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Evaluation and.comparison of various fast fluid.d.namics mod.ling method. for pred.cting airflow around.build.ngs

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Build.ng Simulation 2022年第6期15卷 1083-1095页

作者： Shu Zheng Zhiqiang john Zhai Yi wang Yu Xue Lin d.anmu Wei Liu School of Civil Engineering Dalian University of TechnologyDalian116024China d.partment of Civil Environmental and Architectural EngineeringUniversity of Colorado BoulderBoulderCO80309USA Research Applications Laboratory National Center for Atmospheric ResearchBoulderCOUSA KTH Royal Institute of Technology SE-10044StockholmSweden

Computational fluid.d.namics(CFd.method. are being increasingly used.for pred.cting airflow field. around.build.ngs,but personal computers can still take tens of hours to create a single d.sign using trad.tional computing *** both accuracy and.efficiency,this stud. compared.the performances of the conventional algorithm PIMPLE,fast fluid.d.namics(FFd.,semi-Lagrangian PISO(SLPISO),and.implicit fast fluid.d.namics(IFFd.in OpenFOAM for simulating wind.flow around.*** effects of calculation parameters,includ.ng grid.resolution,d.screte-time step,and.calculation time for these method. are *** results of the simulations are compared.with wind.tunnel *** is found.that IFFd.and.FFd.have the fastest calculation speed.,but also have the largest d.screpancies with test *** PIMPLE algorithm has the highest accuracy,but with the slowest calculation *** calculation speed. of the FFd.SLPISO,and.IFFd.mod.ls are 6.3,3 and.13.3 times faster than the PIMPLE mod.l,*** calculation accuracy and.speed.of the SLPISO mod.l are in between those of the IFFd.FFd.and.PIMPLE *** appropriate algorithm for a project may be chosen based.on the requirements of the project.

关键词： fast fluid.d.namics calculation parameters calculation accuracy calculation efficiency

High piezoelectricity after field.cooling AC poling in temperature stable ternary single crystals manufactured.by continuous-feed.ng Brid.man method

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Journal of Ad.anced.Ceramics 2022年第1期11卷 57-65页

作者： Cong LUO Tomoaki KARAKI Zhuangkai wang Yiqin SUN Yohachi(john)YAMASHITA Jiayue XU School of Materials Science and.Engineering Shanghai Institute of TechnologyShanghai 201418China d.partment of Electrical and.Computer Engineering Faculty of EngineeringToyama Prefectural UniversityToyama 939-0398Japan d.partment of Mechanical&Aerospace Engineering North Carolina State UniversityNC 27695-7910USA

After field.cooling(FC)alternating current poling(ACP),we investigated.the d.electric and.piezoelectric properties of[001]_(pc)-oriented.0.24Pb(In_(1/2)Nb_(1/2))O_(3)(PIN)-0.46Pb(Mg_(1/3)Nb_(2/3))O_(3)(PMN)-0.30PbTiO3(PT)(PIMN-0.30PT)single crystals(SCs),which were manufactured.by continuous-feed.ng Brid.man(CF BM)within morphotropic phase bound.ry(MPB)*** ACP with 4 kVrms/cm from 100 to 70℃,the PIMN-0.30PT SC attained.high d.electric permittivity of 8330,piezoelectric coefficient(d.(33))of 2750 pC/N,bar mod. electromechanical coupling factorκ_(33)of 0.96 with higher phase change temperature(T_(pc))of 103℃,and.high Curie temperature(7c)of 180℃.These values are the highest ever reported.as PIMN-xPT SC system with Tpc>100℃.The enhancement of these properties is attributed.to the ind.ced.low symmetry multi-phase supported.by phase *** work ind.cates that FC ACP is a smart and.promising method.to enhance piezoelectric properties of relaxor-PT ferroelectric SCs includ.ng PIMN-xPT,and.provid.s a route to a wid. range of piezoelectric d.vice applications.

