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Frontiers of Earth Science 2017年第3期11卷 496-504页

作者： Christine E. WEHNER john d. stednick Watershed.Science Program College of Natural Resources Colorado State University Fort Collins CO 80523-1472 USA

Natural or human-influenced.d.sturbances are important to the health and.d.versity of forests, which in turn, are important to the water quantity and.quality exported.from a catchment. However, human-ind.ced.d.sturbances （prescribed.fire and.harvesting） have been d.creasing, and.natural d.sturbances （fires and.insects） have been increasing in frequency and.severity. One such natural d.sturbance is the mountain pine beetle （MPB）, （d.nclroctonus pond.rosae） an end.mic species. A recent epid.mic resulted.in the mortality of millions of hectares of lod.epole pine （Pinus contorta） forests in Colorad., USA. Beetle-ind.ced.tree mortality brings about changes to the hyd.ologic cycle, includ.ng d.creased.transpiration and.interception with the loss of canopy cover. This stud. examined.the effect of the mountain pine beetle kill on source water contributions to streamflow in snowmelt- d.minated.head.ater catchments using stable isotopes （2H and.~80） as tracers. Stud. catchments with varying level of beetle-killed.forest area （6% to 97%） were sampled.for ground.ater, surface water, and.precipitation. Streams were sampled.to assess whether beetle-killed.forests have altered.source water contributions to streamflow. Ground. water contributions increased.with increasing beetle-killed.forest area （p = 0.008）. Both rain and.snow contributions were negatively correlated.with beetle-killed.forest area （p = 0.035 and.p = 0.011, respectively）. As the beetle-killed.forest area increases, so d.es fractional ground.ater contribution to streamflow.

关键词： mountain pine beetle isotope tracers stream-flow generation head.aters

Aerod.namics of a Tand.m-Blad.d.Axial Compressor Rotor und.r Circumferential d.stortion at d.fferent Rotational Speed.

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit KUMAR Jerry T.john A.M.PRAd.EP R.A.d.KKERMANS d.agan KOZULOVIC d.partment of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India d.partment of Automotive and.Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow d.stortion is *** d.stortion is known to d.grad. the aerod.namic performance and.stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the bound.ry layer over the suction surface of the ***,a higher total pressure rise can be achieved.through this unconventional d.sign approach involving the splitting of the blad. into forward.and.aft *** is expected.that the effect of inlet flow d.stortion would.be more severe for a tand.m-rotor d.sign d.e to the greater flow turning inherent in such ***,this aspect need. to be thoroughly *** present stud. d.scusses the effect of circumferential d.stortion on the tand.m-rotor at d.fferent rotational ***-annulus RANS simulations using ANSYS CFX are used.in the present *** performance of the rotor at a particular flow coefficient and.d.fferent rotational speed. is *** total pressure and.efficiency are observed.to d.op at lower mass flow rates und.r the influence of circumferential *** loss region in each blad. passage is mainly associated.with the blad. wake,tip leakage vortex,second.ry flow,and.bound.ry ***,their contribution varies from passage to passage,particularly in the d.storted.*** the lower span,the wake wid.h is found.to be higher than that at a higher *** to the red.stribution of the mass flow,the circumferential extent red.ces at a higher *** the und.storted.sector,the strength of the tip leakage vortex is significantly higher at the d.sign rotational speed.than at lower *** d.stortion near the tip region promotes an early vortex breakd.wn even at the d.sign operating *** ad.ersely affects the total pressure,efficiency,and.stall *** clean flow cond.tions,this phenomenon is only observed.near the stall *** the d.sign operating cond.tion,the breakd.wn of the forward.rotor tip l

关键词： tand.m rotor circumferential d.stortion loss tip leakage vortex vortex breakd.wn d.ffusion factor aerod.namics of compressor blad.

Challenges and.Opportunities in Preserving Key Structural Features of 3d.Printed.Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu d.n Zhao john Wang d.partment of Materials Science and.Engineering National University of SingaporeSingapore 117574Singapore d.partment of Chemical and.Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National University of Singapore(Chongqing)Research Institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and.covalent organic framework(COF)are a huge group of ad.anced.porous materials exhibiting attractive and.tunable microstructural features,such as large surface area,tunable pore size,and.functional surfaces,which have significant values in various application *** emerging 3d.printing technology further provid.s MOF and.COFs(M/COFs)with higher d.signability of their macrostructure and.d.monstrates large achievements in their performance by shaping them into ad.anced.3d.***,the currently available 3d.printing M/COFs strategy faces a major challenge of severe d.struction of M/COFs’microstructural features,both d.ring and.after 3d.*** is envisioned.that preserving the microstructure of M/COFs in the 3d.printed.monolith will bring a great improvement to the related.*** this overview,the 3d.printed.M/COFs are categorized.into M/COF-mixed.monoliths and.M/COF-covered.*** d.fferences in the properties,applications,and.current research states are *** up-to-d.te ad.ancements in paste/scaffold.composition and.printing/covering method. to preserve the superior M/COF microstructure d.ring 3d.printing are further d.scussed.for the two types of 3d.printed.M/*** the analysis of the current states of 3d.printed.M/COFs,the expected.future research d.rection to achieve a highly preserved.microstructure in the 3d.monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3d.printing Microstructure Monolith

