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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-chang Gan Xiao-Zhong Qiu Zhe-chen Gao Huan Wang Shi-Xuan chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec Mccarthy johnson V.john Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research center of clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western china Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(EcM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Projected changes in Extreme Event Indices for Alaska

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Atmospheric and climate Sciences 2024年第2期14卷 191-209页

作者： john E. Walsh Kyle Redilla Norman Shippee Lukas cheung David Bigelow Ronni Wilcock International Arctic Research center University of Alaska Fairbanks Fairbanks USA Stantec Ottawa Canada Stantec Montreal Canada Stantec Calgary Canada Two Bears Environmental consulting Anchorage USA

As climate has warmed in recent decades, Alaska has experienced a variety of high-impact extreme events that include heat waves, wildfires, coastal storms and freezing rain. Because the warming is projected to continue, it is essential to consider future changes when planning adaptation actions and building resilience. In this study, we synthesize information on future changes in extreme events in Alaska from an ensemble of regional climate model simulations performed as part of Arctic-cORDEX (coordinated Regional climate Downscaling Experiment). A set of 13 extreme event indices, based on those developed by the World climate Research Programme’s Expert Team on climate change Detection and Indices (ETccDI), are evaluated from the Arctic-cORDEX output for Alaska. Of the 13 indices, six pertain to temperature, five to total precipitation, one to wind and one to snow. The results for locations in seven different climate zones of Alaska include large increases (5˚c - 10˚c) in the temperature thresholds for the five hottest and coldest days of the year, and large increases in warm spell duration and decreases in cold spell duration. changes in the cold day temperature threshold are generally larger than the changes in the hot day temperature threshold, consistent with the projections of a stronger warming in winter than in summer in Alaska yearly maximum 1-day and 5-day precipitation amounts as well as the yearly number of consecutive wet days are projected to increase at all locations. The indices for heavy snow days and high-wind days show mixed changes, although the results indicate increases in heavy snow days at the more northern locations and increases in windy days at coastal locations. The changes in the extreme event indices continue through 2100 under the higher-emission (RcP 8.5) emission scenario, while the changes generally stabilize under the lower-emission (RcP 4.5) scenario. .

关键词： Extreme Events Temperature Precipitation Alaska climate

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Impact of Storage Temperature on Microbial Diversity and Probiotic Effect of Liquid Brewers’ Yeast

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Open Journal of Animal Sciences 2024年第3期14卷 168-182页

作者： Peter Alphonce Obuong Alaru Alfred Anakalo Shitandi Symon Maina Mahungu john Muasya Kilumba Muia Department of Dairy and Food Science and Technology Egerton University Nakuru Kenya Dairy Research Institute Kenya Agricultural and Livestock Research Organization Naivasha Kenya School of Pure and Applied Sciences Kisii University Kisii Kenya

Using probiotics as animal feed additives instead of antibiotics is gaining momentum to avert adverse negative effects on human health. Liquid brewers yeast (LBY) is an industrial by-product containing probiotic microorganisms and is also used as a protein supplement for dairy animals. Nevertheless, value chain actors lack of appropriate handling practices compromises the by-products quality and safety. This study aimed to determine the effect of variation in temperature on microbial diversity and probiotic effects during the storage time of LBY sampled from distributors and farmers from Githunguri sub-county of Kenya. The samples were stored at 20c, 25c and 30c, then tested on 0, 5, 10, 15 and 20 days. The studys parameters involved determining the pH levels, lactic acid bacteria (LAB), total coliform count (Tcc), mould, and yeast in LBY. The rate (k) of the reaction kinetics model was used to extrapolate the expected probiotic shelf life. The LAB and yeast populations were reduced in a first-order reaction at all storage temperatures. The rate of reduction in the numbers of LAB reduced with an increase in temperature (k = 0.019 and 0.023) at 20c and 30c, respectively. Yeasts highest rate of growth reduction was 25c (k = 0.009) and least at 30c (k = 0.043). The minimum effective concentration for probiotics of 106 cFU/mL needed to observe the beneficial physiological impact on farm animals was achieved between 34.9 and 35.5 days at the tested storage temperatures. The study provides insight into the unexploited low-cost probiotic potential of LBY in dairy production. conversely, handling practices and environmental microbial contamination along the value chain can compromise product quality and safety. There is a need to advocate its use in dairy for improved productivity and sensitize farmers to appropriate hygienic measures along the LBY value chain.

