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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan chen Zhesheng chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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水性上光油疑难问题分析

印刷技术 2004年第15期 112-112页

作者： john.h.chen 上海印佳印刷包装有限公司

目前,国内许多印刷厂家都已采用水性上光油,但是,在平版联机水性上光的过程中,经常会遇到许多问题.希望本文能帮助印刷厂解决实际生产中遇到的问题,提高生产效率.

关键词：联机水性上光水性上光油印刷品抗磨性实验方法干燥

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集装箱航运业的潜在机遇

中国远洋航务 2015年第2期 56-59页

作者：麦肯锡专家团队 john chen Timo Glave Martin Joerss Steve Saxon 麦肯锡新加坡分公司麦肯锡哥本哈根分公司麦肯锡北京分公司

在过去A？5年里，全I求集装箱航运业经历了严重的整体亏损。更使其雪上加霜的是，微薄的盈利还经历着剧烈波动。造成这种状况的原因有：全球金融危机以来，贸易复苏时好时坏（这是较为显著的原因）；企业客户成倍加强成本控制的力度等... 详细信息

在过去A？5年里，全I求集装箱航运业经历了严重的整体亏损。更使其雪上加霜的是，微薄的盈利还经历着剧烈波动。造成这种状况的原因有：全球金融危机以来，贸易复苏时好时坏（这是较为显著的原因）；企业客户成倍加强成本控制的力度等。如此困难的情境，其部分原因是航运公司自己造成的：在上一轮周期中，由于整个行业都判断大好时机将要到来，预计将出现一波不具有可持续性的爆发式增长，于是各大船公司都在积极增加运力。而现在看来，绝大多数运力的增加并不必要。

关键词：集装箱航运业金融危机成本控制企业客户航运公司可持续性原因船公司

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适用于VLSI隔离的光-CVD

微电子学与计算机 1988年第2期 18-23页

作者： john Yuan-tai chen Richard C.Henderson James T.Hall john W.Peters 孙建诚

本文论述了光化学增强气相淀积（光-CVD）技术在硅集成电路工艺中的应用。用光-CVD工艺在温度低到50℃淀积了SiO2薄膜(PHOTOXTM).讨论了淀积工艺、薄膜特性及PHOTOX-SiO2薄膜在晶体管之间的横向隔离和双层布线之间的纵向隔离中的应用.采... 详细信息

本文论述了光化学增强气相淀积（光-CVD）技术在硅集成电路工艺中的应用。用光-CVD工艺在温度低到50℃淀积了SiO2薄膜(PHOTOXTM).讨论了淀积工艺、薄膜特性及PHOTOX-SiO2薄膜在晶体管之间的横向隔离和双层布线之间的纵向隔离中的应用.采用PHOTOX淀积新工艺并配合光刻胶剥离可用来获得完全的等平面隔离。光-CVD还可以制作其它电介质,如氮化硅和氧化铝。

关键词： CVD 氮化硅 Hg 四氮化三硅氮化物淀积淀积速率 VLSI

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新颖独特的中国驻美使馆新建筑

中外建筑 2009年第2期 34-37页

作者：陈少明张伟峰美籍华人建筑师退休教授上海建工集团美洲有限公司总裁

在北京第二十九届奥运会开幕之际，当巨型画卷在众人面前徐徐展开时，新的中国驻美使馆及新的美国驻华使馆相继举行了开馆仪式，这说明中美外交关系新的一页已经来临。新的中国驻美使馆及新的美国驻华使馆都是它们在当地最大的使馆建筑... 详细信息

在北京第二十九届奥运会开幕之际，当巨型画卷在众人面前徐徐展开时，新的中国驻美使馆及新的美国驻华使馆相继举行了开馆仪式，这说明中美外交关系新的一页已经来临。新的中国驻美使馆及新的美国驻华使馆都是它们在当地最大的使馆建筑，单就这一事实就己表明双方对互相关系的重视。

