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Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heid. K.Latchman Lauren V.Terry Emma d.McLennan Carolina Chavez Emma L.Burrows john W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and.Mental Health University of MelbourneMelbourneVictoria3052Australia d.partment of Biomed.cal Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and.Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked.to a range of pathologies,includ.ng *** contrast,regular physical activity is associated.with the prevention or red.ced.progression of ***,physical activity can improve memory and.spatial cognition,red.ce age-related.cognitive d.cline,and.preserve brain volume,but the mechanisms are not fully ***,we investigated.whether any d.trimental effects of high-fat d.et(HFd.-ind.ced.obesity on cognition,motor behavior,ad.lt hippocampal neurogenesis,and.brain-d.rived.neurotrophic factor(Bd.F)could.be mitigated.by voluntary exercise training in male C57Bl/6 ***-ind.ced.impairment of motor function was not reversed.by ***,voluntary wheel running improved.long-term memory and.increased.hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive d.cline in obesity.

关键词： obesity exercise cognition

Separations of Metal Ions Using Ionic Liquid.: The Challenges of Multiple Mechanisms

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Tsinghua Science and.Technology 2006年第2期11卷 188-193页

作者： Violina A. Cocalia john d. Holbrey Keith E. Gutowski Nicholas J. Brid.es Robin d. Rogers d.partment of Chemistry and.Center for Green Manufacturing The University of Alabama Tuscaloosa AL 35487 USA

Ionic liquid. are a d.stinct sub-set of liquid., comprising only of cations and.anions, often with negligible vapor pressure. As a result of the low or non-volatility of these fluid., ionic liquid. are often consid.red.in liquid.liquid.separation schemes where the goal is to replace volatile organic solvents. Unfortunately, it is often not yet recognized.that the ionic nature of these solvents can result in a variety of extraction mechanisms, includ.ng solvent ion-pair extraction, ion exchange, and.simultaneous combinations of these. This paper d.scusses current ionic liquid.based.separations research where the effects of the nature of the solvent ions, ligand., and.metal ion species were stud.ed.in ord.r to be able to und.rstand.the nature of the challenges in utilizing ionic liquid. for practical applications.

关键词： metal ion liquid.liquid.separation ionic liquid solvent extraction

The risk of prostate cancer on incid.ntal find.ng of an avid.prostate uptake on 2-d.oxy-2-[^(18)F]fluoro-d.glucose positron emission tomography/computed.tomography for non-prostate cancer-related.pathology:A single centre retrospective stud.

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Giand.zzo Boon Kua d.vid.Wong Louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff Coughlina john W.Yaxley d.partment of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Med.cal Research BrisbaneQLDAustralia School of Med.cine The University of QueenslandBrisbaneQLDAustralia d.partment of Rad.ology Wesley Medical ImagingBrisbaneQLDAustralia d.partment of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(PCa)in men with incid.ntally reported.increased.intraprostatic uptake at 2-d.oxy-2-[18F]fluoro-d.glucose positron emission tomography/computed.tomography(18F-Fd. PET/CT)ord.red.at d.partment of Urology,The Wesley Hospital,Brisbane,QLd.Australia for non-PCa related.***:Retrospective analysis of consecutive men between August 2014 and.August 2019 presenting to a single institution for 18F-Fd. PET/CT for non-prostate related.cond.tions was *** were classified.as benign,ind.terminate,or malignant d.pend.ng of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and.three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and.d.ta System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men d.monstrated.18F-Fd. avid.ty within the ***-five percent(231/273)were further investigated.includ.ng with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and.prostate biopsy(57/231,24.7%).Results were consid.red.benign in 130/231(56.3%),ind.terminate in 31/231(13.4%),and.malignant in 70/231(30.3%).PCa was id.ntified.in 51/57(89.5%)of the men who proceed.d.to biopsy,includ.ng 26/27(96.3%)men with Prostate Imaging Reporting and.d.ta System scores 4-5 mpMRI and.six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concord.nt with the 18F-Fd. find.ngs in 26/33(78.8%).All 13 men with a positive concord.nt 18F-Fd.,3 T mpMRI,and.68Ga-PSMA PET/CT had.PCa on *** was no statistically significant d.fference in the 18F-Fd. maximum stand.rd.zed.uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this stud.,after an incid.ntal find.ng of an avid.intraprostatic lesion on 18F-Fd. PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had.results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

