检索结果-南通市图书馆

世界科学 2002年第5期 46-46页

作者： john t.finn ,余家驹

对爱德华·特勒强硬的政治态度和他在发展氢弹方面所起的作用几乎没人会提出疑义;然而,几乎没有哪一位科学家会像他那样招致意见相左的激烈反响.

关键词：奥本海默原子弹裂变武器氢弹核爆炸实验室

targeting trkB–PSD-95 coupling to mitigate neurological disorders

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

tropomyosin receptor kinase B(trkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic trkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with trkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss trkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of trkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with trkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated trkB.t1 *** trkB agonists and antibodies that activate trkB are being intensively investigated,they cannot distinguish the multiple human trkB splicing isoforms or cell type-specific *** trkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost trkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity trkB

Fracture strength evaluation of titanium alloys using modified average stress criterion

在线全文

学校读者我要写书评

暂无评论

transactions of Nonferrous Metals Society of China 2013年第4期23卷 1072-1079页

作者： H.BRIGHtON ISAAC john t.CHRIStOPHER Sardar Raja College of Engineering AlangulamTirunelveli-627808India Government College of Engineering PerumalpuramTirunelveli-627007India

Structural integrity procedures were used to demonstrate the fitness for the purpose of engineering components transmitting loads. the prediction of the fracture strength of titanium alloys containing sharp notches through the damage model depends on the un-notched strength and the critical length of the damage zone ahead of the notch. In general, the critical length of the damage zone depends on the material, specimen, and size of the sharp notch. Modifications were made in one of the stress fracture criteria known as the average stress criterion for accurate prediction of notched tensile strength of titanium alloy specimen containing sharp notches. to examine the adequacy of these modifications, fracture data of center-cracked titanium alloys with various thicknesses are considered. the notched （fracture） strength estimates are found to be close to the test results. the modified average stress criterion is very simple to predict the notched tensile strength.

关键词： titanium alloys center crack tensile specimen stress criterion failure assessment diagram fracture strength

Boundary Elements: theory and Applications 1st ed.

在线全文

学校读者我要写书评

暂无评论

trends in outpatient breast cancer surgery among Medicare fee-for-service patients in the United States from 1993 to 2002

2002年

作者： Katsikadelis, john t.

ISBN: (数字)9780080528243

ISBN: (纸本)9780080441078

the author's ambition for this publication was to make BEM accessible to the student as well as to the professional engineer. For this reason, his maintask was to organize and present the material in such a way so that the book becomes "user-friendly" and easy to comprehend, taking into account only the mathematics and mechanics to which students have been exposed during their undergraduate studies. this effort led to an innovative, in many aspects, way of presentingBEM, including the derivation of fundamental solutions, the integral representation of the solutions and the boundary integral equations for various governing differentialequations in a simple way minimizing a recourse to mathematics with which the student is not familiar. the indicial and tensorial notations, though they facilitate the author's work and allow to borrow ready to use expressions from the literature, have been avoided in the present book. Nevertheless, all the necessary preliminary mathematical concepts have been included in order to make the book complete and *** the book, every concept is followed by example problems, which have been worked out in detail and with all the necessary clarifications. Furthermore, each chapter of the book is enriched with problems-to-solve. these problems serve a threefold purpose.

关键词： Boundary element methods.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2011年第3期30卷 197-203页

作者： john Bian1 Michael t. Halpern Atlanta Veterans Affairs Medical Center RtI International

the practice of outpatient breast cancer surgery has been controversial in the United States. this study aimed to update time trends and geographic variation in outpatient breast cancer surgery among elderly Medicare fee-for-service women in the United States. Using the 1993-2002 linked Surveillance, Epidemiology and End Results (SEER)-Medicare claims data and the Area Resource Files, we identified 2 study samples, including the women whose breast cancers were the first-ever-diagnosed cancer at age 65 years or older from 9 regions continuously covered by the SEER registries since 1993. the first sample included the women receiving unilateral mastectomy for stage 0-IV cancer; the second included the women receiving the breast-conserving surgery with lymph node dissection (BCS/LND) for stage 0-II cancer. the proportions of patients receiving outpatient surgery increased from 3.2% to 19.4% for mastectomy and from 48.9% to 77.8% for BCS/LND from 1993 to 2002. We observed substantial geographic variation in the average proportion of the patients receiving outpatient surgery in the studied areas across the 10-year period, ranging from 3.9% in Connecticut to 27.2% in Utah for mastectomy and from 54.7% in Hawaii to 78.1% in Seattle, Washington, for BCS/LND. As the popularity of outpatient breast cancer surgery continues to grow, more evidence-based analyses related to quality and outcomes of outpatient breast cancer surgery among various populations are needed in order to facilitate the public debates about state and federal mandated health benefit legislations.

关键词：医疗费用有偿服务乳腺癌手术门诊患者美国 SEER

在线全文

学校读者我要写书评

暂无评论

种蛋管理、孵化率和雏鸡质量新进展

中国家禽 2004年第21期26卷 39-46页

作者： john t.Brake 北卡罗来纳州立大学家禽科学系

1 种蛋的物理构成1.1胶护膜临产前,蛋壳表面有一层透明的保护膜,称为胶护膜.在子宫中,液体和溶质可透过湿的胶护膜,产出后,胶护膜的结构紧缩,防止随后有微生物进入.

