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LC-HRMS Based Non-Targeted Metabolomic Profiling of Wheat (<I>Triticum aestivum</I>L.) under Post-Anthesis Drought Stress

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American Journal of Plant Sciences 2017年第12期8卷 3024-3061页

作者： Mohammad Atikur Rahman Masum Akond Md Ali Babar Chris Beecher john erickson Kayla Thomason Felice A De Jong Richard Esten Mason Agronomy Department IFAS University of Florida Gainesville FL USA Southeast Center for Integrated Metabolomics (SECIM) University of Florida Gainesville FL USA IROA Technologies LLC Ann Arbor MI USA Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA

Drought stress at the reproductive stage causes severe damage to productivity of wheat. However, little is known about the metabolites associated with drought tolerance. The objectives of this study were to elucidate changes in metabolite levels in wheat under drought, and to identify potential metabolites associated with drought stress through untargeted metabolomic profiling using a liquid chromatography-high resolution mass spectrometry (LC-HRMS)-based technique called Isotopic Ratio Outlier Analysis. Metabolomic analysis was performed on flag leaves of drought-stressed and control (well-watered) plants after 18 days of post-anthesis drought stress at three-hour intervals over a 24-hour period. Out of 723 peaks detected in leaves, 221 were identified as known metabolites. Sixty known metabolites were identified as important metabolites by 3 different methods, PLS-DA, RF and SAM. The most pronounced accumulation due to drought stress was demonstrated by tryptophan, proline, pipecolate and linamarin, whereas the most pronounced decrease was demonstrated by serine, trehalose, N-acetyl-glutamic acid, DIBOA-glucoside etc. Three different patterns of metabolite accumulation were observed over 24-hour period. The increased accumulated metabolites remained higher during all 8 time points in drought stressed leaves. On the contrary, metabolites that showed decreased level remained significantly lower during all or the most time points. However, the levels of some decreased metabolites were lower during the day, but higher during night in drought stressed leaves. Both univariate and multivariate analyses predicted that N-acetyl-glutamic acid, proline, pipecolate, linamarin, tryptophan, and DIBOA-glucoside could be potential metabolite biomarkers, and their levels could serve as indicators of drought tolerance in wheat.

关键词： Drought Post-Anthesis Wheat Metabolites LC-MS

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警犬汉克历险记

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作者： (美)约翰·R·埃里克森(john R. erickson)

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Ionospheric longitudinal variations at midlatitudes: Incoherent scatter radar observation at Millstone Hill

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Science China(Technological Sciences) 2012年第5期55卷 1153-1160页

作者： COSTER Anthea HOLT john FOSTER john erickson Phil MIT Haystack Observatory Off Route 40 Westford MA 01866 USA

Incoherent scatter radar （ISR） extra-wide coverage experiments during the period of 1978-2011 at Millstone Hill are used to investigate longitudinal differences in electron density. This work is motivated by a recent finding of the US east-west coast difference in TEC suggesting a combined effect of changing geomagnetic declination and zonal winds. The current study pro- vides strong supporting evidence of the longitudinal change and the plausible mechanism by examining the climatology of electron density Ne on both east and west sides of the radar with a longitude separation of up to 40% for different heights within 300-450 kin. Main findings include： 1） The east-west difference can be up to 60% and varies over the course of the day, being positive （East side Ne 〉 West side Ne） in the late evening, and negative （West side Ne 〉 East side Ne） in the pre-noon. 2） The east-west difference exists throughout the year. The positive （relative） difference is most pronounced in winter; the negative （relative） difference is most pronounced in early spring and later summer. 3） The east-west difference tends to enhance toward decreasing solar activity, however, with some seasonal dependence; the enhancements in the positive and negative differences do not take place simultaneously. 4） Both times of largest positive and largest negative east-west differences in Ne are earlier in summer and later in winter. The two times differ by 12-13 h, which remains constant throughout the year. 5） Variations at different heights from 300-450 km are similar. Zonal wind climatology above Millstone Hill is found to be perfectly consistent with what is expected based on the electron density difference between the east and west sides of the site. The magnetic declination-zonal wind mechanism is true for other longitude sectors as well, and may be used to understand longitudinal variations elsewhere. It may also be used to derive thermospheric zonal winds.

