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EECP in the treatment of endothelial dysfunction： preventing progression of cardiovascular disease

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Journal of Geriatric Cardiology 2010年第2期7卷 79-87页

作者： john ck hui William E Lawson Gregory W Barsness Cardiology Division State University of New York Stony Brook New York USA Cardiovascular Disease and Internal Medicine Mayo Clinic College of Medicine Rochester Minn USA

Enhanced external counterpulsation Extemal counterpulsation （ECP） was originally conceived to be a circulatory assist device to promote blood flow to areas of the heart muscle that were lacking adequate blood supply due to obstruction of the coronary artery. During ECP the lower extremities are compressed to squeeze both arterial and venous blood back to the heart during diastole, increasing coronary perfusion pressure and right ventricular filling. The compression is released during systole,

关键词：心血管疾病功能障碍血管内皮体外预防治疗冠状动脉血液供应

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-hui Liu Si-En Lin Alec McCarthy johnson V.john Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior:Two case reports

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World Journal of Clinical Cases 2024年第22期12卷 5124-5130页

作者： hui-hui Cao Hong Li Xiao-Hong Guo Zhi-Xing Cao Bo-hui Zhang Department of Pathology Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University)Zhuhai 519000Guangdong ProvinceChina

BAckGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic *** cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment *** SUMMARY Herein,we report two patients with ESC *** 1 was a young woman with classical pathological *** 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis *** of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy *** The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.

关键词： Eosinophilic solid and cystic renal cell carcinoma Solid and cystic growth pattern ck20 TSC1 mutations TSC2 mutations Case report

Effect of Catechins on Myocardial Injury and Inflammatory Factors in Rats with Coronary Heart Disease under PI3K/Akt/eNOS Signaling Pathway

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Chinese Journal of Biomedical Engineering 2024年第2期33卷 47-53+68页

作者： JIANG hui-qiong HONG Yan-ling Quanzhou First Hospital

Objective: To discuss the effect of catechins on myocardial injury and inflammatory factors in rats with coronary heart disease under PI3K/Akt/eNOS signaling pathway. Methods: A total of 50 healthy adult pathogen-free(SPF)-grade SD rats were divided into five groups by random number table method. Except for the blank group, the other four groups were fed with high fat to construct a rat model of coronary artery disease. After the model was successfully constructed, the blank group and the model group were given saline by gavage, the positive group was given 25 mg/kg aspirin by gavage, the low-dose group was given 20 mg/kg catechin by gavage, and the high-dose group was given 60 mg/kg catechin by gavage. The expression levels of PI3K/Akt/eNOS signaling pathway-related proteins, myocardial injury markers, myocardial infarction and myocardial inflammatory factors were observed and compared in the five groups. Results:Overall, there were significant differences in the expression levels of PI3K, p-Akt/Akt,and p-eNOS/eNOS in the five groups of rats(Pck-MB and c Tn I in the five groups of rats(P<0.05); there were significant differences in ischemic area, infarct area, and myocardial infarction range in the four groups of rats, except for the blank group(P<0.05); there were significant differences in the expression levels of IL-1β, IL-18, TNF-α, and ET-1 in the five groups of rats(P<0.05). Conclusion: Catechins can reduce the severity of myocardial injury, reduce the range of myocardial infarction, and reduce myocardial inflammation in rats with coronary heart disease by up-regulating expression level of PI3K/Akt/eNOS signaling pathway-related proteins. Compared with aspirin, high-dose catechins have a more prominent protective effect on the myocardium of rats with coronary heart disease.

