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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov Fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick john stuart winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

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ALPHA SPACE-WHERE PLANTS FLY BEYOND THE VERTICAL GARDEN

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Journal of Green Building 2015年第2期10卷 1-23页

作者： Lloyd Godman john Power stuart Jones Grant Harris 不详 Hyder Consulting in Melbourne

In 1996,my interests as a passionate gardener and photo-based artist,that both dated from the 1970s,collided when I made the connection that plants are actually a form of photography;(photography from the Greek-meaning light drawing).Both photography and plants use the magical,mysterious ingredient that is LIGHT and the essential force that drives life on the *** fact,the largest photosensitive emulsion we know of is the planet earth.I draw inspiration and endless fascination from the awareness that the earth rotates in space and orbits the sun at a precise distance for the sun’s radiation to affect the elegant process of photosynthesis through the myriad of plants that have evolved and grow on the *** earth is a three dimensional living *** atmosphere and biosphere are also key factors that mediate the harshness of radiation bombarding the earth and nurture life on the planet that we know and depend *** process is an amazing thing and something we should revere and *** the earth as a basket ball,wrapped in the thinnest paper you could *** thickness of this delicate paper is equivalent to the atmosphere,and the depth of the paper’s texture is thicker than the tallest trees,even thicker than the tallest high rise buildings!Image sequences from NASSA shows how vegetation grows,dies back,changes colour with the seasons,how the“photographic image”that is our planet *** human intervention plays a larger role in transforming the image of the globe we *** foliated land as a photo-sensor(like in a digital camera).

关键词： Environmental Art Green Urban Spaces Roof and Vertical Gardening Air Plants Plants as Weather Shields and Screens Extreme Gardening

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Simplified seismic fatigue evaluation for rigid steel connections

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Earthquake Engineering and Engineering Vibration 2003年第2期2卷 245-253页

作者： AymanA.Shama john B.Mander stuart.S.Chen Parsons Corporation 100 BroadwayNew York.NY 10005USA Ph.D.P.E Department of Civil Engineering University of CanterburyNew Zealand Professor Department of Civil Structural & Environmental EngineeringState University of New York at BuffaloBuffaloNY 14260USA Associated Professor

A simplified fatigue-life model is proposed for assessing the seismic inelastic rotational capacity of steel *** relations are developed for rigid steel connections under lateral *** this is extended to account for the effects of the welded steel moment frame(WSMF)connections of the so-called pre-Northridge *** seismic fatigue theory is validated against experimental *** experiments were conducted under increasing ductility amplitudes until the onset of ***'rule was used to convert the test results to given an equivalent constant amplitude cyclic fatigue *** agreement is obtained when comparing the experimental observations with the theoretical predictions.

关键词： fatigue cyclic load seismic pile-to-cap moment frames connections steel

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Current Therapeutics in Primary Sclerosing Cholangitis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1267-1281页

作者： Natassia Tan john Lubel William Kemp stuart Roberts Ammar Majeed Department of Gastroenterology and Hepatology Alfred HealthCentral Clinical SchoolMonash UniversityMelbourneAustralia

Primary sclerosing cholangitis(PSC)is an orphan,cholestatic liver disease that is characterized by inflammatory biliary strictures with variable progression to end-stage liver *** pathophysiology is poorly *** biliary inflammation is likely driven by immune dysregulation,gut dysbiosis,and environmental exposures resulting in gutliver crosstalk and bile acid metabolism *** is no proven medical therapy that alters disease progression in PSC,with the commonly prescribed ursodeoxycholic acid being shown to improve liver biochemistry at low-moderate doses(15–23 mg/kg/day)but not alter transplant-free survival or liver-related *** transplantation is the only option for patients who develop end-stage liver disease or refractory complications of *** and antifibrotic agents have not proven to be effective,but there is promise for manipulation of the gut microbiome with fecal microbiota transplantation and *** acid manipulation via alternate synthetic bile acids such as norursodeoxycholic acid,or interaction at a transcriptional level via nuclear receptor agonists and fibrates have shown potential in phase II trials in PSC with several leading to larger phase III *** view of the enhanced malignancy risk,statins,and aspirin show potential for reducing the risk of colorectal cancer and cholangiocarcinoma in PSC *** patients who develop clinically relevant strictures with cholestatic symptoms and worsening liver function,balloon dilatation is safer compared with biliary stent insertion with equivalent clinical efficacy.

