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Targeting Trkb–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase b(Trkb)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic Trkb resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with Trkb enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss Trkb-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of Trkb signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with Trkb signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated Trkb.T1 *** Trkb agonists and antibodies that activate Trkb are being intensively investigated,they cannot distinguish the multiple human Trkb splicing isoforms or cell type-specific *** Trkb–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost Trkb signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity Trkb

Highly cross-linked polyethylene is the new‘gold standard’bearing material for total hip arthroplasty

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biosurface and biotribology 2021年第2期7卷 53-59页

作者： john b.Medley Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooOntarioCanada

Conventional polyethylene is not used much in total hip arthroplasty(THA);it has been supplanted by oxidation-resistant cross-linked polyethylene(≥50 kGy irradiation).However,studies persist that de-emphasize or ignore cross-linked polyethylene.A se-lective literature review is used briefly to present the early use of conventional poly-ethylene and its implication in wear particle-induced osteolysis leading to premature revision *** current situation is established based on Australian registry data and other studies that advocate the use of cross-linked polyethylene in preference to conventional *** some studies suggest caution in using cross-linked polyethylene,overall it is strongly *** the author’s opinion,cross-linked polyethylene is the new reference standard bearing material in THA.

关键词： cross Highly planted

Study of hybrid nanofluid flow in a stationary cone-disk system with temperature-dependent fluid properties

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 677-694页

作者： A.S.john b.MAHANTHESH G.LORENZINI Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India School of Mathematical and Statistical Sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Department of Engineering and Architecture University of ParmaParma 43124Italy

Cone-disk systems find frequent use such as conical diffusers,medical devices,various rheometric,and viscosimetry *** this study,we investigate the three-dimensional flow of a water-based Ag-Mg O hybrid nanofluid in a static cone-disk system while considering temperature-dependent fluid *** the variable fluid properties affect the dynamics and heat transfer features is studied by Reynolds's linearized model for variable viscosity and Chiam's model for variable thermal *** single-phase nanofluid model is utilized to describe convective heat transfer in hybrid nanofluids,incorporating the experimental *** model is developed as a coupled system of convective-diffusion equations,encompassing the conservation of momentum and the conservation of thermal energy,in conjunction with an incompressibility condition.A self-similar model is developed by the Lie-group scaling transformations,and the subsequent self-similar equations are then solved *** influence of variable fluid parameters on both swirling and non-swirling flow cases is ***,the Nusselt number for the disk surface is *** is found that an increase in the temperature-dependent viscosity parameter enhances heat transfer characteristics in the static cone-disk system,while the thermal conductivity parameter has the opposite effect.

关键词： hybrid nanofluid cone-disk system laminar flow variable fluid property Nusselt number

Nanoparticle meta-grid for enhanced light extraction from light-emitting devices

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Light(Science & Applications) 2020年第1期9卷 842-852页

作者： Debabrata Sikdar john b.Pendry Alexei A.Kornyshev Department of Chemistry Molecular Sciences Research HubImperial College LondonWhite CityLondon W120BZUK Department of Electronics and Electrical Engineering Indian Institute of Technology GuwahatiGuwahati 781039India The blackett Laboratory Department of PhysicsImperial College LondonLondon SW72AZUK Thomas Young Centre for Theory and Simulation of Materials Imperial College LondonLondon SW72AZUK

based on a developed theory,we show that introducing a meta-grid of sub-wavelength-sized plasmonic nanoparticles(NPs)into existing semiconductor light-emitting-devices(LEDs)can lead to enhanced transmission of light across the LED-chip/encapsulant *** results from destructive interference between light reflected from the chip/encapsulant interface and light reflected by the NP meta-grid,which conspicuously increase the efficiency of light extraction from ***“meta-grid”,should be inserted on top of a conventional LED chip within its usual encapsulating *** described by the theory,the nanoparticle composition,size,interparticle spacing,and distance from the LED-chip surface can be tailored to facilitate maximal transmission of light emitted from the chip into its encapsulating layer by reducing the Fresnel *** analysis shows that transmission across a typical LEDchip/encapsulant interface at the peak emission wavelength can be boosted up to ~99%,which is otherwise mere~84% at normal *** scheme could provide improved transmission within the photon escape cone over the entire emission spectrum of an *** would benefit energy saving,in addition to increasing the lifetime of LEDs by reducing ***,the scheme will be easy to implement and adopt into existing semiconductor-device technologies,and it can be used separately or in conjunction with other methods for mitigating the critical angle loss in LEDs.

