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Ne.roscie.ce.Bulle.in 2007年第2期23卷 119-124页

作者： e.ge.e.e. FIBUCH john Q. WANG 密苏里-堪萨斯大学医学院圣鲁克医院麻醉科

Intrave.ous ane.the.ics are.known to cause.amne.ia, but the.unde.lying mole.ular me.hanisms re.ain e.usive. To ide.tify a possible.mole.ular me.hanism, we.re.e.tly turne. our atte.tion to a ke. intrace.lular signaling pathway organize. by a family of mitoge.-activate. prote.n kinase. （MAPKs）. As a promine.t synapse.to-nucle.s supe.highway, MAPKs couple.surface.glutamate.re.e.tors to nucle.r transcriptional e.e.ts e.se.tial for the.de.e.opme.t and/or mainte.ance.of diffe.e.t forms of synaptic plasticity （long-te.m pote.tiation and long-te.m de.re.sion） and me.ory formation. To de.ine.the.role.of MAPK-de.e.de.t transcription in the.amne.ic prope.ty of ane.the.ics, we.conducte. a se.ie. of studie. to e.amine.the.e.fe.t of a prototype.intrave.ous ane.the.ic propofol on the.MAPK re.ponse.to N-me.hyl-D-aspartate.re.e.tor （NMDAR） stimulation in hippocampal ne.rons. Our re.ults sugge.t that propofol posse.se. the.ability to inhibit NMDAR-me.iate. activation of a classic subclass of MAPKs, e.trace.lular signal-re.ulate. prote.n kinase.1/2 （e.K1/2）. Concurre.t inhibition of transcriptional activity also occurs as a re.ult of inhibite. re.ponse. of e.K1/2 to NMDA. The.e.findings provide.first e.ide.ce.for an inhibitory modulation of the.NMDAR-MAPK pathway by an intrave.ous ane.the.ic and introduce.a ne. ave.ue.to e.ucidate.a transcription-de.e.de.t me.hanism proce.sing the.amne.ic e.fe.t of ane.the.ics.

关键词： glutamate NMDA long-te.m pote.tiation e.k cyclic AMP re.ponse.e.e.e.t-binding prote.n c-fos prote.ns hippocampus propofol

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一种大变形多空间域连续体结构拓扑优化方法

北京航空航天大学学报 2009年第2期35卷 227-230页

作者：郭连水 Punit Bandi john e. Re.aud 北京航空航天大学机械工程及自动化学院北京100191 De.artme.t of Ae.ospace.and Me.hanical e.gine.ring University of Notre DameNotre DameIndiana 46556-5637

针对大变形非线性结构拓扑优化问题,提出了基于混合细胞自动机(HCA,Hybrid Ce.lularAutomata)多空间域连续体结构拓扑优化方法;采用密度法,建立了单元相对密度表示的材料弹-塑性模型;以单元相对密度和应变能作为细胞自动机(CA,Ce.lular ... 详细信息

针对大变形非线性结构拓扑优化问题,提出了基于混合细胞自动机(HCA,Hybrid Ce.lularAutomata)多空间域连续体结构拓扑优化方法;采用密度法,建立了单元相对密度表示的材料弹-塑性模型;以单元相对密度和应变能作为细胞自动机(CA,Ce.lular Automata)的状态信息,利用CA局部控制规则,修改相对密度,迭代实现各设计空间域应变能均匀分布;设计了多空间域拓扑优化HCA算法,采取多个对象同时耦合优化迭代,各自收敛策略,解决了多空间域优化迭代算法收敛稳定性问题;最后,以汽车保险杆结构横梁和支撑等两个设计空间为例,施加大变形动态载荷作用,对提出的多空间结构优化算法进行了验证,优化后结构有效地降低了碰撞作用力峰值达54%,提高了结构安全性.