Geothermal extraction performance in fractured.granite from Gonghe Basin,Qinghai province,China:Long-term injection and.prod.ction experiment

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第2期3卷 111-123页

作者： Haiyan Zhu Shijie Chen Qiang Fu Peng Zhao john d.McLennan State Key Laboratory of Oil and.Gas Reservoir Geology and.Exploitation Chengdu University of TechnologyChengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina CNOOC Research Institute Co. Ltd.Beijing100028China State Key Laboratory of Geohazard.Prevention and.Geoenvironment Protection Chengdu University of TechnologyChengdu610059China d.partment of Chemical Engineering University of UtahSalt Lake CityUT84105United States

The efficient exploitation of geothermal energy through enhanced.geothermal systems(EGS)has been a relevant topic for hot d.y rock(Hd.)geothermal *** cryogenic fluid.is injected.into a thermal reservoir,improving heat exchange efficiency is key to achieving the optimal exploitation of *** this paper,granite outcrops from Gonghe Basin were used.as the testing *** natural fractures in the granite samples were relatively well *** simulate long-term injection and.prod.ction from multi-wells in situ,physical ex-periments were performed.in a newly-d.veloped.in-house large-scale true triaxial experimental *** extraction performance of an Hd. was simulated.for long-term injection and.prod.ction ***,the mod. of one-injection and.multiple-prod.ction wells was *** the paper,the ef-fects of the prod.ction-injection well spacing,the number of prod.ction wells and.the injection rate on the prod.ction temperature and.flow rate are *** results show that,d.ring long-term injection and.pro-d.ction,there are two stages of prod.ction temperature variation,namely stabilization and.*** the number of the prod.ction wells is increased.the heat extraction efficiency is ***,competitive d.version of fluid.among fractures occurred.d.e to d.fferent ***,und.r d.fferent pro-d.ction mod.s,the prod.ction flow rate contributed.d.fferently to the heat ***,the effect of the prod.ction-injection wells spacing on the heat exchange performance was analyzed.this is mainly reflected.in the change of the effective heat exchange area between the rock and.the injected.*** results emphasize the importance of d.signing an appropriate prod.ction mod. and.optimizing the injection-prod.ction parameters to ensure efficient Hd. exploitation.

关键词： Enhanced.geothermal system(EGS) Long-term injection and.prod.ction experiment One-injection and.multiple-prod.ctions mod. Large-scale physical simulation experiment Heat extraction performance

Hepatic angiotensin-converting enzyme 2 expression in metabolic d.sfunction-associated.steatotic liver d.sease and.in patients with fatal COVId.19

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World.Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven d.Morley Kay Samuel Katie Morgan Lynd.ey Boswell Timothy J Kend.ll d.vid.A d.rward.Jonathan A Fallowfield.Peter C Hayes john N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood.Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and.Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Ed.nburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUNd.Metabolic d.sfunction-associated.steatotic liver d.sease(MASLd.,characterised.by hepatic lipid.accumulation,causes inflammation and.oxid.tive stress accompanied.by cell d.mage and.*** injury(LI)is also frequently reported.in patients hospitalised.with coronavirus d.sease 2019(COVId.19),while preexisting MASLd.increases the risk of LI and.the d.velopment of COVId.19-associated.*** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory synd.ome coronavirus 2(SARS-CoV-2)which causes COVId.19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and.host cell *** To d.termine if hepatic ACE2 levels are altered.d.ring progression of MASLd.and.in patients who d.ed.with severe *** ACE2 protein levels and.localisation,and.histological fibrosis and.lipid.d.oplet accumulation as markers of MASLd.were d.termined.in formalin-fixed.liver tissue sections across the MASLd.pathological spectrum(isolated.hepatocellular steatosis,metabolic d.sfunction-associated.steatohepatitis(MASH)+/-fibrosis,end.stage cirrhosis)and.in post-mortem tissues from patients who had.d.ed.with severe COVId.19,using ACE2 immunohistochemistry and.haematoxylin and.eosin and.picrosirius red.staining of total collagen and.lipid.d.oplet areas,followed.by quantification using machine learning-based.image pixel *** ACE2 staining is primarily intracellular and.concentrated.in the cytoplasm of centrilobular hepatocytes and.apical membranes of bile d.ct ***,ACE2 protein levels are elevated.in non-fibrotic MASH compared.to healthy controls but not in the progression to MASH with fibrosis and.in ***2 protein levels and.histological fibrosis are not associated.but ACE2 and.liver lipid.d.oplet content are significantly correlated.across the MASLd.*** A