关键词： Primary sclerosing cholangitis Bile acid Microbiome 24-Norursodeoxycholic acid Farnesoid X receptor agonists Liver transplant

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The effect of particle size on the pollution reduction potential of a South African coal-derived low-smoke fuel

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Energy Geoscience 2020年第3期1卷 165-173页

作者： Lungile Sumbane-Prinsloo john Bunt Ratale Matjie stuart Piketh Hein Neomagus Frans Waanders Centre of Excellence in Carbon-based Fuels Faculty of EngineeringNorth West UniversityPotchefstroom2520South Africa Climate Research Group School of Geo-and Spatial ScienceNorth West UniversityPotchefstroom2520South Africa

The coal combustion in cast-iron stoves leads to health hazards and air *** this study the CO,SO2,NOx,PM and VOC emission concentrations were measured whilst combusting four fuel particle sizes(15,20,30,and 40 mm)as well as a composite of the sizes(all pre-devolatilized at a temperature of 550C)in a cast-iron *** results were compared to their raw coal analogues to evaluate the emission performance of each fuel *** factors for NOx and SO2 were found to depend on the fuel nitrogen and sulphur contents in the coal and the combustion conditions used during *** PM,SO2 and VOC emissions show a strong dependence on the ash percentage and volatile matter yields,which both increased with increasing particle *** addition,the PM,SO2 and VOC missions were found to only depend on particle size on a mechanistic *** VOCs and PM emission factors are inversely correlated with particle *** results from this study offer insight into the combustion environment in the Falkirk Union No 7 cast-iron stove as well as how this environment applies to low smoke *** work contributes to the emission and performance inventories from South African domestic coal combustion in this stove used in informal settlements.

关键词： Coal combustion Low-smoke fuel Emissions Particle size Cast-iron stove

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The influence of particle size on the thermal performance of coal and its derived char in a Union stove

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Energy Geoscience 2021年第2期2卷 148-159页

作者： Lungile Sumbane-Prinsloo john Bunt stuart Piketh Hein Neomagus Frans Waanders Ratale Matjie Centre of Excellence in Carbon-based Fuels Faculty of EngineeringNorth West UniversityPotchefstroom2520South Africa Climate Research Group School of Geo-and Spatial ScienceNorth West UniversityPotchefstroom2520South Africa

For low-income communities in South Africa,coal is the most common solid fuel which is burnt in a variety of devices,including imbaulas and cast-iron *** present work was conducted with the aim of determining the effect of the fuel particle size on the performance of coal,typically sourced in low-income households in townships in South Africa,and to subsequently compare the performance with a feed char of a common cast iron *** fuel particle sizes of 15,20,30,and 40 mm,as well as a composite of the sizes were tested at 550C,against their untreated coal analogues to evaluate the thermal performance of each *** thermal performance assessment metrics are ignition time,water boiling time,heat transfer and combustion efficiencies,while CO and CO_(2)emissions were measured for the calculations of CO/CO_(2)*** times were found to decrease from coals to chars and to decrease with increasing particle *** effects of fuel type on the water boiling time were only observed in the later stages of the burn cycle,with the char boiling a 2 L batch of water in an average 24 min,while the coals reported an average boiling time of 20 *** transfer efficiencies showed no significant variation with fuel type or particle size,with the average efficiency for the coals and that of the chars being around 66%.The fuels’performance was better gauged by the combustion efficiency,which was found to improve marginally from the coal fuels to the chars,and to increase with increasing particle *** from this testwork could contribute to the performance inventories from the combustion of domestic coal mined in South Africa in a typical cast iron stove which is used in informal settlements.

关键词： Coal and its derived char combustion Heterogeneous testing protocol Efficiency Particle size Cast-iron stove

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Microalloyed Steels for Heat Treating Applications at Higher Process Temperatures

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Journal of Iron and Steel Research International 2011年第S1期18卷 80-89页

作者： David K.Matlock john G.Speer Steven G.Jansto Marcus stuart Advanced Steel Processing and Products Research Center Colorado School of MinesGoldenColorado USA CBMM-Reference Metals BridgevillePA CBMM Sao PauloBrasil

The potential is considered for use of microalloyed bar steels,in conjunction with thermomechanical processing,to enhance the properties of steels heat treated at higher process temperatures than have been used *** examples are highlighted:microalloyed spring steels with enhanced resistance to tempering and Nb-modified gear steels for high temperature vacuum carburizing,*** the order of 1050℃ versus 930℃ for a typical gas carburizing *** the spring steel example,the Nb+V steel results in significantly finer prior austenite grain sizes than the other steels considered,enhanced fatigue performance,and improved *** the Nb-modified carburizing steel,Nb additions up to 0.1 wt pct to a Ti-modified 8620 steel,in conjunction with thermomechanical processing to control initial precipitate distributions prior to carburizing,are shown to lead to materials with improved resistance to abnormal austenitic grain growth at the higher process *** content and heating rate to the carburizing temperature were shown to be important variables and suppression of abnormal grain growth was correlated with the development of a critical distribution of fine NbC precipitates,stable at the austenitizing temperature leading to improved fatigue performance in steels with fine and uniform grain *** for extending the results of this study to alloy design and controlled rolling in bar mills are assessed.