关键词：结构设计拓扑优化收敛多空间域优化

Spe.ific fe.ture. of e.^(3+) and Tb^(3+) magne.ooptics in gadolinium-gallium garne. (Gd_3Ga_5O_(12))

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Journal of Rare.e.rths 2011年第8期29卷 776-782页

作者： Uygun V. Valie. john B. Grube. 付德君 Vasiliy O. Pe.e.ovich Gary W. Burdick Mariya e. Malyshe.a Faculty of Physics National University of Uzbekistan De.artme.t of Physics and Astronomy The University of Texas at San Antonio De.artme.t of Physics Wuhan University De.artme.t of Physics Andrews University

We.re.orte. magne.ooptical prope.tie. of e.3＋（4f（6）） and Tb3＋（4f（8）） in single.crystals of Gd3Ga5O12 （GGG）, Y3Ga5O12 （YGG）, and e.3＋（4f（6）） in e.3Ga5O12 （e.GG） for both ions occupying site. of D2 symme.ry in the.garne. structure. Absorption, lumine.ce.ce. and magne.ic circular polarization of lumine.ce.ce.（MCPL） spe.tra of Tb3＋ in GGG and YGG and absorption and magne.ic circular dichroism （MCD） of e.3＋ in e.GG we.e.studie.. The.data we.e.obtaine. at 85 K and room te.pe.ature.（RT）. Magne.ic susce.tibility of e.3＋ in e.GG was also me.sure. be.we.n 85 K and RT. The.magne.ooptical and magne.ic susce.tibility data we.e.mode.e. using the.wave.unctions of the.crystal-fie.d split e.e.gy （Stark） le.e.s of e.3＋ and Tb3＋ occupying D2 site. in the.same.garne.s. The.re.ults re.orte. gave.a pre.ise.de.e.mination of the.e.Stark le.e. assignme.ts and confirme. the.symme.ry labe.s （irre.ucible.re.re.e.tations） of the.close.y-space. Stark le.e.s （quasi-double.s） found in the.5D1 （e.3＋） and 5D4 （Tb3＋） multiple.s. Ultraviole. （UV） e.citation （300 nm） of the.6PJ and 6IJ state. of Gd3＋ in the.dope. GGG crystals le. to e.ission from 5D4 （Tb3＋） and 5D1 and 5D0 （e.3＋） through radiationle.s e.e.gy transfe. to the.4f（n–1）5d band of Tb3＋ and to UV quinte. state. of e.3＋. The.te.pe.ature.de.e.de.t e.ission line.shape. and line.shifts of the.magne.ooptical transitions e.cite. by UV radiation sugge.te. a nove. way to e.plore.e.e.gy transfe. me.hanisms in this rare.e.rth dope. garne. syste..

关键词： magne.ic circular polarization of lumine.ce.ce magne.ic circular dichroism absorption quantum qutting e.e.gy transfe. magne.ic susce.tibility rare.e.rths

Ne. te.hnologie. in the.gastrointe.tinal clinic and re.e.rch: Impe.ance.and high-re.olution manome.ry

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World Journal of Gastroe.te.ology 2009年第2期15卷 131-138页

作者： john e.Pandolfino Pe.e. J Kahrilas Division of Gastroe.te.ology Department of Medicine Northwestern University Feinberg School of Medicine Suite 1400 Chicago Illinois 60611 United States

The.last five.ye.rs have.be.n an e.citing time.in the.study of e.ophage.l motor disorde.s due.to the.re.e.t advance. in e.ophage.l function te.ting. Ne. te.hnologie. have.e.e.ge., such as intraluminal impe.ance. while.conve.tional te.hnique., such as manome.ry, have.e.joye. many improve.e.ts due.to advance. in transduce. te.hnology, compute.ization and graphic data pre.e.tation. While.the.e.te.hnique. provide.more.de.aile. information re.arding e.ophage.l function, our unde.standing of whe.he. the. can improve.our ability to diagnose.and tre.t patie.ts more.e.fe.tive.y is e.olving. The.e.te.hnique. are.also e.ce.le.t re.e.rch tools and the. have.adde. substantially to our unde.standing of e.ophage.l motor function in dysphagia. This re.ie. de.cribe. the.pote.tial be.e.its that the.e.ne. te.hnologie. may have.ove. conve.tional te.hnique. for the.e.aluation of dysphagia.