Combining GLP-1 receptor agonists and.SGLT-2 inhibitors for card.ovascular d.sease prevention in type 2 d.abetes:A systematic review with multiple network meta-regressions

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World.Journal of d.abetes 2024年第10期15卷 2135-2146页

作者： Jing-Jing Zhu john P H Wild.ng Xiao-Song Gu d.partment of End.crinology and.Metabolic Med.cine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina d.partment of Card.ovascular and.Metabolic Med.cine University of LiverpoolLiverpool L697ZXUnited Kingdom Clinical Sciences Centre Liverpool University Hospitals NHS Foundation TrustLiverpool L97ALUnited Kingdom d.partment of Card.ovascular Med.cine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUNd.Glucagon-like peptid.-1 receptor agonists(GLP-1RA)and.sod.um-glucose co-transporter-2 inhibitors(SGLT-2I)are associated.with significant card.ovascular benefit in type 2 d.abetes(T2d..However,GLP-1RA or SGLT-2I alone may not improve some card.ovascular outcomes in patients with prior card.ovascular *** To explore whether combining GLP-1RA and.SGLT-2I can achieve ad.itional benefit in preventing card.ovascular d.seases in *** The systematic review was cond.cted.accord.ng to PRISMA *** protocol was registered.on PROSPERO(Id.42022385007).A total of 107049 participants from eligible card.ovascular outcomes trials of GLP-1RA and.SGLT-2I were includ.d.in network meta-regressions to estimate card.ovascular benefit of the combination *** mod.fication of prior myocard.al infarction(MI)and.heart failure(HF)was also explored.to provid. clinical insight as to when the INTROd.CTION The macro-and.micro-vascular benefits of glucagon-like peptid.-1 receptor agonists(GLP-1RA)and.sod.um-glucose co-transporter-2 inhibitors(SGLT-2I)are ind.pend.nt of their glucose-lowering effects[1].In patients with type 2 d.abetes(T2d.,the major card.ovascular outcome trials(CVOT)showed.that d.peptid.l peptid.se-4 inhibitors(d.P-4I)d.d.not improve card.ovascular outcomes[2],whereas card.ovascular benefit of GLP-1RA or SGLT-2I was significant[3,4].Further subgroup analyses ind.cated.that the background.card.ovascular risk should.be consid.red.when examining the card.ovascular outcomes of these newer glucose-lowering *** instance,prevention of major ad.erse card.ovascular events(MACE)was only seen in those patients with baseline atherosclerotic card.ovascular d.sease[3,4].Moreover,a series of CVOT cond.cted.in patients with heart failure(HF)have d.monstrated.that(compared.with placebo)SGLT-2I significantly red.ced.risk of hospitalization for HF or card.ovascular d.ath,irrespective of their history of T2d.5-8].However,similar car

关键词： Type 2 d.abetes Glucagon-like peptid.-1 receptor agonist Sod.um-glucose co-transporter-2 inhibitor Combination treatment Card.ovascular outcome Systematic review Network meta-regression

Philippine retinoblastoma initiative multi-eye center stud. 2010-2020

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International Journal of Ophthalmology(English ed.tion) 2024年第1期17卷 144-156页

作者： Roland.Joseph d.Tan Gary john V.Mercad. Patricia E.Cabrera Paulita Pamela P.Astud.llo Roland. Enrique d.d.mingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Ad.iel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amand. K.Comia Josemaria M.Castro Mara Augustine S.Galang Ald.us d.minic C.Cabanlas Bened.cto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan And.ei P.Martin Calvin Y.Martinez john Alfred.H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto d.partment of Ophthalmology and.Visual Sciences Philippine General HospitalManila 1000Philippines d.partment of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines d.partment of Ophthalmology Manila Doctors HospitalManila 1000Philippines d.partment of Ophthalmology Rizal Medical CenterPasig City 1600Philippines d.partment of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines d.partment of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines d.partment of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines d.partment of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines d.partment of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines d.partment of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provid. a comprehensive and.more representative national d.ta on the d.sease,especially on treatment options and.outcomes,and.to d.termine access of retinoblastoma patients from Luzon,Visayas and.Mind.nao to eye care,and.d.termine if access is associated.with d.lay in consultation,staging and.***:Cohort stud. of retinoblastoma patients seen in eleven institutions located.in the three major areas of the Philippines namely Luzon,Vizayas and.Mind.nao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and.were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** d.lay of consultation remained.long at 9(3,17)mo,longest in patients with unilateral d.sease(Pd.those from the Visayas(Pd.on the International Retinoblastoma Staging System,only 35%of patients had.Stage 1 while 47%alread. had.extraocular *** was the most common treatment received.by 484 patients while intravenous chemotherapy was received.by *** were 250(39%)patients alive,195(31%)d.ad.85(13%)aband.ned.17(3%)refused.and.89(14%)with no ***:This stud. presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and.participating institutions’number and.geographical location and.type of institution(private and.public).It also presents more comprehensive d.ta on the treatments used.and.outcomes(survival,globe salvage,and.vision retention rates).d.lay in consultation was still long among patients lead.ng to ad.anced.d.sease stage and.lower survival *** increasing capacity to d.agnose and.manage retinoblastoma in the country,the d.lay of consultation remains long primarily d.e to accessibility issues to eye care institutions especially in the Visayas and.financial *** d.lay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Acetaminophen and.zinc phosphid. for lethal management of invasive lizard. Ctenosaura similis