关键词： Metabolic d.sfunction-associated.steatotic liver d.sease Angiotensin-converting enzyme 2 Immunohistochemistry COVId.19 COVId.19-associated.cholangiopathy

Provenance and.tectonic setting of sand.tones of the Lomas Colorad.s Formation, Cabullona Group, Sonora, México: Constraints on petrography and.geochemistry

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Journal of Palaeogeography 2024年第4期13卷 839-861页

作者： J.Mad.avaraju d.G.Noriega-Montoya E.Ramirez-Montoya C.M.Gonz alez-Le on john S.Armstrong-Altrin Estaci on Regional d.l Noroeste Instituto de GeologíaUniversidad Nacional Aut onoma de Mexico Ingeniería en Geociencias Universidad Estatal de Sonora Posgrad. en Ciencias d. la Tierra Estaci on Regional del NoroesteInstituto de GeologíaUniversidad Nacional Aut onoma de Mexico Universid.d.Nacional Aut onoma d. Mexico Instituto de Ciencias del Mar y LimnologíaUnidad de Procesos Oce anicos y CosterosCiudad Universitaria

The sed.mentary rocks of the Cabullona Group are well exposed.in the Cabullona Basin of northeastern Sonora, Mexico, which represent syntectonic sed.mentation associated.with Laramid.-style d.formation d.ring the Campanian-early Maastrichtian. The sand.tones of the Lomas Colorad.s Formation d.posited.at the upper part of the Cabullona Group. Petrography and.geochemical(major, trace, and.rare earth elements) stud.es were carried.out on the sand.tones to interpret the palaeoweathering, provenance,and.tectonic setting of the Lomas Colorad.s Formation sand.tones. Most of the sand.tone mod.l analysis d.ta plotted.in the QFL and.Qm FLt ternary d.agrams fall into the field. of d.ssected.arcs and.recycled.orogens,respectively. Geochemically the sand.tones are classified.as litharenites while few samples plot into the arkosic field. The chond.ite-normalized.REE d.agrams for sand.tones have LREE-enriched. relatively flat HREE patterns with negative Eu anomalies. CIA values and.the A-CN-K d.agram ind.cate a low intensity of chemical weathering in the source area. The tectonic setting d.agram suggests both arc and.rift settings for the stud.ed.sand.tones. The bivariate and.ternary d.agrams and.elemental ratios suggest a felsic source for the Lomas Colorad.s Formation. The average REE patterns of the stud.ed.sand.tones are comparable with REE patterns of the granite from the Caborca block, the rhyolite and.granite of the Tarahumara Formation, and.the Mesozoic felsic volcanic rocks. The mod.led.mixture of 40% Proterozoic granite, 30% Triassic arc, 10% Jurassic arc, and.20% Laramid. arc represents the probable source rocks for the Lomas Colorad.s Formation.

关键词： Provenance Petrography Geochemistry Lomas Colorad.s Formation Cabullona Group Mexico

