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An Unusual, Fangless Short-tailed Snake(Squamata, Serpentes, Homalopsidae) from Sumatra, Indonesia

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Asian Herpetological Research 2013年第2期4卷 140-146页

作者： john c.MURPHY Harold K.VORIS Science and Education Field Museum

Two genera of fangless homalopsid snakes Brachyorrhos and calamophis from eastern Indonesia have been described as basal members of the clade. A third genus belonging to this group from Sumatra, Indonesia is described here based upon morphology. Fangless homalopsid snakes share 19 dorsal scale rows at mid-body, fused dorsal scales above the cloaca, 5 to 7 upper labials, divided anal plate, divided subcaudals, 15-21 teeth on the dentary, frontal bone about 23% of skull length and other morphological characters that suggest they are related. All the three genera are known only from Indonesia. The new genus and species have a distinctive skull morphology with an absent premaxilla, a more depressed skull, and a larger eye than are present in Brachyorrhos.

关键词： Brachyorrhos calamophis Karnsophis basal homalopsids skull osteology

PVDF ultrafiltration membranes of controlled performance via blending PVDF-g-PEGMA copolymer synthesized under different reaction times

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Frontiers of Environmental Science & Engineering 2018年第2期12卷 29-40页

作者： Shuai Wang Tong Li chen chen Baicang Liu john c. crittenden college of Architecture and Environment Sichuan University Chengdu 610207 China Institute of New Energy and Low carbon Technology Sichuan University Chengdu 610207 China Research center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Litree Purifying Technology co. Ltd Haikou 571126 China Brook Byers Institute for Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

Polyvinylidene fluoride grafted with poly（ethylene glycol） methyl ether methacrylate （PVDF-g- PEGMA） was synthesized using atomic transfer radical polymerization （ATRP） at different reaction times （9 h, 19 h, and 29 h）. The corresponding conversion rates were 10%, 20% and 30%, respectively. PVDF was blended with the copolymer mixtnre containing PVDF-g-PEGMA, solvent and residual PEGMA under different reaction times. In this study, we explored the effect of the copolymer mixture additives with different synthesis times on cast membrane performance. Increasing the reaction time of PVDF-g-PEGMA causes more PVDF-g-PEGMA and less residual PEGMA to be found in the casting solution. Incremental PVDF-g-PEGMA can dramatically increase the viscosity of the casting solution. An overly high viscosity led to a delayed phase inversion, thus hindering PEGMA segments in PVDF- g-PEGMA from migrating to the membrane surface. However, more residual PEGMA contributed to helping rnore PEGMA segments migrate to the membrane surface. The pure water fluxes of the blended membrane with reaction times of 9 h, 19 h, and 29 h are 5445 L. m 2.h I 1068 L- m 2.h land 1179 L.m 2.h I respectively, at 0.07 MPa. Delayed phase inversion can form smaller surface pore size distributions, thus decreasing the water flux for the membranes with PVDF-g-PEGMA at 19 h and 29 h. Therefore, we can control the membrane pore size distribution by decreasing the reaction time of PVDF-g-PEGMA to obtain a better flux performance. The membrane with PVDF-g-PEGMA at 19 h exhibits the best foulant rejection and cleaning recovery due to its narrow pore size distribution and high surface oxygen content.

关键词： Polyvinylidene fluoride ultrafiltvation mem-braneAmphiphilic copolymerBlended modificationHigh fluxAtomic transfer radical polymerization

Asymmetric reinforcement in Lucania killifish:assessing reproductive isolation when both sexes choose

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current Zoology 2021年第2期67卷 215-224页

作者： Michelle E.ST.john Rebecca c.FULLER School of Integrative Biology University of liois Urbana-ChampaignChampaignIL 61820USA

Reinforcement can occur when maladaptive hybridization in sympatry favors the evolution of con-specific preferences and target traits that promote behav ioral isolation(BI).In many systems,enhanced BI is due to increased female preference for *** others,BI is driven by male preference,and in other systems both sexes exert *** of these patterns can be atributed to classic sex-specific costs and benefits of ***,sex differences in conspecific preference can emerge due to asymmetric postzygotic isolation(e.g.,hybrid offspring from female A × male B have lower fitness than hybrid offspring from female B × male A),which can lead to asymmetric BI(e.g.,female A and male B are less likely to mate than female B and male A).Understanding reinforcement requires understanding how conspecific preferences evolve in ***,estimating conspecific preferences can be difficult when both sexes are *** this study,we use Lucania killifish to test the hypothesis that patterns of reinforcement are driven by asymmetric postzygotic isolation between *** true,we predicted that sympatric female Lucania goodei and sympatric male *** should have lower levels of BI compared with their sympatric counterparts,as they produce hybrid offspring with the highest *** address the problem of measuring BI when both sexes are choosy,we inferred the contribution to BI of each partner using assays where one sex in the mating pair comes from an allopatric population with potentially low preference,whereas the other comes from a sympatric population with high *** one hybrid cross direction,we found that both female *** and male *** have high contributions to BI in *** the other hybrid cross direction,we found that only female *** contribute to *** male *** readily engaged in hybrid spawnings with allo-patric *** *** results indicate that both asymmetric postzygotic isolation

