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Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris *** for Artemisia annua *** Western Uganda

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TMR Integrative Medicine 2023年第4期7卷 1-13页

作者： Ivan Kahwa Clement Olusoji Ajayi Reenu Yadav Nagendra Singh Chauhan Kamal Shah Abdelgadir Alamin Abdelgadir Efrata Ashuro Shegena Salome Daniel Timothy Omara john Baptist Asiimwe Hilda Ikiriza Shabnoor Iqbal Casim Umba Tolo Anke Weisheit patrick Engeu Ogwang Pharm-BioTechnology and Traditional Medicine Centre Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy Faculty of MedicineMbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy IES UniversityBhopal-462044Madhya PradeshIndia Drugs Testing Laboratory Avam Anusandhan Kendra Raipur(CG)492010India Institute of Pharmaceutical Research GLA UniversityMathuraUttar Pradesh 281406India Department of Pharmacognosy Faculty of PharmacyUniversity of GeziraP.O Box 20Wad MadaniSudan Department of Pharmaceutics and Pharmacy Practice Kampala International UniversityP.O.Box 9790Dares SalaamTanzania Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Konrad-Lorenz-Straße 243430Tulln an der DonauAustria Aga Khan University P.O.Box 8842KampalaUganda Department of Biology Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Zoology Government College UniversityFaisalabadPunjab 38000Pakistan

Background:Different parts of Artemisia vulgaris L.(***)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and ***,anecdotal evidence shows that the plant is often substituted for Artemisia annua L.(***)by herbalists in Western Uganda due to similarities in their *** of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine *** safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly ***:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of *** leaves compared to *** to ease its correct ***:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf *** leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for *** and dark green for ***)can be used by the local community to distinguish between *** artemisinin content was higher in *** leaves(1.72%)than in ***(1.43%),but the reverse was observed for the total flavonoid ***:This observation could justify the change in the use of *** by the indigenous community in western *** studies should consider the pharmacognostic comparison of *** with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

关键词： Artemisinin traditional medicine misidentification microscopic studies

Quality of Life in Men Treated for Early Prostate Cancer: A Prospective Patient Preference Cohort Study

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Journal of Cancer Therapy 2011年第4期2卷 448-457页

作者： Carmel Nirupa Anandadas Susan Elizabeth Davidson Noel William Clarke Stephen Charles William Brown john Paul Logue Lynne Gilmore Richard Swindell Gerald Nicholas Collins patrick Henry O’Reilly Guy David Wemyss-Holden Maurice Waiming Lau Pradip Madhukar Javle Vijay Alini Chandi Ramani Richard James Brough James Pinson Wylie Richard Andrew Cowan 不详

Objectives: In 1997, a study was launched to investigate the treatment of early prostate cancer. Using a patient preference design, health-related quality-of-life (HRQOL) and disease specific HRQOL was assessed prospectively to compare men undergoing radical prostatectomy (RP), hypo-fractionated conformal radiotherapy (CRT) or brachytherapy (BT). Methods: Patients with localised prostate cancer were counselled by a urological surgeon, clinical oncologist and specialist uro-oncology nurse. Patients received treatment according to individual preference. 430 men chose and received RP (n = 217), CRT (n = 161) and BT (n = 52). 354 (82%) completed pre-treatment RAND 36-Item Short-Form Health survey version-2 (SF36v2) and University of California, Los Angeles Prostate cancer index (UCLA-PCI) questionnaires. HRQOL score changes from baseline to 24 months were compared using Kruskall-Wallis test. Results: Pre-treatment, the CRT cohort scored lower for physical function (p = 0.0029) and general health perception (p = 0.0021). The BT cohort reported better baseline scores for urinary function (p = 0.0291), urinary bother (p = 0.0030), sexual function (p = 0.0009) and bowel bother (p = 0.0063). At 24 months, bowel function was similar for CRT and BT but both modalities were worse than RP (p = 0.0010). Urinary continence deteriorated most following RP (p < 0.0001) but BT had worse urinary bother (p = 0.0153). Sexual function deteriorated most following RP and BT (p < 0.0005). Percentages of patients achieving erections adequate for sexual activity (from baseline to 24 months) were 66% to 29% for RP, 62% to 49% for CRT and 88% to 65% for BT. Conclusion: This data demonstrates significant differences in disease specific quality-of-life between RP, CRT and BT and should be available for men with early prostate cancer making treatment decisions.