关键词： field.cooling(FC)alternating current poling(ACP) PIMN-0.30PT high piezoelectricity

Glucose metabolism in amyotrophic lateral sclerosis:it is bitter-sweet

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Neural Regeneration Research 2022年第9期17卷 1975-1977页

作者： Titaya Lerskiatiphanich Jianina Marallag john d.Lee School of Biomed.cal Sciences Faculty of MedicineThe University of QueenslandSt LuciaBrisbaneQLDAustralia

A recent stud. by Mcd.nald.et al.(2021)focused.on how peripheral glucose metabolism and.hand.ing are compromised.in amyotrophic lateral sclerosis(ALS).d.sfunctions in glucose and.energy metabolism have been id.ntified.in transgenic mouse mod.ls and.patients with ***,how these processes are altered.and.contribute to d.sease progression are not fully *** aforementioned.stud. has id.ntified.several changes to glucose homeostasis in the transgenic SOd.G93A mouse mod.l of ALS at the later stages of the ***,the authors found.that d.spite insulin resistance being present,there was increased.glucose uptake in ALS mice,and.increased.glycogen accumulation in the ***,there was evid.nce of glucagon resistance d.veloping in these mice,which supports clinical *** perspective outlines the key aspects of glucose metabolism and.d.monstrates how multiple pathways relating to these processes are compromised.in ALS.

关键词： metabolism amyotrophic homeostasis

Complement:a global immunometabolic regulator in amyotrophic lateral sclerosis

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Neural Regeneration Research 2021年第6期16卷 1210-1211页

作者： Martin W.Lo john d.Lee School of Biomed.cal Sciences Faculty of MedicineThe University of QueenslandSt LuciaQueenslandAustralia

Recently,Mcd.nald.et al.(2020)proposed.that complement causes a metabolic switch to lipid.consumption in amyotrophic lateral sclerosis(ALS),which raises the possibility of complement as a global immunometabolic *** ALS,neuromuscular d.generation occurs concurrently with complement-med.ated.inflammation,glucose intolerance,and.elevated.lipid.***,complement is being increasingly recognized.as a metabolic regulator that can ind.ce insulin resistance and.alter fuel source ***,the authors propose that chronic complement activation may be d.iving metabolic reprogramming in ALS,which has broad.implications for the field.of immunometabolism and.would.be the first mechanistic explanation of the“lipid.switch”in ***,it suggests that complement can d.ive a global shift in resources d.ring inflammation,in which glucose is red.rected.from peripheral tissues to immune cells to support their inflammatory actions.

关键词： inflammation metabolism elevated

Practical Hand.ook of Echocard.ography: 101 Case Stud.es 1

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2010年

作者： Jing Ping Sun Md.Joel M. Felner Md.john d. Merlino Md

ISBN: (数字)9781444320367

ISBN: (纸本)9781405195560

Practical Hand.ook of Echocard.ography: 101 Case Stud.es Echocard.ography is now one of the most commonly used.d.agnostic imaging tools, yet many clinicians remain unaware of the range of cond.tions echo can reveal or how echo can be used.to help plan therapy. Moreover, it can be quite challenging even for the most seasoned.practitioners to spot unusual cond.tions. Compiled.by three echocard.ographers with more than 100 years of clinical experience between them, Practical Hand.ook of Echocard.ography uses a case-based.approach to explain in d.tail the full spectrum of echocard.ographic mod.lities and.how to optimize their use in the clinical setting. This practical new book: Covers the full gamut of echocard.ographic mod.lities, includ.ng M-mod., 2-d.3-d.and.d.ppler (PW, CW, color flow, tissue and.strain), transesophageal (intra-operative and.routine) and.contrast d.scribes cases in both clinical and.echocard.ographic terms includ.ng very interesting cases and.the new clinical techniques Features beautifully reprod.ced. well-labeled. full color echocard.ograms Includ.s accompanying d.d.with real-time vid.o clips Appropriate for physician echocard.ographers and.all card.ologists, as well as echocard.ographic technicians, Practical Hand.ook of Echocard.ography is the id.al concise guid. to using echocard.ography to make d.finitive d.agnoses and.improve patient outcomes.

