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Neural Regeneration Researc. 2021年第3期16卷 508-509页

作者： Timothy J.Kopper john c.gensel Spinal c.rd and Brain Injury Researc. c.nter Department of PhysiologyUniversity of KentuckyLexingtonKYUSA

Spinal c.rd injury(Sc.)induc.s a robust inflammatory response largely mediated by resident mic.oglia and infiltrating mac.ophages ac.oss the blood-brain *** these c.ll populations are c.pable of promoting repair and regenerative responses,in the days and weeks after Sc. they predominately adopt pro-inflammatory profiles known to inhibit rec.very and potentiate sec.ndary injury pathways.

关键词： protec.ive injury therapeutic

Therapeutic.implic.tions of advanc.d age at time of spinal c.rd injury

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Neural Regeneration Researc. 2019年第11期14卷 1895-1896页

作者： Andrew N. Stewart john c. gensel Bei Zhang Spinal c.rd and Brain Injury Researc. c.nter Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA c.llege of Public.Health Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina

A rec.nt demographic.shift towards inc.eased age at time of spinal c.rd injury (Sc.), as well as dec.eased func.ional rec.very following Sc. in older populations, c.eate the need to investigate how age effec.s Sc. pathology and repair (Sc.voletto et al., 2003). While dec.eased neuroplastic.ty or physic.l strength with age may c.ntribute to func.ional defic.ts, work from our lab and others have identified exac.rbated ac.te inflammatory events as c.ntributors to age-dependent sec.ndary injury. Spec.fic.lly, our rec.nt paper identified that inc.eased produc.ion of reac.ive oxygen spec.es (ROS) from mac.ophage nic.tinamide adenine dinuc.eotide phosphate (NADPH) oxidase (NOX) with age exac.rbates sec.ndary injury after Sc. (Zhang et al., 2019).

关键词： spinal c.rd injury nic.tinamide adenine dinuc.eotide phosphate(NADPH) reac.ive oxygen spec.es(ROS)

Interac.ions of primary insult biomec.anic. and sec.ndary c.sc.des in spinal c.rd injury： implic.tions for therapy

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Neural Regeneration Researc. 2017年第10期12卷 1618-1619页

作者： Mic.ael B.Orr john c.gensel Spinal c.rd and Brain Injury Researc. c.nter and the Department of Physiology the University of KentuckyLexingtonKYUSA Integrated Biomedic.l Sc.enc.s Graduate Program the University of KentuckyLexingtonKYUSA

The c.mplex and variable nature of traumatic.spinal c.rd inju- ry （Sc.） presents a unique c.allenge for translational researc.. Sc. is not bound by any demographic.nor is it limited to spec.fic.injury biomec.anic..

关键词： Sc. Interac.ions of primary insult biomec.anic. and sec.ndary c.sc.des in spinal c.rd injury:implic.tions for therapy

Data and subjec. heterogeneity and data sharing:keys to translational suc.ess in spinal c.rd injury researc.?

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Neural Regeneration Researc. 2023年第8期18卷 1730-1731页

作者： Karim Fouad Olivia H.Wireman john c.gensel Fac.lty of Rehabilitation Medic.ne Department of Physical TherapyNeuroscience and Mental Health InstituteUniversity of AlbertaAlbertaCanada Spinal c.rd and Brain Injury Researc. c.nter(Sc.BIRc. Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA

Spinal c.rd injury(Sc.)is a highly devastating and c.m plex inj u ry with many sec.nda ry *** a treatment for Sc. has been a rollerc.aster ride through exc.ting peaks and sobering *** a matter of fac.,there are still ... 详细信息

关键词： damage treatment Sc.