关键词： Early Prostate Cancer Quality of Life Patient Preference Prostatectomy Hypo-Fractionated Radiotherapy Brachytherapy

Report of the first international workshop on onchocerciasis-associated epilepsy

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Infectious Diseases of Poverty 2018年第1期7卷 238-242页

作者： Robert Colebunders Michel Mandro Alfred K.Njamnshi Michel Boussinesq An Hotterbeekx Joseph Kamgno Sarah O’Neill Adrian Hopkins patrick Suykerbuyk Maria-Gloria Basanez Rory J.Post Belen Pedrique Pierre-Marie Preux Wilma A.Stolk Thomas B.Nutman Richard Idro Global Health Institute University of AntwerpAntwerpBelgium Provincial Health Division of Ituri BuniaDemocratic Republic of the Congo Department of Neurology Yaounde Central Hospital/University of Yaounde 1Brain Research Africa Initiative(BRAIN)YaoundeCameroon Institut de Recherche pour le Developpement(IRD) MontpellierFrance Centre for Research on Filariasis and other Tropical Diseases(CRFilMT) and Faculty of Medicine and Biomedical SciencesUniversity of Yaounde 1YaoundeCameroon Department of Public Health Institute of Tropical MedicineAntwerpBelgium Neglected and Disabling Diseases of Poverty Consultant KentUK London Centre for Neglected Tropical Disease Research Imperial College LondonLondonUK London School of Hygiene&Tropical Medicine and Liverpool john Moores University LondonUK Drugs for Neglected Diseases initiative GenevaSwitzerland Preux Pierre-Marie INSERMUniversity LimogesCHU LimogesUMR_S 1094Tropical NeuroepidemiologyInstitute of Neuroepidemiology and Tropical NeurologyCNRS FR 3503 GEIST87000 LimogesFrance Department of Public Health Erasmus MCUniversity Medical Centre RotterdamRotterdamThe Netherlands Laboratory of Parasitic Diseases National Institutes of HealthBethesdaMarylandUSA Makerere University College of Health SciencesKampalaUganda

Background:Recently,several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy(OAE)may constitute an important but neglected public health problem in many countries where onchocerciasis is still *** text:On October 12-14th 2017,the first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,*** workshop was attended by 79 participants from 20 different *** research findings strongly suggest that *** is an important contributor to epilepsy,particularly in meso-and hyperendemic areas for *** with *** is associated with a spectrum of epileptic seizures,mainly generalised tonic-clonic seizures but also atonic neck seizures(nodding),and stunted *** is characterised by an onset of seizures between the ages of 3-18 *** working groups discussed topics such as how to 1)strengthen the evidence for an association between onchocerciasis and epilepsy,2)determine the burden of disease caused by OAE,3)prevent OAE,4)improve the treatment/care for persons with OAE and affected families,5)identify the pathophysiological mechanism of OAE,and 6)deal with misconceptions,stigma,discrimination and gender violence associated with *** OAE Alliance was created to increase awareness about OAE and its public health importance,stimulate research and disseminate research findings,and create partnerships between OAE researchers,communities,advocacy groups,ministries of health,non-governmental organisations,the pharmaceutical industry and funding ***:Although the exact pathophysiological mechanism underlying OAE remains unknown,there is increasing evidence that by controlling and eliminating onchocerciasis,OAE will also ***,OAE constitutes an additional argument for strengthening onchocerciasis elimination *** the high numbers of people with epilepsy

关键词： Onchocerciasis Epilepsy Nodding syndrome Nakalanga syndrome Prevalence Burden of disease Africa