关键词： midlatitude ionosphere geomagnetic declination thermospheric zonal winds longitudinal variation incoherent scatterradar

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A More Renewable-Friendly Electrical Grid: Thermal Storage Refrigeration for Demand Response in California and Denmark

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Smart Grid and Renewable Energy 2012年第4期3卷 316-323页

作者： Kurt Kornbluth john Cook Paul erickson Agriculture and Resource Economics University of California Davis USA Department of Mechanical Engineering University of California Davis USA Program for International Energy Technologies University of California Davis USA

Energy storage technologies, which enable demand response, are being explored throughout the world as a component of strategies for switching to renewable intermittent energy sources and reducing peak loads. This study examines thermal storage refrigeration (TSR) technology as a case study for the potential value of demand response in California and Denmark. Using technical specifications from a TSR prototype developed at UC Davis and market data from California and Denmark, the analysis examines possible business models for the TSR refrigerators and highlights market characteristics that are important to its adoption. Results suggest that the TSR technology is not a viable option in the current market environment in Denmark, but could payback in less than 6 years in California if a part of a demand response based virtual power plant. In a hypothetical future scenario involving real-time pricing in the retail market, a high degree of price volatility would be needed to make TSR technology appealing to residential consumers. Based on this analysis, an interesting area of future work would focus on the market potential of TSR technology for commercial and industrial applications.

关键词： Refrigeration Demand-Response Thermal Storage Wind Energy California Denmark Electricity Grid

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New findings of ionospheric longitudinal variations at mid-latitudes

New findings of ionospheric longitudinal variations at mid-l...

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第十四届全国日地空间物理学术研讨会

作者： john Foster Anthea Coster Phil erickson john Holt MIT Haystack Observatory Westford MA 01886 USA

＜正＞This paper reports on new findings of pronounced longitudinal variations in mid‐latitude electron density over the continental US, manifested as a large-scale east-west coast difference in TEC as well as east-west difference in electron density from incoherent scatter radar （ISR） extra-wide coverage over Millstone *** implication of these results on other longitudes is also addressed. A common feature of these longitudinal east-west differences is a clear local-time variation where in the evening sectorelectron density

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Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells

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World Journal of Gastroenterology 2006年第35期12卷 5628-5634页

作者： William L Riles Jason erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian Department of Medicine Division of Gastroenterology John H. Stroger Hospital of Cook County Chicago IL 60612 United States

AIM： To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which （AGS and SNU-1） express p53 and one （KATO-M） with deleted p53. METHODS： Nuclear fragmentation was used to quantitate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression, RESULTS： Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub-cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- 111 cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION： These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells.

关键词： Resveratrol Chemoprevention Apoptosis p53 Survivin Cytochrome C oxidase

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Principles for managing marine ecosystems prone to tipping points

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Ecosystem Health and Sustainability 2015年第5期1卷 15-32页

作者： Kimberly A.Selkoe Thorsten Blenckner Margaret R.Caldwell Larry B.Crowder Ashley L.erickson Timothy E.Essington James A.Estes Rod M.Fujita Benjamin S.Halpern Mary E.Hunsicker Carrie V.Kappel Ryan P.Kelly john N.Kittinger Phillip S.Levin john M.Lynham Megan E.Mach Rebecca G.Martone Lindley A.Mease Anne KSalomon Jameal F.Samhouri Courtney Scarborough Adrian C.Stier Crow White Joy Zedler National Center for Ecological Analysis and Synthesis 735 State StreetSuite 300Santa BarbaraCalifornia 93101 USA Hawaii Institute of Marine Biology University of HawaiiKaneoheHawaii 96744 USA Stockholm Resilience Centre Stockholm UniversityKra¨ftriket 2B10691 StockholmSweden Center for Ocean Solutions Stanford Woods Institute for the EnvironmentStanford University473 Via Ortega Room 193StanfordCalifornia 94305 USA School of Aquatic and Fishery Sciences University of WashingtonSeattleWashington 98195 USA Department of Ecology and Evolutionary Biology 100 Shaffer RoadUniversity of CaliforniaSanta CruzCalifornia 95060 USA Environmental Defense Fund 123 Mission Street28th FloorSan FranciscoCalifornia 94105 USA Bren School of Environmental Science and Management University of CaliforniaSanta BarbaraCalifornia 93106 USA Imperial College London Silwood Park CampusBuckhurst RoadAscot SL57PY United Kingdom School of Marine and Environmental Affairs University of Washington3707 Brooklyn Avenue NESeattleWashington 98105-6715 USA Conservation International Betty and Gordon Moore Center for Science and Oceans7192 Kalaniana‘ole HighwaySuite G230HonoluluHawaii 96825 USA Conservation Biology Division Northwest Fisheries Science CenterNational Marine Fisheries ServiceNational Oceanic and Atmospheric Administration2725 Montlake Boulevard EastSeattleWashington 98112 USA Department of Economics University of Hawaii at ManoaHonoluluHawaii 96822 USA School of Resource and Environmental Management Simon Fraser UniversityBurnabyBritish Columbia V5A1S6 Canada Department of Biological Sciences California Polytechnic State UniversitySan Luis ObispoCalifornia 93407 USA Botany Department University of WisconsinMadisonWisconsin 53706 USA