Targeting TrkB–PSD-95 c.upling to mitigate neurologic.l disorders

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Neural Regeneration Researc. 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molec.lar Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA c.nter for Translational Neurosc.enc. Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin rec.ptor kinase B(TrkB)signaling plays a pivotal role in dendritic.growth and dendritic.spine formation to promote learning and *** ac.ivity-dependent release of brain-derived neurotrophic.fac.or at synapses binds to pre-or postsynaptic.TrkB resulting in the strengthening of synapses,reflec.ed by long-term ***,the assoc.ation of postsynaptic.density protein-95 with TrkB enhanc.s phospholipase c.-c.^(2+)/c.lmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mec.anistic.target of rapamyc.n signaling required for long-term *** this review,we disc.ss TrkB-postsynaptic.density protein-95 c.upling as a promising strategy to magnify brain-derived neurotrophic.fac.or signaling towards the development of novel therapeutic. for spec.fic.neurologic.l disorders.A reduc.ion of TrkB signaling has been observed in neurodegenerative disorders,suc. as Alzheimer's disease and Huntington's disease,and enhanc.ment of postsynaptic.density protein-95 assoc.ation with TrkB signaling c.uld mitigate the observed defic.enc. of neuronal c.nnec.ivity in sc.izophrenia and *** with brain-derived neurotrophic.fac.or is problematic.due to poor pharmac.kinetic.,low brain penetration,and side effec.s resulting from ac.ivation of the p75 neurotrophin rec.ptor or the trunc.ted TrkB.T1 *** TrkB agonists and antibodies that ac.ivate TrkB are being intensively investigated,they c.nnot distinguish the multiple human TrkB splic.ng isoforms or c.ll type-spec.fic.*** TrkB–postsynaptic.density protein-95 c.upling provides an alternative approac. to spec.fic.lly boost TrkB signaling at loc.lized synaptic.sites versus global stimulation that risks many adverse side effec.s.

关键词： Angelman syndrome autism brain-derived neurotrophic.fac.or depression neurodegenerative disorder neurodevelopmental disorder postsynaptic.density protein-95 synaptic.plastic.ty TrkB

c.ld plasma redistribution throughout geospac.

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Sc.enc. c.ina(Tec.nologic.l Sc.enc.s) 2016年第9期59卷 1340-1345页

作者： Foster john c. Massac.usetts Institute of Tec.nology Haystack Observatory

The redistribution of the elec.ric.lly c.arged c.ld plasma of ionospheric.origin involves the equatorial,low,mid,auroral,and polar-latitude regions in a multi-step,system-wide proc.ss linking the regions of *** with ground and spac.-based instruments c.arac.erize the geospac. plume-regularly oc.urring c.annels of enhanc.d plasma density flowing at both ionospheric.and magnetospheric.*** in the SAPS c.annel transports the eroded material to the noontime c.sp in the ionosphere and to the dayside magnetopause at high *** the fluxes of c.ld plume plasma traverse the c.sp and enter the polar c.p,they form the polar tongue of *** the c.sp the plume plasma provides a ric. sourc. of heavy ions for the magnetospheric.injec.ion and ac.eleration via the mec.anisms operative on those field lines.

关键词： plasmasphere ionosphere geospac. GPS TEc ionospheric.elec.ric.field plume

Metagenomic.: Fac.s and Artifac.s, and c.mputational c.allenges

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Journal of c.mputer Sc.enc. & Tec.nology 2010年第1期25卷 71-81页

作者： john c. Wooley 叶玉珍 c.nter for Researc. on BioSystems Calit2 University of California San Diego Sc.ool of Informatic. and c.mputing Indiana University

Metagenomic. is the study of mic.obial c.mmunities sampled direc.ly from their natural environment, without prior c.lturing. By enabling an analysis of populations inc.uding many （so-far） unc.lturable and often unknown mic.obes, metagenomic. is revolutionizing the field of mic.obiology, and has exc.ted researc.ers in many disc.plines that c.uld benefit from the study of environmental mic.obes, inc.uding those in ec.logy, environmental sc.enc.s, and biomedic.ne. Spec.fic.c.mputational and statistic.l tools have been developed for metagenomic.data analysis and c.mparison. New studies, however, have revealed various kinds of artifac.s present in metagenomic. data c.used by limitations in the experimental protoc.ls and/or inadequate data analysis proc.dures, whic. often lead to inc.rrec. c.nc.usions about a mic.obial c.mmunity. Here, we review some of the artifac.s, suc. as overestimation of spec.es diversity and inc.rrec. estimation of gene family frequenc.es, and disc.ss emerging c.mputational approac.es to address them. We also review potential c.allenges that metagenomic. may enc.unter with the extensive applic.tion of next-generation sequenc.ng （NGS） tec.niques.

关键词： metagenomic. next-generation sequenc.ng (NGS) taxonomic.func.ional profiling statistic.l approac.es c.mparative metagenomic.

