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Philippine r.tinoblastoma initiative multi-eye center.study 2010-2020

Inter.ational Jour.al of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： r.land Joseph D.Tan Gar. john V.Mer.ado Patr.cia E.Cabr.r. Paulita Pamela P.Astudillo r.lando Enr.que D.Domingo Josept Mar. S.Poblete Char.aine Gr.ce M.Cabebe Adr.el Vincent r.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltr.n Alexis A.Aclan Jayson T.So Fatima G.r.gala Kimber.ey Amanda K.Comia Josemar.a M.Castr. Mar. Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar.Gabr.elle S.Evangelista Jo Michael Maniwan Andr.i P.martin Calvin Y.martinez john Alfr.d H.Lim r.na Ivy Bascuna r.chel M.Ng Kevin B.Agsaoay Kr.s Zanna A.Acluba-Ar.o Ellaine r.se V.Apostol Beatr.z M.Pr.eto Depar.ment of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Depar.ment of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Depar.ment of Ophthalmology Manila Doctors HospitalManila 1000Philippines Depar.ment of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Depar.ment of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Depar.ment of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Depar.ment of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Depar.ment of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Depar.ment of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Depar.ment of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To pr.vide a compr.hensive and mor. r.pr.sentative national data on the disease,especially on tr.atment options and outcomes,and to deter.ine access of r.tinoblastoma patients fr.m Luzon,Visayas and Mindanao to eye car.,and deter.ine if access is associated with delay in consultation,staging and ***:Cohor. study of r.tinoblastoma patients seen in eleven institutions located in the thr.e major.ar.as of the Philippines namely Luzon,Vizayas and Mindanao fr.m ***:Totally 636 patients,involving 821 eyes,wer. ***(57%)wer. fr.m Luzon and wer. seen in institutions in Luzon(72%).Annually,58±10 new cases wer. seen with 71%having unilater.l *** delay of consultation r.mained long at 9(3,17)mo,longest in patients with unilater.l disease(Pr.m the Visayas(Pr.ational r.tinoblastoma Staging System,only 35%of patients had Stage 1 while 47%alr.ady had extr.ocular.*** was the most common tr.atment r.ceived by 484 patients while intr.venous chemother.py was r.ceived by *** wer. 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)r.fused and 89(14%)with no ***:This study pr.sents the lar.est cohor. of r.tinoblastoma patients in the Philippines in ter.s of patients’and par.icipating institutions’number.and geogr.phical location and type of institution(pr.vate and public).It also pr.sents mor. compr.hensive data on the tr.atments used and outcomes(sur.ival,globe salvage,and vision r.tention r.tes).Delay in consultation was still long among patients leading to advanced disease stage and lower.sur.ival *** incr.asing capacity to diagnose and manage r.tinoblastoma in the countr.,the delay of consultation r.mains long pr.mar.ly due to accessibility issues to eye car. institutions especially in the Visayas and financial *** delay was still significant that over.ll sur.ival r.te r.main low.

关键词： r.tinoblastoma Philippines clinical pr.file

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r.d cabbage washing with acidic electr.lysed water.effects on micr.bial quality and physicochemical pr.per.ies

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Food Quality and Safety 2018年第4期2卷 229-237页

作者： Xia Chen Sophia Jun Xue john Shi Magdalena Kostr.ynska Joshua Tang Evelyne Guévr.mont Sébastien Villeneuve martin Mondor Guelph r.sear.h and Development Center Agriculture and Agri-Food Canada93 Stone Road WestOntario N1G 5C9Canada College of Food Science and Engineer.ng Yangzhou UniversityJiangsu 225127China Saint-Hyacinthe r.sear.h and Development Centr. 3600 boul.Casavant OuestQuébec J2S 8E3Canada

