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Immunothe.apy of gastric cance.:Pre.e.t status and future.pe.spe.tive.

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World Journal of Gastroe.te.ology 2024年第8期30卷 779-793页

作者： john K Triantafillidis Manousos M Konstadoulakis Apostolos e.Papalois Inflammatory Bowe. Dise.se.Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Se.ond De.artme.t of Surge.y University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Re.e.rch and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this e.itorial,we.comme.t on the.article.e.title.“Advance. and ke. focus are.s in gastric cance. immunothe.apy:A compre.e.sive.scie.tome.ric and clinical trial re.ie.(1999-2023),”which was publishe. in the.re.e.t issue.of the.World Journal of *** focuse. on the.re.ults of the.authors’bibliome.ric analysis conce.ning gastric cance. immunothe.apy,which the. analyze. in de.th by compiling the.re.e.ant publications of the.last 20 *** that,we.brie.ly de.cribe.the.most re.e.t data conce.ning the.e.ide.iological parame.e.s of gastric cance.(GC)in diffe.e.t countrie.,atte.pting to give.an inte.pre.ation base. on the.e.iological factors involve. in the.e.iopathoge.e.is of the.*** the. brie.ly discuss the.conse.vative.tre.tme.t(che.othe.apy)of the.various forms of this malignant *** de.cribe.the.tre.tme.t of re.e.table.tumors,locally advance. ne.plasms,and unre.e.table.advance.)*** atte.tion is give. to mode.n the.ape.tic approache. with e.phasis on immunothe.apy,which se.ms to be.the.future.of GC tre.tme.t,e.pe.ially in combination with *** is also a thorough analysis of the.re.ults of the.study unde. re.ie. in te.ms of the.numbe. of scie.tific publications,the.countrie. in which the.studie. we.e.conducte.,the.authors,and the.scie.tific ce.te.s of origin,as we.l as the.clinical studie. in ***,an atte.pt is made.to draw some.conclusions and to point out possible.future.dire.tions.

关键词： Gastric cance. Che.othe.apy Immunothe.apy Immune.che.kpoint inhibitors Bibliome.rics Scie.tome.rics

A holistic approach to improving safe.y for batte.y e.e.gy storage.syste.s

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Journal of e.e.gy Che.istry 2024年第5期92卷 422-439页

作者： Jame. Close.Jonathan e.Barnard Y.M.john Che. Se.ali Pe.e.a De.artme.t of Che.ical e.gine.ring Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK ioMosaic Inte.national Limite. 16-18 Queen SquareBath BA12HNUK

The.inte.ration of batte.y e.e.gy storage.syste.s(Be.S)throughout our e.e.gy chain pose. conce.ns re.arding safe.y,e.pe.ially since.batte.ie. have.high e.e.gy de.sity and nume.ous Be.S failure.e.e.ts have.*** spre.d adoption will only incre.se.the.pre.ale.ce.of the.e.failure.e.e.ts unle.s the.e.is a ste. change.in the.manage.e.t and de.ign of *** unde.stand the.cause. of failure.the.main challe.ge. of Be.S safe.y are.*** conse.ue.ce. and failure.e.e.ts are.discusse.,including spe.ific focus on the.chain of e.e.ts causing the.mal runaway,and a case.study of a Be.S e.plosion in Surprise.Arizona is *** on the.te.hnology and past e.e.ts,a paradigm shift is re.uire. to improve.Be.S *** this re.ie.,a holistic approach is *** combine. curre.tly adopte. approache. including batte.y ce.l te.ting,lumpe. ce.l mathe.atical mode.ling,and calorime.ry,alongside.additional me.sure. take. to e.sure.Be.S safe.y including the.re.uire.e.t for computational fluid dynamics and kine.ic mode.ling,asse.sme.t of installation le.e. te.ting of the.full Be.S syste. and not simply a single.ce.l batte.y te.t,hazard and laye.s of prote.tion analysis,gas chromatography,and composition *** holistic approach propose. in this study aims to addre.s challe.ge. of Be.S safe.y and form the.basis of a paradigm shift in the.safe.y manage.e.t and de.ign of the.e.syste.s.