慢性乙型肝炎患者144周治疗期间未发现丙酚替诺福韦耐药

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慢性乙型肝炎患者144周治疗期间未发现丙酚替诺福韦耐药

第十届全国疑难及重症肝病大会

作者： Henry Lik-Yuen Chan patrick Marcellin Calvin Q.Pan Andrea L Cathcart Neeru Bhardwaj Yang Liu Bandta Parhy Eric Zhou David Hsieh Silvia Chang Ross Martin Becket Feierbach Hongmei Mo Anuj Gaggar john F Flaherty Shalimar Namiki Izumi Young-Suk Lim The Chinese University of Hong Kong

背景在2项评价丙酚替诺福韦(TAF)或富马酸替诺福韦二吡呋酯(TDF)用于HBeAg+或HBeAg-慢性乙型肝炎初治或经治成人患者时的3期临床研究(GS-US-320-0108,GS-US-320-0110)中进行了累积耐药性分析。方法患者按照2:1的比例进行随机分组,并按照...

背景在2项评价丙酚替诺福韦(TAF)或富马酸替诺福韦二吡呋酯(TDF)用于HBeAg+或HBeAg-慢性乙型肝炎初治或经治成人患者时的3期临床研究(GS-US-320-0108,GS-US-320-0110)中进行了累积耐药性分析。方法患者按照2:1的比例进行随机分组,并按照HBV DNA水平和治疗状态进行分层接受TAF

关键词：

来源： cnki会议评论

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当手机遇到玩具

创业邦 2012年第9期 128-128页

作者： john patrick Pullen 金笙

Orbotix公司的发明让全世界变成有趣的游戏场。

关键词：智能手机玩具发展现状创新蓝牙技术

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Temboo 创客的后花园

创业邦 2014年第4期 54-54页

作者： john patrick Pullen Yelena Xu

Temboo的庞大资源库为App开发者省了大把时间。

关键词：后花园开发者 App 资源库

Richard Sheridan用创新创造快乐

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创业邦 2014年第6期 86-86页

作者： john patrick Pullen Yelena Xu

Menlo用实验性的方法减轻员工对工作的恐惧、迷茫和猜疑。2013年2月,Lisamarie Babik入职IT公司Dynamic Edge有3个月了,她被要求＂顺从＂。这个退伍兵出身的程序员曾在Menlo Innovations做了10年软件开发,她发现自己已经不能适应新公司... 详细信息

Menlo用实验性的方法减轻员工对工作的恐惧、迷茫和猜疑。2013年2月,Lisamarie Babik入职IT公司Dynamic Edge有3个月了,她被要求＂顺从＂。这个退伍兵出身的程序员曾在Menlo Innovations做了10年软件开发,她发现自己已经不能适应新公司的旧思维。或许对Menlo的员工来说,这家公司确实太新鲜了。这个成立于2001年的公司位于密歇根州Ann Arbor,首要目标是盈利,但公司能用非传统的手段创造欢乐。联合创始人Richard Sheridan著有《快乐工作：如何打造人见人爱的公司》一书,

关键词：快乐工作 IT公司创新 2001年 Edge 软件开发密歇根州实验性

Scottevest有37个口袋的超级夹克

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创业邦 2014年第2期 70-70页

作者： john patrick Pullen 鲁行云

Scottevest生产一种能随身装下各种电子产品的服装，还能隐藏各种电子产品的连接线以免剐蹭。

关键词：电子产品连接线服装行业服装设计

流行病学和临床研究中数据缺失的多重填补：机会和陷阱

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英国医学杂志中文版 2009年第6期12卷 371-375页

作者： Jonathan A C Sterne Ian R White john B Carlin Michael Spratt patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) Department ofSocial Medicine University of BristolBristol BS8 2PR MRC BiostatisticsUnit Institute of PublicHealth CambridgeCB2 0SR Clinical Epidemiologyand BiostatisticsUnit MurdochChildren's ResearchInstitute andUniversityof MelbourneParkville Victoria3052 Australia Cancer andStatistical MethodologyGroups MRCClinical Trials UnitLondon NW1 2DA Medical StatisticsUnit kondon Schoolof Hygiene andTropical Medicinelondon WC1E 7HT Depamnent ofPublic Health andPrimary Care Instituteof Public HealthCambridge 北京协和医科大学流行病学教研室

许多研究都存在缺失数据。Jonathan

关键词：多重填补数据缺失临床研究流行病学缺失数据填补方法