关键词： microalloying niobium thermomechanical processing carburizing abnormal grain growth

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In Vivo Phosphorylation Site Mapping and Functional Characterization of Arabidopsis Phototropin 1

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Molecular Plant 2008年第1期1卷 178-194页

作者： stuart Sullivan Catriona E. Thomson Douglas J. Lamont Matthew A. Jones john M. Christie Plant Science Group Division of Biochemistry and Molecular Biology. Institute of Biomedical and Life Sciences University of Glasgow. University Avenue. Glasgow Scotland UK FingerPrints Proteomics Facility Post-Genomics and Molecular Interactions Centre. School of Life Sciences MSI/WTB/CIR Complex University of Dundee. Dundee Scotland UK

Phototropins （phot1 and phot2） are blue-light receptor kinases controlling a range of responses that optimize the photosynthetic efficiency of plants. Light sensing is mediated by two flavin-binding motifs, known as LOVl and LOV2, located within the N-terminal region of the protein. Photoexcitation via LOV2 leads to activation of the C-terminal kinase domain and consequently receptor autophosphorylation. However, knowledge of the in-vivo phosphorylation sites for Arabidopsis phototropins is lacking and has impeded progress in elucidating the functional significance of receptor phos- phorylation. We have purified photl from Arabidopsis and identified the in-vivo sites of receptor phosphorylation by liquid chromatography tandem mass spectrometry. Arabidopsis-derived photl binds flavin mononucleotide as chromophore and is phosphorylated at four major sites located upstream of LOV2 （Ser^58, Ser^85, Ser^350, and Ser^410）, three of which are induced by blue light. Nevertheless, structure-function analysis indicates that the biological activity of photl can be attributed to a modular unit comprising the LOV2-kinase region of the protein. Thus, peptide regions upstream of LOV2, including the sites of receptor phosphorylation identified here, do not appear to be important for receptor signaling. By contrast, these regions may be necessary for maximizing stomatal performance and possibly light-induced relocalization of photl.

关键词： MODULAR UNIT Phototropins chromophores Phosphorylation Site Function analysis Upstream photosynthetic efficiency Arabidopsis PHOSPHONATION Receptor Signaling Flavin Mononucleotide Receptor

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Tracking invasion and invasiveness in Queensland fruit flies： From classical genetics to ＇omics＇

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Current Zoology 2015年第3期61卷 477-487页

作者： William B. SHERWIN Marianne FROMMER john A. SVED Kathryn A. RAPHAEL john G. OAKESHOTT Deborah C.A. SHEARMAN A. stuart GILCHRIST Evolution and Ecology Research Centre University of NSW Sydney NSW 2052 Australia Murdoch University Cetacean Research Unit Murdoch University South Road Murdoch WA 6150 Australia CSIRO Land & Water Flagship Cltmies Ross St Canberra ACT 2601 Australia

Three Australian tephritid fruit flies （Bactrocera tryoni - Q-fly, Bactrocera neohumeralis - NEO, and Bactrocera jarvisi - JAR） are promising models for genetic studies of pest status and invasiveness. The long history of ecological and physi- ological studies of the three species has been augmented by the development of a range of genetic and genomic tools, including the capacity for forced multigeneration crosses between the three species followed by selection experiments, a draft genome for Q-fly, and tissue- and stage-specific transcriptomes. The Q-fly and NEO species pair is of particular interest. The distribution of NEO is contained entirely within the wider distribution of Q-fly and the two species are ecologically extremely similar, with no known differences in pheromones, temperature tolerance, or host-fruit utilisation. However there are three clear differences be- tween them： humeral callus colour, complete pre-mating isolation based on mating time-of-day, and invasiveness. NEO is much less invasive, whereas in historical times Q-fly has invaded southeastern Australia and areas of Western Australia and the North- em Territory. In southeastern fruit-growing regions, microsatellites suggest that some of these outbreaks might derive from ge- netically differentiated populations overwintering in or near the invaded area. Q-fly and NEO show very limited genome diffe- rentiation, so comparative genomic analyses and QTL mapping should be able to identify the regions of the genome controlling mating time and invasiveness, to assess the genetic bases for the invasive strains of Q-fly, and to facilitate a variety of improve- ments to current sterile insect control strategies for that species

关键词： Bactrocera Genomics STERILE-insect-technique Interspecific-hybridisation

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Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype

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World Journal of Gastrointestinal Oncology 2017年第5期9卷 209-217页

作者： Jeremy stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins john Beynon Dean Anthony Harris Department of General and Colorectal Surgery Singleton Hospital Department of Pathology Singleton Hospital Department of Life Sciences Swansea University

To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation (P = 0.01). There were 14 (9%) patients with a pathological complete response (pCR) compared to 116 (73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pCR had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant (P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurre

关键词： Rectal cancer CpG islands Methylation

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