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Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer’s: A Multi-Modality Brain Imaging Study

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Advances in Molecular Imaging 2014年第4期4卷 43-57页

作者： Dawn C. Matthews Michelle Davies john murray Schantel Williams Wai H. Tsui Yi Li Randolph D. Andrews Ana Lukic Pauline McHugh Shankar Vallabhajosula Mony J. de Leon Lisa Mosconi ADM Diagnostics Chicago USA Department of Psychiatry New York University School of Medicine New York USA Citigroup Biomedical Imaging Center Weill Cornell Medical College New York USA

Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer’s disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD. Methods: Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, 11C-Pittsburgh Compound B (PiB) and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined. Voxel-wise multivariate partial least square (PLS) regression was used to examine the effects of LTA, MeDi and their interaction on brain biomarkers. Age, gender, ethnicity, education, caloric intake, BMI, family history of AD, Apolipoprotein E (APOE) genotype, presence of hypertension and insulin resistance were examined as confounds. Subjects were dichotomized into more and less physically active (LTA+ vs. LTA-;n = 21 vs. 24), and into higher vs. lower MeDi adherence groups (n = 18 vs. 27) using published scoring methods. Spatial patterns of brain biomarkers that represented the optimal association between the images and the groups were generated for all modalities using voxel-wise multivariate Partial Least Squares (PLS) regression. Results: Groups were comparable for clinical and neuropsychological measures. Independent effects of LTA and MeDi factors were observed in AD-vulnerable brain regions for all modalities (p β load and lower glucose metabolism) were observed in LTA- compared to LTA+ subjects, and in MeDi- as compared to MeDi+ subjects. A gradient effect was observed for all modalities so that LTA+/MeDi+ subjects had the highest and LTA+/MeDi+ subjects had the lowest AD-burden (p < 0.001), although the LTA × MeDi interaction was significant

关键词： Alzheimer’s Disease Mediterranean Diet Physical activity PET Imaging Amyloid Glucose Metabolism MRI Early Detection Brain Aging

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美国Malwarebytes公司办公室

现代装饰 2016年第6期 46-51页

作者： Melissa Hanley Zach Meade Liz Evoy Emily Burchill john Hunter bruce Damonte 姜敏华 Blitz

Malwarebytes是一家发展迅速的网络安全公司,帮助个人和公司用户抵御各种各样的网络恶意软件。他们的使命很简单：打造最优质的网络保护解决方案,对抗世界上最致命的网络威胁。为了满足公司日益壮大的人员需求,该公司邀请Blitz建筑事务... 详细信息

Malwarebytes是一家发展迅速的网络安全公司,帮助个人和公司用户抵御各种各样的网络恶意软件。他们的使命很简单：打造最优质的网络保护解决方案,对抗世界上最致命的网络威胁。为了满足公司日益壮大的人员需求,该公司邀请Blitz建筑事务所在美国加利福利亚州圣克拉拉市的一栋办公大楼里为他们打造了一个全新的两层空间的办公室。从这里眺望,硅谷的全景尽收眼底,还可以俯瞰49人足球队的大本营——李维斯体育场。

关键词：办公室美国加利福利亚州网络安全建筑事务所恶意软件网络保护网络威胁

FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer’s Disease

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Advances in Molecular Imaging 2014年第2期4卷 15-26页

作者： john murray Wai H. Tsui Yi Li Pauline McHugh Schantel Williams Megan Cummings Elizabeth Pirraglia Lilja Solnes Ricardo Osorio Lidia Glodzik Shankar Vallabhajosula Alexander Drzezga Satoshi Minoshima Mony J. de Leon Lisa Mosconi New York University School of Medicine New York USA University of Cologne Cologne Germany University of Washington Seattle USA Weill Cornell Medical College New York USA