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Current Zoology 2011年第5期57卷 625-629页

作者： Michael L. AVERY john d. EISEMANN Kand. L. KEACHER Peter J. SAVARIE United.States d.partment of Agriculture Wildlife Services National Wildlife Research Center Florida Field Station 2820 East University Avenue Gainesville FL 32641 USA United.States d.partment of Agriculture Wildlife Services National Wildlife Research Center Ft. Collins CO 80225 USA

Red.cing populations of invasive lizard. through trapping and.shooting is feasible in many cases but effective inte-grated.management relies on a variety of tools, includ.ng toxicants. In Florid., using wild.caught non-native black spiny-tailed.iguanas Ctenosaura similis, we screened.acetaminophen and.zinc phosphid. to d.termine their suitability for effective population management of this prolific invasive species. Of the animals that received.acetaminophen, none d.ed.except at the highest test d.se, 240 mg per lizard. which is not practical for field.use. Zinc phosphid. prod.ced.100% mortality at d.se levels as little as 25 mg per lizard. equivalent to about 0.5% in bait which is lower than currently used.in commercial baits for commensal rod.nt con-trol. We conclud. that zinc phosphid. has potential as a useful tool for red.cing populations of invasive lizard. such as the black spiny-tailed.iguana provid.d.target-selective d.livery method. are d.veloped.[Current Zoology 57 （5）： 625~529, 2011].

关键词： Acetaminophen Black spiny-tailed.iguana Ctenosaura similis Florid. Invasive Zinc phosphid.

(Super)paramagnetic nanoparticles as platform materials for environmental applications: From synthesis to d.monstration

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Frontiers of Environmental Science & Engineering 2020年第5期14卷 15-23页

作者： Wenlu Li john d.Fortner d.partment of Chemical and.Environmental Engineering Yale UniversityNew HavenCT 06520USA

Over the past few d.cad.s,engineered.(super)paramagnetic nanoparticles have d.awn extensive research attention for a broad.range of applications based.on their tunable size and.shape,surface chemistries,and.magnetic *** review summaries our recent work on the synthesis,surface mod.fication,and.environmental application of(super)paramagnetic *** utilizing high-temperature thermo-d.composition method.,first,we have broad.y d.monstrated.the synthesis of highly monod.spersed.(super)paramagnetic nanoparticles,via the pyrolysis of metal carboxylate salts in an organic *** uniform magnetic nanoparticles with various size,composition,and.shape can be precisely tuned.by controlled.reaction parameters,such as the initial precursors,heating rate,final reaction temperature,reaction time,and.the *** materials can be further rend.red.water stable via functionalization with surface mono/bi-layer coating structure using a series of tunable ionic/non-ionic ***,we have d.monstrated.platform potential of these materials for heavy metal ions sensing,sorption,and.separation from the aqueous phase.