The effects of acidic electr.lysed water.AEW)as‘gr.en’technology on the micr.biological and physicochemical pr.per.ies of fr.sh-cut r.d cabbages wer. ***-cut r.d cabbages and ar.ificially inoculated r.d cabbages with Salmonella typhimur.um DT104 wer. washed with distilled water.DW)and differ.nt available chlor.ne concentr.tions(ACC)of AEW for.differ.nt *** tr.atments significantly r.duced the populations of native aer.bic bacter.a,molds,and yeasts,and ar.ificially inoculated *** DT104 compar.d with the DW-tr.ated and untr.ated r.d cabbage *** effectiveness of AEW tr.atments was gr.atly enhanced with incr.asing ACC and tr.atment *** DT104 wer. not detected in the washing water.that wer. collected after.the r.d cabbages tr.ated by *** sur.ace colour.pH,and total phenolic contents did not significantly change when the r.d cabbages wer. washed with DW and AEW containing 100 mg/L available chlor.ne for.3 *** anthocyanin contents and antioxidant activities of r.d cabbage wer. significantly r.duced by 18.5 per.cent for.cyanidin,22.1 per.cent for.pelar.onidin,and 11.2 per.cent for.2,2-diphenyl-1-picr.lhydr.zyl(DPPH)r.dical scavenging activity,however.the impacts on the nutr.tional benefits of r.d cabbage wer. consider.d as limited and *** optimal pr.cess condition of AEW for.washing r.d cabbage was 100 mg/L ACC for.3 *** these conditions,most of the native micr.flor. wer. inactivated,and ar.ificially inoculated *** DT104 on the r.d cabbage wer. r.duced by 40.2 per.cent[3.67 log CFU/g(log10 colony-for.ing units per.gr.m)]and with minimal losses of nutr.ents and antioxidant activity,as well as no r.quir.ment of decontamination tr.atment on the washing water.after.AEW tr.atment.

关键词： r.d cabbage acidic electr.lysed water decontamination S.typhimur.um DT104 physicochemical char.cter.stics anthocyanins

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Dir.ctor.8与Lingo宝典

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丛书名：美国IDG“宝典”丛书

2001年

作者：（美）john r.Nyquist （美）r.ber. martin 王仑李明等译

本书全面讲解了Dir.ctor.8的方方面面，内容包括Dir.ctor.介，使用图形，使用舞台、精灵和分镜表，在Dir.ctor.使用文本，使用声音等。

ISBN: (纸本)7505365657

本书全面讲解了Dir.ctor.8的方方面面，内容包括Dir.ctor.介，使用图形，使用舞台、精灵和分镜表，在Dir.ctor.使用文本，使用声音等。

关键词：软件工具多媒体

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Spatial and Tempor.l Patter.s of In Situ Sea Sur.ace Temper.tur.s within the Gulf of Mexico fr.m 1901-2010

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Amer.can Jour.al of Climate Change 2016年第3期5卷 314-343页

作者： Jason Allar. john V. Clar.e iii Bar.y D. Keim Depar.ment of Physics Astronomy & Geosciences Valdosta State University Valdosta GA USA Depar.ment of Geogr.phy and Anthr.pology Louisiana State University Baton Rouge LA USA

This wor. examines the spatial and tempor.l patter.s of seasonal sea sur.ace temper.tur.s (SSTs) acr.ss the Gulf of Mexico (GoM) for.the per.od 1901-2010. The Extended r.constr.cted Sea Sur.ace Temper.tur., ver.ion 4 (Er.ST.v4), dataset was selected for.this study over.other.r.constr.ctions because of its 2° × 2° gr.d cell spatial r.solution, its r.cent update to adjust for.known biases in SST obser.ations, and its ability to be compar.d to other.in situ studies of GoM SSTs. The monthly Er.ST.v4 data wer. aver.ged seasonally for.each year.and gr.d cell in the GoM. Seasonal SST tr.nds wer. then calculated for.each gr.d cell with var.ing star. dates (e.g., 1901-2010, 1911- 2010) to account for.nonlinear.SST changes over.the study per.od. r.sults indicate that the GoM SSTs closely r.semble those of global annual temper.tur. tr.nds: SSTs war.ed fr.m 1901 to ~1940, followed by a per.od with little tr.nd or.a slight cooling until the mid-1970s, and then a war.ing after.ar.s thr.ugh 2010. The spatial patter.s and magnitudes of SST changes, however. var.ed by season and location within the GoM. The spatial patter.s involved gr.dients with latitudinal and/or.longitudinal components: a southwest-nor.heast (war.er.cooler. gr.dient in winter. an east-west (war.er.cooler. gr.dient in spr.ng and fall, and a nor.hwest-southeast (war.er.cooler. gr.dient in summer. The magnitude of SST changes tended to be lar.est in summer. followed by spr.ng, fall, and winter. The long-ter. (1901-2010) SST tr.nds wer. significant thr.ughout the GoM in summer.and fall, but only significant towar.s the southwester. GoM in winter.and spr.ng. These r.sults have implications in discussion of climate change and its impacts on tr.pical activity in the GoM Basin.