关键词：鸡种蛋物质构成管理孵化率雏鸡质量

Some Insights in Novel Risk Modeling of Liquefied Natural Gas Carrier Maintenance Operations

在线全文

学校读者我要写书评

暂无评论

Journal of Marine Science and Application 2016年第2期15卷 144-156页

作者： t. C. Nwaoha Andrew john Marine Engineering Department College of Technology Federal University of Petroleum Resources Effurun P.M.B. 1221 Nigeria Welding and Offshore Engineering Department Petroleum Training Institute Effurun P.M.B. 20 Nigeria

this study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas （LNG） carrier operations in the maritime environment. the usefulness of these algorithms in the LNG carrier industry in the areas of risk assessment and maintenance modeling as a standalone or hybrid algorithm are identified. this is evidenced with illustrative case studies.

关键词： safety risk modeling maintenance LNG carrier fuzzylogic genetic algorithm evidential reasoning

在线全文

学校读者我要写书评

暂无评论

肉鸡腹水征的控制方法

中国家禽 2001年第22期23卷 21-22页

作者： john t.Brake 美国北卡罗来纳州立大学家禽系

1 鸡舍通风在冬季,鸡舍的通风换气受影响,鸡舍内存在大量的氨气,当鸡吸入氨气后呼吸系统的主要表现为:呼吸系统的粘液分泌增加,呼吸道的管道壁增厚并由于氨气的毒性造成纤毛运动减慢;其中,呼吸系统的粘液分泌增加和呼吸道壁增厚将降低... 详细信息

1 鸡舍通风在冬季,鸡舍的通风换气受影响,鸡舍内存在大量的氨气,当鸡吸入氨气后呼吸系统的主要表现为:呼吸系统的粘液分泌增加,呼吸道的管道壁增厚并由于氨气的毒性造成纤毛运动减慢;其中,呼吸系统的粘液分泌增加和呼吸道壁增厚将降低氧气进入血液的总量.同时,心脏的反应为压迫更多的血液到血管中,从而使血压升高(高血压).当纤毛的清扫作用降低后将使细菌、尤其是大肠杆菌进入肺和气囊中,从而使巨噬细胞进入肺脏器官的数量增加,造成肺脏粘液分泌增加及肺脏充血.

关键词：肉鸡腹水证控制方法鸡舍通风生长速度控制舍温控制饲料

在线全文

学校读者我要写书评

暂无评论

细胞免疫与癌免疫最新研究进展

国外医学（肿瘤学分册） 1991年第2期18卷 90-93页

作者： Lotze Mt.finn OJ 李登华

基础免疫学家、动物实验者和临床医生于年初共同分析了细胞免疫用于癌症治疗的研究状况,探讨了进一步评价和利用癌细胞免疫反应所存在的关键问题。显然,免疫物质可使癌肿缩小,其中对t细胞反应的特异性给人类癌症治疗带来很大希望。以往... 详细信息

基础免疫学家、动物实验者和临床医生于年初共同分析了细胞免疫用于癌症治疗的研究状况,探讨了进一步评价和利用癌细胞免疫反应所存在的关键问题。显然,免疫物质可使癌肿缩小,其中对t细胞反应的特异性给人类癌症治疗带来很大希望。以往认为癌症为免疫学所做的贡献比免疫学对癌症的贡献要大,近年来免疫学的发展已改变了这种观念。关于t细胞对抗原提呈,识别、激活、生长、转运和与内皮细胞反应的新见解。

关键词：细胞免疫癌免疫

Annual yields of multispecies grassland mesocosms outperformed monocultures across a drought gradient due to complementarity effects and rapid recovery

在线全文

学校读者我要写书评

暂无评论

Grassland Research 2023年第4期2卷 309-321页

作者： Eamon Haughey Jennifer C.McElwain john A.finn Department of Natural Resources and the Environment Atlantic Technological UniversityGalwayIreland Botany Department School of Natural SciencesTrinity College DublinDublinIreland teagasc Environment Research CentreJohnstown CastleWexfordIreland

Background:More frequent and severe drought events due to climate change pose a major challenge for sustainable forage production in managed *** study investigated whether multispecies grassland communities can provide greater resistance to and/or recovery from drought compared to monoculture ***:Mesocosms of Lolium perenne L.,Cichorium intybus L.,trifolium repens *** trifolium pratense *** established as monocultures,and a four-species mixture.A drought gradient with five levels of water supply ranging from a mild to a severe treatment was applied for 10 weeks,in each of 2 *** biomass was harvested to assess drought resistance,drought recovery and annual *** mass density and specific root length were measured in Year ***:Across the drought gradient,four-species communities had significantly larger annual yields than each of the four monocultures,indicating transgressive *** was despite relatively low drought resistance for four-species communities compared with *** and *** *** of yields following drought was high for all ***:Multispecies swards with complementary traits can provide a viable adaptation option across a wide range of drought *** of a stress gradient methodology allowed a more detailed understanding of stress responses.

关键词： climate change drought forage production functional biodiversity perturbation gradient resilience root traits