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Immunotherapy of gastric cancer:Present status and future perspectives

World Journal of Gastroenterology 2024年第8期30卷 779-793页

作者： john K Triantafillidis Manousos M Konstadoulakis Apostolos E Papalois Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we comment on the article entitled“Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliometric analysis concerning gastric cancer immunotherapy,which they analyzed in depth by compiling the relevant publications of the last 20 *** that,we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer(GC)in different countries,attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatment(chemotherapy)of the various forms of this malignant *** describe the treatment of resectable tumors,locally advanced neoplasms,and unresectable(advanced)*** attention is given to modern therapeutic approaches with emphasis on immunotherapy,which seems to be the future of GC treatment,especially in combination with *** is also a thorough analysis of the results of the study under review in terms of the number of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attempt is made to draw some conclusions and to point out possible future directions.

关键词： Gastric cancer Chemotherapy Immunotherapy Immune checkpoint inhibitors Bibliometrics Scientometrics

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Aerodynamics of a Tandem-Bladed Axial Compressor Rotor under Circumferential Distortion at Different Rotational Speeds

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit KUMAR Jerry T.john A.M.PRADEEP R.A.DAKKERMANS Dragan KOZULOVIC Department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynamic performance and stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational ***-annulus RANS simulations using ANSYS CFX are used in the present *** performance of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential *** loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass flow,the circumferential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region promotes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenomenon is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

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Robust Machine Learning Mapping of sEMG Signals to Future Actuator Commands in Biomechatronic Devices

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Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr Sydney Bell Rachel L.Whittaker Clark R.Dickerson john McPhee Systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and Health Sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted Surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-Surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

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The first record of a Konservat-Lagerstätten in which early post-settlement stages of fossil archaeobalanids(Cirripedia:Balanomorpha)are preserved

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Integrative Zoology 2024年第2期19卷 200-223页

作者： Tomáš KOCÍ Rok GAŠPARIC john BUCKERIDGE Martina KOCOVÁ VESELSKÁ Aleš ŠOSTER Ivancická581 PragueCzech Republic Palaeontological Department Natural History MuseumNational MuseumPragueCzech Republic Oertijdmuseum Bosscheweg 80Boxtel5293 WBThe Netherlands Institute for Palaeobiology and Evolution Novi TrgKamnikSlovenia Earth and Oceanic Systems Group RMIT UniversityMelbourneAustralia Museums Victoria CarltonVictoriaAustralia Department of Paleobiology and Paleoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Institute of Geology and Palaeontology Charles UniversityPragueCzech Republic Faculty of Natural Sciences and Engineering University of LjubljanaLjubljanaSlovenia

A diverse sessile barnacle fauna from a Miocene shallow-water deposit at Dolnja Stara vas in Slovenia is *** includes the first descriptions of early post settlement juveniles of Actinobalanus sloveniensis attached to mangrove *** represent three distinct growth phases,the earliest being interpreted as being less than 24 h post settlement,the others being 1 to 2 days post *** assessment of their taphonomy is *** adult balanomorphs are attached to a variety of organic substrates,including mangrove leaves and branches,fragments of the conifers?Taxodioxylon,Carapoxylon,pine cones,molluscs,and cetacean *** barnacles include ***,Amphibalanus venustus,and Perforatus perforatus—many with opercula retained within the *** retains some of the original shell *** is the second record of barnacle–plant associations from the Central Paratethys from Kamnik and *** paleoecology and paleogeography of the site are discussed.

关键词： acorn barnacles barnacle metamorphosis epibiont paleoecology taxonomy

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The synergistic interplay of artificial intelligence and digital twin in environmentally planning sustainable smart cities:A comprehensive systematic review

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Environmental Science and Ecotechnology 2024年第4期20卷 79-104页

作者： Simon Elias Bibri Jeffrey Huang Senthil Kumar Jagatheesaperumal john Krogstie Swiss Federal Institute of Technology Lausanne(EPFL) Institute of Computer and Communication Sciences(IINFCOM)School of ArchitectureCivil and Environmental Engineering(ENAC)Media and Design Laboratory(LDM)1015LausanneSwitzerland Department of Electronics&Communication Engineering Mepco Schlenk Engineering CollegeSivakasi626005TamilnaduIndia Department of Computer Science Norwegian University of Science and Technology(NTNU)TrondheimNorway

