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作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Financial and managerial accounting :information for decisions

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2005年

作者： john j. wild Kermit D. Larson barbara Chiappetta

"Volume 1 chapters 1-11, Volume 2 chapters 12-21."

ISBN: (数字)0073044350

ISBN: (纸本)9780073046846

"Volume 1 chapters 1-11, Volume 2 chapters 12-21."

关键词： Accounting.

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Financial Accounting Information for Decisions john j. wild 3rd ed.

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2005年

作者： john j. wild

"Krispy Kreme 2003 annual report" inserted.

ISBN: (数字)0072843179

ISBN: (纸本)0072843179

"Krispy Kreme 2003 annual report" inserted.

关键词： Accounting.

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Fundamental accounting principles 17th ed., international ed. 17th ed.; international ed.

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2005年

作者： Kermit D. Larson john j. wild.barbara Chiappetta

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Financial and managerial accounting information for decisions 2nd ed.

Financial and managerial accounting information for decision...

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2007年

作者： barbara Chiappetta. john j. wild

Includes index.

ISBN: (纸本)9780073526683

Includes index.

关键词： Accounting.Managerial accounting.

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PRINCIPLES OF FINANCIAL ACCOUNTING /

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2005年

作者： KERMIT D. LARSON john j. wild.barbara CHIAPPETTA

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Importance of Quaternary research to society

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Episodes 2008年第2期31卷 203-206页

作者： john j. Clague Cenlre for Natural Hazard Research Simon Fraser University Burnaby BC Canada V5A 1S6

The Quaternary Period, although only an instant in the 4.5 billion year expanse of geologic time, is disproportionately important because it is the interval during which humans evolved and because it includes the present. Events of the Quaternary are preserved in sediments, ice sheets, and landforms with a greater degree of completeness and temporal resolution than those of any earlier period of comparable length. Studies of these historical and environmental archives continue to provide the essential context that allows scientists to evaluate what is happening with Earth＇s climate today and to clarify our vulnerability to hazardous natural processes, for example earthquakes, tsunami, volcanic eruptions, floods, and landslides.

关键词：地质学科学研究第四纪地质年代

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A statistical study of the interdependence of solar wind parameters

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Chinese j.urnal of Astronomy and Astrophysics 2009年第4期9卷 485-493页

作者： Shollykutty john P. j. Kurian Department of Physics St Joseph’s CollegeAlappuzha.Kerala-688012 India Physics Research Centre St.Berchmans’ CollegeChanganacherry Kerala-686101 India

Correlation analysis of solar wind parameters, namely solar wind velocity, proton density, proton temperature and mean interplanetary magnetic field （IMF） from the ACE spacecraft data near Earth, was done. To our best knowledge, this study is a novel one since we consider here only the parameters inside the solar wind, including the mean IMF and, hence, the solar wind is a self consistent system. We have proposed a Multiple Linear Regression （MLR） model for the prediction of the response variable （solar wind velocity） using the parameters proton density, proton temperature and mean IMF measured as daily averages. About 60% of the observed value can be predicted using this model. It is shown that, in general, the correlation between solar wind parameters is significant. A deviation from the prediction at the solar maximum is interpreted. These results are verified by a graphical method.

关键词： solar wind-statistical model-correlation-solar wind parameters

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Financial accounting information for decisions 2nd ed.

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2003年

作者： wild john j.

Includes index.

ISBN: (纸本)0072456914

Includes index.

关键词： Accounting.

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