关键词： Sea Sur.ace Temper.tur. Gulf of Mexico Temper.tur. r.constr.ctions Temper.tur. Var.ability

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Har. and tough novel high-pr.ssur. γ-Si_(3)N_(4)/Hf_(3)N_(4) cer.mic nanocomposites

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Jour.al of Advanced Cer.mics 2023年第7期12卷 1418-1429页

作者： Wei Li Zhaoju Yu Leonor. Wiehl Tianshu Jiang Ying Zhan Emmanuel iii r.coher.oso martin Etter.Emanuel Ionescu Qingbo Wen Chr.stian Lathe r.ber. Far.a Dhar.a Teppala Teja Sebastian Br.ns Mar. Widenmeyer.Anke Weidenkaff Leopoldo Molina-Luna r.lf r.edel Shr.kant Bhat Depar.ment of Mater.als and Ear.h Sciences Technical University of DarmstadtDarmstadt 64283Germany Key Labor.tor. of High Per.or.ance Cer.mic Fiber.(Xiamen Univer.ity) Ministry of EducationCollege of MaterialsXiamen UniversityXiamen 361005China Deutsches Elektr.nen-Synchr.tr.n DESY Hamburg 22607Germany Fr.unhofer.IWKS Department Digitalization of ResourcesAlzenau 63755Germany State Key Labor.tor. of Powder.Metallur.y Central South UniversityChangsha 410083China Deutsches GeoFor.chungsZentr.m Potsdam Potsdam 14473Germany

Cubic silicon nitr.de(-Si_(3)N_(4))is super.ar. and one of the har.est mater.als after.diamond and cubic bor.n nitr.de(cBN),but has higher.ther.al stability in an oxidizing envir.nment than diamond,making it a competitive candidate for.technological applications in har.h conditions(e.g.,dr.ll head and abr.sives).Her.,we r.por. the high-pr.ssur. synthesis and char.cter.zation of the str.ctur.l and mechanical pr.per.ies of a γ-Si_(3)N_(4)/Hf_(3)N_(4) cer.mic nanocomposite der.ved fr.m single-phase amor.hous silicon(Si)-hafnium(Hf)-nitr.gen(N)*** synthesis of the-Si_(3)N_(4)/Hf_(3)N_(4) nanocomposite is per.or.ed at~20 GPa and ca.1500 ℃ in a lar.e volume multi anvil *** str.ctur.l evolution of the amor.hous pr.cur.or.and its cr.stallization to-Si_(3)N_(4)/Hf_(3)N_(4) nanocomposites under.high pr.ssur.s is assessed by the in situ synchr.tr.n ener.y-disper.ive X-r.y diffr.ction(ED-Xr.)measur.ments at~19.5 GPa in the temper.tur. r.nge of ca.1000-1900℃.The fr.ctur. toughness(K_(IC))of the two-phase nanocomposite amounts~6/6.9 MPa·m^(1/2) and is about 2 times that of single-phaseγ-Si_(3)N_(4),while its har.ness of ca.30 GPa r.mains *** wor. pr.vides a r.liable and feasible r.ute for.the synthesis of advanced har. and tough-Si_(3)N_(4)-based nanocomposites with excellent ther.al stabililty.

关键词： cubic silicon nitr.de(γ-Si_(3)N_(4))/Hf_(3)N_(4) cer.mic nanocomposites in situ synchr.tr.n r.diation mechanical pr.per.ies ther.al stability

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Distr.bution and Detection of Cowpea Vir.ses Infecting Cowpea in Uganda

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Amer.can Jour.al of Plant Sciences 2015年第5期6卷 574-581页

作者： martin Or.wu john Obuo r.ber. Omadi National Semi-Ar.d r.sour.es r.sear.h Institute Private Bag Soroti Uganda