关键词：驻华使馆中国新建筑外交关系使馆建筑奥运会美国

THE PROGRAMME OF WORK OF COMMITTEE 2 OF ICRP ON INTERNAL DOSIMETRY

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中国辐射卫生 1998年第1期 4-11页

作者： john W Stather and chen Xingan Laboratory of Industrial Hygiene,Ministry of Public Health,Beijing 100088,People’s Republic of China[KH*4〗(National Radiological Protection Board,Chilton,Didcot,Oxon OX11 ORQ UK)

ＴＨＥＰＲＯＧＲＡＭＭＥＯＦＷＯＲＫＯＦＣＯＭＭＩＴＴＥＥ２ＯＦＩＣＲＰＯＮＩＮＴＥＲＮＡＬＤＯＳＩＭＥＴＲＹＪｏｈｎＷＳｔａｔｈｅｒａｎｄＣｈｅｎＸｉｎｇａｎ（ＮａｔｉｏｎａｌＲａｄｉｏｌｏｇｉｃａｌＰｒｏｔｅｃ... 详细信息

ＴＨＥＰＲＯＧＲＡＭＭＥＯＦＷＯＲＫＯＦＣＯＭＭＩＴＴＥＥ２ＯＦＩＣＲＰＯＮＩＮＴＥＲＮＡＬＤＯＳＩＭＥＴＲＹＪｏｈｎＷＳｔａｔｈｅｒａｎｄＣｈｅｎＸｉｎｇａｎ（ＮａｔｉｏｎａｌＲａｄｉｏｌｏｇｉｃａｌＰｒｏｔｅｃｔｉｏｎＢｏａｒｄ，Ｃｈｉｌｔｏｎ...

关键词： ICRP Internal dosimetry Dosimetric model

华北克拉通东部地壳和上地幔结构的接收函数研究

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地球物理学报 2012年第11期55卷 3591-3600页

作者：郭震唐有彩陈永顺宁杰远冯永革岳汉北京大学地球与空间科学学院地球物理研究所北京100871

利用北京大学和早期中国科学院地质与地球物理研究所在华北克拉通东部地区布设的共34台宽频带地震仪记录的远震体波资料,获取P波接收函数和S波接收函数,再分别通过偏移成像和共转换点叠加(CCP)和倾斜叠加得到了华北克拉通东部横跨郯庐... 详细信息

利用北京大学和早期中国科学院地质与地球物理研究所在华北克拉通东部地区布设的共34台宽频带地震仪记录的远震体波资料,获取P波接收函数和S波接收函数,再分别通过偏移成像和共转换点叠加(CCP)和倾斜叠加得到了华北克拉通东部横跨郯庐断裂带地区沿剖面的地壳和上地幔速度间断面分布.研究结果表明,鲁西隆起下方的莫霍面的深度要比华北盆地和青岛地区浅约5km,形成类似屋顶状的莫霍面隆起.郯庐断裂带和聊考断裂带下方的莫霍面有明显的错断.岩石圈与软流圈的分界面(以下简称LAB)的深度从太行山山前的约100km深度上升到鲁西隆起下方约60km深,向东在青岛地区下方LAB深度进一步变浅.我们利用倾斜叠加计算台站下方波速比得到地壳内的泊松比变化,结果显示鲁西隆起泊松比值分布相对均匀,而青岛地区内泊松比变化剧烈,可能反应了该地区作为苏鲁大别超高压变质带的北缘经历了较为复杂的地质演化过程.

关键词：华北克拉通地壳和上地幔间断面 S波接收函数 LAB 泊松比鲁西隆起苏鲁大别超高压变质带

Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheikh Prashant Kesharwani Waleed H.Almalki Salem Salman Almujri Linxin Dai Zhe‑Sheng chen Amirhossein Sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

Fame First,Singing Second

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城市漫步（GBA版） 2024年第2期 15-17页

作者： Kirby john Carney 不详

With close to half a million W;followers on Instagram,Autumn chen knows a thing or two about growing on social *** tells us that the main two things are finding something special about you,the biggest,best one and then a smaller *** on the smaller one and"people will find you the best at where you're the most special,"she tells us over the *** says this is her number one advice for growing on social *** what's next for her?

关键词： something finding things