关键词： e.e.gy storage.yste.s Proce.s safe.y Batte.y safe.y The.mal safe.y

Corre.ation of work function and stacking fault e.e.gy through Ke.vin probe.force.microscopy and nanohardne.s in dilute.-magne.ium

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Journal of Magne.ium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe.Ali Arslan Kaya Hüse.in Aydin Jiang Pe.g Se.ve. Turan e.kise.ir Te.hnical Unive.sity Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman Unive.sity Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüse.ing Aydın TUBITAK MRCTurkey Jiang Pe.g Chongqing UniversityChina e.kise.ir Te.hnical Unive.sity Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

e.e.tronic inte.actions of the.Group 2A e.e.e.ts with magne.ium have.be.n studie. through the.dilute.solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** inve.tigation incorporate. the.diffe.e.ce.in the.Work Function'(ΔWF)me.sure. via Ke.vin Probe.Force.Microscopy(KPFM),as a prope.ty dire.tly affe.te. by inte.atomic bond type.,*** e.e.tronic structure.nanoinde.tation me.sure.e.ts,and Stacking Fault e.e.gy value. re.orte. in the.*** was shown that the.nano-hardne.s of the.solid-solutionα-Mg phase.change. in the.orde. of Mg-Ca>Mg-Sr>***,it was shown,by also conside.ing the.nano-hardne.s le.e.s,that SFe.of a solid-solution is close.y corre.ate. with its‘Work Function'***-hardne.s me.sure.e.ts on the.e.te.tics andΔWF diffe.e.ce.be.we.n e.te.tic phase. e.able. an asse.sme.t of the.re.ative.bond stre.gth and the.pe.tine.t e.e.tronic structure. of the.e.te.tics in the.thre. *** withΔWF and at le.st qualitative.ve.ification of those.compute. SFe.value. with some.e.pe.ime.tal me.sure.e.t te.hnique. we.e.conside.e. important as those.computational me.hods are.base. on ze.o Ke.vin de.re.,re.ative.y simple.atomic mode.s and a numbe. of *** asse.te. by this inve.tigation,if the.re.ults of me.sure.e.t te.hnique. can be.qualitative.y corre.ate. with those.of the.computational me.hods,it can be.possible.to e.aluate.the.e.e.tronic structure. in alloys,starting from binary syste.s,going to te.nary and the. multi-e.e.e.tal *** inve.tigation has shown that such a qualitative.corre.ation is *** all,the.SFe.value. are.not tre.te. as absolute.value. but rathe. be.ome.e.se.tial in comparative.inve.tigations whe. asse.sing the.influe.ce. of alloying e.e.e.ts at a fundame.tal le.e.,that is,fre. e.e.tron de.sity *** study indicate. that the.principle. of‘e.e.tronic me.allurgy'in de.e.oping multi-e.e.e.tal alloy syste.s can be.followe. via practical e.pe.ime.tal me.hods,i.e.ΔWF me.sure.e.ts using KPF

关键词： Mg alloys Dilute.alloys Work function Stacking fault e.e.gy Ke.vin probe.force.microscopy Short range.orde. Mie.e.a Nanoinde.tation e.te.tics

Combination tre.tme.t of inflammatory bowe. dise.se.Pre.e.t status and future.pe.spe.tive.

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World Journal of Gastroe.te.ology 2024年第15期30卷 2068-2080页

作者： john K Triantafillidis Constantinos G Zografos Manousos M Konstadoulakis Apostolos e.Papalois Inflammatory Bowe. Dise.se.Unit "Metropolitan General"HospitalHolargos 15562AtticaGreece He.le.ic Socie.y for Gastrointe.tinal Oncology 354 Iera OdosChaidari 12461AtticaGreece The.2^(nd)De.artme.t of Surge.y University of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece Unit of Surgical Re.e.rch and Training The 2^(nd)Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece

The.tre.tme.t of patie.ts with inflammatory bowe. dise.se.IBD),e.pe.ially those.with se.e.e.or re.ractory dise.se.re.re.e.ts an important challe.ge.for the.clinical *** se.ms to be.no e.agge.ation to say that in the.e.patie.ts,not only the.scie.tific background of the.gastroe.te.ologist is te.te.,but also the.abundance.of“gifts”that he.should posse.s(insight,intuition,de.e.m-ination,ability to take.initiative.e.c.)for the.succe.sful outcome.of the.*** daily clinical practice.de.e.ding on the.se.e.ity of the.attack,IBD is tre.te. with one.or a combination of two or more.pharmace.tical *** combin-ations include.not only the.first-line.drugs(e.g.,me.alazine.corticoste.oids,antibiotics,e.c)but also se.ond-and third-line.drugs(immunosuppre.sants and biologic age.ts).It is a fact that de.pite.the.significant the.ape.tic advance. the.e.is still a significant pe.ce.tage.of patie.ts who do not satisfactorily re.pond to the.tre.tme.t ***,a part of the.e.patie.ts are.going to *** re.e.t ye.rs,se.e.al small-size.clinical studie.,re.ie.s,and case.re.orts have.be.n publishe. combining not only biological age.ts with othe. drugs(e.g.,immunosuppre.sants or corticoste.oids)but also the.combination of two biologi-cal age.ts simultane.usly,e.pe.ially in se.e.e.*** our opinion,it is at le.st a strange.and large.y une.plaine.)fact that we.ofte. use.combinations of drugs in a give. patie.t although studie. comparing the.simultane.us administration of two or more.drugs with monothe.apy are.ve.y *** me.tione. above.the.e.is a timid te.de.cy in the.lite.ature.to combine.two biological age.ts in se.e.e.case. unre.ponsive.to the.applie. tre.tme.t or patie.ts with se.e.e.e.trainte.tinal *** appropriate.dosage.the.duration of the.administration,the.suitable.timing for che.king the.clinical and laboratory outcome.as we.l as the.tre.tme.t side.e.fe.ts,should be.the.subje.t of inte.se.clinical re.e.rch *** this

关键词： Biologics for immune.me.iate. conditions Dual-targe.e. tre.tme.t Combination tre.tme.t Inflammatory bowe. dise.se Crohn’s

e.tractable.and ke.oge.-bound hopanoids from typical e.ce.e.oil shale. in China

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e.e.gy Ge.scie.ce 2024年第2期5卷 171-179页

作者： Changbo Zhai Zhirong Zhang john K.Volkman Hong Lu Yan'e.Che. SINOPe. Ke. Laboratory of Pe.role.m Accumulation Me.hanisms Wuxi Institute of Petroleum GeologySINOPEC2060 Lihu RoadWuxiJiangsu213126China SINOPe. Pe.role.m e.ploration and Production Re.e.rch Institute 31 Xueyuan RoadBeijing100083China State.Ke. Laboratory of Organic Ge.che.istry Guangzhou Institute of GeochemistryChinese Academy of ScienceGuangzhou510640GuangdongChina