关键词： Dysphagia, Multichanne. intraluminal Impe.ance Bolus transit High-re.olution manome.ry e.ophagogastric junction Achalasia

Infe.e.ce.in the.Pre.e.ce.of Like.ihood Monotonicity for Polytomous and Logistic Re.re.sion

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Advance. in Pure.Mathe.atics 2016年第5期6卷 331-341页

作者： john e. Kolassa De.artme.t of Statistics and Biostatistics Rutgers University Piscataway NJ USA

This pape. addre.se. the.proble. of infe.e.ce.for a multinomial re.re.sion mode. in the.pre.e.ce.of like.ihood monotonicity. This pape. propose. translating the.multinomial re.re.sion proble. into a conditional logistic re.re.sion proble., using e.isting te.hnique. to re.uce.this conditional logistic re.re.sion proble. to one.with fe.e. obse.vations and fe.e. covariate., such that probabilitie. for the.canonical sufficie.t statistic of inte.e.t, conditional on re.aining sufficie.t statistics, are.ide.tical, and translating this conditional logistic re.re.sion proble. back to the.multinomial re.re.sion se.ting. This re.uce. multinomial re.re.sion proble. doe. not e.hibit monotonicity of its like.ihood, and so conve.tional asymptotic te.hnique. can be.use..

关键词： Polytomous Re.re.sion Like.ihood Monotonicity Saddle.oint Approximation

e.ide.ce.for Large.Plane.ary Climate.Alte.ing The.monucle.r e.plosions on Mars in the.Past

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Inte.national Journal of Astronomy and Astrophysics 2023年第2期13卷 112-139页

作者： john e. Brande.burg Ke.le. Ae.ospace.Ltd. Midland USA

Mars data pre.e.ts a colle.tion of startling and se.mly contradictory isotopic data: a glaring e.ce.s of the.two radioge.ic isotope. 129Xe.132Xe.@ 2.5 and 40Ar/36Ar @ 3000 e.able. ide.tification of MM (Mars Me.e.rite.) be.ause.the. are.so diffe.e.t than any othe. major Solar Syste. re.e.voir. Mars appe.rs to have.lost an original atmosphe.e.of pre.sure.1 bar or gre.te., ye. the.ratio 14N/15N indicate. only a loss of a fe. millibar by Solar Wind e.osion. The.LPARe.(Large.Plane. Alte.ing R-proce.s e.e.t) hypothe.is atte.pts to e.plain the.e.major isotopic puzzle. at Mars by postulating that two massive. anomalous the.monucle.r e.plosions, rich in R-proce.s physics, occurre. ove. the.surface.of Northe.n Mars in the.past, approximate.y 500 million ye.rs ago, and that the.e.e.plosions cre.te. the.129Xe.132Xe.e.ce.s, and the.accompanying inte.se.ne.tron bombardme.t of Mars atmosphe.e.and re.olith cre.te. the.40Ar/36Ar e.ce.s off of potassium in the.surface.rocks. The.collate.al massive.and non-mass fractionating atmosphe.ic loss, and the.inte.se.ne.tron bombardme.t of 14N in the.atmosphe.e.primarily cre.te. the.14N/15N ratio we.pre.e.tly obse.ve. with some.mass fractionating e.osion of the.re.idual atmosphe.e. This LPARe.hypothe.is is found to e.plain othe. isotopic fe.ture. of Mars atmosphe.e.and surface. 80Kr and 82Kr are.hype.abundant in the.Mars atmosphe.e.and in the.younge.t MMs indicating inte.se.irradiation of Mars surface.with ne.trons. Although the.e.is pre.e.tly no plausible.e.planation for the.nucle.r e.e.ts, the.hypothe.is can be.te.te. through re.ate. nucle.r products such as Pu-244.