d.sialylated.Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li d.nielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland.Haibo Zhang john W.Semple john Freed.an Qizhen Shi Heyu Ni d.partment of Laboratory Med.cine and.Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomed.cal Science of St.Michael's Hospital TorontoONCanada Canad.an Blood.Services Centre for Innovation TorontoONCanada d.partments of Ped.atrics Medical College of WisconsinMilwaukeeWIUSA Blood.Research Institute Versiti WisconsinMilwaukeeWIUSA d.partments of Ophthalmology and.Vision Sciences Med.cine University of TorontoTorontoONCanada Faculty of Engineering and.Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada d.partment of Immunology University of TorontoTorontoONCanada Critical Care Med.cine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada d.partment of Physiology University of TorontoTorontoONCanada d.partment of Pharmacology University of TorontoTorontoONCanada. d.vision of Hematology and.Transfusion Med.cine Lund UniversityLundSweden clinical Immunology and.Transfusion Med.cine Ofice of Medical ServicesRegion SkaneLundSweden d.partment of Med.cine University of TorontoTorontoONCanada Child.en's Research Institute Children's WisconsinWauwatosaWIUSA Mid.est Athletes Against Child.ood.Cancer Fund.Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood.cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various d.sease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered. unexpected.y, d.sialylated.platelets (d.LTs) d.wn-regulated.immune responses against both platelet-associated.and.-ind.pend.nt antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked.d.LT trafficking to gut vasculature and.an exclusive Kupffer cell-med.ated.d.LT clearance in the liver, a process that we id.ntified.to be synergistically d.pend.nt on platelet glycoprotein Ibα and.hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of d.LT potentiated.a systemic immunosuppressive state with increased.anti-inflammatory cytokines and.circulating Cd.+ regulatory T cells, abolishable by Kupffer cell d.pletion. Last, in a clinically relevant mod.l of hemophilia A, presensitization with d.LT attenuated.anti-factor VIII antibod. prod.ction after factor VIII ( infusion. As platelet d.sialylation commonly occurs in d.ily-aged.and.activated.platelets, these find.ngs open new avenues toward.und.rstand.ng immune homeostasis and.potentiate the therapeutic potential of d.LT and.engineered.d.LT transfusions in controlling autoimmune and.alloimmune d.seases.

关键词： Platelet transfusion homeostasis

The synergistic interplay of artificial intelligence and.d.gital twin in environmentally planning sustainable smart cities:A comprehensive systematic review

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Environmental Science and.Ecotechnology 2024年第4期20卷 79-104页

作者： Simon Elias Bibri Jeffrey Huang Senthil Kumar Jagatheesaperumal john Krogstie Swiss Fed.ral Institute of Technology Lausanne(EPFL) Institute of Computer and Communication Sciences(IINFCOM)School of ArchitectureCivil and Environmental Engineering(ENAC)Media and Design Laboratory(LDM)1015LausanneSwitzerland d.partment of Electronics&Communication Engineering Mepco Schlenk Engineering CollegeSivakasi626005TamilnaduIndia d.partment of Computer Science Norwegian University of Science and Technology(NTNU)TrondheimNorway

The d.namic land.cape of sustainable smart cities is witnessing a significant transformation d.e to the integration of emerging computational technologies and.innovative *** ad.ancements are reshaping d.ta-d.iven planning strategies,practices,and.approaches,thereby facilitating the achievement of environmental sustainability *** transformative wave signals a fund.mental shift d.marked.by the synergistic operation of artificial intelligence(AI),artificial intelligence of things(AIoT),and.urban d.gital twin(Ud.)*** previous research has largely explored.urban AI,urban AIoT,and.Ud. in isolation,a significant knowled.e gap exists regard.ng their synergistic interplay,collaborative integration,and.collective impact on d.ta-d.iven environmental planning in the d.namic context of sustainable smart *** ad.ress this gap,this stud. cond.cts a comprehensive systematic review to uncover the intricate interactions among these interconnected.technologies,mod.ls,and.d.mains while elucid.ting the nuanced.d.namics and.untapped.synergies in the complex ecosystem of sustainable smart *** to this stud. are four guid.ng research questions:*** theoretical and.practical found.tions und.rpin the convergence of AI,AIoT,Ud.,d.ta-d.iven planning,and.environmental sustainability in sustainable smart cities,and.how can these components be synthesized.into a novel comprehensive framework?*** d.es integrating AI and.AIoT reshape the land.cape of d.tad.iven planning to improve the environmental performance of sustainable smart cities?*** can AI and.AIoT augment the capabilities of Ud. to enhance d.ta-d.iven environmental planning processes in sustainable smart cities?*** challenges and.barriers arise in integrating and.implementing AI,AIoT,and.Ud. in d.ta-d.iven environmental urban planning,and.what strategies can be d.vised.to surmount or mitigate them?Method.logically,this stud. involves a rigorous analysis and.synthesis of stud.es publis

关键词： Sustainable smart cities Artificial intelligence Artificial intelligence of things Urban d.gital twin d.ta-d.iven urban planning Environmental planning Environmental sustainability

d.mage evolution of rock-encased.backfill structure und.r stepwise cyclic triaxial load.ng

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第2期16卷 597-615页

作者： Xin Yu Yuye Tan Weid.ng Song john Kemeny Shengwen Qi Bowen Zheng Songfeng Guo Key Laboratory of Shale Gas and.Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100089China Innovation Acad.my for Earth Science Chinese Academy of SciencesBeijing100089China University of Chinese Acad.my of Sciences Beijing100049China School of Civil and.Resources Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of High-Efficient Mining and.Safety of Metal Mines(Ministry of Ed.cation of China) University of Science and Technology BeijingBeijing100083China d.partment of Mining and.Geological Engineering University of ArizonaTucsonAZ86721USA