Having a parent affected by late-onset Alzheimer’s disease (AD) is a major risk factor for cognitively normal (NL) individuals. This study explores the potential of PET with 18F-FDG and the amyloid-β (Aβ) tracer 11C-Pittsburgh Compound B (PiB) for detection of individual risk in NL adults with AD-parents. Methods: FDG- and PiB-PET was performed in 119 young to late-middle aged NL individuals including 80 NL with positive family history of AD (FH+) and 39 NL with negative family history of any dementia (FH-). The FH+ group included 50 subjects with maternal (FHm) and 30 with paternal family history (FHp). Individual FDG and PiB scans were Z scored on a voxel-wise basis relative to modality-specific reference databases using automated procedures and rated as positive or negative (+/-) for AD-typical abnormalities using predefined criteria. To determine the effect of age, the cohort was separated into younger (49 ± 9 y) and older (68 ± 5 y) groups relative to the median age (60 y). Results: Among individuals of age >60 y, as compared to controls, NL FH+ showed a higher frequency of FDG+ scans vs. FH- (53% vs. 6% p < 0.003), and a trend for PiB+ scans (27% vs. 11%;p = 0.19). This effect was observed for both FHm and FHp groups. Among individuals of age ≤60 y, NL FHm showed a higher frequency of FDG+ scans (29%) compared to FH- (5%, p = 0.04) and a trend compared to FHp (11%) (p = 0.07), while the distribution of PiB+ scans was not different between groups. In both age cohorts, FDG+ scans were more frequent than PiB+ scans among NL FH+, especially FHm (p < 0.03). FDG-PET was a significant predictor of FH+ status. Classification according to PiB status was significantly less successful. Conclusions: Automated analysis of FDG- and PiB-PET demonstrates higher rates of abnormalities in at-risk FH+ vs FH-subjects, indicating potentially ongoing early AD-pathology in this population. The frequency of metabolic abnormalities was higher than that of Aβ pathology in the younger c

关键词： Alzheimer’s Disease Early Detection Positron Emission Tomography Amyloid Imaging Glucose Metabolism Normal Aging

Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample

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World Journal of Gastrointestinal Endoscopy 2019年第10期11卷 504-514页

作者： Tooba Tariq Patrick Karabon Furqan B Irfan Sachin Goyal Matthew Masaru Mayeda Austin Parsons Stephanie Judd murray Ehrinpreis Department of Internal Medicine Western Michigan University Homer Stryker M.D.School of MedicineKalamazooMI 49008United States Oakland University William Beaumont School of Medicine Oakland UniversityDetroitMI 48309United States College of Osteopathic Medicine Michigan State UniversityEast LansingMI 48824United States 不详 Department of Internal Medicine Division of GastroenterologyJohn D Dingell VA Medical CenterDetroitMI 48201United States

BACKGROUND Chronic kidney disease is associated with angiodysplasia of gastrointestinal tract leading to increased risk of gastrointestinal *** To determine the nationwide prevalence,trends,predictors and resource utilization of angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease *** The Nationwide Inpatient Sample database from 2009 to 2014,was utilized to conduct a retrospective study on patients with angiodysplasia associatedgastrointestinal bleeding and end-stage renal *** with endstage renal disease were included in the Nationwide Inpatient Sample database and a subset of hospitalizations with end-stage renal disease and angiodysplasiaassociated gastrointestinal bleeding were identified with International Classification of Diseases,9th revision,Clinical Modification codes for both endstage renal disease(585.6)and angiodysplasia(569.85,537.83).RESULTS The prevalence of angiodysplasia-associated gastrointestinal bleeding was 0.45%(n=24709)among all end-stage renal disease patients(n=5505252)that were *** analysis indicated that the following were significant factors associated with higher odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients:an increasing trend from 2009-2014(P<0.01),increasing age(P<0.0001);African American race(P=0.0206);increasing Charlson-Deyo Comorbidity Index(P<0.01);hypertension(P<0.0001);and tobacco use(P<0.0001).Diabetes mellitus(P<0.0001)was associated with lower odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease *** comparison with urban teaching hospitals,rural and urban nonteaching hospitals were associated with decreased odds of angiodysplasia associated-gastrointestinal *** Angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease patients showed an increasing trend from *** age,African American

关键词： Angiodysplasia Renal Gastrointestinal Hemorrhage

Molecular Biology of the Cell 5th ed.

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2008年

作者： bruce Alberts Alexander johnson Julian Lewis Martin Raff Keith Roberts Peter Walter

ISBN: (纸本)9780815341055

For nearly a quarter century, "Molecular Biology of the Cell" has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of "Molecular Biology of the Cell" have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book. And for the first time, "Molecular Biology of the Cell" now contains end-of-chapter questions. These problems, written by john Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint[registered] presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies - animations, videos, and molecular models - all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this eno

关键词： Cell.

