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Journal of Genetics and Genomics 2015年第6期42卷 287-299页

作者： Gerson Dierley Keppeke s.john Calise Edward K.L.Chan Luis Eduardo C.Andrade Rheumatology Division Federal University of Sao Paulo Department of Oral Biology University of Florida Immunology Division Fleury Medicine and Health Laboratories

Inhibition of guanosine triphosphate（GTP） and cytidine triphosphate（CTP） biosynthetic pathways induces cells to assemble rod/ring（RR） structures,also named cytoophidia,which consist of the enzymes cytidine triphosphate synthase（CTPs） and inosine-50-monophosphate dehydrogenase 2（IMPDH2）.We aim to explore the interaction of CTPs and IMPDH2 in the generation of RR *** La and COs-7 cells were cultured in normal conditions or in the presence of 6-diazo-5-oxo-L-norleucine（DON）,ribavirin,or mycophenolic acid（MPA）.Over 90% of DON-treated cells presented RR *** He La cells,35% of the RR structures were positive for IMPDH2 alone,26% were CTPs alone,and 31% were IMPDH2/CTPs mixed,while in COs-7 cells,42% of RR were IMPDH2 alone,41% were CTPs alone,and 10% were IMPDH2/CTPs *** and MPA treatments induced only IMPDH2-based *** were also transfected with an N-terminal hemagglutinin（NHA）-tagged CTPs1 *** 95% of NHA-CTPs1 transfected cells with DON treatment presented IMPDH2-based RR and almost 100% presented CTPs1-based RR;when treated with ribavirin,over 94% of transfected cells presented IMPDH2-based RR and 37% presented CTPs1-based RR,whereas 2% of untreated transfected cells presented IMPDH2-based RR and 28% presented CTPs1-based *** results may help in understanding the relationship between CTP and GTP biosynthetic pathways,especially concerning the formation of filamentous RR structures.

关键词： Nucleotide synthesis Enzyme aggregation Enzyme inhibition IMPDH2 CTPs

Dysphagia after vertical sleeve gastrectomy: Evaluation of risk factors and assessment of endoscopic intervention

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World Journal of Gastroenterology 2016年第47期22卷 10371-10379页

作者： Anand Nath sayali Yewale Tung Tran john s Brebbia Timothy R shope Timothy R Koch Department of Medicine Med Star-Washington Hospital Center and Georgetown University School of Medicine Washington DC 20010 United States Unterberg Children’s Hospital at Monmouth Medical Center Long Branch NJ07740 United States Center for Advanced Laparoscopic General and Bariatric surgery MedS tar-Washington Hospital Center and Georgetown University School of Medicine Washington DC 20010 United States

AIM To evaluate the risks of medical conditions, evaluate gastric sleeve narrowing, and assess hydrostatic balloon dilatation to treat dysphagia after vertical sleeve gastrectomy(VsG).METHODs VsG is being performed more frequently worldwide as a treatment for medically-complicated obesity, and dysphagia is common post-operatively. We hypothesize that post-operative dysphagia is related to underlying medical conditions or narrowing of the gastric sleeve. This is a retrospective, single institution study of consecutive patients who underwent sleeve gastrectomy from 2013 to 2015. Patients with previous bariatric procedures were excluded. Narrowing of a gastric sleeve includes: inability to pass a 9.6 mm gastroscope due to stenosis or sharp angulation or spiral hindering its *** Of 400 consecutive patients, 352 are included; the prevalence of dysphagia is 22.7%; 33 patients(9.3%) have narrowing of the sleeve with 25(7.1%) having sharp angulation or a spiral while 8(2.3%) have a stenosis. All 33 patients underwent balloon dilatation of the gastric sleeve and dysphagia resolved in 13 patients(39%); 10 patients(30%) noted resolution of dysphagia after two additional dilatations. In a multivariate model, medical conditions associated with post-operative dysphagia include diabetes mellitus, symptoms of esophageal reflux, a low whole blood thiamine level, hypothyroidism, use of non-steroidal anti-inflammatory drugs, and use of *** Narrowing of the gastric sleeve and gastric sleeve stenosis are common after VsG. Endoscopic balloon dilatations of the gastric sleeve resolves dysphagia in 69% of patients.