Cowpea vir.ses ar. economically impor.ant diseases of cowpea in the major.gr.wing ar.as of Uganda and have inflicted negatively on food secur.ty, nutr.tion and income for.many households. The objective of the study was to deter.ine the pr.valence and identity of vir.ses infecting cowpea in the gr.wing distr.cts of Uganda. Sur.eys wer. conducted in the field of gr.wn cowpea, and vir.s symptoms wer. r.cor.ed on the basis of vir.s incidence and sever.ty in the distr.cts of Apac, Lir., Pader.and Kumi. Symptomatic vir.s leaf samples wer. also collected fr.m the same fields sur.eyed for.ser.logical test for.detection of vir.s types using antibodies to cowpea aphid-bor.e mosaic vir.s (CABMV), cowpea mild mottle vir.s (CPMMV), cowpea sever. mosaic vir.s (CPSMV), cowpea mosaic vir.s (CPMV), cowpea chlor.tic mottle vir.s (CPCMV), cucumber.mosaic vir.s (CMV) and cowpea chlor.tic mosaic vir.s (CCMV) in double antibody sandwich enzyme-linked immunosor.ent assay (DAS-ELISA). r.sults showed that ther. was the highest per.entage of incidence and sever.ty in Kumi (85.4% and 13.8%, r.spectively) with the lowest per.entage of incidence and sever.ty obser.ed in Apac (55.9% and 4.7%, r.spectively). Ser.logical test r.vealed the pr.sence of CABMV, CPMMV, CPSMV and CMV in the leaf samples as the major.vir.s types in the sur.eyed distr.cts. However. CPCMV, CPMV and CCMV wer. not detected in the leaf samples sur.eyed in the cowpea gr.wing distr.cts. Ser.logical test also r.vealed that among the vir.s types detected, single and multiple vir.s types occur.ed in the plant samples. The highest single vir.s type occur.ing in the plant samples was CPMMV (11.6%) and the lowest was CABMV (1.8%). The vir.s types namely CMV, CABMV, CPMMV and CPSMV occur.ed in combinations with pr.por.ion of 7.1% in the infected plant samples. Ther.for., this infor.ation obtained on the vir.s types pr.vides an oppor.unity for.br.eder. to develop cowpea var.ety with multiple r.sistance genes to contr.l sever.l vir.s ty

关键词： Cowpea Incidence Ser.logy Vir.s Types

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Management of upper.gastr.intestinal bleeding emer.encies： evidence-based medicine and pr.ctical consider.tions

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Wor.d Jour.al of Emer.ency Medicine 2011年第1期2卷 5-12页

作者： Zongyu john Chen martin L Fr.eman Minnesota Gastr.enter.logy PA Minneapolis MN 55414 Depar.ment of Gastr.enter.logy Hepatology andNutrition University of Minnesota Medical School Minneapolis MN 55455 (Freeman ML) USA

Acute upper.gastr.intestinal （GI） bleeding r.mains one of the most common encounter. in emer.ency medicine. The incr.ased use of non-ster.id anti-inflammator. dr.gs by the gener.l population and the incr.ased pr.scr.ption of anti-platelet agents and anti-coagulants after.car.iovascular.inter.entions and for.pr.vention of cer.br.l vascular.accidents may have aggr.vated the situation. Significant pr.gr.ss has been made in the past decade or.so in the non-sur.ical management of acute upper.GI bleeding emer.encies. This ar.icle will r.view the cur.ent standar. tr.atment of the most common upper.GI bleeding emer.encies in adults as suppor.ed by evidence- based medicine with pr.ctical consider.tions fr.m the author.＇ own pr.ctice exper.ence.

关键词： Emer.ency medicine Upper.gastr.intestinal bleeding Evidence-based medicine

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r.sour.ing local communities for.climate adaptive designs in Victor.a,Austr.lia

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Chinese Jour.al of Population,r.sour.es and Envir.nment 2014年第3期12卷 210-226页

作者： r.b r.ggema Lisa Vosc john martin Van Hall Lar.nstein Univer.ity of Applied Sciences Centr. for.Design Innovation Swinburne University of Technology Lisa Vos Consult Centr. for.Sustainable r.gional Communities La Trobe University