The dynamic landscape of sustainable smart cities is witnessing a significant transformation due to the integration of emerging computational technologies and innovative *** advancements are reshaping data-driven planning strategies,practices,and approaches,thereby facilitating the achievement of environmental sustainability *** transformative wave signals a fundamental shift d marked by the synergistic operation of artificial intelligence(AI),artificial intelligence of things(AIoT),and urban digital twin(UDT)*** previous research has largely explored urban AI,urban AIoT,and UDT in isolation,a significant knowledge gap exists regarding their synergistic interplay,collaborative integration,and collective impact on data-driven environmental planning in the dynamic context of sustainable smart *** address this gap,this study conducts a comprehensive systematic review to uncover the intricate interactions among these interconnected technologies,models,and domains while elucidating the nuanced dynamics and untapped synergies in the complex ecosystem of sustainable smart *** to this study are four guiding research questions:*** theoretical and practical foundations underpin the convergence of AI,AIoT,UDT,data-driven planning,and environmental sustainability in sustainable smart cities,and how can these components be synthesized into a novel comprehensive framework?*** does integrating AI and AIoT reshape the landscape of datadriven planning to improve the environmental performance of sustainable smart cities?*** can AI and AIoT augment the capabilities of UDT to enhance data-driven environmental planning processes in sustainable smart cities?*** challenges and barriers arise in integrating and implementing AI,AIoT,and UDT in data-driven environmental urban planning,and what strategies can be devised to surmount or mitigate them?Methodologically,this study involves a rigorous analysis and synthesis of studies publis

关键词： Sustainable smart cities Artificial intelligence Artificial intelligence of things Urban digital twin Data-driven urban planning Environmental planning Environmental sustainability

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A new species of Discostella guiyangensis ***.(Bacillariophyta,Stephanodiscales)from Guiyang,China:morphology and phylogeny

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Journal of Oceanology and Limnology 2024年第4期42卷 1312-1324页

作者： Yandan XIANG Fangru NAN Xudong LIU Shulian XIE john Patrick KOCIOLEK Qi LIU School of Life Science Shanxi UniversityTaiyuan 030006China Department of Ecology and Evolutionary Biology and Museum of Natural History University of ColoradoBoulder CO 80309USA

We describe a new species of Discostella from Guiyang based on light and scanning electron microscopic observations,as well as molecular *** species is morphologically distinguished from other species by a relatively smooth and slightly recessed central area with marginal striae of unequal lengths forked near the *** fultoportulae and a single rimoportula are situated between every two costae or on the *** morphological characters and the concatenated data of rbc L and SSU rDNA indicate that Discostella guiyangensis is a unique and new *** to divergence time estimation analysis,Discostella guiyangensis is the oldest species among the Discostella species sequenced *** addition,we complement molecular data of Discostella asterocostata and Discostella stelligera.

关键词： Discostella morphology molecular analysis divergence time estimation new species

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Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives:A Study among Indian Youths

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： Divya P.Vijayan Tokani Ghuhato Eslavath Rajkumar Allen Joshua George Romate john john Abraham Department of Psychology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common people by smartphones and has become a common practice across the globe in no *** technological advancement and the popularity of smartphones,selfie-taking has grown rapidly within a short *** light of the new trend set by the generation,this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults.A purposive sampling method was adopted to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and posting on social media give positive feelings,and it acts as a mood modifier dependent mostly on the favourability and feedback about the post which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

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A holistic approach to improving safety for battery energy storage systems

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Journal of Energy Chemistry 2024年第5期92卷 422-439页

作者： James Close Jonathan E.Barnard Y.M.john Chew Semali Perera Department of Chemical Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK ioMosaic International Limited 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage systems(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and numerous BESS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the management and design of *** understand the causes of failure,the main challenges of BESS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing thermal runaway,and a case study of a BESS explosion in Surprise Arizona is *** on the technology and past events,a paradigm shift is required to improve BESS *** this review,a holistic approach is *** combines currently adopted approaches including battery cell testing,lumped cell mathematical modelling,and calorimetry,alongside additional measures taken to ensure BESS safety including the requirement for computational fluid dynamics and kinetic modelling,assessment of installation level testing of the full BESS system and not simply a single cell battery test,hazard and layers of protection analysis,gas chromatography,and composition *** holistic approach proposed in this study aims to address challenges of BESS safety and form the basis of a paradigm shift in the safety management and design of these systems.