关键词： Liquid Brewers’ Yeast Microbial Diversity Probiotics Shelf Life

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大规模侵权案与公司策略:破产、和解还是其他

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董事会 2024年第5期 54-58页

作者：约翰·c科菲王珊珊(译) 李高宇(译) 哥伦比亚大学法学院对外经济贸易大学法学院

大规模侵权案件往往因其天价赔偿而引人注目,如何在消费者权益保护与企业存续发展之间实现精妙的平衡是一个法律难题,强生公司案与普渡制药案提供了两种思路。2023年12月,美国最高法院审理了哈灵顿诉普渡制药公司案。该案或将带来三个... 详细信息

大规模侵权案件往往因其天价赔偿而引人注目,如何在消费者权益保护与企业存续发展之间实现精妙的平衡是一个法律难题,强生公司案与普渡制药案提供了两种思路。2023年12月,美国最高法院审理了哈灵顿诉普渡制药公司案。该案或将带来三个重要影响:一是从根本上降低公司在面对大规模侵权纠纷时。

关键词：美国最高法院消费者权益保护法律难题制药公司哈灵顿侵权纠纷强生公司侵权案件

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预先通知章程:能否补强“毒丸计划”

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董事会 2024年第1期 91-95页

作者：约翰·c.科菲知诗卓玛(编译) 李高宇(编译) 哥伦比亚大学法学院对外经济贸易大学法学院

在美国公司并购领域,“毒丸计划”变得式微,而预先通知章程开始崭露头角。预先通知章程的流行引发了对冲基金界对于敏感信息披露的争议。法院也必须做好更加充分的准备,以应对未来司法可能面临的挑战“商场如战场”,军事战略和收购策略... 详细信息

在美国公司并购领域,“毒丸计划”变得式微,而预先通知章程开始崭露头角。预先通知章程的流行引发了对冲基金界对于敏感信息披露的争议。法院也必须做好更加充分的准备,以应对未来司法可能面临的挑战“商场如战场”,军事战略和收购策略存在共通之处。战场指挥官和公司并购律师都有必要意识到,昔日的王牌如今已威力不再:在无人机的注视下,坦克显得十分脆弱,它无法像以往那样叱咤战场;同样,“毒丸计划”也不再具有阻止收购的绝对防御效果,即便激进对冲基金也只是为了争夺董事会的一小部分席位而发起委托书争夺,“毒丸计划”被其规避的情况已非罕见。

关键词：对冲基金商场如战场公司并购信息披露防御效果军事战略毒丸计划董事会

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Materials-oriented integrated design and construction of structures in civil engineering—A review

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Frontiers of Structural and civil Engineering 2022年第1期16卷 24-44页

作者： Xing MING john c.HUANG Zongjin LI Institute of Applied Physics and Materials Engineering University of MacaoMacao SAR 999078China cHc Engineering LLCFairfaxVA 20030USA

Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through *** is a decision-making exploration:the design outcome may vary greatly depending on the designer’s knowledge and *** design is one type of design philosophy that takes an interdisciplinary and holistic *** civil engineering,structural design is such an activity for creating buildings and ***,structural design in many countries has emphasized a performance-based philosophy that simultaneously considers a structure’s safety,durability,serviceability,and ***,integrated design in civil engineering has become more popular,useful,and ***-oriented integrated design and construction of structures(MIDcS)combine materials engineering and structural engineering in the design stage:it fully utilizes the strengths of materials by selecting the most suitable structural forms and construction *** paper will explore real-world examples of MIDcS,including the realization of MIDcS in timber seismic-resistant structures,masonry arch structures,long-span steel bridges,prefabricated/on-site extruded light-weight steel structures,fiber-reinforced cementitious composites structures,and fiber-reinforced polymer bridge ***,advanced material design methods such as bioinspired design and structure construction technology of additive manufacturing are briefly reviewed and discussed to demonstrate how MIDcS can combine materials and structures.A unified strengthdurability design theory is also introduced,which is a human-centric,interdisciplinary,and holistic approach to the description and development of any civil infrastructure and includes all processes directly involved in the life cycle of the ***,this paper lays out future research directions for further development in the field.