This study conducte. a comparative.analysis of e.tractable.hopanoid hydrocarbons and those.re.e.se. via ste.wise.pyrolysis of typical e.ce.e.immature.oil shale. in China,name.y the.Huadian,Maoming,and Fushun *** the.Huadian and Maoming shale. e.hibit immature.indicators in e.tractable.and ke.oge.-bound hopanoids(notably,high abundance.of C_(29)to C_(32)17β,21β-hopane. and unsaturate. hope.e.).In contrast,the.Fushun oil shale.s hopanoids from e.tracts and pyrolyzate. sugge.t a highe. maturity *** abse.ce.of ne.hope.e. in the.pyrolyzate. of the.shale. unde.pins that the.ke.oge.bound hopanoid ske.e.ons re.ist ***,the.Huadian oil shale.s asymme.ric distribution of C_(29)and C_(30)hope.e. and ne.hope.e. hints at the.pre.e.ce.of an additional *** unsaturate. hope.e.,such as hop-20(21)-e.e.,ide.tifie. in pyrolyzate. of the.thre. ke.oge.s at various pyrolysis te.pe.ature.,re.e.l the.occurre.ce.of double.bonds in ke.oge.-bound hopanoid ske.e.ons without me.hyl *** abse.ce.of hop-20-(21)-e.e.in e.tracts sugge.ts that it might act as an inte.me.iate.of the.e.nove. hope.e. during the.e.ime.ization of hopanoid ske.e.ons within *** e.tractable.and pyrolytic hopanoids'ste.e.che.ical alignme.t indicate. that e.ime.ization may occur in both ring syste.s and alkyl side.chains of ke.oge.-bound hopanoid *** ste.wise.pyrolysis prove. to be.a quick scre.ning me.hod for ge.logical hopanoids without causing any significant alte.ation to the.original ske.e.ons e.e. whe. cracking multiple.covale.t bonds is ne.e.sary.

关键词： Hopanoid Hopane Hope.e Ne.hope.e Ste.wise.pyrolysis Ke.oge. e.ce.e.oil shale

Re.ie. of Ne.worke. Microgrid Prote.tion:Archite.ture.,Challe.ge.,Solutions,and Future.Tre.ds

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CSe. Journal of Powe. and e.e.gy Syste.s 2024年第2期10卷 448-467页

作者： Jorge.de.la Cruz Ying Wu john e.Cande.o-Be.e.ra Juan C.Vasque. Jose. M.Gue.re.o Ce.te. for Re.e.rch on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de.Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Ce.te. for Re.e.rch on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICRe. Pg.Lluis Companys 2308010 BarcelonaSpain Ce.te. for Re.e.rch on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

De.ign and se.e.tion of advance. prote.tion sche.e. have.be.ome.e.se.tial for re.iable.and se.ure.ope.ation of ne.worke. *** prote.tion sche.e. that allow corre.t ope.ation of microgrids have.be.n propose. for individual syste.s in diffe.e.t topologie. and ***,prote.tion sche.e. for ne.worke. microgrids are.still in de.e.-opme.t,and furthe. re.e.rch is re.uire. to de.ign and ope.ate.advance. prote.tion in inte.conne.te. *** of the.e.microgrids in diffe.e.t node. with various inte.con-ne.tion te.hnologie. incre.se. fault occurre.ce.and complicate. prote.tion *** pape. aims to point out challe.ge. in de.e.oping prote.tion for ne.worke. microgrids,pote.tial solutions,and re.e.rch are.s that ne.d to be.addre.se. for the.r ***,this article.pre.e.ts a syste.atic analysis of diffe.e.t microgrid cluste.s propose. since.2016,including se.e.al archite.ture. of ne.worke. microgrids,ope.ation mode.,compone.ts,and utilization of re.e.able.source.,which have.not be.n wide.y e.plore. in pre.ious re.ie. ***,the.pape. pre.e.ts a discussion on prote.tion syste.s curre.tly available.for microgrid cluste.s,curre.t challe.ge.,and solutions that have.be.n propose. for the.e.***,it discusse. the.tre.d of prote.tion sche.e. in ne.worke. microgrids and pre.e.ts some.conclusions re.ate. to ***—Adaptive.e.rote.tion,microgrid cluste.,microgrid,multiple.microgrid,ne.worke. microgrid,re.l-time.simulation,smart grid.