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医学中的全科医学——从《柳叶刀》200年历史看现代医学中的全科医学发展(五):约翰·弗莱的国家间全科比较研究

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中国全科医学 2024年第6期27卷 I0001-I0004页

作者：杨辉澳大利亚Monash大学

约翰·弗莱(john Fry,1922-1994)可谓是高产的学术型全科医生了。20世纪50年代到90年代40年间在《柳叶刀》(The Lancet)上发表过7篇文章,分别研究伦敦雾霾对全科服务的影响,全科患者急性尿路感染与慢性肾盂肾炎的关系,军队全科医学及其... 详细信息

约翰·弗莱(john Fry,1922-1994)可谓是高产的学术型全科医生了。20世纪50年代到90年代40年间在《柳叶刀》(The Lancet)上发表过7篇文章,分别研究伦敦雾霾对全科服务的影响,全科患者急性尿路感染与慢性肾盂肾炎的关系,军队全科医学及其与民间全科医学的比较分析,全科患者对预约系统的看法,南非与英国全科服务的比较研究,全科医学对偏头痛的管理,初级保健对美国医疗系统的拯救机会等。这只是他作品的一小部分,他撰写或合著的著作达65本,他也在著名的《英国医学杂志》上发表过很多文章。

关键词：全科医学全科医生约翰·弗莱 The Lancet 比较研究

Effects of Water-retaining Agents on Growth, Development, Yield and Quality of Soybean under Drought Stress

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Plant Diseases and Pests 2024年第3期15卷 34-39页

作者： hui XIA Yan ZHANG Yun HAN Shasha HU Hengbin ZHANG Agricultural Science Research Institute of the Fourth Division of the Xinjiang Production and Construction Corps Ili 835219China

[Objectives]The paper was to explore the effects of different doses of water-retaining agent on the growth and development indicators,yield and quality of soybean plants subjected to drought stress.[Methods]The effects of drought stress(MDS)and drought stress with low(MDS-L),medium(MDS-M)and high doses(MDS-H)of the water-retaining agent on the growth and development indicators,root activity,MDA content,antioxidant enzyme activity,yield and quality of soybean were studied by field plot test,with the normal water supply serving as the control(ck).[Results]In response to drought stress,the plant height,stem diameter,and yield of soybean exhibited a notable ***,the contents of protein,fat,linoleic acid,and linolenic acid in seeds demonstrated a significant ***,the root activity and antioxidant enzyme activity exhibited a noticeable decline,while the MDA content exhibited an *** application of varying doses of the water-retaining agent was found to significantly enhance soybean growth,stimulate root activity,and elevate antioxidant enzyme activity,while concurrently reducing MDA *** observed effects were found to be dose-dependent,with the greatest effects observed at the highest *** comparison to MDS,the yields of soybean in the MDS-L,MDS-M,and MDS-H treatments exhibited a 18.38%,25.58%,and 46.26%increase,***,the content of protein,fat,linoleic acid,and linolenic acid in seeds demonstrated a notable enhancement.[Conclusions]The application of the water-retaining agent has been demonstrated to significantly promote the growth of soybean plants under conditions of drought stress,resulting in an improvement in both the yield and the quality of the soybean *** recommended dosage of the water-retaining agent is 3.3 kg/667 m 2.

关键词： Soybean Water-retaining agent Yield Quality Growth and development Antioxidant enzyme activity

“艺格敷词”与女性凝视:《维莱特》中的女性主体身份建构

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外语导刊 2024年第3期47卷 47-54,159页

作者：薛慧莹北京电影学院人文学部北京100088

“艺格敷词”作为对文学与视觉艺术、语言与图像关系的研究,已成为近年来西方跨学科研究的热点之一。在英国作家夏洛蒂·勃朗特的小说《维莱特》中,艺格敷词的运用非常广泛。本文将聚焦小说中视觉艺术的呈现,以劳拉·穆尔维的“男性凝... 详细信息

“艺格敷词”作为对文学与视觉艺术、语言与图像关系的研究,已成为近年来西方跨学科研究的热点之一。在英国作家夏洛蒂·勃朗特的小说《维莱特》中,艺格敷词的运用非常广泛。本文将聚焦小说中视觉艺术的呈现,以劳拉·穆尔维的“男性凝视”和约翰·伯格的《观看之道》为理论基础,解读女主人公露西·斯诺如何通过视觉体验与艺术评论实现对男性凝视的消解。勃朗特通过露西对荷兰现实主义绘画的赞美和对女性肖像画及其隐喻的批判揭示了女性视觉主体性的觉醒,并由此展开对主体与客体、自我与他者关系的讨论,在现实主义写作中为女性主体身份的建构提供了重新阐释的空间。