关键词： reinforcement behavioral isolatin female mate choice male mate choice asymmetric costs to hybridization

高、低核酸含量原核生物应对资源可利用性降低和原生动物选择性摄食的适应性策略

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中国科学：地球科学 2024年第6期54卷 1901-1913页

作者：胡晨余柳倩陈晓炜刘纪化张瑶 john BATT 肖喜林石蔷张锐骆庭伟焦念志徐大鹏厦门大学环境与生态学院厦门361102 近海海洋环境科学国家重点实验室厦门大学海洋与地球学院福建省海洋碳汇重点实验室厦门361102 Joint Lab for Ocean Research and Education(LORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China 香港科技大学(广州)地球与海洋大气科学学域广州510000 山东大学海洋研究院青岛266237 Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada 深圳大学高等研究院深圳518060 厦门大学碳中和创新研究中心厦门361102

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体... 详细信息

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体系中进行了73天的培养实验,深入研究HNA和LNA亚群对资源可利用性降低和原生动物选择性摄食随时间变化的动态响应.研究结果显示,当培养环境资源充足时, HNA亚群的代谢活性高于LNA亚群,但随着资源日益稀缺, HNA亚群代谢下降速度比LNA亚群快,从而使LNA亚群对原核生物活性的贡献稳步增加.与此同时,随着培养体系资源可利用性逐步降低,原生动物的摄食偏好从HNA亚群转向LNA亚群,使得LNA亚群对培养体系的碳流贡献增加.这些结果突显了LNA亚群在资源有限环境中的韧性,阐明了原生动物选择性摄食在资源条件变化时平衡不同亚群中的关键作用,并展示了在不同环境背景下原生动物和原核生物之间复杂的相互适应性.

关键词：微生物环大体积培养实验原核生物自上而下和自下而上调控作用碳流

Envita’s Precision cancer care: 35-Fold Improvement in Response Rates

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Journal of cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany john c. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart christopher Aussems Jon Moma Shannon Miller Zach Poteet conner coffin courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel conway chad Burk Ruth Tan-Lim Dino Prato Envita Medical centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National comprehensive cancer Network (NccN) guidelines, utilized by prominent cancer institutions. cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical centers over a two-year period. compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical centers Late-stage cancer Overall Response Rate Quality of Life circulating Tumor cells (cTcs) Mutant Allele Frequency (MAF) Precision care

Effect of pneumatic compression therapy on lymph movement in lymphedema-affected extremities,as assessed by near-infrared fuorescence lymphatic imaging.

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Journal of Innovative Optical Health Sciences 2017年第2期10卷 110-123页

作者： Melissa B.Aldrich Deborah Gross john Rodney Morrow caroline E.Fife john c.Rasmussen center for Molecular Imaging The Brown Institute for Molecular Medicine UTHealth HoustonTexasUSA Mego Afek/Lympha Press USA Freehold New JerseyUSA cHI St.Luke's Health The Woodlands Hospital The Woodlands TexasUSA

Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy(PcT)for lymphedema(LE).Insurers,such as the centers for Medicare/Medicaid(cMS),however,desire visual proof that PcT moves *** infrared fuorescence lymphatic imaging(NIRFLI)was used to visualize lymphatic anatomy and function in four subjects with primary and cancer treatment-related LE of the lower extremities before,during,and after *** transparent and windowed PcT garments allowed visualization of lymph movement during single,1h PcT treatment *** revealed significant extravascular and lymphatic vascular movement of intradermally injected dye in all *** one subject with sufficient patent lymphatic vessels to allow quantification of lymph pumping velocities and frequencies,these values were significantly increased during and after PcT as compared to pre-treatment *** contractile activity in patent lymphatic vessels occurred in concert with the sequential cycling of *** visualization revealed increased lymphatic function,during and after PcT therapy,in all LE-affected *** studies are warranted to assess the effects of PcT pressure and sequences on lymph uptake and movement.

关键词： Lymphedema pneumatic compression therapy near-infrared fAuorescence

Positional goods and the challenge of chinese regional inequality

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Economic and Political Studies 2018年第1期6卷 4-10页

作者： john V.c.Nye Department of Economics George Mason UniversityFairfaxVAUSA NRU-Higher Schoolof Economics MoscowRussia

Scholars have focussed on income inequality as a major source of social *** the focus on crude income inequality has masked the deeper developmental problem facing many fast-growing *** is an extreme case of this issue inasmuch as its coastal regions can be viewed as comparable to middle income states,while the greater part of its rural and west-erm areas would be comparable to the poorer nations of the *** means that the new middle class pays attention to issues such as pollution and status or positional goods than simple material *** costs of houses are in particular less than *** status goods are similar because they are not amenable to simple productivity *** will make policies more difficult as conflict increases between those areas who are still eager for basic economic development and those richer areas whose wants and needs start to more closely resemble the preferences of richer developed countries.