关键词： integrated design and construction fiber-reinforced concrete fiber-reinforced polymer light-weight steel structures digital fabrication composites

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An Improved Evolvable Oscillator and Basis Function Set for control of an Insect-Scale Flapping-Wing Micro Air Vehicle

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Journal of computer Science & Technology 2012年第5期27卷 966-978页

作者： john c.Gallagher Michael W.Oppenheimer Department of computer Science and Engineering Wright State University control Sciences Branch Air Force Research Laboratory

This paper introduces an improved evolvable and adaptive hardware oscillator design capable of supporting adaptation intended to restore control precision in damaged or imperfectly manufactured insect-scale flapping-wing micro air vehicles. It will also present preliminary experimental results demonstrating that previously used basis function sets may have been too large and that significantly improved learning times may be achieved by judiciously culling the oscillator search space. The paper will conclude with a discussion of the application of this adaptive, evolvable oscillator to full vehicle control as well as the consideration of longer term goals and requirements.

关键词： evolvable and adaptive hardware micro air vehicle evolutionary algorithm

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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(cUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan Ling Na Wang john Shi Wei-chun Pan Qi-Zhen Du Jun-Feng Yin Tea Research Institute chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture college of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research center， Agriculture and Agri-Food canada college of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (cUMS) mouse model. Male c57BL/6J mice were divided into control， cUMS model， and cUMS+TG groups with varying doses. The cUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the cUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that cUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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Human thrombin for the treatment of gastric and ectopic varices

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World Journal of Gastroenterology 2012年第41期18卷 5912-5917页

作者： Norma c McAvoy john N Plevris Peter c Hayes Department of Hepatology University of EdinburghRoyal Infirmary of EdinburghEdinburgh EH16 4SAUnited Kingdom

AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic ***:Retrospective observational study in a Tertiary Referral *** January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic *** details including age,gender and aetiology of liver disease/segmental portal hypertension were *** thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection *** patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was *** haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin *** duration of follow up was also *** study was conducted according to the United Kingdom research ethics ***:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per ***-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy ***-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy *** re-bleeding occurred in this ***:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices.

关键词： Variceal haemorrhage Ectopic Varices Gastric varices, Portal hypertension Thrombin

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识别液态和固态水的四波段水指数及其在咸海流域的应用

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中国科学：地球科学 2024年第3期54卷 788-807页

作者：岳兵陈曦李赛博杜正平 john WILSON 杨筠慧焦毅蒙黄双燕周成虎中国科学院新疆生态与地理研究所乌鲁木齐830011 中国科学院大学资源与环境学院北京100049 中国科学院地理科学与资源研究所北京100101 Spatial Sciences Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km... 详细信息

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km^(2)到2百万km^(2)不等.因此,我们首先界定咸海流域、锡尔河和阿姆河流域以及它们的上、中、下游的边界,然后提出可识别液态水和固态水的四波段指数(ILSW),以解决传统水指数的误别偏差问题.ILSW基于绿色、红色、近红外和热红外波段反射值,是归一化差异水指数(NDWI)和地表温度(LST)的合成.验证结果显示,ILSW水指数在咸海流域的准确性远远超过其他指数.研究结果表明,南咸海的水域面积平均每年缩小963km^(2),而北咸海几乎没有变化;由于气候变暖,咸海流域上游常年冰雪面积有大幅度退缩趋势,阿姆河上游和锡尔河上游常年冰雪的退缩速率分别为年均6233和384km^(2)/a.气候变化和人类活动引起了严重的水亏问题.自20世纪90年代以来,水亏呈增长趋势,平均每年增长3.778亿m^(3).2011~2020年期间,整个咸海流域平均总水亏量为76.967亿m^(3),而锡尔河流域上游(咸海流域的一个组成部分)水盈余量为25.461亿m^(3).研究结果对制定咸海流域可持续发展战略具有重要意义.

关键词：咸海流域锡尔河流域阿姆河流域水指数水面积覆盖水亏缺气候变化

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