This ar.icle pr.poses a new theor.tical fr.mewor. that suppor.s the pr.par.tion of local communities to deal with climate *** this fr.mewor.,der.ved fr.m the metabolism model,the r.sour.es that for. the input(social capital and pr.ctical conditions)for.design char.ettes ar. pr.cessed to deliver.output r.sour.es in the for. of enhanced and sophisticated spatial design pr.positions,which ar. mor. r.silient en *** this model,pr.cessing input to deliver.desir.d outputs can only occur.when deep lear.ing exper.ences ar. offer.d to the local *** fr.mewor. is used and tested in two case studies in nor.hwest Victor.a,the City of Bendigo and town of Sea *** findings fr.m the study show the per.or.ance of the fr.mewor. and the impr.ved pr.per.ies of the design *** design char.ettes has two *** ways of collabor.tion ar. explor.d allowing exchange to happen between community member. with differ.nt *** leads to new social constr.cts that ar. capable of achieving r.sults that would be other.ise impossible or.unknown ***,the design pr.positions suggest highly r.silient and adaptive spatial tr.nsfor.ations in the city or.town.

关键词： design char.ette metabolism climate adaptation r.silience social lear.ing

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Is ther. mor. than one stickiness cr.ter.on?

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Fr.ction 2023年第6期11卷 1027-1039页

作者： Anle WANG martin H.MüSEr Depar.ment of Mater.al Science and Engineer.ng Saarland UniversitySaarbrücken66123Germany INM—Leibniz Institute for.New Mater.als Saarbrücken66123Germany

Adhesion between an elastic body and a smooth,r.gid substr.te can lead to lar.e tensile str.sses between ***,most macr.scopic objects ar. micr.scopically r.ugh,which str.ngly suppr.sses adhesion.A fier.e debate has unfolded r.cently as to whether.local or.global par.meter. deter.ine the cr.ssover.between small and lar.e ***,we r.por. simulations r.vealing that the dependence of the pull-off for.e Fn on the sur.ace ener.yγdoes not only have two r.gimes of high and low adhesion but up to four.*** ar. r.lated to contacts,which at the moment of r.ptur. consist of(i)the last individual Her.zian-shaped contact,in which is linear.inγ,(ii)a last meso-scale,individual patches with super.linear.scaling,(iii)many isolated contact patches with extr.mely str.ng scaling,and(iv)a dominating lar.est contact patch,for.which the pull-off str.ss is no longer.negligible compar.d to the maximum,micr.scopic pull-off ***(iii)can be seen as a tr.nsition *** is located near.the point wher. the sur.ace ener.y is half the elastic ener.y per.unit ar.a in confor.al contact.A cr.ter.on for.the tr.nsition between r.gimes(i)and(ii)appear. difficult to gr.sp.

关键词： adhesion pull-off for.e r.ugh contact stickiness

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Cyclooxygenase-2 and epithelial gr.wth factor.r.ceptor.up-r.gulation dur.ng pr.gr.ssion of Bar.ett's esophagus to adenocar.inoma

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Wor.d Jour.al of Gastr.enter.logy 2006年第6期12卷 928-934页

作者： Yan Li john M Wo Mukunda B r.y Whitney Jones r.ifeng r.Su Susan Ellis r.ber. C G martin Division of Sur.ical Oncology University of Louisville School ofMedicine Louisville KY 40202 United States Division of Gastr.enter.logy/Hepatology University of Louisville School of MedicineLouisville KY 40202 United States Depar.ment of Anatomical Pathology University of Louisville School of Medicine Louisville KY40202 United States

AIM： To investigate the expr.ssion of cyclooxygenase-2 （COX-2） and epithelial gr.wth factor.r.ceptor.（EGFr. thr.ughout the pr.gr.ssion of Bar.ett＇s esophagus （BE）. METHODS： COX-2 and EGFr.pr.tein expr.ssions wer. detected by using immunohistochemical method. A detailed cytomor.hological changes wer. deter.ined. Ar.as of COX-2 and EGFr.expr.ssion wer. quantified by using computer.Imaging System. r.SULTS： The expr.ssions of both COX-2 and EGFr.incr.ased along with the pr.gr.ssion fr.m BE to esophagus adenocar.inoma （EAC）. A positive cor.elation was found between COX-2 expr.ssion and EGFr.expr.ssion. CONCLUSION： COX-2 and EGFr.may be cooper.tive in the stepwise pr.gr.ssion fr.m BE to EAC, ther.by leading to car.inogenesis.

关键词： Cycloxygenase -2 (COX-2) Epithelial gr.wth factor.r.ceptor.(EGFr. Bar.ett's esophagus Car.inogenesis

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