关键词： Positional goods regional inequality statusgoods

Epidemiology of Mpox Outbreaks and Implications for Surveillance in Imo State, Nigeria

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Advances in Infectious Diseases 2024年第1期14卷 206-212页

作者： Adeniyi A. Adeniran Ebubechi c. Eronini Olugbenga Asaolu Simisola Adedeji Adaeze Joy Ugwu Marcus Oludare Faith Ehiaghe Ugba Aibinuomo Ayomide Oluwaseyi Tella Adedamola Dania Oluyinka Olayiwola Olanike Suliat Oladele Tinuola Daniel Musa Haruna Adebayo O. Amao john O. Ibitoye Oluwagbemiga Obembe christopher Obanubi Abdulmalik Abubakar Department of Public and Allied Health Babcock University Ilishan-Remo Nigeria Department of Public Health University of Suffolk Waterfront Building UK Department of Public Health EUCLID University Greater Bajul The Gambia Department of Public Health Liverpool John Moores University Liverpool UK college of Medicine Obafemi Awolowo University Ile-Ife Nigeria Department of Environmental Health Sciences University of Ibadan Ibadan Nigeria Department of Public Health Texila American University Georgetown Guyana School of Public Health University of Port Harcourt Port Harcourt Nigeria Department of community Medicine University College Hospital Ibadan Nigeria Department of Nursing Adeleke University Ede Nigeria Department of Public Health Central University of Nicaragua Managua Nicaragua Faculty of Basic clinical Sciences Lagos State University College of Medicine Ikeja Nigeria catholic Relief Services Abuja Nigeria Department of Political Science Faculty of Social Sciences Bayero University Kano Kano Nigeria

Mpox disease is caused by a double-stranded DNA virus, genus Orthopoxvirus of the family Poxviridae. The incubation period is usually 6 to 13 days but can range from 5 to 21 days while symptoms and signs may persist for 2 to 5 weeks. Although, the clinical features are usually less severe when compared to the deadly smallpox, the disease can be fatal with case fatality rate between 1% and 10%. In Imo State, Nigeria, there has been a changing epidemiology of the disease in the last 6 years and the frequency and geographic distribution of cases have progressively increased. This study aims to conduct a review of the disease epidemiology between 2017 and 2023 and implications for surveillance in Imo State. Surveillance data from the Surveillance Outbreak Response and Management System (SORMAS) was extracted between January 2017 and December 2023 across the 27 Local Government Areas (LGAs) of Imo State. A line list of 231 suspected cases was downloaded into an excel template and analyzed using SPSS® version 20 software. Analysis was done using descriptive statistics and associations were tested using Fischer’s exact at 0.05 level of significance. Of the 231 suspected cases, 57.1% (132) were males, 42.9% (99) were females and the modal age group was between the ages of 0 - 4 (32.5%). Eight (8) LGAs (districts) accounted for 71% (n = 164) of all the suspected cases. 21.2% (49) were confirmed positive, 27 males (55.1%) and 22 females (44.9%) (p > 0.05). Modal age group was 20 - 24 (22.4%, n = 11), 18% (9) were children under 14 years, p > 0.05. case fatality rate was 8% (n = 4). There was no significant association between mortality and age group. Five (5) LGAs accounted for about 60% (29) of all confirmed cases. These LGAs contribute only 20% to the total population in the State. Only 5.6% and 4% of suspected and confirmed cases, respectively, had knowledge of contact with an infectious source. The study described the epidemiology of Mpox outbreaks between 2017

关键词： Mpox Epidemiology Outbreak Surveillance

Some Insights in Novel Risk Modeling of Liquefied Natural Gas carrier Maintenance Operations

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Journal of Marine Science and Application 2016年第2期15卷 144-156页

作者： T. c. Nwaoha Andrew john Marine Engineering Department College of Technology Federal University of Petroleum Resources Effurun P.M.B. 1221 Nigeria Welding and Offshore Engineering Department Petroleum Training Institute Effurun P.M.B. 20 Nigeria

This study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas （LNG） carrier operations in the maritime environment. The usefulness of these algorithms in the LNG carrier industry in the areas of risk assessment and maintenance modeling as a standalone or hybrid algorithm are identified. This is evidenced with illustrative case studies.

关键词： safety risk modeling maintenance LNG carrier fuzzylogic genetic algorithm evidential reasoning