关键词：肥胖 Bariatric 外科垂直袖子 gastrectomy 咽下困难胃膨胀

Theory-directed discovery of high-temperature superconductivity in clathrate hydrides at high pressure

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The Innovation 2022年第2期3卷 9-10页

作者： Xin Zhong john s.Tse Russell J.Hemley Hanyu Liu International Center for Computational Method&software and state Key Laboratory of superhard Materials College of PhysicsJilin UniversityChangchun 130012China Department of Physics and Engineering Physics University of SaskatchewanSaskatoon S7N 5E2Canada Departments of Physics Chemistryand Earth and Environmental SciencesUniversity of Illinois ChicagoChicagoIL 60607USA International Center of Future science Jilin UniversityChangchun 130012China

The search for room-temperature superconductivity has been one of the great challenges in condensedmatter physics ever since the first observation of superconductivity with a critical temperature(T_(c))of 4 K in mercury in *** recent years,we have been witness to the successful observation of superconductivity in highly compressed sH_(3)(T_(c)=203 K at 155 GPa)and classes of clathrate hydrides(e.g.,CaH_(6),YH_(6),YH_(9),LaH_(10)).

关键词： hydrides superconductivity high

Male Burmese pythons follow female scent trails and show sex-specific behaviors

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Integrative Zoology 2019年第5期14卷 460-469页

作者： shannon A.RICHARD Eric A.TILLMAN john s.HUMPHREY Michael L.AVERY M.Rockwell PARKER Department of Biology James Madison UniversityHarrisonburgVirginiaUSA National Wildlife Research Center Florida Field StationU.S.Department of AgricultureGainesvilleFloridaUSA

Animals communicate with potential mates using species-specific signals,and pheromones are powerful sexual signals that modify conspecific behavior to facilitate mate *** the vertebrates,snakes are especially adept in mate searching via chemical trailing,which is particularly relevant given that many snake species are invasive outside their native *** signals used in mate choice are,thus,potentially valuable tools for management of invasive snake *** Burmese python(Python bivittatus)is an invasive snake in the Florida Everglades where it is negatively impacting native *** this study,we sought to:(i)determine if males can follow conspecific chemical trails in a Y-maze;and(ii)describe the mate searching behaviors exhibited by males while *** males consistently followed a single female scent trail in the maze,but when only a male scent trail was present they did not discriminate between the male and blank *** of tongue-flicking,a proxy for chemosensory sampling,was also marginally higher when males were following female versus male scent ***,when both female and male scent trails were simultaneously present in the Y-maze,males did not show a preference for the female arm,although the tongue-flick rate was higher in the female-only trial compared to female versus *** of multiple male behaviors individually and using an ethogram revealed that behaviors were more frequent and complex in the female-only trials compared to male-only *** behavioral trials are needed to determine if an effective pheromonal approach to Burmese python management is possible.

关键词： chemical ecology invasive species pheromone snake trailing

Redefining Human Vitamin D sufficiency:Back to the Basics

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Bone Research 2013年第1期1卷 2-10页

作者： john s.Adams Jonathan Ramin Brandon Rafison Charles Windon Annika Windon Philip T.Liu Orthopaedic Hospital Research Center UCLA-Orthopaedic Hospital Department of Orthopaedic SurgeryDavid Geffen School of MedicineUCLA Department of Molecular Cell and Developmental BiologyDivision of Life SciencesCollege of Letters and ScienceUCLA

The role of the endocrine vitamin D pathway in regulating the serum calcium concentration in man is well described. In the presence of a low serum calcium level, the vitamin D metabolic pathway is called upon to produce more of the active vitamin D hormone, 1, 25-dihydroxyvitamin D （1, 25D）, via up-regulation of the CYP27b1-hydroxylase activity in the kidney. The consequence is mobilization of skeletal calcium stores to return the circulating calcium level back to the normal range. On the other hand, when the serum calcium level increases, endocrine forces move to suppress renal 1, 25D production and squelch bone resorption. It is now known that vitamin D metabolites also operate in an autocrine, paracrine and intracrine mode to control vitamin D receptor-directed biological responses at the tissue level. Because the metabolism and action of vitamin D occurs at the tissue level in this situation, use of circulating vitamin D metabolites and biomarkers to ascertain the local action of the vitamin D pathway is often misleading. This mini-review seeks to compare and contrast the operation of the vitamin D pathway at the endocrine and tissue level.