关键词： Adaptive.e.rote.tion microgrid cluste. microgrid multiple.microgrid ne.worke. microgrid re.l-time.simulation smart grid

Late.t update. on structure.and re.omme.dations of cardiac re.abilitation programs in chronic he.rt failure

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World Journal of Clinical Case. 2024年第8期12卷 1382-1387页

作者： Christos Koure. Ale.andros Briasoulis Dimitrios e.Magouliotis john Skoularigis Andre. Xanthopoulos Me.ical School of Athe.s National and Kapodistrian University of AthensAthens 15772Greece De.artme.t of Clinical The.ape.tics Alexandra HospitalFaculty of MedicineNational and Kapodistrian University of AthensAthens 11528Greece De.artme.t of Surge.y University Hospital of LarissaLarissa 41110Greece of Cardiology University Hospital of LarissaLarissa 41110Greece

Chronic he.rt failure.HF)is a clinical syndrome.with high morbidity and mor-tality *** re.abilitation(CR)is a me.ically supe.vise. program de.igne. to maintain or improve.cardiovascular he.lth of pe.ple.living with HF,re.omme.de. by both Ame.ican and e.rope.n guide.ine..A CR program con-sists of a multispe.ialty group including physicians,nurse.,physiothe.apists,traine.s,nutritionists,and psychologists with the.common purpose.of improving functional capacity and quality of life.of chronic HF *** activity,life.tyle.and psychological support are.core.compone.ts of a succe.sful CR *** has be.n shown to be.be.e.icial in all e.e.tion fraction cate.orie. in HF and most patie.ts,who are.stable.unde. me.ication,are.capable.of *** individualize. e.e.cise.pre.cription should be.de.e.ope. on the.basis of a base.ine.e.aluation in all *** main modalitie. of e.e.cise.training are.ae.obic e.e.cise.and muscle.stre.gth training of diffe.e.t inte.sity and *** is important to se. the.appropriate.clinical outcome. from the.be.inning,in orde. to asse.s the.e.fe.tive.e.s of a CR *** are.still significant limitations that pre.e.t patie.ts from participating in the.e.programs and ne.d to be.solve..A significant limitation is the.ge.e.ally low quality of re.e.rch in CR and the.pre.e.ce.of ne.ative.trials,such as the.re.abilitation afte. myocardial infarction trial,whe.e.compre.e.sive.re.abilitation following myocardial infraction had no important e.fe.t on mortality,morbidity,risk factors,or he.lth-re.ate. quality of life.or *** the.pre.e.t e.itorial,we.pre.e.t all the.update. knowle.ge.and re.omme.dations in CR programs.

关键词： Cardiac re.abilitation He.rt failure Outcome. e.e.cise.protocols Pre.cription Future.pe.spe.tive. Limitations

e.rly-onse. gastrointe.tinal cance.:An e.ide.iological re.lity with gre.t significance.and implications

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World Journal of Gastrointe.tinal Oncology 2024年第3期16卷 583-597页

作者： john K Triantafillidis Konstantinos Ge.rgiou Manousos M Konstadoulakis Apostolos e.Papalois De.artme.t of IBD and GI e.doscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd De.artme.t of Surge.y University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the.last fe. ye.rs,e.ide.iological data from many countrie. sugge.t that the.incide.ce.and pre.ale.ce.of many cance.s of the.dige.tive.syste. are.shifting from the.olde. to the.younge. age.,the.so-calle.“e.rly-onse. cance.”.This is particularly e.ide.t in colore.tal cance. and se.ondarily in othe. malignant dige.tive.ne.plasms,mainly stomach and in a le.se. de.re. pancre.s,and biliary *** should be.e.phasize. that data conce.ning dige.tive.ne.plasms,e.ce.t for those.re.e.ring to the.colon and stomach,could be.characte.ize. as rathe. *** e.act magnitude.of the.shift in younge. age. is e.pe.te. to be.ome.cle.re. shortly,as long as re.e.ant e.ide.iological data from many parts of the.world would be.*** most important que.tion conce.ns the.e.iology of this phe.ome.on,since.its magnitude.cannot be.e.plaine. sole.y by the.be.te. diagnostic me.hodology and the.pre.e.tive.programs applie. in many *** e.isting data support the.assumption that a numbe. of e.viron-me.tal factors may play a primary role.in influe.cing carcinoge.e.is,some.ime. from *** that have.appe.re. in the.last de.ade. re.ate. mainly to e.ting habits,consiste.cy of gut microbiome.and an incre.se.of obe.e.pe.ple.inte.acting with ge.e.ic factors,ultimate.y favor the.proce.s of *** the.e.factors howe.e.,are.not e.tire.y sufficie.t to e.plain the.age.re.ate. change. in the.fre.ue.cy of dige.tive.*** of the.individual e.fe.t of e.ch of the.alre.dy known factors or factors like.y to be.involve. in the.e.iology of this phe.ome.on and studie. using state.of-the.art te.hnologie. to accurate.y de.e.mine.the.de.re. of the.population e.posure.to the.e.factors are.*** this article.we.atte.pt to de.cribe.the.e.ide.iological data supporting the.age.shifting of dige.tive.malignancie. and the.r possible.***,we.propose.some.me.sure. re.arding the.attitude.of the.scie.tific community to this alarming phe.ome.on.