As climatic changes and human uses intensify,resource managers and other decision makers are taking actions to either avoid or respond to ecosystem tipping points,or dramatic shifts in structure and function that are often costly and hard to *** indicates that explicitly addressing tipping points leads to improved management *** on theory and examples from marine systems,we distill a set of seven principles to guide effective management in ecosystems with tipping points,derived from the best available *** principles are based on observations that tipping points(1)are possible everywhere,(2)are associated with intense and/or multifaceted human use,(3)may be preceded by changes in earlywarning indicators,(4)may redistribute benefits among stakeholders,(5)affect the relative costs of action and inaction,(6)suggest biologically informed management targets,and(7)often require an adaptive response to *** suggest that early action to preserve system resilience is likely more practical,affordable,and effective than late action to halt or reverse a tipping *** articulate a conceptual approach to management focused on linking management targets to thresholds,tracking early-warning signals of ecosystem instability,and stepping up investment in monitoring and mitigation as the likelihood of dramatic ecosystem change *** approach can simplify and economize management by allowing decision makers to capitalize on the increasing value of precise information about threshold relationships when a system is closer to tipping or by ensuring that restoration effort is sufficient to tip a system into the desired regime.

关键词： critical transition ecosystem-based management marine spatial planning nonlinear relationships restoration ecology stakeholder engagement

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从海产培养基去除微量金属

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水产科技 2009年第3期36卷 41-42页

作者：刘清神 EARL W.DAVEY john H.GENTILE STANTON J.erickson PETER BETZER 华南农业大学广州510642 美国内政部联邦水污染控制管理局国家海洋水质实验室

纯化后的钠形式Chelex–100能用来去除人工和天然海水中的微量金属,而不改变主要阴阳离子组成,且不生成有机毒物或螯合剂。通常以有毒的浓度存在于人工海水中的特定的污染性微量金属,能被降低到可使敏感海洋浮游植物生长和某些无脊椎动... 详细信息

纯化后的钠形式Chelex–100能用来去除人工和天然海水中的微量金属,而不改变主要阴阳离子组成,且不生成有机毒物或螯合剂。通常以有毒的浓度存在于人工海水中的特定的污染性微量金属,能被降低到可使敏感海洋浮游植物生长和某些无脊椎动物从卵发育到早期幼虫阶段的水平。主要微量金属的浓度降低到特定的海洋浮游植物物种的安全浓度以下。

关键词：微量金属安全浓度人工海水天然海水海洋浮游植物有机毒物螯合剂浮游植物生长阴阳离子污染性

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Medial ulnar collateral ligament reconstruction of the elbow in major league baseball players:Where do we stand?

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World Journal of Orthopedics 2016年第6期7卷 355-360页

作者： Brandon J erickson Bernard R Bach Jr Charles A Bush-Joseph Nikhil N Verma Anthony A Romeo Midwest Ortho-paedics at Rush Rush University Medical Center

The ulnar collateral ligament(UCL) is a vital structure to the overhead athlete,especially the baseball *** reasons not completely understood,UCL injurieshave become increasingly more common in major league baseball(MLB) pitchers over the past 10 *** reconstruction(UCLR) is the current gold standard of treatment for these injuries in MLB pitchers who wish to return to sport(RTS) at a high level and who have failed a course of non-operative *** following UCLR in MLB pitchers have been encouraging,with multiple RTS rates now cited at greater than 80%.Unfortunately,with the rising number of UCLR,there has also been a spike in the number of revision UCLR in MLB *** to primary UCLR,the etiology of the increase in revision UCLR,aside from an increase in the number of pitchers who have undergone a primary UCLR,remains *** current literature has attempted to address several questions including those surrounding surgical technique(method of exposure,graft choice,management of the ulnar nerve,concomitant elbow arthroscopy,etc.),post-operative rehabilitation strategies,and timing of RTS following *** some questions have been answered,many remain *** literature surrounding UCLR in MLB pitchers will be reviewed,and future directions regarding this injury in these high level athletes will be discussed.

关键词： Ulnar collateral ligament Ulnar collateral ligament reconstruction Tommy john Major league baseball Pitcher Baseball

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