关键词：夏洛蒂·勃朗特维莱特艺格敷词男性凝视现实主义女性主体性身份建构

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根瘤内生菌群对南洋楹苗木生长的影响

林业科学研究 2024年第2期37卷 134-143页

作者：林千禧郑会全路国辉黄荣韦如萍王润辉晏姝华南师范大学生命科学学院广东广州510631 广东省林业科学研究院/广东省森林培育与保护利用重点实验室广东广州510520

[目的]探究根瘤内生菌群对南洋楹苗木的促生效应,并揭示根瘤优势内生菌组成及其与苗木生长的关系,为南洋楹菌肥研发提供参考。[方法]以来源于广东广州、惠州和茂名等3个地区的南洋楹根瘤提取液为接种菌液(YZ、YD和YX),开展南洋楹组培苗... 详细信息

[目的]探究根瘤内生菌群对南洋楹苗木的促生效应,并揭示根瘤优势内生菌组成及其与苗木生长的关系,为南洋楹菌肥研发提供参考。[方法]以来源于广东广州、惠州和茂名等3个地区的南洋楹根瘤提取液为接种菌液(YZ、YD和YX),开展南洋楹组培苗接种对比试验,并对回接根瘤进行16S rRNA基因测序鉴定和数据分析。[结果]与对照相比,3种接种处理的南洋楹苗木均能成功接根瘤,其苗期生长与结瘤、生物量积累、光合及固氮等相关指标均显著优于对照,其中苗高、根长、相对叶绿素含量和总氮量等表征南洋楹苗木的综合情况的指标分别比对照增加了53.74%~95.65%、52.91%~98.41%、74.04%~86.18%和7.6~15.9倍。3种接种处理中,接种菌液YZ对苗木促生、结瘤和固氮效应最为显著。回接根瘤内生菌群组成存在一定差异,YZ处理的根瘤内生菌的比例最均衡、细菌物种数(OTU数)最多和α多样性(香农指数)最高。根瘤内生菌中一种反硝化Fe-Ⅱ氧化细菌与南洋楹苗高、回接根瘤数呈极显著正相关,与含氮量、总氮量和固氮量呈显著正相关;OTU数和香农指数与南洋楹苗高、根瘤数、总氮量和固氮量等呈极显著或显著正相关关系。[结论]南洋楹根瘤提取液能对南洋楹苗期的生长与结瘤、生物量积累、光合及固氮起到积极的促进作用,不同来源的接种菌液对苗木的促生效应及回接根瘤内生菌群组成存在一定差异,根瘤内生菌种类越丰富、相对丰度越均衡,对南洋楹幼苗促生和固氮作用越显著。

关键词：南洋楹根瘤接种菌液内生菌群促生效应相关性

Reaction Mechanism and Product Branching Ratios of OH+C2H3F Reaction:A Theoretical Study

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Chinese Journal of Chemical Physics 2020年第2期33卷 203-209,I0003页

作者： Chih-Hao Chin Tong Zhu john Zeng-hui Zhang School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062China Department of Chemistry New York UniversityNew York 10003United States of America

Ab initio CCSD(T)/CBS//B3LYP/6-311G(d,p)calculations of the potential energy surface for possible dissociation channels of HOC2H3F,as well as Rice-Ramsperger-Kassel-Marcus(RRKM)calculations of rate constants,were carried out,in order to predict statistical product branching ratios in dissociation of HOC2H3F at various internal *** most favorable reaction pathway leading to the major CH2CHO+HF products is as the following:OH+C2H3F→i2→TS14→i6→TS9→i3→TS3→CH2CHO+HF,where the rate-determining step is HF elimination from the CO bridging position via TS11,lying above the reactants by 3.8 kcal/*** CH2O+CH2F products can be formed by F atom migration from Cαto Cβposition via TS14,then H migration from O to Cαposition via TS16,and C-C breaking to form the products via TS5,which is 1.8 kcal/mol lower in energy than the reactants,and 4.0 kcal/mol lower than TS11.

关键词： Ab initio Potential energy surface Reaction mechanism Rice-Ramsperger-Kassel-Marcus Branching ratio