关键词： metabolism endocrine autocrine hormone biomarkers

The Making of a Health Profession:How Chinese Medicine Became a Nationally Registered Allied Health Profession in Australia

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Chinese Medicine and Culture 2024年第1期7卷 51-62页

作者： john L McDonald Judy B James school of Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Australia Brisbane 4120Australia

In 2012, traditional Chinese medicine(TCM) practitioners in Australia became nationally-registered allied health professionals in three categories: acupuncturist, Chinese herbal medicine practitioner, and Chinese herbal medicine dispenser. Australia was the first Western country to introduce national registration for Chinese medicine, followed by Portugal and, recently, New Zealand. The practice of TCM in Australia can be traced back to the beginning of Chinese immigration to Australia during the Victorian Gold Rush which began in the 1850s. The process which led to national registration commenced in the early 1970s with the establishment of the first acupuncture courses. Decades of gradual development of courses from unaccredited part-time diplomas to accredited bachelor degrees, and the development, by the profession, of national consensus on educational standards were essential elements in the process which led to registration. Professional associations, such as the Australian Acupuncture and Chinese Medicine Association Ltd.(AACMA), also developed a framework of professional selfregulation, including Codes of Ethics, Codes of Conduct, ongoing professional development requirements and Infection Control Guidelines, and provided leadership in the development of the profession. After decades of tribalism and division within the TCM profession, the National Academic standards Committee brought almost all stakeholders together to reach a consensus on the Australian Guidelines for Traditional Chinese Medicine Education which were published by AACMA in 2001. Professional associations also collaborated on joint submissions to the government in support of registration, which was introduced first in the state of Victoria in 2000, and subsequently became national in 2012. Despite national registration, some barriers still remain, and professional associations continue to lobby the federal government for inclusion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regulation Education standards Australia TCM

高浓度氩气稀释对C2H2-2．5O2气体直接起爆临界能量影响的实验研究

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高压物理学报 2012年第1期26卷 55-62页

作者：张博 Lee john H s 白春华北京理工大学爆炸科学与技术国家重点实验室北京100081 Department of Mechanical Engineering McGill University Montreal H3A 2K6Canada

采用高压电点火进行直接起爆,通过放电过程中电流的输出信号确定起爆能量,实验测定了C2H2-2.5O2气体和加入摩尔浓度为70%氩气的C2H2-2.5O2混合气体直接起爆的临界起爆能量,研究了高浓度氩气稀释对C2H2-2.5O2混合物临界起爆能量的影响。... 详细信息

采用高压电点火进行直接起爆,通过放电过程中电流的输出信号确定起爆能量,实验测定了C2H2-2.5O2气体和加入摩尔浓度为70%氩气的C2H2-2.5O2混合气体直接起爆的临界起爆能量,研究了高浓度氩气稀释对C2H2-2.5O2混合物临界起爆能量的影响。实验测得的混合物临界起爆能量实验值与Lee等人的表面积能量理论值基本吻合。研究表明:C2H2-2.5O2气体和加入摩尔浓度为70%氩气的C2H2-2.5O2混合气体的临界起爆能量均依赖于初始压力,并呈反相关指数关系;在相同实验条件下,高浓度氩气稀释极大提高了混合气体直接起爆的临界起爆能量。分析认为,由于临界起爆能量正比于诱导区长度的3次方,因此在相同初始压力下,高浓度氩气的稀释增加了C2H2-2.5O2混合气体爆轰诱导区长度,并最终导致其临界起爆能量的显著上升。

关键词：直接起爆临界起爆能量诱导区长度电火花点火氩气

Robust Machine Learning Mapping of sEMG signals to Future Actuator Commands in Biomechatronic Devices

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Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr sydney Bell Rachel L.Whittaker Clark R.Dickerson john McPhee systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and Health sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

Outcomes of microwave versus radiofrequency ablation for hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2022年第4期10卷 220-237页