关键词： Energy storagesystems Process safety Battery safety Thermal safety

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Impact of COVID-19 pandemic on cardiovascular health in sedentary and athletes:Consensus,uncertainties,and ways for mitigation

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Sports Medicine and Health Science 2024年第3期6卷 205-208页

作者： john C.Quindry Lei Xi School of Integrative Physiology and Athletic Training University of MontanaMissoulaMT59812USA Pauley Heart Center Department of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA23298-0204USA

More than 4 years has elapsed since the World Health Organization(WHO)ofﬁcially announced the coronavirus disease 2019(COVID-19)as a pandemic outbreak in March 11,*** the ongoing investigations and political debates upon the origin,exacerbation,resurgence,andﬁnal control of COVID-19,medical and scientiﬁc consensus indicates that the now endemic COVID-19 virus is one of the worst public health crises in our *** every person on earth has been directly or indirectly impacted by the adverse effects of the highly contagious viral pathogen-SARS-CoV-2(severe acute respiratory syndrome coronavirus 2).Indeed,the population reach of the COVID-19 infection includes governmental response measures(e.g.,lockdowns and social distancing,mandates for masks and face coverings,vaccines,etc.)that have restricted entrenched societal routines,personal mobility,and ***,the host of health problems linked to this viral infection linger to this day,with selective groups of people experiencing a higher risk for untoward medical outcomes and/or elevated levels of vulnerability to the post-acute sequelae of COVID-19(***-COVID).For example,a 2021 study by Logue et *** initial evidence that 10%–30%of individuals in United States may experience prolonged symptoms following SARS-CoV-2 infection,including cardiovascular abnormalities.1 Similarly,a 2021 retrospective cohort study in England suggest that the incidence of major adverse cardiovascular events(*** failure,myocardial infarction,ischemic stroke.

关键词： cardiovascular routine Impact

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Managerial perspectives of scaling up robotic-assisted surgery in healthcare systems:A systematic literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 113-122页

作者： Ravichandran Anitha Komattu Chacko john Gnanadhas Jabarethina Sri Ramachandra Faculty of Management Sciences Sri Ramachandra Institute of Higher Education and Research(Category-I Deemed to be University)ChennaiIndia

Objectives Robotic-assisted surgery(RAS)is a minimally invasive technique practiced in multiple *** training is essential for the acquisition of RAS *** cost of RAS is considered to be high,which makes it a burden for institutes and unaffordable for *** systematic literature review(SLR)focused on the various RAS training methods applied in different surgical specialties,as well as the cost elements of RAS,and was to summarize the opportunities and challenges associated with scaling up *** An SLR was carried out based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses reporting *** PubMed,EBSCO,and Scopus databases were searched for reports from January 2018 through January ***-text reviews and research articles in the English language from Asia-Pacific countries were *** that outlined training and costs associated with RAS were *** The most common training system is the da Vinci *** simulation technique,which includes dry-lab,wet-lab,and virtual reality training,was found to be a common and important *** cost of RAS encompasses the installation and maintenance costs of the robotic system,the operation theatre rent,personnel cost,surgical instrument and material cost,and other miscellaneous *** synthesis of SLR revealed the challenges and opportunities regarding RAS training and *** The results of this SLR will help stakeholders such as decision-makers,influencers,and end users of RAS to understand the significance of training and cost in scaling up RAS from a managerial *** any healthcare innovation to reach a vast population,cost-effectiveness and standard training are crucial.

关键词： da Vinci system Healthcare Robotic-assisted surgery Robotic surgery Robotic training Robotic surgery cost

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