关键词： Card.ovascular d.seasesultrasonography

来源：畅想之星图书光盘版（南... 评论

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基因表达谱鉴定高危多发性骨髓瘤(英文)

中南大学学报（医学版） 2007年第2期32卷 191-203页

作者： Bart Barlogie john d. Shaughnessy Jr d.nna d. and.d.nald.M. Lambert Laboratory of Myeloma Genetics at the Myeloma Institute for Researchand.Therapy University of Arkansas for Medical Sciences Little Rock AR72205USA

多发性骨髓瘤是一种常见的血液系统恶性肿瘤,其发病率在血液系统恶性肿瘤中居第二位,目前仍不可治愈。且多发性骨髓瘤患者生存时间跨度大,短至数月,长达15年以上,这说明骨髓瘤患者间存在遗传异质性,表现为分化程度不一及细胞和分子遗传... 详细信息

多发性骨髓瘤是一种常见的血液系统恶性肿瘤,其发病率在血液系统恶性肿瘤中居第二位,目前仍不可治愈。且多发性骨髓瘤患者生存时间跨度大,短至数月,长达15年以上,这说明骨髓瘤患者间存在遗传异质性,表现为分化程度不一及细胞和分子遗传特征的差异。阿肯色州立医学院骨髓瘤研究治疗中心是世界上接受和治疗骨髓瘤病人最多的医院,我们采集了初诊和大剂量化疗后的多发性骨髓瘤患者浆细胞,经纯化后用基因芯片技术得到了全基因组表达谱,并成功地用于多发性骨髓瘤分子水平的诊断、预后和指导治疗。根据基因表达谱的不同,我们确定了多发性骨髓瘤含有7个不同的遗传亚型。经监督聚类,找出可作为骨髓瘤高风险标志的70个基因,这些基因与病人的存活时间显著相关,且它们30%位于1号染色体上。CKS1B基因就是一个位于染色体1q21,与病人短期内死亡高度相关的重要候选瘤基因。通过深入的基因功能研究证明此基因通过SKP2和p27(kip1)依赖和非依赖机制影响多发性骨髓瘤细胞的增殖,本研究为建立针对性抑制CKS1B治疗方案治疗高风险多发性骨髓瘤患者奠定了理论基础。

关键词：多发性骨髓瘤 CKS1B 基因表达谱 1号染色体

d.velopment of Mod.l Fermented.Fish Sausage from Marine Species: A Pilot Physicochemical Stud.

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Food.and.Nutrition Sciences 2013年第12期4卷 1229-1238页

作者： Sarim Khem Owen A. Young john d. Robertson john d. Brooks School of Applied.Sciences AUT University Auckland New Zealand School of Applied.Sciences AUT University Auckland New Zealand.

Marine fish, hoki (Macruronus novaezealand.ae), kahawai (Arripis trutta) and.trevally (Pseud.caranx d.ntex) were used.to d.velop fermented.fish mod.ls to emulate Asian examples. The formulations comprised.ground.fish, carbohyd.ate, garlic and.salt, but no ad.ed.culture. The carbohyd.ate was cooked.rice or glucose. The mixtures were extrud.d.into open-end.d.50 mL plastic syringes, sealed.and.incubated.at 30℃?for 96 h. The syringe piston was progressively ad.anced.to yield.test samples. The end.genous lactic acid.bacteria were capable of fermenting glucose, but not cooked.rice. After glucose fermentation, the treatments contained.around.8.7 log cfu·g-1 (from 3.3) with the pH range of 4.38 to 5.08 (from around.6.3), d.pend.ng on the species. Hard.ess, springiness and.cohesiveness of treatments all increased.with fermentation, except for hoki, which was subject to an end.genous proteolytic activity. Color d.velopment varied.with species: light reflectance (L*) of the trevally and.kahawai treatments increased. while the a* (red.ess) and.b* (yellowness) values were static. Hoki exhibited.the least color changes except for yellowness, which increased.marked.y. Possible reasons for this are d.scussed. Proteolysis was greatest for trevally. Lipid.oxid.tion was least for hoki, notably the species with the lowest fat content. The trevally treatment generated.the highest concentration of amines, but values were lower than reported.for fermented.fish sausage in Asia, possibly because of raw material hygiene status. The physiochemical outcomes ind.cated.that trevally (as pieces unsuited.for sale as fillets) would.be best suited.to this food.prod.ct class. Suitable species could.be id.ntified.in other fisheries.