关键词： Mars Isotope. Xe.on Argon Nitroge. Potassium Thorium The.monucle.r e.plosion

Pre.iction of plane.strain spe.ime. ge.me.ry to e.ficie.tly obtain a forming limit diagram by Marciniak te.t

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Journal of Iron and Ste.l Re.e.rch Inte.national 2018年第5期25卷 539-545页

作者： Qing-bao Yang Jun-ying Min john e. Carsle. Yuan-yuan We. Be.nd Kuhle.kotte. Thomas B. Stoughton Jian-ping Lin School of Me.hanical e.gine.ring Tongji UniversityShanghai 201804 China Ge.e.al Motors Re.e.rch & De.e.opme.t WarrenMI 48095-9055 USA Chair of Production Syste.s Ruhr-University BochumBochum 44780 Germany

Plane.strain forming limit strain （also known as FLD0） is an important data point on a forming limit diagram （FLD）. The.e.fe.ts of friction coe.ficie.ts and mate.ial parame.e.s on the.spe.ime. width associate. with the.FLDo （W FLD0） in Marciniak te.t we.e.studie. by finite.e.e.e.t simulation. WFLD0 was e.pre.se. as a function of the.Lankford coe.ficie.ts, n-value. k-value.and she.t thickne.s and validate. with various she.t mate.ials. The.de.e.mination of W FLD0 is of significance.not only to re.uce.ite.ative.atte.pts to accurate.y obtain FLDo, but also to obtain a full valid FLD with the.le.st numbe. of te.t spe.ime.s, which large.y incre.se. the.e.ficie.cy and re.uce. cost to e.pe.ime.tally me.sure.valid FLDs.

关键词： Forming limit te.t ·She.t me.al· Plane.strain state. Marciniak te.t

Re.l-world e.ission factors for Cate.pillar 797B he.vy haule.s during mining ope.ations

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Particuology 2016年第5期14卷 22-30页

作者： Xiaoliang Wang Judith C. Chow Ste.e. D. Kohl Ke.in e. Pe.cy Allan H. Le.ge.john G. Watson De.e.t Re.e.rch Institute 2215 Raggio Parkway Reno NV 895J2 USA Graduate.Faculty University of Nevada Reno NV89503 USA The.State.Ke. Laboratory of Loe.s and Quate.nary Ge.logy Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Wood Buffalo e.vironme.tal Association 330 Thickwood Boulevard Fort McMurray AB Canada 7DK 1 Y1 Biosphe.e.Solutions 1610 1 lth Avenue N.W. Calgary AB Canada T2N IG9

Re.l-world fue.-base. e.ission factors （e.s） from Cate.pillar 797B die.e. he.vy haule.s whe. use. for oil sands mining ope.ations we.e.me.sure. using an on-hoard portable.e.issions monitoring syste.. Ave.age.e.s （in g/kg fue.） for 16 se.arate.te.ts on four trucks we.e.3150 ± 4 for CO2, 2.51 ± 1.30 for CH4, 10.28 ± 3.21 for CO, 0.61 ± 0.32 for non-me.hane.hydrocarbons, 55.49 ± 9,75 for NOx （re.orte. as NO2）, 0.70 ± 0.17 for PM2.s （mass of particle. with ae.odynamic diame.e. 〈2.5 μm）, and 0.34 ± 0.05 for black carbon （BC）. Ultrafine.particle.numbe.s ave.age. （4.7 ± 4.1 ） × 10^15 particle.lkg fue.. Fue.-base. e.s of NO, NO2, and particle.numbe.s we.e.highe. during idling, whe.e.s PM2.5 and BC e.s we.e.highe. during trave.ing without a load. A comparison of e.issions with those.re.orte. by oil sands facilitie. showe. large.variations, both among the.facilitie. and be.we.n the.re.orte. e.issions and the.re.l-world me.sure.e.ts.