作者： Myo Jin Tang Guy D Eslick john s Lubel Ammar Majeed Avik Majumdar William Kemp stuart K Roberts Department of Gastroenterology Alfred HospitalMelbourne 3004VictoriaAustralia Monash Medical school Monash UniversityMelbourne 3004VictoriaAustralia Department of statistics Clued Pty LtdSydney 2006New South WalesAustrali Central Clinical school Monash UniversityMelbourne 3004VictoriaAustralia Department of Gastroenterology Austin HospitalHeidelberg 3084VictoriaAustralia Department of Medicine Austin CampusUniversity of MedicineMelbourne 3084VictoriaAustralia

BACKGROUND studies to date comparing outcomes of microwave ablation(MWA)with radiofrequency ablation(RFA)on patients with hepatocellular carcinoma have yielded conflicting results,with no clear superiority of one technique over the *** aim of this systematic review and meta-analysis was to compare the efficacy and safety of MWA with *** To perform a systematic review and meta-analysis comparing the efficacy and safety of MWA with *** A systematic literature search was performed using Ovid Medline,Embase,PubMed,Reference Citation Analysis,Cochrane Central and Cochrane systematic Review databases,and Web of *** and full manuscripts were screened for inclusion utilising predefined inclusion and exclusion criteria comparing outcomes of MWA and RFA.A random-effects model was used for each ***-regression analysis was performed to adjust for the difference in follow-up period between the *** outcome measures included complete ablation(CA)rate,local recurrence rate(LRR),survival[local recurrence-free survival(LRFs),overall survival(Os)]and adverse *** A total of 42 published studies[34 cohort and 8 randomised controlled trials(RCT)]with 6719 patients fulfilled the selection *** was no significant difference in tumour size between the treatment *** rates between MWA and RFA groups were similar in prospective cohort studies[odds ratio(OR)0.95,95%confidence interval(CI)0.28–3.23]and RCTs(OR 1.18,95%CI 0.64–2.18).However,retrospective studies reported higher rates with MWA(OR 1.29,95%CI 1.06–1.57).Retrospective cohort studies reported higher Os(OR 1.54,95%CI 1.15–2.05 and lower LRR(OR 0.67,95%CI 0.51–0.87).No difference in terms of LRFs or 30-d mortality was observed between both *** had an increased rate of adverse respiratory events when compared to RFA(OR 1.99,95%CI 1.07–3.71,P=0.03).CONCLUsION MWA achieves similar CA rates and as good or better longer-term outcomes in relation to LRR and O

关键词： Microwave ablation Radiofrequency ablation Hepatocellular carcinoma survival Recurrence Meta-analysis

The first record of a Konservat-Lagerstätten in which early post-settlement stages of fossil archaeobalanids(Cirripedia:Balanomorpha)are preserved

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Integrative Zoology 2024年第2期19卷 200-223页

作者： Tomáš KOCÍ Rok GAŠPARIC john BUCKERIDGE Martina KOCOVÁ VEsELsKÁ Aleš ŠOsTER Ivancická581 PragueCzech Republic Palaeontological Department Natural History MuseumNational MuseumPragueCzech Republic Oertijdmuseum Bosscheweg 80Boxtel5293 WBThe Netherlands Institute for Palaeobiology and Evolution Novi TrgKamnikSlovenia Earth and Oceanic systems Group RMIT UniversityMelbourneAustralia Museums Victoria CarltonVictoriaAustralia Department of Paleobiology and Paleoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Institute of Geology and Palaeontology Charles UniversityPragueCzech Republic Faculty of Natural sciences and Engineering University of LjubljanaLjubljanaSlovenia

A diverse sessile barnacle fauna from a Miocene shallow-water deposit at Dolnja stara vas in slovenia is *** includes the first descriptions of early post settlement juveniles of Actinobalanus sloveniensis attached to mangrove *** represent three distinct growth phases,the earliest being interpreted as being less than 24 h post settlement,the others being 1 to 2 days post *** assessment of their taphonomy is *** adult balanomorphs are attached to a variety of organic substrates,including mangrove leaves and branches,fragments of the conifers?Taxodioxylon,Carapoxylon,pine cones,molluscs,and cetacean *** barnacles include ***,Amphibalanus venustus,and Perforatus perforatus—many with opercula retained within the *** retains some of the original shell *** is the second record of barnacle–plant associations from the Central Paratethys from Kamnik and *** paleoecology and paleogeography of the site are discussed.

关键词： acorn barnacles barnacle metamorphosis epibiont paleoecology taxonomy