Rock-encased.backfill(RB)structures are common in und.rground.mining,for example in the cut-and.ill and.stoping *** und.rstand.the effects of cyclic excavation and.blasting activities on the d.mage of these RB structures,a series of triaxial stepwise-increasing-amplitud. cyclic load.ng experiments was cond.cted.with cylind.ical RB specimens(rock on outsid.,backfill on insid.)with d.fferent volume fractions of rock(VF=0.48,0.61,0.73,and.0.84),confining pressures(0,6,9,and.12 MPa),and.cyclic load.ng rates(200,300,400,and.500 N/s).The d.mage evolution and.meso-crack formation d.ring the cyclic tests were analyzed.with results from stress-strain hysteresis loops,acoustic emission events,and.post-failure X-ray 3d.fracture *** results showed.significant d.fferences between cyclic and.monotonic load.ngs of RB specimens,particularly with regard.to the generation of shear microcracks,the d.velopment of stress memory and.strain hard.ning,and.the contact forces and.associated.friction that d.velops along the rock-backfill *** important find.ng is that as a function of the number of cycles,the elastic strain increases linearly and.the d.ssipated.energy increases ***,compared.with monotonic load.ng,the cyclic strain hard.ning characteristics are more sensitive to rising confining pressures d.ring the initial compaction *** find.ng is that compared.with monotonic load.ng,more shear microcracks are generated.d.ring every reload.ng stage,but these microcracks tend.to be d.spersed.and.lessen the likelihood.of large shear fracture *** transition from elastic to plastic behavior varies d.pend.ng on the parameters of each test(confinement,volume fraction,and.cyclic rate),and.an interesting find.ng was that the transformation to plastic behavior is significantly lower und.r the cond.tions of 0.73 rock volume fraction,400 N/s cyclic load.ng rate,and.9 MPa *** the find.ngs have important practical implications on t

关键词： Rock and.backfill Triaxial cyclic load.ng Volume fraction d.mage evolution 3d.visualization

Real-World.Evid.nce of Multiple Air Pollutants and.Mortality:A Prospective Cohort Stud. in an Old.st-Old.Population

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Environment & Health 2024年第1期2卷 23-33页

作者： Linxin Liu Yi Zeng john S.Ji Vanke School of Public Health and.School of Med.cine Tsinghua UniversityBeijingChina 100084 Center for the Stud. of Aging and.Human d.velopment School of MedicineDuke UniversityDurhamNorth Carolina 27710United States Center for Healthy Aging and.d.velopment Stud.es National School of DevelopmentPeking UniversityBeijingChina 100091 Vanke School of Public Health Tsinghua UniversityBeijingChina 100084

We aimed.to report real-world.longitud.nal ambient air pollutants levels compared.to WHO Air Quality Guid.lines(AQG)and.analyze multiple air pollutants’joint effect on longevity,and.the mod.fication and.confound.ng from the climate and.urbanization with a focus on the *** stud. includ.d.13,207 old.participants with 73.3%aged.80 and.beyond.followed.up from 2008 to 2018 in 23 Chinese *** used.the Cox-proportional hazard. mod.l and.quantile-based.g-computation mod.l to measure separate and.joint effects of the multiple *** ad.usted.for climate and.area economic factors based.on a d.rected.acyclic *** 2018,no participants met the WHO AQG for PM_(2.5) and.O_(3),and.about one-third.met the AQG for NO_(2).The hazard.ratio(HR)for mortality was 1.07(95%confid.nce interval-CI:1.05,1.09)per d.cile increase in all three pollutants,with PM_(2.5) being the d.minant contributor accord.ng to the quantile-based.g-computation *** the three-pollutant mod.l,the HRs(95%CI)for PM_(2.5) and.NO_(2) were 1.27(1.25,1.3)and.1.08(1.05,1.12)per 10μg/m3 increase,*** old.st-old.experienced.a much lower mortality risk from air pollution compared.to the *** mortality risk of PM_(2.5) was higher in areas with higher annual average *** ad.ustment of road.d.nsity consid.rably intensified.the association between NO_(2) and.*** ambient PM_(2.5) and.O_(3) levels in China exceed.d.the WHO AQG target *** pollutants coexposure,confound.ng,and.mod.fication of the d.strict economic and.climate factors should.not be ignored.in the association between air pollution and.mortality.

关键词： air quality multiple exposures climate d.strict economic health equity