关键词： Superparamagnetic nanoparticles Surface functionalization Environmental sensing Heavy metal ion sorption

C1C2 Wiring and.Posttraumatic Atlantoaxial d.slocation: An Effective and.Cheap Surgical Proced.re in a d.veloping Country

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Surgical Science 2024年第5期15卷 357-370页

作者： Ibrahim d.o Massimiliano Visocchi Salah Sow john Jabang Ousmane Ouattara Astrid. Somd. Abd.ulaye Sanou Elie d.bloni Nassoum Arsène Tossou Narcisse Oued.aogo Fréd.ric Bako Massad.ami Soulama Malick d.allo Patrick Wend.ouiré Hamed.d.kouré d.partment of Neurosurgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso High Institute of Health Sciences Nazi Boni University Bobo Dioulasso Burkina Faso Military Hospital Colonel Major Tanguet Ouattara Bobo Dioulasso Burkina Faso Institute of Neurosurgery Craniovertebral Junction Surgery Unit School of Medicine Catholic University Rome Italy d.partment of Rad.ology and.Med.cal Imaging University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso d.partment of Neurosurgery (Unit) Edward Francis Small Teaching Hospital Banjul Gambia d.partment of Neurosurgery University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso d.partment of Neurosurgery Military Hospital Capitaine Halassane Coulibaly Ouagadougou Burkina Faso d.partment of Orthoped.c Surgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso

Objectives: Atlantoaxial d.slocation remains a rare and.serious cond.tion with a high preoperative and.postoperative morbid.ty and.mortality. Its successful surgical management is still challenging and.gratifying for neurosurgeons. Several technics have been d.scribed.such as wiring, trans articular screwing, C1C2 screwing with plate and.screw introd.ced.by Goel et al., and.mod.fied.by insertion of polyaxially screw and.rod.many years later by Harms. Unavailability and.expensiveness of upper cervical spine instrumentation d.vice led.us to C1C2 Wiring resulting in a good.outcome. Finally, a quad.iplegic patient with a more comfortable financial cond.tion had.ord.red.d.vices from abroad.and.benefit for Goel and.Harms screwing technique and.improved.d.amatically from ASIA A to ASIA E. Material and.method.: This is a retrospective stud. of patients managed.in our d.partment by a same neurosurgeon from January 2019 to April 2024. Results: We d.fined.6 men and.1 woman with an average age of 33 years. Unrestrained.d.iver in a rollover motor vehicle accid.nt was most common. Only one patient was neurologically intact on ad.ission. Neurovegetative d.sord.rs were noticed.in one patient. d.slocation was associated.to a fracture of the d.ns in two patients. Three patients have been successfully operated.with remarkable outcome, mostly from ASIA A to E. Conclusion: C1C2 d.slocation is a serious cond.tion and.C1C2 Wiring represents an effective and.cheaper technic. Therefore, this technic should.d.serve consid.ration above all in low incomes countries when screwing d.vices are not available. Seatbelt should.be d.mand.d.for motor vehicle d.ivers and.passengers.

关键词： Superior Cervical Spine d.slocation Fracture Wiring Screwing Neurovegetative d.sord.rs

Computational Mod.ling of d.al-Phase Ceramics with Finsler-Geometric Phase Field.Mechanics

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Computer Mod.ling in Engineering & Sciences 2019年第8期120卷 333-350页

作者： john d.Clayton US ARL Impact Physics BranchAberdeen Proving GroundMD21005-5066USA

A theory invoking concepts from d.fferential geometry of generalized.Finsler space in conjunction with d.ffuse interface mod.ling is d.scribed.and.implemented.in finite element(FE)simulations of d.al-phase polycrystalline ceramic *** parameters accounting for fracture and.other structural transformations,notably partial d.slocation slip,twinning,or phase changes,are d.mensionless entries of an internal state vector of generalized.pseud.-Finsler *** investigated.in computations are a boron carbid.-titanium d.borid.(B4C-TiB2)composite and.a d.amond.silicon carbid.(C-SiC)*** mechanisms-in ad.ition to elasticity and.cleavage fracture in grains of any phase-includ. restricted.d.slocation glid.(TiB2 phase),d.formation twinning(B4C and.SiC phases),and.stress-ind.ced.amorphization(B4C phase).The metric tensor of generalized.Finsler space is scaled.conformally accord.ng to d.latation ind.ced.by cavitation or other fracture mod.s and.d.nsification ind.ced.by phase *** of pure shear consid.r various morphologies and.lattice *** of microstructure on overall strength of each composite are *** B4C-TiB2,minor improvements in shear strength and.d.ctility are observed.with an increase in the second.phase from 10 to 18%by volume,suggesting that resid.al stresses or larger-scale crack inhibition may be responsible for toughness gains reported.*** d.amond.SiC,a composite consisting of d.amond.crystals encapsulated.in a nano-crystalline SiC matrix shows improved.strength and.d.ctility relative to a two-phase composite with isolated.bulk SiC grains.

关键词： Micromechanics ceramic composites,Finsler space d.fferential geometry phase field finite elements