关键词： light particle reflected

A perspective on the Li-ion battery

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Science China Chemistry 2019年第12期62卷 1555-1556页

作者： john b.Goodenough Hongcai Gao Texas Materials Institute and Materials Science Program The University of Texas at Austin Cockrell School of Engineering

In the 1960s,Rouxel in France and Robert Schroeder in Germany explored the chemistry of reversible intercalation of Li^+between MS2(M=transition metal)layers held together by weak Van der Waals bonding[1].In 1967,Kummer and Webber of the Ford Motor *** discovered fast 2D Na+diffusion at 300℃in incompletely occupied Na^+and O layers between spinel blocks of an aluminum oxide and had invented a sodium-sulfur battery operating above 300℃.

关键词： battery incomplete occupied

Coping with the environmental effects of point-source discharges

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Journal of Environmental Sciences 1992年第1期4卷 1-9页

作者： john Caims b.R.Niederlehner University Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061-0415 USAUniversity Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061-0415 USA Jr

Current methods for assessing the environmental impact of point source discharges in the United States are reviewed. The emphasis of many assessments of damage from pollution is shifting from chemical or technological standards to biological standards, i.e., the protection of biological integrity in the receiving system. The importance of integrating information from chemical measurements, toxicity tests, and field surveys in impact assessment is re-emphasized. Ways in which environmental professionals can improve methods for assessing damage from pollution and its control are discussed.

关键词： effluents biological integrity environmental assessment toxicity tests water pollution.

Diagenesis and Fluid Flow History in Sandstones of the Upper Permian black Jack Formation, Gunnedah basin, Eastern Australia

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Acta Geologica Sinica(English Edition) 2007年第3期81卷 433-441页

作者： bAI Guoping john b. KEENE Key Laboratory for Hydrocarbon Accumulation of Education Ministry China University of Petroleum Beijing 102249 China School of Geosciences University of Sydney NSW 2006 Australia

The fluid flow history during diagenesis of sandstones in the Upper Permian black Jack Formation of the Gunnedah basin has been investigated through integrated petrographic observations, fluid inclusion investigations and stable isotope analyses. The early precipitation of mixed-layer illite/smectite, siderite, calcite, ankerite and kaolin proceeded at the presence of Late Permian connate meteoric waters at temperatures of up to 60℃. These evolved connate pore waters were also parental to quartz, which formed at temperatures of up to 87℃. The phase of maximum burial was characterized by development of filamentous illite and late calcite at temperatures of up to -90℃. Subsequent uplifting and cooling led to deep meteoric influx from surface, which in turn resulted in dissolution of labile grains and carbonate cements, and formation of second generation of kaolin. Dawsonite was the last diagenetic mineral precipitated and its formation is genetically related to deep-seated mamagtic sourced CO2.

关键词： diagenesis fluid flow history Gunnedah basin fluid inclusion stable isotope

All-angle reflectionless negative refraction with ideal photonic Weyl metamaterials

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Light(Science & Applications) 2022年第10期11卷 2444-2450页

作者： Yachao Liu Guo Ping Wang john b.Pendry Shuang Zhang College of Electronics and Information Engineering Shenzhen University518060 ShenzhenChina School of Physics&Astronomy University of BirminghamBirmingham B152TTUK The blackett Laboratory Department of PhysicsImperial College LondonLondon SW72AZUK Department of Physics University of Hong KongHong KongChina Department of Electrical&Electronic Engineering University of Hong KongHong KongChina

Negative refraction,an unnatural optical phenomenon in which the incident and the refracted waves reside on the same side of the surface normal,has been demonstrated with the invention of negative index media based on artificially engineered photonic structures called *** has received wide attention due to its potential applications in imaging,nonlinear optics,and electromagnetic ***,it is highly challenging to realize negative refraction operating at all angles and with the perfect *** this work,leveraging the recent development in topological photonics,we propose to realize reflection less negative refraction for all incident angles with a topological *** proposed metamaterial possesses two Weyl points of opposite topological *** interfacing the metamaterial with a perfect electric conductor(PEC)or a perfect magnetic conductor(PMC),the Fermi arc connecting the two Weyl points can take the form of a half-circle possessing a positive or a negative refractive ***,due to the topological protection,there is no reflection at the interface between the PEC and PMC covered areas,leading to the observation of all-angle negative refraction without reflection at the *** work provides a new platform for manipulating the propagation of surface waves,which may find applications in the construction of integrated photonic devices.

关键词： refraction topological perfect

Interactions of primary insult biomechanics and secondary cascades in spinal cord injury： implications for therapy

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Neural Regeneration Research 2017年第10期12卷 1618-1619页

作者： Michael b.Orr john C.Gensel Spinal Cord and brain Injury Research Center and the Department of Physiology the University of KentuckyLexingtonKYUSA Integrated biomedical Sciences Graduate Program the University of KentuckyLexingtonKYUSA

The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.

关键词： SCI Interactions of primary insult biomechanics and secondary cascades in spinal cord injury:implications for therapy