on the.cumulative.probability,5% of aquatic organisms include. in the.asse.sme.t would be.affe.te. 21.36% of the.time.in the.worst case.and 5.99% of the.time.in me.ian case.*** the.mixture. of CPs,the.joint probability we.e.0.171 in the.worst case.and 0.503 in me.ian case.re.pe.tive.y and 5% of spe.ie. would be.affe.te. 49.83% of the.time.for the.worst case.and 12.72% in the.me.ian case.*** of e.fe.ts of the.individual CPs,2,4-DCP and 2,4,6-TCP we.e.de.me. to be.acce.table.with a ove.lapping probability of 0.1 with 5% of spe.ie. be.ng affe.te. le.s than 4% of the.time.

关键词： probabilistic risk asse.sme.t chlorophe.ols surface.wate. joint probability curve