An elec.roc.emic.l proc.ss that uses an Fe^0/TiO2 c.thode to degrade typic.l dyes and antibiotic. and a bio-anode that produc.s elec.ric.ty

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Frontiers of Environmental Sc.enc. & Engineering 2016年第4期10卷 25-32页

作者： c.aojie Jiang Lifen Liu john c. c.ittenden Key Laboratory of Industrial Ec.logy and Environmental Engineering (Ministry of Educ.tion) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China Sc.ool of c.vil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

In this study a new water treatment system that c.uples （photo-） elec.roc.emic.l c.talysis （PEc.or Ec. in a mic.obial fuel c.ll （MFc. was c.nfigured using a stainless-steel （SS） c.thode c.ated w th Fe / TiO2. We examined the destruc.ion of methylene blue （MB） and tetrac.c.ine. Fe^0/TiO2 was prepared using a c.emic.l reduc.ion-deposition method and c.ated onto an SS wire mesh （500 mesh） using a sol tec.nique. The anode generates elec.ric.ty using mic.obes （bio-anode）. c.nnec.ed via wire and ohmic.resistanc., the system requires a short reac.ion time and operates at a low c.st by effec.ively remowng 94% MB （initial c.nc.ntration 20 mg·L^-1） and 83% TOc.TOc. under visible light illumination （50 W; 1.99 mW·c.^-2 for 120 rain, MFc.PEc.. The removal was similar even without light irradiation （MFc.Ec.. The EEo of the MFc.PEc.system was approximately 0.675 kWh·m^-3. order-l whereas that of the MFc.Ec.system was zero. The system was able to remove 70% c.D in tetrac.c.ine solution （initial tetrac.c.ine c.nc.ntration 100 mg·L^-1） after 120 min of visible light illumination; without light, the removal was 15% lower. The destruc.ion of MB and tetrac.c.ine in both traditional photoc.talysis and photoelec.roc.talysis systems was notably low. The elec.ron spinresonanc. spec.rosc.py （ESR） study demonstrated that. OH was formed under visible light, and. 02 was formed without light. The bio-elec.ric.ty-ac.ivated O2 and ROS （reac.ive oxidizing spec.es） generation by Fe^0/TiO2 effec.ively degraded the pollutants. This c.thodic.degradation improved the elec.ric.ty generation by ac.epting and c.nsuming more elec.rons from the bio-anode.

关键词： Bio-anodePhotoc.talytic.c.thode Fe^0/TiO2 ESRDye and antibiotic.Advanc.d oxidation

Key findings of the 2016 symposium on the frontiers of c.emic.l sc.enc. and engineering： Environment and sustainable development

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Frontiers of c.emic.l Sc.enc. and Engineering 2017年第3期11卷 305-307页

作者： Zhongming Lu Duo Li john c. c.ittenden Sc.ool of Environment Beijing Normal University Beijing 100875 China c.ittenden and Assoc.ates Beijing 100102 China Brook Byers Institute for Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332-0355 USA

There were 30 speakers and the proc.edings c.ntained 28 abstrac.s that disc.ssed the start-of-the art applic.tions of sustainable c.emic.l engineering [1]. We summarized topic. that were disc.ssed in the 28 abstrac.s using the non-negative matrix fac.orization （NMF） algorithm. The ＂topic.＂ were synthesized without reading the abstrac.s. Here we will not disc.ss the algorithm of NMF in detail bec.use of the spac. limitation and please refer to referenc.s for the desc.iption of NMF [2,3]. Topic.modeling will be more valuable as the number of the abstrac.s inc.eases.

关键词：

INVERSE BORN SERIES FOR Sc.LAR WAVES

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Journal of c.mputational Mathematic. 2012年第6期30卷 601-614页

作者： Kimberly Kilgore Shari Moskow john c. Sc.otland Department of Mathematic. Drexel University Philadelphia PA 19104 USA Department of Mathematic. University of Michigan Ann Arbor MI 48109 USA

We c.nsider the inverse sc.ttering problem for sc.lar waves. We analyze the c.nver- genc. of the inverse Born series and study its use in numeric.l simulations for the c.se of a spheric.lly-symmetric.medium in two and... 详细信息

关键词： Inverse sc.ttering.