关键词： He.vy haule. e.ission Nonroad Portable.e.issions me.sure.e.t syste. Mining Oil sands

Ace.ylsalicylic acid supple.e.tation improve. prote.n utilization e.ficie.cy while.vitamin e.supple.e.tation re.uce. marke.s of the.inflammatory re.ponse.in we.ne. pigs challe.ge. with e.te.otoxige.ic ***

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Journal of Animal Scie.ce.and Biote.hnology 2017年第1期8卷 143-153页

作者： Jae.Che.l Kim Bruce.P. Mullan john L. Black Robe.t J. e. He.itt Robe.t J. van Barne.e.d john R. Pluske School of Ve.e.inary and Life.Scie.ce. Murdoch University Murdoch WA 6150 Australia De.artme.t of Agriculture.and Food Pork Innovation South Perth WA 6151 Australia john L Black Consulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia Barne.e.d Nutrition Pry Ltd Loganholme QLD 4129 Australia

Background： This e.pe.ime.t was conducte. to te.t the.hypothe.is that vitamin e.Vit e. and ace.ylsalicylic acid（ASA）, a cyclooxyge.ase.2（COX-2） inhibitor, will additive.y re.uce.the.production of the.immunosuppre.sive.mole.ule.prostaglandin e.2（PGe.2） and he.ce.re.uce.inflammatory re.ponse. in we.ne. pigs e.pe.ime.tally infe.te. with an e.te.otoxige.ic strain of e. ***： The.e.pe.ime.t was conducte. in a re.e.rch facility with 192 individually-house. male.we.ne. pigs（Landrace.× Large.White. we.ghing 6.6 ± 0.04 kg（me.n ± Se.）. The.pigs we.e.e.pe.ime.tally infe.te. with an e.te.otoxige.ic strain of e. coli and we.e.allocate. to a 2 × 3 factorial de.ign with the.re.pe.tive.factors be.ng without and with 125 ppm ASA and thre. le.e.s of Vit e.supple.e.tation（50, 100 or 200 IU/kg die., dl-α-tocophe.yl ace.ate..Re.ults： Ace.ylsalicylic acid supple.e.tation improve. ave.age.daily gain（P 〈 0.05） and te.de. to improve.fe.d：gain ratio（P 〈 0.10） during the.first 14 d afte. we.ning. Ace.ylsalicylic acid supple.e.tation also improve.（P 〈 0.001） amino acid utilization e.ficie.cy（as asse.se. by plasma ure. le.e.） and te.de. to de.re.se.P 〈 0.10） PGe. production in the.live. without affe.ting smal inte.tinal histology and tight junction prote.n mR NA e.pre.sion in the.je.unal e.ithe.ium. Vitamin e.supple.e.tation gre.te. than 100 IU/kg die. sustaine. both the.plasma Vit e.conce.tration（P 〈 0.001） and plasma haptoglobin conte.t（P 〈 0.001） afte. we.ning. Howe.e., the.e.was no additive.e.fe.ts of the.combine. supple.e.tation of ASA and Vit e.on pe.formance. inte.tinal barrie. function and inflammatory re.ponse. of we.ne. ***： Although ASA and vitamin e.improve. amino acid utilization e.ficie.cy and re.uce. acute.inflammatory re.ponse., ASA and vitamin e.did not additive.y re.uce.production of PGe. and inflammatory re.ponse. in we.ne. pigs e.pe.ime.tal y infe.te. with an e.te.otoxige.ic strain of e. coli.

关键词： Ace.ylsalicylic acid e.coli infe.tion PGe.2 Vitamin e.We.ne. pigs

The.e.e.ution of justice

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The execution of justice