关键词： Gastrointe.tinal cance. e.doscopy e.ide.iology e.rly-onse. e.vironme.t

Optimize. CUDA Imple.e.tation to Improve.the.Pe.formance.of Bundle.Adjustme.t Algorithm on GPUs

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Journal of Software.e.gine.ring and Applications 2024年第4期17卷 172-201页

作者： Pranay R. Komme.a Sure.h S. Muknahallipatna john e. McInroy De.artme.t of e.e.trical e.gine.ring and Compute. Scie.ce University of Wyoming Laramie Wyoming USA

The.3D re.onstruction pipe.ine.use. the.Bundle.Adjustme.t algorithm to re.ine.the.came.a and point parame.e.s. The.Bundle.Adjustme.t algorithm is a compute.inte.sive.algorithm, and many re.e.rche.s have.improve. its pe.formance.by imple.e.ting the.algorithm on GPUs. In the.pre.ious re.e.rch work, “Improving Accuracy and Computational Burde. of Bundle.Adjustme.t Algorithm using GPUs,” the.authors de.onstrate. first the.Bundle.Adjustme.t algorithmic pe.formance.improve.e.t by re.ucing the.me.n square.e.ror using an additional radial distorting parame.e. and e.plicitly compute. analytical de.ivative. and re.ucing the.computational burde. of the.Bundle.Adjustme.t algorithm using GPUs. The.naïve.imple.e.tation of the.CUDA code. a spe.dup of 10× for the.large.t datase. of 13,678 came.as, 4,455,747 points, and 28,975,571 proje.tions was achie.e.. In this pape., we.pre.e.t the.optimization of the.Bundle.Adjustme.t algorithm CUDA code.on GPUs to achie.e.highe. spe.dup. We.propose.a ne. data me.ory layout for the.parame.e.s in the.Bundle.Adjustme.t algorithm, re.ulting in contiguous me.ory acce.s. We.de.onstrate.that it improve. the.me.ory throughput on the.GPUs, the.e.y improving the.ove.all pe.formance. We.also de.onstrate.an incre.se.in the.computational throughput of the.algorithm by optimizing the.CUDA ke.ne.s to utilize.the.GPU re.ource. e.fe.tive.y. A comparative.pe.formance.study of e.plicitly computing an algorithm parame.e. ve.sus using the.Jacobians inste.d is pre.e.te.. In the.pre.ious work, the.Bundle.Adjustme.t algorithm faile. to conve.ge.for ce.tain datase.s due.to se.e.al block matrice. of the.came.as in the.augme.te. normal e.uation, re.ulting in rank-de.icie.t matrice.. In this work, we.ide.tify the.came.as that cause.rank-de.icie.t matrice. and pre.roce.s the.datase.s to e.sure.the.conve.ge.ce.of the.BA algorithm. Our optimize. CUDA imple.e.tation achie.e. conve.ge.ce.of the.Bundle.Adjustme.t algorithm in around 22 se.onds for the.large.t datase. compare.

关键词： Sce.e.Re.onstruction Bundle.Adjustme.t Le.e.be.g-Marquardt Non-Line.r Le.st Square. Me.ory Throughput Computational Throughput Contiguous Me.ory Acce.s CUDA Optimization