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印度VS中国

商业周刊（中文版） 2014年第V期 22-23页

作者：竹西 bruce Einhom

印度有望成为下一个制造业大国鉴于印度惯常性的停电、破败不堪的道路和其他糟糕的基础设施，这个国家对于约翰·吉纳斯克（john Ginascol）而言应该没有什么吸引力。作为雅培制药（Abbott Laboratories）的副总裁，吉纳斯克负责确保该... 详细信息

印度有望成为下一个制造业大国鉴于印度惯常性的停电、破败不堪的道路和其他糟糕的基础设施，这个国家对于约翰·吉纳斯克（john Ginascol）而言应该没有什么吸引力。作为雅培制药（Abbott Laboratories）的副总裁，吉纳斯克负责确保该公司的食品生产工厂在全球范围内顺利运行。在电力、水等必需品方面，他无法承受任伺意外情况。他表示：“像我这样的人渴望拥有现成的、可靠的良好基础设施。”

关键词：印度中国基础设施食品生产意外情况制造业吸引力副总裁

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关于不同年龄儿童喉部横断面积的研究

麻醉与镇痛 2010年第6期6卷 73-78页

作者： Priti G. Dalal David murray Anna H. Messner Angela Feng john McAllister David Molter 滕凌雅(译) 李士通(校) Department of Anesthesiology Penn State Milton S Hershey Medical Center Hershey Pennsylvania Department of Anesthesiology Washington University School of Medicine St Louis Children's Hospital St Louis Missouri Department of Otolaryngology/Head and Neck Surgery Lucile Packard Children's Hospital Stanford University Palo Alto Californial Kaiser Foundation Hospital OaklandCalifornia Department of Otolaryngology Washington University School of Medicine St Louis Children's Hospital St Louis Missouri 不详

背景环状软骨被认为是儿童的漏斗状气道最狭窄的部分。随着生长发育，慢慢地向成人的圆柱状气道转变。实际工作中，大量的儿童气道评估是建立在这种转变基础之上的。本研究的主要目的是建立各个年龄阶段儿童的气道测量参考值。方法从6... 详细信息

背景环状软骨被认为是儿童的漏斗状气道最狭窄的部分。随着生长发育，慢慢地向成人的圆柱状气道转变。实际工作中，大量的儿童气道评估是建立在这种转变基础之上的。本研究的主要目的是建立各个年龄阶段儿童的气道测量参考值。方法从6个月到13岁不等的135例儿童（ASA生理状态1或2级）参与了本次研究。在全身麻醉下，运用视频支气管镜检查技术，分别测量在声门和环状软骨水平的横断面积、前后径及横径。结果在本次研究的135例儿童中，由于图像质量不好的原因有7例被排除。在此项研究的128例儿童（79例男孩、49例女孩）中，人口统计学资料显示：平均年龄5．9±3．3岁，身高113．5±22．2cm，体重23．5±3kg。最终结果显示：环状软骨水平的横断区域面积大于声门水平的横断区域面积（48．9±15．5mill2VS30±16．5mm2）。这种关系对此项研究中的所有JtAt都成立（P〈0．001，r=0．45，检验效能=1）。声门水平横断区域面积和环状软骨水平横断区域面积的平均比例为2．1±1．2。声门水平横断区域面积和环状软骨水平横断区域面积与年龄（r=0．36，P〈0．001；r=0．27，P=0．001）、身高（r=0．34，P〈0．001；r=0．29，P=0．001）、体重（r=0．35，P〈0．001；r=0．25，P=0．003）呈正相关。而性别差异对研究参数并无影响。结论此项关于婴儿和儿童的研究显示，声门是儿童气道中最狭窄的部位，而不是环状软骨。与成人类似，在这些视频支气管镜图像上，儿童气道呈现圆柱状比呈现漏斗状的多。至于这些在麻醉及肌肉松弛状态下的静态气道测量能否反映儿童声门和环状软骨的动态特性还需进一步的研究。

关键词：横断面积平均年龄儿童环状软骨喉部生理状态全身麻醉支气管镜

Molecular Classification of Osteosarcoma:Towards Personalized Predictive Care

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Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial

中国抗癌协会第七届全国小儿肿瘤学术会议

作者： Ching C.Lau Tsz-Kwong Man Jianhe Shen Joyce Gu Jaya Visvanathan Laszlo Perlaky john Hicks Mark johnson Nelson Davino Jeffrey murray Lee Helman William Meyer Daniel Wai Timothy Triche Kwong-Kwok Wong Murali Chintagumpala Baylor College of Medicine HoustonTX Cook Children’s Hospital Fort WorthTX National Cancer Institute BethesdaMD University of Oklahoma Health Sciences Center Oklahoma CityOK Children’s Hospital Los Angeles Los AngelesCA.

Osteosarcoma is the most common malignant bone tumor in *** initial diagnosis is made with a biopsy, treatment consists of pre-operative chemotherapy followed by definitive surgery and post-operative *** degree of tumor necrosis in response to pre-operative chemotherapy is a reliable prognostic factor and is used to guide the choice of post-operative chemotherapy.

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Stroke & Vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf Yassi Henry Zhao Leonid Churilov bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders john Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance Victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute