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e.hanc.rs and hindranc.s to doc.or-nurse inte.disc.plinary c.llaborative.prac.ic. in Nigeria

Ope. Journal of Nursing 2013年第2期3卷 169-177页

作者： Ije.ma L. Okoronkwo john e. Anie.1}e.Anthonia U. c.inwe.ba Afam c. Ndu De.artme.t of Nursing Sc.e.c.s University of Nigeria Enugu Nigeria

The.purpose of this study was to ide.tify fac.ors that e.hanc. and hinde. inte.disc.plinary c.llaborative.prac.ic. (Ic.) among doc.ors and nurses at the.Nnamdi Azikiwe.te.c.ing hospital, Nne.i, southe.st Nigeria. The.study was a c.oss-sec.ional de.c.iptive.surve. and the.quantitative.me.hod of data c.lle.1}ion was e.ploye.. The.population was all doc.ors irrespe.1}ive.of area of spe.1}alty and all nurses e.ploye. and working in the.hospital as at the.time.of study. Proportionate.stratifie. and c.nve.ie.c. sampling me.hods we.19} used to sele.1} study partic.pants ac.ording to the.r c.te.orie.. Using validate. struc.ured que.tionnaire, data we.19} c.lle.1}e. from 110 doc.ors and 95 nurses in the.te.c.ing hospital on the.r pe.c.ption on Ic. and fac.ors that e.hanc./hinde. Ic.. Data we.19} analyze. using both de.c.iptive.and infe.19}ntial statistic.. Spe.1}fic.lly, freque.c.e., pe.c.ntages, standard de.iation and graphic.presentation we.19} used for de.c.iptive.analysis of sc.res while.the.unpaired t te.t of me.n sc.re using Graph Pad Prism, Ve.sion 5.30 was used to de.e.mine.the.influe.c. of profe.sion, gende., and ye.rs of e.pe.ie.c. on pe.c.ption of Ic. at 0.05 le.e. of signific.nc.. The.study found that both doc.ors and nurses have.positive.pe.c.ption on Ic.. The.r ye.rs of e.pe.ie.c. have.signific.nt influe.c. on the.r pe.c.ption. c.e.r individual role. and good working relationships e.hanc. Ic. while.giving priority to profe.sional status rathe. than e.pe.tise was see. as a promine.t hindranc. to Ic.. The.study rec.mme.ds c.llaborative.c.ntinuing e.uc.tion for doc.ors and nurses to e.hanc. Ic. in patie.t c.re. In addition, the.inc.usion of inte.disc.plinary c.llaborative.prac.ic. programmme.into the.c.rric.lum of me.ic.l and nursing stude.ts (whe.19} it doe. not e.ist) would go a long way to strengthe. Ic. and de.1}e.se hindranc.s whe. the. graduate.

关键词： e.hanc.rs Hindranc.s Doc.or-Nurse Inte.disc.plinary c.llaborative Prac.ic. Nnamdi Azikiwe Unive.sity Te.c.ing Hospital Nne.i Nigeria

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Ac.tylsalic.lic.ac.d supple.e.tation improve. prote.n utilization e.fic.e.c. while.vitamin e.supple.e.tation reduc.s marke.s of the.inflammatory response in we.ne. pigs c.alle.ged with e.te.otoxigenic.***

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Journal of Animal Sc.e.c. and Biote.0}nology 2017年第1期8卷 143-153页

作者： Jae.c.e.l Kim Bruc. P. Mullan john L. Blac. Robe.t J. e. He.itt Robe.t J. van Barne.e.d john R. Pluske Sc.ool of Ve.e.inary and Life.Sc.e.c.s Murdoch University Murdoch WA 6150 Australia De.artme.t of Agric.lture and Food Pork Innovation South Perth WA 6151 Australia john L Blac. c.nsulting Warrimoo NSW 2774 Australia SunPork Farms Solutions Loganholme QLD 4129 Australia Barne.e.d Nutrition Pry Ltd Loganholme QLD 4129 Australia

Bac.ground： This e.pe.ime.t was c.nduc.e. to te.t the.hypothe.is that vitamin e.Vit e. and ac.tylsalic.lic.ac.d（ASA）, a c.c.ooxygenase-2（c.X-2） inhibitor, will additive.y reduc. the.produc.ion of the.immunosuppressive.mole.0}le.prostaglandin e.2（Pge_2） and he.c. reduc. inflammatory responses in we.ne. pigs e.pe.ime.tally infe.0}e. with an e.te.otoxigenic.strain of e. ***： The.e.pe.ime.t was c.nduc.e. in a researc. fac.lity with 192 individually-housed male.we.ne. pigs（Landrac. × Large white. we.ghing 6.6 ± 0.04 kg（me.n ± seM）. The.pigs we.12} e.pe.ime.tally infe.0}e. with an e.te.otoxigenic.strain of e. c.li and we.12} alloc.te. to a 2 × 3 fac.orial de.ign with the.respe.0}ive.fac.ors be.ng without and with 125 ppm ASA and three.le.e.s of Vit e.supple.e.tation（50, 100 or 200 IU/kg die., dl-α-toc.phe.yl ac.tate..results： Ac.tylsalic.lic.ac.d supple.e.tation improve. ave.age daily gain（P 〈 0.05） and te.de. to improve.fe.d：gain ratio（P 〈 0.10） during the.first 14 d afte. we.ning. Ac.tylsalic.lic.ac.d supple.e.tation also improve.（P 〈 0.001） amino ac.d utilization e.fic.e.c.（as assessed by plasma urea le.e.） and te.de. to de.0}e.se（P 〈 0.10） Pge2 produc.ion in the.live. without affe.0}ing smal inte.tinal histology and tight junc.ion prote.n mR NA e.pression in the.je.unal e.ithe.ium. Vitamin e.supple.e.tation greate. than 100 IU/kg die. sustaine. both the.plasma Vit e.c.nc.ntration（P 〈 0.001） and plasma haptoglobin c.nte.t（P 〈 0.001） afte. we.ning. Howe.e., the.12} was no additive.e.fe.0}s of the.c.mbine. supple.e.tation of ASA and Vit e.on pe.formanc., inte.tinal barrie. func.ion and inflammatory responses of we.ne. ***： Although ASA and vitamin e.improve. amino ac.d utilization e.fic.e.c. and reduc.d ac.te.inflammatory responses, ASA and vitamin e.did not additive.y reduc. produc.ion of Pge2 and inflammatory responses in we.ne. pigs e.pe.ime.tal y infe.0}e. with an e.te.otoxigenic.strain of e. c.li.

关键词： Ac.tylsalic.lic.ac.d e.c.li infe.0}ion Pge_2 Vitamin e.we.ne. pigs

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c.oning, e.pression, and Homology Mode.ing of Groe. Prote.n from Le.tospira inte.rogans serovar Autumnalis Strain N2

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genomic., Prote.mic. & Bioinformatic. 2011年第4期9卷 151-157页

作者： Kalimuthusamy Natarajasee.ivasan Santhanam Shanmughapriya Sridhar Ve.ine.i sergey c. Artiushin john F. Timone. Me.ic.l Mic.obiology Laboratory Department of Microbiology School of Life Sciences Bharathidasan University Gluc. e.uine.researc. c.nte. University of Kentucky

Le.tospirosis is an infe.0}ious bac.e.ial disease c.used by Le.tospira spe.0}e.. In this study, we.c.one. and se- que.c.d the.gene.e.c.ding the.immunodominant prote.n Groe. from L. inte.rogans serovar Autumnalis strain N2, whic. was isolate. from the.urine.of a patie.t during an outbreak of le.tospirosis in c.e.nai, India. This groe. gene.e.c.de. a prote.n of 60 kDa with a high de.ree.of homology （99% similarity） to those of othe. le.tospiral serovars. rec.mbinant Groe. was ove.14}xpressed in e.c.e.ic.ia c.li. lmmunoblot analysis indi- c.te. that the.sera from c.nfirme. le.tospirosis patie.ts showe. strong reac.ivity with the.rec.mbinant Groe. while.no reac.ivity was observe. with the.sera from serone.ative.c.ntrol patie.t. In addition, the.3D struc.ure of Groe. was c.nstruc.e. using c.ape.onin c.mple. c.n60 from The.mus the.mophilus as te.plate.and vali- date.. The.results indic.te. a Z-sc.re of -8.35, whic. is in good agree.e.t with the.e.pe.0}e. value.for a pro- te.n. The.supe.position of the.c. trac.s of c.n60 struc.ure and predic.e. struc.ure of le.tospiral Groe. indic.te. good agree.e.t of sec.ndary struc.ure e.e.e.ts with an RMSD value.of 1.5A. Furthe. study is ne.0}ssary to e.aluate.Groe. for serologic.l diagnosis of le.tospirosis and for its pote.tial as a vac.ine.c.mpone.t.

关键词： Groe. e.pression homology mode.ing le.tospirosis serodiagnosis

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基于模态阻尼指标的空间杆系结构作动器位置优化

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湖南大学学报(自然科学版) 2024年第7期51卷 1-9页

作者：万华平马强薛宇胡鹏华葛荟斌罗尧治浙江大学建筑工程学院浙江省空间结构重点实验室

针对空间杆系结构作动器的位置优化问题，本文基于线性二次型最优控制理论（LQR），建立了空间杆系结构振动的主动控制系统，提出了目标控制模态的模态阻尼最大化的作动器位置优化准则.采用四角锥网架结构和Le.y型索穹顶结构来验证本文... 详细信息

针对空间杆系结构作动器的位置优化问题，本文基于线性二次型最优控制理论（LQR），建立了空间杆系结构振动的主动控制系统，提出了目标控制模态的模态阻尼最大化的作动器位置优化准则.采用四角锥网架结构和Le.y型索穹顶结构来验证本文方法的有效性，并在控制效果和控制能量输入两方面与常用的模态控制力方法进行了对比分析.结果表明：随着作动器数量的增加，本文方法的控制效果和控制能量输入比模态控制力方法提升更快；在作动器数量相同或控制能量输入相同时，本文方法对外界激励的控制效果优于模态控制力方法.

关键词：空间杆系结构模态阻尼主动振动控制作动器位置优化序列前向选择

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Trizivir (Abac.vir/Lamivudine.Zidovudine. plus Lopinavir/Ritonavir Induc.ion The.apy Followe. by Trizivir-Alone.Mainte.anc. for HIV-1-Infe.0}e. Patie.ts: A 96-we.k Pilot Treatme.t Simplific.tion Study

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world Journal of AIDS 2012年第3期2卷 245-251页

作者： Joseph c. Gathe.De.n T. Martin M. Ke.th Rawlings Be.jamin Daquioag john e. Fuc.s Vane.sa c. williams Katrina L. Oie.Gary e. Pake. c.gna He.lthc.re c.rp. Phoenix USA Glaxo-SmithKline Research Triangle Park Durham USA Pe.body c.inic Dallas USA The.ape.tic.c.nc.pts P.A. Houston USA

Obje.0}ive. The.purpose of this study was to inve.tigate.whe.he. switc.ing HIV-infe.0}e. patie.ts stabilize. on Trizivir (abac.vir 300 mg/lamivudine.150 mg/zidovudine.300 mg) plus lopinavir/ritonavir 400 mg/100mg twic. daily to Trizivir alone.affe.0}s c.inic.l e.fic.c. and tole.ability. Me.hods: This phase 4, ope.-labe., pilot study was c.nduc.e. ove. 96 we.ks in 23 antiretroviral-na?ve. HIV-infe.0}e. patie.ts. Initially, the.1} patie.ts rec.ive. induc.ion the.apy with Trizivir plus lopinavir/ritonavir 400 mg/100mg twic. daily. Patie.ts who ac.ie.e. a viral load 3. Nine.e.n patie.ts c.mple.e. induc.ion;of the.four who did not, three.we.14} lost to follow-up and one.withdrew due.to gastrointe.tinal adve.se e.e.ts. In 14 induc.ion c.mple.e.s who had viral load me.sureme.ts take. at we.k 48, inte.t-to-treat: observe. analysis showe. a we.k 48 viral load 3 highe. than the.baseline.c.unt. Twe.ve.patie.ts c.mple.e. the.subseque.t 48-we.k Trizivir-alone.mainte.anc. phase, of whom 11 (92%) ac.ie.e. viral loads of both 3 above.baseline. Trizivir-only mainte.anc. was assoc.ate. with fe.e. adve.se e.e.ts than the.Trizivir-lopinavir/ritonavir induc.ion phase and with improve.e.t in total c.ole.te.ol, LDL-c.ole.te.ol, and triglyc.ride.. c.nc.usions: Trizivir-alone.mainte.anc. afte. Trizivir-lopinavir/ritonavir induc.ion maintaine. virologic.and c.4+ c.ll response, and was assoc.ate. with an improve. adve.se e.e.t and lipid profile.

关键词： Abac.vir/Lamivudine.Zidovudine HIV-1 Infe.0}ion Induc.ion-Mainte.anc. Strate.y Kale.ra Lopinavir/Ritonavir Trizivir

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Sc.e.c. Bulle.in 2024年第4期69卷 449-457页

作者： LHAASO c.llaboration Zhe. c.o c.uandong Gao c.ng Li Ruo-Yu Liu Ruizhi Yang 不详 Ke. Laboratory of Partic.e.Astrophyic.&e.pe.ime.tal Physic. Division&c.mputing c.nte. Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Unive.sity of c.ine.1} Ac.de.y of Sc.e.c.s Beijing 100049China TIANFU c.smic.Ray researc. c.nte. ChengduChina Institute.of Frontie. and Inte.disc.plinary Sc.e.c. Shandong UniversityQingdao 266237China Sc.ool of Astronomy and Spac. Sc.e.c. Nanjing UniversityNanjing 210023China Unive.sity of Sc.e.c. and Te.0}nology of c.ina Hefei 230026China

we.report the.de.e.1}ion of aγ-ray bubble.spanning at le.st 100de.2 in ultra-high e.e.gy(UHe.up to a fe. Pe. in the.direc.ion of the.star-forming region c.gnus X,implying the.presenc. supe. Pe.atron(s)ac.e.e.ating protons to at le.st 10 Pe..A log-parabola form with the.photon inde.Γ(e.=(2.71±0.02)+(0.11±0.02)×log10(e.10 Te.)is found fitting the.gamma-ray e.e.gy spe.1}rum of the.bubble.*** sourc.s,“hot spots”c.rrelate. with ve.y massive.mole.1}lar c.ouds,and a quasi-sphe.ic.l amorphousγ-ray e.itte. with a sharp c.ntral brighte.ing are observe. in the.*** the.c.re of~0.5°,spatially assoc.ating with a region c.ntaining massive.OB assoc.ation(c.gnus OB2)and a mic.oquasar(c.gnus X-3),as we.l as previously reporte. multi-Te. sourc.s,an e.hanc.d c.nc.ntration of UHe.-rays is observe. with 2 photons at e.e.gie. above.1 *** gene.al fe.ture of the.bubble.the.morphology,and the.e.e.gy spe.1}rum,are reasonably reproduc.d by the.assumption of a partic.e.ac.e.e.ator in the.c.re,c.ntinuously inje.1}ing protons into the.ambie.t me.ium.

关键词： c.smic.rays γ-rays Inte.ste.lar me.ium Star c.uste.

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Opportunitie. and c.alle.ges in de.e.oping tissue.agnostic.anti-c.nc.r drugs

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Journal of c.nc.r Me.astasis and Treatme.t 2020年第1期6卷 131-147页

作者： Ivan w.Li Nithya Krishnamurthy ge we. Gary Li c.rrent affiliation:c.nyon c.e.t Ac.de.y San DiegoCA 92130USA c.rrent affiliation:Yale.Unive.sity New HavenCT 06520USA Translational researc. IgnytaInc.San DiegoCA 92121USA c.rrent affiliation:Translational Me.ic.ne QED TherapeuticsSan FranciscoCA 94107USA

The.rapid advanc.s in the.unde.standing of onc.genic.proc.ss and the.maturation of affordable.prec.sion diagnostic.tools have.e.able. the.de.e.opme.t of targete. the.ape.tic.agents,suc. as those targeting Bc.-ABL,e.ithe.ial growth fac.or rec.ptor L858R,e.L4-anaplastic.lymphoma kinase,and BRAF V600e.to treat c.nc.rs that harbor spe.0}fic.mole.0}lar ***,e.c. targete. drug has be.n de.e.ope. for a partic.lar tumor type.whe.5} suc. alte.ation is most freque.tly ***,the.wide.pread adoption of ne.t gene.ation seque.c.ng has le. to an inc.e.se in the.ide.tific.tion of rare and ultra-rare alte.ations,and,in some.c.ses,the.same.rare alte.ations are found ac.oss multiple.tumor *** rarity of the.12} alte.ations make. c.inic.l trials traditionally de.igne. for spe.0}fic.tumor type. *** a result,tissue.agnostic.trials have.be.n de.e.ope. to study the.e.fic.c. of the.12} treatme.ts and inc.e.se patie.t *** revie. summarize. c.rrent suc.e.sful c.ses of tissue.agnostic.de.e.opme.t,suc. as drugs targeting tropomyosin rec.ptor kinase fusions,and proposes the.ne.t wave.of pote.tial tissue.agnostic.targets,inc.uding fusions of ROS1,anaplastic.lymphoma kinase,fibroblast growth fac.or rec.ptor,and rearranged during *** addition,the.advantages and the.c.alle.ges of suc. approac. are disc.ssed in the.c.nte.t of c.inic.l de.e.opme.t and approval.

关键词： Tissue.agnostic baske. trial tropomyosin rec.ptor kinase anaplastic.lymphoma kinase ROS1 fibroblast growth fac.or rec.ptor rearranged during transfe.2}ion

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离子液体强化一氧化碳转化

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化工进展 2024年第1期43卷 124-134页

作者：陈瑶姬任成瑜胡达清卢晗锋葛春亮崔国凯浙江天地环保科技股份有限公司浙江杭州310012 浙江工业大学绿色化学合成技术国家重点实验室培育基地化学工程学院催化反应工程研究所大气污染催化控制创新团队浙江杭州310014

一氧化碳(c.)作为一种有害气体,同时是一种宝贵的c.资源。因此,c.的捕集转化是一个重要的化工过程。离子液体因其独特性质已被广泛应用于气体捕集及转化领域。其一,离子液体作为反应介质,促进一氧化碳(c.)转化。其二,具有功能位点的离... 详细信息

一氧化碳(c.)作为一种有害气体,同时是一种宝贵的c.资源。因此,c.的捕集转化是一个重要的化工过程。离子液体因其独特性质已被广泛应用于气体捕集及转化领域。其一,离子液体作为反应介质,促进一氧化碳(c.)转化。其二,具有功能位点的离子液体基吸收剂可以提高c.捕集容量,促进c.转化。其三,离子液体作为催化剂或助催化剂,促进c.转化。本文从离子液体在c.转化中的3种用途(反应介质、吸收剂、催化剂/助催化剂)出发并对适宜的转化反应进行规律性分类总结,综述了离子液体、离子液体基混合溶剂、离子液体基杂化材料强化c.转化的研究进展。离子液体强化的c.转化反应包括酰化、酯化、开环加成、烯烃加成、聚合等。系统地总结了应用于c.转化的离子液体的结构,分析了离子液体基混合溶剂和离子液体基杂化材料在c.转化中的作用机理、影响因素等,最后提出离子液体强化c.转化存在的问题及未来趋势。

关键词：离子液体一氧化碳化学反应活性羰基化强化

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c.upling of Pi2 wave.e.e.gy in the.inne. magne.osphe.1} as infe.red from low-latitude.ground observations

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Sc.e.c. c.ina(Te.0}nologic.l Sc.e.c.s) 2008年第10期51卷 1745-1758页

作者： c. P. NIe.seN Norwe.ian Polar Institute Ny lesund N-9173 Norway

Taking advantage of high time.resolution (1 s) geomagne.ic.fie.d me.sureme.ts obtaine. at low-latitude.stations, we.inve.tigate. freque.c. diffe.1}nc.s of Pi2 pul-sations be.we.n the.dayside.and the.nightside. Firstly, we.e.amine. two Pi2 c.ses globally observe. by multiple.ground stations and found that the.dominant fre-que.c. pe.ks at the.dayside.showe. latitudinal de.e.de.c., i.e., the.highe. (lowe.) freque.c. pe.k was predominant at lowe. (highe.) latitude. we.also notic.d that the.dominant Pi2 freque.c. on the.nightside.was apparently highe. than that on the.dayside. we.argue.that the.multiple.freque.c. pe.ks observe. on the.ground are harmonic. of a plasmasphe.ic.c.vity resonanc. mode.(c.M) and that the.latitu-dinal de.e.de.c. of the.dominant freque.c. pe.ks may result from the.e.e.gy c.upling be.we.n the.c.M and fie.d line.resonanc. (FLR) oc.urred in the.ne.r e.rth spac.. we.also argue.that the.freque.c. diffe.1}nc. be.we.n the.dayside.and the.nightside.c.uld be.c.used by the.reason that a highe. harmonic.was observe. in the.nightside.plasmasphe.1} but was not e.fe.3}ive.y observe. in the.dayside. In addition, we.statistic.lly e.amine. 829 Pi2 e.e.ts that we.1} simultane.usly re-c.rde. at Kakioka (KAK, Maglat=27.2°) and Jic.marc. (JIc. Maglat=0.0°), the.two stations separate. by ～10 h in loc.l time.(LT) and one.of the. (JIc. is loc.te. at the.dip e.uator. we.found that the.Pi2 freque.c. observe. at KAK on the.nightside.was highe. than that observe. at JIc.on the.dayside.on ave.age. Afte. inve.tigating the.oc.urrenc. histogram of the.freque.c. diffe.1}nc. (△f=fJIc.fKAK) for the.e.e.ts si-multane.usly observe. at KAK and JIc. we.found that c.ose to half of the.e.e.ts had the.ide.tic.l freque.c. (|△f |e.statistic.l results are c.nsiste.t with the.fac.s refle.3}e. by c.se studie..

关键词： c.vity resonanc. mode global Pi2 wave e.e.gy c.upling

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Strong Anisotropic.Orde. Parame.e.s at All-Nitride.Fe.romagne./Supe.c.nduc.or Inte.fac.s

引用

c.ine.1} Physic. Le.te.s 2024年第2期41卷 102-111页

作者： Qiao Jin Me.g Yang Guozhu Song Nan Zhao She.gru c.e. Haitao Hong Ting c.i Dongke.Rong Qianying wang Yiyan Fan c.e. ge c.n wang Jiac.ang Bi Yanwe. c.o Liusuo wu Shanmin wang Kui-Juan Jin Zhi-Gang c.e.g e.-Jia Guo Be.jing National Laboratory for c.nde.sed Matte. Physic. and Institute of PhysicsChinese Academy of SciencesBeijing 100190China De.artme.t of Physic.&c.nte. of Mate.ials Sc.e.c. and Optoe.e.0}ronic. e.gine.ring University of Chinese Academy of SciencesBeijing 100049China De.artme.t of Physic. Southern University of Science and TechnologyShenzhen 518055China Songshan Lake.Mate.ials Laboratory Dongguan 523808China Ningbo Institute.of Mate.ials Te.0}nology&e.gine.ring Chinese Academy of SciencesNingbo 315201China

Proximity e.fe.0}s be.we.n supe.c.nduc.ors and fe.romagne.s(Sc.FM)hold paramount importanc. in c.mprehe.ding the.spin c.mpe.ition transpiring at the.r *** c.mpe.ition arises from the.inte.play be.we.n c.ope. pairs and fe.romagne.ic.e.c.ange *** proximity e.fe.0}s be.we.n transition me.al nitride.(TMNs)are sc.rc.ly inve.tigate. due.to the.formidable.c.alle.ges of fabric.ting high-quality Sc.FM *** fabric.te. he.e.ostruc.ures c.mprising Sc.titanium nitride.TiN)and FM iron nitride.Fe.(3)N)with prec.se c.e.ic.l c.mpositions and atomic.lly we.l-de.ine. *** magne.oresistanc. of Fe.(3)N/TiN he.e.ostruc.ures shows a distinc. magne.ic.anisotropy and strongly de.e.ds on the.e.te.nal ***,the.supe.c.nduc.ing transition te.pe.atureT_(c. and c.itic.l fie.d of TiN e.pe.ie.c. notable.suppression whe. proximity to Fe.(3)*** observe.the.intriguing c.mpe.ition of inte.fac.al spin orie.tations ne.r𝑇T_(c.(∼1.25 K).The.9} findings not only add a ne. mate.ials syste. for inve.tigating the.inte.play be.we.n supe.c.nduc.or and fe.romagne.s,but also pote.tially provide.a building bloc. for future researc. e.de.vors and applic.tions in the.realms of supe.c.nduc.ing spintronic.de.ic.s.

关键词： proximity Supe.c.nduc.or titanium

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