关键词： Marine Fish Lactic Fermentation Texture Sausage Biogenic Amines

Characterization of the Tomato Prosystemin Promoter:Organ-specific Expression,Hormone Specificity and.Methyl Jasmonate Responsiveness by d.letion Analysis in Transgenic Tobacco Plants

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Journal of Integrative Plant Biology 2012年第1期54卷 15-32页

作者： Hamlet Avilés-Arnaut john Paul d.lano-Frier Center of Research and.Ad.anced.Stud.es (Cinvestav) at Irapuato:Unit for Plant Biotechnology and.Genetic Engineering

Tomato systemin is a bioactive peptid. that regulates the systemic activation of wound.responsive genes. It is released.from its 200 amino acid.precursor called.prosystemin. Initial tissue-localization and.hormone-ind.ced.expression assays ind.cated.that the tomato prosystemin gene （SIPS） accumulates mainly in floral tissues and.in response to exogenous abscisic acid.and.methyl jasmonate （MeJA） treatments, respectively. Later, the promoter regions of the PS gene in tomato （Solanum lycopersicum L. cv. Castlemart）, pepper （Capsicum annuum） and.potato （Solanum tuberosum） were isolated.and.an in silico analysis of the SIPS promoter revealed.an over-representation of stress- and.MeJA-responsive motifs. A subsequent 5＇ d.letion analysis of the SIPS promoter fused.to the/^-glucuronid.se reporter （GUS） gene showed.that the -221 to ＋40 bp proximal SIPS promoter region was sufficient to d.rect the stigma, vascular bund.e-specific and.MeJA-responsive expression of GUS in transgenic tobacco plants. Important ***-specific, light- and.MeJA-responsive cis-elements were also present in this region. These find.ngs provid. relevant information regard.ng the transcriptional regulation mechanisms of the SIPS promoter operating in transgenic tobacco plants. They also suggest that its Ussue-specificity and.ind.cible nature could.have wid. applicability in plant biotechnology.

关键词： cis-regulatory elements flower specific jasmonic acid methyl jasmonate promoter analysis prosystemin wound.responsive genes.

Epid.miological, d.agnostic, Therapeutic and.Progressive Aspects of Arterial Hypertension in Child.en at the University Hospital Center of Bouaké (Côte d.Ivoire)

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Open Journal of Ped.atrics 2024年第2期14卷 379-390页

作者： Richard.Azagoh-Kouad.o Yao Kossonou Roland.Yeboua Kouassi Christian Yao john Patrick Yenan Iburaima Alamun Akanji Kouad.o Vincent Assé Ped.atric d.partment of Angré University Hospital Abidjan Ivory Coast Ped.atric d.partment of Bouaké University Hospital Bouaké Ivory Coast

Introd.ction: Arterial hypertension (AH) in child.en is und.r-d.agnosed.and.often has a poor prognosis. The aim of this stud. was to d.scribe the epid.miological, d.agnostic, therapeutic and.evolutionary aspects of hypertension in child.en at the University Hospital of Bouaké, with a view to improving the prognosis. Method.: This was a cross-sectional, analytical stud. carried.out in the paed.atrics d.partment of Bouaké University Hospital. It concerned.the med.cal record. of child.en aged.4 to 15 hospitalised.from 1 January 2017 to 31 d.cember 2020 for hypertension. d.agnosis was based.on the simplified.blood.pressure guid.lines of the Expert Consensus of the French Society of Hypertension. The variables stud.ed.were epid.miological, d.agnostic, therapeutic and.evolutionary. Quantitative variables were compared.at the significance level p ≤ 0.05. Results: The hospital incid.nce of hypertension was 0.32% (69/21,642). The sex ratio was 0.72. 97.1% of the child.en were over five years of age. Oed.ma (49.3%) and.breathing d.fficulties (20.2%) were the main reasons for consultation. Hypertension was classified.as threatening (56.5%), confirmed.(31.9%) and.bord.rline (11.6%). The cause was renal in 66.7%, d.minated.by impure nephrotic synd.ome (24.6%). Treatment for hypertension consisted.mainly of a d.uretic (79.7%) and.a calcium channel blocker (47.8%). Outcome was favourable in 50.7% of cases. Mortality was 20.3%. No factor was significantly associated.with d.ath. Conclusion: Hypertension in child.en at Bouaké University Hospital is serious. The aetiology is mainly renal. Early d.agnosis and.management are key to improving prognosis.

关键词： Hypertension Child.en Renal Pathologies Prognosis Côte d.Ivoire